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Research

Publications: Prof Victoria Marta Sanz-Moreno

George S, Georgouli M, Sanz-Moreno V ( 2022 ) . Protocol to drive human monocyte-to-macrophage polarization in vitro using tumor conditioned media . STAR Protocols vol. 3 , ( 4 )
Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V, Malanchi I ( 2022 ) . Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth . Cancer Letters vol. 544 ,
Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG et al. ( 2022 ) . Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment . Cancer Research vol. 82 , ( 10 ) 1909 - 1925 .
Graziani V, Rodriguez-Hernandez I, Maiques O, Sanz-Moreno V ( 2022 ) . The amoeboid state as part of the epithelial-to-mesenchymal transition programme . Trends in Cell Biology vol. 32 , ( 3 ) 228 - 242 .
Adams R, Osborn G, Mukhia B, Laddach R, Willsmore Z, Chenoweth A, Geh JLC, MacKenzie Ross AD et al. ( 2022 ) . Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies . OncoImmunology vol. 11 , ( 1 )
Maiques O, Sanz-Moreno V ( 2022 ) . Location, location, location: Melanoma cells “living at the edge” . Experimental Dermatology vol. 31 , ( 1 ) 82 - 88 .
Barcelo J, Sanz-Moreno V ( 2022 ) . NECTIN1 is a melanoma metastasis suppressor gene . Nature Genetics
Crosas-Molist E, Samain R, Kohlhammer L, Orgaz JL, George SL, Maiques O, Barcelo J, Sanz-Moreno V ( 2022 ) . RHO GTPase SIGNALING IN CANCER PROGRESSION AND DISSEMINATION . Physiological Reviews vol. 102 , ( 1 ) 455 - 510 .
de Winde CM, George SL, Crosas-Molist E, Hari-Gupta Y, Arp AB, Benjamin AC, Millward LJ, Makris S et al. ( 2021 ) . Podoplanin drives dedifferentiation and amoeboid invasion of melanoma . iScience vol. 24 , ( 9 )
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL et al. ( 2021 ) . A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma . British Journal of Cancer vol. 125 , ( 5 ) 699 - 713 .
Candido JB, Maiques O, Boxberg M, Kast V, Peerani E, Tomás-bort E, Weichert W, Sananes A et al. ( 2021 ) . Kallikrein-related peptidase 6 is associated with the tumour microenvironment of pancreatic ductal adenocarcinoma . Cancers vol. 13 , ( 16 )
Jung-Garcia Y, Maiques O, Rodriguez-Hernandez I, Fanshawe B, Domart M-C, Renshaw M, Marti R, Matias-Guiu X et al. ( 2021 ) . LAP1 supports nuclear plasticity during constrained migration .
Rosell AP, Maiques O, Chakravarty P, Ombrato L, Sanz-Moreno V, Malanchi I ( 2021 ) . Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth .
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL et al. ( 2020 ) . WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion . Nature Communications vol. 11 , ( 1 )
McLeod R, Kumar R, Papadatos-Pastos D, Mateo J, Brown JS, Ingles Garces AH, Ruddle R, Decordova S et al. ( 2020 ) . First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors . Clinical Cancer Research vol. 26 , ( 18 ) 4777 - 4784 .
Farrugia AJ, Rodríguez J, Orgaz JL, Lucas M, Sanz-Moreno V, Calvo F ( 2020 ) . CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion . Journal of Cell Biology vol. 219 , ( 9 )
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al. ( 2020 ) . Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells . Cell vol. 181 , ( 6 ) 1346 - 1363.e21 .
Orgaz JL, Sanz-Moreno V ( 2020 ) . What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation . Molecular and Cellular Oncology vol. 7 , ( 3 )
Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y et al. ( 2020 ) . Erratum: PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells (Cell Reports (2019) 29(11) (3385–3393.e6), (S2211124719314871), (10.1016/j.celrep.2019.11.016)) . Cell Reports vol. 31 , ( 3 )
Samain R, Sanz-Moreno V ( 2020 ) . Cancer-associated fibroblasts: activin A adds another string to their bow . EMBO Molecular Medicine vol. 12 , ( 4 )
Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Rodriguez-Hernandez I, Monger J, Mele S et al. ( 2020 ) . Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance . Cancer Cell vol. 37 , ( 1 ) 85 - 103.e9 .
Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigue A, Camacho L, Martín-Martín N, Cicogna P, Viera-Bardon C et al. ( 2019 ) . PGC1a suppresses prostate cancer cell invasion through ERRA transcriptional control . Cancer Research vol. 79 , ( 24 ) 6153 - 6165 .
Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y et al. ( 2019 ) . PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells . Cell Reports vol. 29 , ( 11 ) 3385 - 3393.e6 .
Rosel D, Fernandes M, Sanz-Moreno V, Brábek J ( 2019 ) . Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis? . Trends in Cancer vol. 5 , ( 12 ) 755 - 756 .
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease . Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E et al. ( 2019 ) . Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition . Cancer Letters vol. 464 , 15 - 24 .
Farrugia A, Rodríguez J, Orgaz J, Lucas M, Sanz-Moreno V, Calvo F ( 2019 ) . Cdc42EP5/BORG3 modulates SEPT9 to promote actomyosin function and melanoma invasion and metastasis .
Rodrigo JP, Diaz RG, Villaronga MA, Prado FH, Menendez ST, Quer M, Vilaseca I, Canteli MS et al. ( 2019 ) . PO-108 Clinical relevance of Cortactin and Focal Adhesion Kinase as predictors of laryngeal cancer risk . Radiotherapy and Oncology vol. 132 ,
Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I et al. ( 2019 ) . Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment . Cell vol. 176 , ( 4 ) 757 - 774.e23 .
Maiques O, Georgouli M, Sanz-Moreno V ( 2019 ) . Recent advances in tissue imaging for cancer research [version 1; peer review: 2 approved] . F1000Research vol. 8 ,
Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, Gordon P, Lall S et al. ( 2018 ) . Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis . Nature Communications vol. 9 , ( 1 )
Sanz-Moreno V, Balkwill FR ( 2018 ) . Mets and NETs: The Awakening Force . Immunity vol. 49 , ( 5 ) 798 - 800 .
Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Murga C ( 2018 ) . Erratum: Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK (Current Biology (2006) 16(20) (2042–2047) (S0960982206021518) (10.1016/j.cub.2006.08.083)) . Current Biology vol. 28 , ( 15 )
Villaronga MÁ, Hermida-Prado F, Granda-Díaz R, Menéndez ST, Álvarez-Teijeiro S, Quer M, Vilaseca I, Allonca E et al. ( 2018 ) . Immunohistochemical expression of cortactin and focal adhesion kinase predicts recurrence risk and laryngeal cancer risk beyond histologic grading . Cancer Epidemiology Biomarkers and Prevention vol. 27 , ( 7 ) 805 - 813 .
Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez-Hernandez I, Matas-Nadal C, Tell G et al. ( 2018 ) . T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 . Pigment Cell and Melanoma Research vol. 31 , ( 4 ) 484 - 495 .
O'Donnell MA ( 2018 ) . Victoria Sanz-Moreno: Rho together for cancer research . J Cell Biol vol. 217 , ( 6 ) 1885 - 1886 .
( 2018 ) . R10 (Quail) . Encyclopedia of Signaling Molecules ,
Orgaz JL, Sanz-Moreno V ( 2018 ) . RhoA . Encyclopedia of Signaling Molecules ,
Wells C, Lam H, Sanz-Moreno V, Sabin V, Sarker D ( 2018 ) . 3D spheroid invasion drug screen platform for pancreatic ductal adenocarcinoma . Journal of Clinical Oncology vol. 36 , ( 15_suppl ) e24212 - e24212 .
Krupina K, Kleiss C, Awal S, Rodriguez-Hernandez I, Sanz-Moreno V, Sumara I ( 2018 ) . UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer . Molecular and Cellular Oncology vol. 5 , ( 2 )
Villaronga MÁ, Teijeiro SÁ, Hermida-Prado F, Garzón-Arango M, Sanz-Moreno V, García-Pedrero JM ( 2018 ) . Analysis of invasive activity of CAF spheroids into three dimensional (3D) collagen matrices . Methods in Molecular Biology , vol. 1731 ,
Pandya P, Orgaz JL, Sanz-Moreno V ( 2017 ) . Actomyosin contractility and collective migration: may the force be with you . Current Opinion in Cell Biology vol. 48 , 87 - 96 .
