Publications: Mr Emanuel Rognoni

Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS et al. ( 2025 ) . Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma . Cancer Communications

Garcha P, Petrof G, Martinez A, McGrath JA, O’Toole EA, Rognoni E, Caley M ( 2024 ) . 182 Dissecting Epidermolysis Bullosa Heterogeneity . Journal of Investigative Dermatology vol. 144 , ( 12 )

Giusto E, Jones E, Ahmed A, Cottle D, Smyth I, Caley M, Rognoni E, O’Toole EA ( 2024 ) . 232 JAK Inhibitors to Restore Skin Barrier Function in a Mouse Model of Harlequin Ichthyosis . Journal of Investigative Dermatology vol. 144 , ( 12 )

Pereira DG, Annusver K, Kirk TB, Yadav S, Matuck B, Byrd K, Rognoni E, O’Toole EA et al. ( 2024 ) . 517 Multiomics Atlas of oral and skin tissues reveals fibroblast heterogeneity . Journal of Investigative Dermatology vol. 144 , ( 12 )

Tekkela S, Drudi E, Shaw TJ, Philpott M, O’Toole EA, Rognoni E ( 2024 ) . 521 Transcriptional and epigenetic changes drive increased cellular plasticity in keloid fibroblasts . Journal of Investigative Dermatology vol. 144 , ( 12 )

Jones EM, Garcha P, Aumailley M, O'Toole EA, Rognoni E, Caley M ( 2024 ) . Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes . JID Innovations vol. 5 , ( 2 )

Macken JH, Senusi A, O’Toole EA, Caley M, Rognoni E, Fortune F ( 2024 ) . Erosive lichen planus: an unmet disease burden . Frontiers in Medicine vol. 11 ,

Kirk T, Ahmed A, Bensa T, Tekkala S, Khan M, Connelly J, Rognoni E ( 2024 ) . O15 Transcriptomic profiling reveals regulators of dermal fibroblast state switching . British Journal of Dermatology vol. 190 , ( 6 ) e75 - e75 .

Jones E, Garcha P, Aumailley M, O’Toole E, Rognoni E, Caley M ( 2024 ) . O19 Improvement of a junctional epidermolysis bullosa mouse model . British Journal of Dermatology vol. 190 , ( 6 ) e77 - e77 .

Garcha P, Jones E, Ahmed AA, Aumailley M, Rognoni E, Caley M ( 2024 ) . O20 Dissecting junctional epidermolysis bullosa heterogeneity . British Journal of Dermatology vol. 190 , ( 6 ) e77 - e78 .

Giusto E, Jones E, Enjalbert F, Ahmed A, Caley M, Rognoni E, O’Toole E ( 2024 ) . P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis . British Journal of Dermatology vol. 190 , ( 6 ) e83 - e84 .

Tekkela S, Hight-Warburton W, Shaw T, Philpott M, O’Toole E, Rognoni E ( 2024 ) . P12 Transcriptional and epigenetic changes drive increased cellular plasticity in keloid fibroblasts . British Journal of Dermatology vol. 190 , ( 6 ) e84 - e84 .

Khan MRA, Kirk T, Caley MP, Rognoni E ( 2024 ) . P16 Fibroblast signalling crosstalk drives junctional epidermolysis bullosa disease progression . British Journal of Dermatology vol. 190 , ( 6 ) e86 - e86 .

Ahmed A, Kirk T, O’Toole E, Rognoni E ( 2024 ) . P17 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis . British Journal of Dermatology vol. 190 , ( 6 ) e86 - e87 .

Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL et al. ( 2024 ) . Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro . Journal of Investigative Dermatology vol. 144 , ( 10 ) 2314 - 2317.e3 .

Bensa T, Tekkela S, Rognoni E ( 2023 ) . Skin fibroblast functional heterogeneity in health and disease . The Journal of Pathology vol. 260 , ( 5 ) 609 - 620 .

Giusto E, Enjalbert F, Rognoni E, Caley M, O’Toole E ( 2023 ) . O13 JAK inhibitors to restore skin barrier function in ARCI . British Journal of Dermatology vol. 189 , ( 1 ) e9 - e10 .

Ahmed A, Kirk T, Forster L, O’Toole E, Gupta H, Rognoni E ( 2023 ) . P08 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis . British Journal of Dermatology vol. 189 , ( 1 ) e17 - e17 .