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G et al. ( 2017 ) . Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis . Nat Cell Biol vol. 19 , ( 7 )
Gandalovičová A, Rosel D, Fernandes M, Veselý P, Heneberg P, Čermák V, Petruželka L, Kumar S et al. ( 2017 ) . Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges . Trends in Cancer vol. 3 , ( 6 ) 391 - 406 .
Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra A, Sanz-Moreno V, Fabregat I ( 2017 ) . The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination . Oncogene vol. 36 , ( 21 ) 3002 - 3014 .
Sanz-Moreno V ( 2017 ) . Cell scientist to watch - Victoria Sanz-Moreno . Journal of Cell Science vol. 130 , ( 7 ) 1199 - 1200 .
Talamillo A, Grande L, Ruiz-Ontañon P, Velasquez C, Mollinedo P, Torices S, Sanchez-Gomez P, Aznar A et al. ( 2017 ) . ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA . Oncogene vol. 36 , ( 12 ) 1733 - 1744 .
Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P et al. ( 2017 ) . Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNFa/MCP-1 signaling . Cancer Research vol. 77 , ( 5 ) 1127 - 1141 .
Cantelli G, Crosas-Molist E, Georgouli M, Sanz-Moreno V ( 2017 ) . TGFΒ-induced transcription in cancer . Seminars in Cancer Biology vol. 42 , 60 - 69 .
Pandya P, Orgaz JL, Sanz-Moreno V ( 2017 ) . Modes of invasion during tumour dissemination . Molecular Oncology vol. 11 , ( 1 ) 5 - 27 .
Orgaz JL, Sanz-Moreno V ( 2016 ) . RhoA . Encyclopedia of Signaling Molecules ,
Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I, Josephs DH, Tosi I et al. ( 2016 ) . Abstract A116: IgG antibody switching and clonal expansion in melanoma and normal skin microenvironments . Conference: Cancer Immunology Research AACRa116 - a116 .
Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I, Josephs DH, Tosi I et al. ( 2016 ) . IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin . Scientific Reports vol. 6 ,
Valcarcel L, Torrano V, Cortazar AR, Liu X, Urosevic J, Castillo M, Morciano G, Graupera M et al. ( 2016 ) . 756 Transcriptional regulation of prostate cancer metabolism . European Journal of Cancer vol. 61 ,
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G et al. ( 2016 ) . The metabolic co-regulator PGC1α suppresses prostate cancer metastasis . Nature Cell Biology vol. 18 , ( 6 ) 645 - 656 .
Herraiz C, Crosas-Molist E, Sanz-Moreno V ( 2016 ) . Reactive oxygen species and tumor dissemination: Allies no longer . Molecular and Cellular Oncology vol. 3 , ( 2 )
Herraiz C, Calvo F, Pandya P, Cantelli G, Rodriguez-Hernandez I, Orgaz JL, Kang N, Chu T et al. ( 2016 ) . Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance between DNA Damage and Tumor Dissemination . Journal of the National Cancer Institute vol. 108 , ( 1 )
Rodriguez-Hernandez I, Cantelli G, Bruce F, Sanz-Moreno V ( 2016 ) . Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] . F1000Research vol. 5 ,
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, Philippe C, Herraiz Serrano C et al. ( 2015 ) . Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts . Nature Communications vol. 6 ,
Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM et al. ( 2015 ) . TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination . Current Biology vol. 25 , ( 22 ) 2899 - 2914 .
Masuzzo P, Martens L, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaes-Tecker C et al. ( 2015 ) . An open data ecosystem for cell migration research . Trends in Cell Biology vol. 25 , ( 2 ) 55 - 58 .
Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J, Nestle FO et al. ( 2014 ) . Diverse matrix metalloproteinase functions regulate cancer amoeboid migration . Nature Communications vol. 5 ,
Orgaz JL, Herraiz C, Sanz-Moreno V ( 2014 ) . Rho GTPases modulate malignant transformation of tumor cells . Small GTPases vol. 5 , ( MAY )
Ruiz-Ontañon P, Orgaz JL, Aldaz B, Elosegui-Artola A, Martino J, Berciano MT, Montero JA, Grande L et al. ( 2013 ) . Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue . Stem Cells vol. 31 , ( 6 ) 1075 - 1085 .
Orgaz JL, Sanz-Moreno V ( 2013 ) . Emerging molecular targets in melanoma invasion and metastasis . Pigment Cell and Melanoma Research vol. 26 , ( 1 ) 39 - 57 .