Tekkela S, Drudi EM, Shaw T, Philpott M, O’Toole E, Rognoni E ( 2023 ) . P31 Dissecting the epigenetic and transcriptional regulators in keloid scars . British Journal of Dermatology vol. 189 , ( 1 ) e26 - e26 .

Ahmed A, Rognoni E, Kirk T, O'Toole E ( 2023 ) . ISID1458 - Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis .

Ahmed A, Kirk T, Forster L, O'Toole E, Gupta H, Rognoni E ( 2023 ) . 1458 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis . Journal of Investigative Dermatology vol. 143 , ( 5 )

Kirk T, Ahmed A, Connelly J, Rognoni E ( 2023 ) . 1512 Combined transcriptome and epigenome profiling reveal regulators of dermal fibroblast state switch . Journal of Investigative Dermatology vol. 143 , ( 5 )

Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E, Caley M ( 2023 ) . 753 Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa . Journal of Investigative Dermatology vol. 143 , ( 5 )

Kirk T, Ahmed A, Connelly J, Rognoni E ( 2022 ) . 591 Exploring the molecular basis for the dermal fibroblast state switch . Journal of Investigative Dermatology vol. 142 , ( 12 )

Pereira DG, Kirk T, Mavros A, Rognoni E, O’Toole EA, Kasper M, Sequeira I ( 2022 ) . 603 Dissecting the role of fibroblasts in homeostasis and wound healing of the oral mucosa . Journal of Investigative Dermatology vol. 142 , ( 12 )

Ahmed A, Kirk T, O’Toole EA, Rognoni E ( 2022 ) . 626 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis . Journal of Investigative Dermatology vol. 142 , ( 12 )

Mariniello K, Pittaway J, Hadjidemetriou I, Borges K, Doroszko M, Doghman M, Lalli E, Rahman N et al. ( 2022 ) . Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice . Endocrine Abstracts

Ahmed A, Kirk T, O'Toole E, Rognoni E ( 2022 ) . ESDR627 - Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis .

Pereira D, Kirk T, Mavros A, Rognoni E, O'Toole E, Kasper M, Sequeira I ( 2022 ) . ESDR603 - Dissecting the role of fibroblasts in homeostasis and wound healing of the oral mucosa .

Sipilä K, Rognoni E, Jokinen J, Tewary M, Vietri Rudan M, Talvi S, Jokinen V, Dahlström KM et al. ( 2022 ) . Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism . Developmental Cell vol. 57 , ( 12 ) 1453 - 1465.e7 .

Mariniello K, Guasti L, Rognoni E ( 2022 ) . DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland . Endocrine Abstracts

Rognoni E ( 2022 ) . Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration . Journal of Investigative Dermatology vol. 142 , ( 6 ) 1516 - 1519 .

Rognoni E, Goss G, Hiratsuka T, Sipilä KH, Kirk T, Kober KI, Lui PP, Tsang VS et al. . Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage . eLife . vol. 10 ,

Kirk T, Ahmed A, Rognoni E ( 2021 ) . Fibroblast Memory in Development, Homeostasis and Disease . Cells vol. 10 , ( 11 )

Rognoni E, Goss G, Hiratsuka T, Lui P, Hawkshaw N, Pilkington S, Ali N, Rhodes L et al. ( 2021 ) . 297 Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage . Journal of Investigative Dermatology vol. 141 , ( 10 )

Goss G, Rognoni E, Salameti V, Watt FM ( 2021 ) . Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair . Frontiers in Cell and Developmental Biology vol. 9 ,

Shaw TJ, Rognoni E ( 2020 ) . Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease . Curr Rheumatol Rep vol. 22 , ( 8 ) 33 - 33 .

Mariniello K, Rognoni E, Guasti L ( 2020 ) . SUN-LB43 DLK1 Expressing Cells Contribute to the Zonation of the Adrenal Gland . Journal of the Endocrine Society vol. 4 , ( Supplement_1 ) sun - lb43 .

Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman S et al. ( 2019 ) . 581 A genome-wide screen identifies YAP/WBP2/TEAD interplay conferring growth advantage on human epidermal stem cells . Journal of Investigative Dermatology . vol. 139 ,

Walko G, Lichtenberger B, Rognoni E ( 2019 ) . A genome-wide screen identifies YAP/WBP2/TEAD interplay conferring growth advantage on human epidermal stem cells .

Rognoni E, Walko G ( 2019 ) . The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin . Cells vol. 8 , ( 5 ) 411 - 411 .

Oulès B, Rognoni E, Hoste E, Goss G, Fiehler R, Natsuga K, Quist S, Mentink R et al. ( 2019 ) . Mutant Lef1 controls Gata6 in sebaceous gland development and cancer . The EMBO Journal vol. 38 , ( 9 )

Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA, Philippeos C, Dilão R et al. ( 2018 ) . Fibroblast state switching orchestrates dermal maturation and wound healing . Molecular Systems Biology vol. 14 , ( 8 ) e8174 - e8174 .

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A et al. ( 2018 ) . Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation . PLOS ONE vol. 13 , ( 6 ) e0199679 - e0199679 .

Rognoni E, Watt FM ( 2018 ) . Skin Cell Heterogeneity in Development, Wound Healing, and Cancer . Trends in Cell Biology vol. 28 , ( 9 ) 709 - 722 .

Telerman SB, Rognoni E, Sequeira I, Pisco AO, Lichtenberger BM, Culley OJ, Viswanathan P, Driskell RR et al. ( 2017 ) . Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth . Journal of Investigative Dermatology vol. 137 , ( 11 ) 2270 - 2281 .

Donati G, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, Kayikci M, Russell R et al. ( 2017 ) . Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties . Nature Cell Biology vol. 19 , ( 6 ) 603 - 613 .

Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB et al. ( 2017 ) . A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells . Nature Communications vol. 8 , ( 1 )

Kaushal G, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM ( 2016 ) . Reply to Chi et al . Journal of Investigative Dermatology vol. 137 , ( 1 ) 247 - 248 .

Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR ( 2016 ) . Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing . Development vol. 143 , ( 14 ) 2522 - 2535 .

Hermann M-R, Jakobson M, Colo GP, Rognoni E, Jakobson M, Kupatt C, Posern G, Fässler R ( 2016 ) . Integrins synergise to induce expression of the MRTF-A–SRF target gene ISG15 for promoting cancer cell invasion . Journal of Cell Science vol. 129 , ( 7 ) 1391 - 1403 .

Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K et al. ( 2016 ) . Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin . eLife vol. 5 ,

Rognoni E, Ruppert R, Fässler R ( 2016 ) . The kindlin family: functions, signaling properties and implications for human disease . Journal of Cell Science vol. 129 , ( 1 ) 17 - 27 .

Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM ( 2015 ) . Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation . Journal of Investigative Dermatology vol. 135 , ( 12 ) 2926 - 2934 .

Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu W-H, Schulz AS, Oostendorp RAJ et al. ( 2015 ) . Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells . Journal of Experimental Medicine vol. 212 , ( 9 ) 1415 - 1432 .

Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE et al. ( 2014 ) . Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation . Nature Medicine vol. 20 , ( 4 ) 350 - 359 .

Fraccaroli A, Franco CA, Rognoni E, Neto F, Rehberg M, Aszodi A, Wedlich-Söldner R, Pohl U et al. ( 2012 ) . Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina . PLOS ONE vol. 7 , ( 10 )

Widmaier M, Rognoni E, Radovanac K, Azimifar SB, Fässler R ( 2012 ) . Integrin-linked kinase at a glance . Journal of Cell Science vol. 125 , ( 8 ) 1839 - 1843 .

Holzmüller R, Mantwill K, Haczek C, Rognoni E, Anton M, Kasajima A, Weichert W, Treue D et al. ( 2011 ) . YB‐1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma . International Journal of Cancer vol. 129 , ( 5 ) 1265 - 1276 .

Rognoni E, Widmaier M, Haczek C, Mantwill K, Holzmüller R, Gansbacher B, Kolk A, Schuster T et al. ( 2009 ) . Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo . Cancer Gene Therapy vol. 16 , ( 10 ) 753 - 763 .

Ussar S, Moser M, Widmaier M, Rognoni E, Harrer C, Genzel-Boroviczeny O, Fässler R ( 2008 ) . Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction . PLOS Genetics vol. 4 , ( 12 )