Ramasamy K, Lekgetho H, Orgaz JL, Anwar A, Sanz-Moreno V, Kazmi MA, Schey S, Calle Y ( 2012 ) . Beta7 Integrins Regulate Podia Formation in Multiple Myeloma (MM) Cells for the Interaction with the Cellular and Non-Cellular Bone Marrow (BM) Stroma . Blood vol. 120 , ( 21 ) 3979 - 3979 .
Ahn J, Sanz-Moreno V, Marshall CJ ( 2012 ) . The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility . Journal of Cell Science vol. 125 , ( 7 ) 1814 - 1826 .
Sanz-Moreno V ( 2012 ) . Tumour invasion: A new twist on Rac-driven mesenchymal migration . Current Biology vol. 22 , ( 11 )
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P ( 2011 ) . Erratum: RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation (Nature Cell Biology (2011) 13 (819-826)) . Nature Cell Biology vol. 13 , ( 8 )
Sanz-Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, Hooper S, Mitter R et al. ( 2011 ) . ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma . Cancer Cell vol. 20 , ( 2 ) 229 - 245 .
Crespo P, Calvo F, Sanz-Moreno V ( 2011 ) . Ras and Rho GTPases on the move: The RasGRF connection . BioArchitecture vol. 1 , ( 4 ) 200 - 204 .
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P ( 2011 ) . RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation . Nature Cell Biology vol. 13 , ( 7 ) 819 - 826 .
Sanz-Moreno V, Marshall CJ ( 2010 ) . The plasticity of cytoskeletal dynamics underlying neoplastic cell migration . Current Opinion in Cell Biology vol. 22 , ( 5 ) 690 - 696 .
Sanz-Moreno V, Marshall CJ ( 2009 ) . Rho-GTPase signaling drives melanoma cell plasticity . Cell Cycle vol. 8 , ( 10 ) 1484 - 1487 .
Casar B, Arozarena I, Sanz-Moreno V, Pinto A, Agudo-Ibáñez L, Marais R, Lewis RE, Berciano MT et al. ( 2009 ) . Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins . Molecular and Cellular Biology vol. 29 , ( 5 ) 1338 - 1353 .
Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ ( 2008 ) . Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement . Cell vol. 135 , ( 3 ) 510 - 523 .
Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ ( 2008 ) . DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells . Current Biology vol. 18 , ( 19 ) 1456 - 1465 .
Sanz-Moreno V, Gadea G, Paterson H, Marshall CJ ( 2008 ) . Rac activation and inactivation control plasticity of tumour cell movement . European Journal of Cancer Supplements vol. 6 , ( 9 )
Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P ( 2007 ) . Mxi2 promotes stimulus-independent ERK nuclear translocation . EMBO Journal vol. 26 , ( 3 ) 635 - 646 .
Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Murga C ( 2006 ) . Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK . Current Biology vol. 16 , ( 20 ) 2042 - 2047 .
Matallanas D, Sanz-Moreno V, Arozarena I, Calvo F, Agudo-Ibáñez L, Santos E, Berciano MT, Crespo P ( 2006 ) . Distinct utilization of effectors and biological outcomes resulting from site-specific ras activation: Ras functions in lipid rafts and golgi complex are dispensable for proliferation and transformation . Molecular and Cellular Biology vol. 26 , ( 1 ) 100 - 116 .
Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muñoz MT, Egea G, Lafarga M et al. ( 2004 ) . Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors . Molecular and Cellular Biology vol. 24 , ( 4 ) 1516 - 1530 .
Sanz-Moreno V, Crespo P ( 2003 ) . P38 Mitogen-Activated Protein Kinases: Their role in carcinogenesis . Clinical and Translational Oncology vol. 5 , ( 6 ) 320 - 330 .
Sanz-Moreno V, Casar B, Crespo P ( 2003 ) . p38α isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels . Molecular and Cellular Biology vol. 23 , ( 9 ) 3079 - 3090 .
Arozarena I, Aaronson DS, Matallanas D, Sanz V, Ajenjo N, Tenbaum SP, Teramoto H, Ighishi T et al. ( 2000 ) . The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF . J Biol Chem vol. 275 , ( 34 ) 26441 - 26448 .
Sanz V, Arozarena I, Crespo P ( 2000 ) . Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2 . FEBS Lett vol. 474 , ( 2-3 ) 169 - 174 .