Publications: Dr Shafaq Sikandar

Sikandar S, Ackland GL ( 2024 ) . Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity . British Journal of Anaesthesia vol. 134 , ( 3 ) 627 - 631 .

Haroun R, Gossage SJ, Iseppon F, Fudge A, Caxaria S, Arcangeletti M, Leese C, Davletov B et al. ( 2024 ) . Novel therapies for cancer-induced bone pain . Neurobiology of Pain vol. 16 ,

Eldridge S, Dajas-Bailador F, Chapman V, Bharde S, Sikandar S, Cici D, Dell’accio F ( 2024 ) . POS0217 AGRIN HAS A DIRECT ANALGESIC EFFECT IN OSTEOARTHRITIS MODELS . Annals of the Rheumatic Diseases . vol. 83 , 257 - 258 .

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E et al. ( 2024 ) . Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis . Science Translational Medicine vol. 16 , ( 742 )

Dajas-Bailador F, Chapman V, Lucci C, Rathbone A, Bharde S, Sikandar S, Dell'Accio F, Eldridge S ( 2024 ) . 069 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITIS . Osteoarthritis and Cartilage vol. 32 ,

Bharde S, Caxaria S, Celik P, Srithasan A, Fuller A, Sikandar S ( 2024 ) . 754 Sex Differences in a Murine Model of Osteoarthritis . Osteoarthritis and Cartilage vol. 32 ,

Haroun R, Gossage SJ, Luiz AP, Arcangeletti M, Sikandar S, Zhao J, Cox JJ, Wood JN ( 2023 ) . Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons Reverses Chronic Neuropathic and Bone Cancer Pain in FLEx PSAM4-GlyR Mice . eNeuro vol. 10 , ( 9 ) eneuro.0151 - eneu23.2023 .

Fuller AM, Bharde S, Sikandar S ( 2023 ) . The mechanisms and management of persistent postsurgical pain . Frontiers in Pain Research vol. 4 ,

Evans R, Caxaria S, Celik P, Fuller AM, Bharde S, Sikandar S ( 2023 ) . POS0255 A PRO-NOCICEPTIVE POPULATION OF NEUTROPHILS INFILTRATE SENSORY GANGLIA AND MEDIATE CHRONIC WIDESPREAD PAIN IN FIBROMYALGIA SYNDROME . Annals of the Rheumatic Diseases vol. 82 , 364 - 365 .

Bharde S, Caxaria S, Celik P, Sikandar S ( 2023 ) . POS0413 SEX DIFFERENCES IN A MURINE MODEL OF OSTEOARTHRITIS . Annals of the Rheumatic Diseases vol. 82 ,

Fuller AM, Luiz A, Tian N, Arcangeletti M, Iseppon F, Sexton JE, Millet Q, Caxaria S et al. ( 2023 ) . Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons . Brain vol. 146 , ( 10 ) 4033 - 4039 .

Caxaria S, Bharde S, Fuller AM, Evans R, Thomas B, Celik P, Dell’Accio F, Yona S et al. ( 2023 ) . Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 17 )

Haroun R, Wood JN, Sikandar S ( 2023 ) . Mechanisms of cancer pain . Frontiers in Pain Research vol. 3 ,

Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A et al. ( 2022 ) . Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine . EMBO Molecular Medicine

Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M et al. ( 2022 ) . AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS . Annals of the Rheumatic Diseases vol. 81 ,

Domingues FS, Gayoso MV, Sikandar S, da Silva LM, Fonseca RG, de Barros GAM ( 2021 ) . Analgesic efficacy of a portable, disposable, and self‐applied transcutaneous electrical nerve stimulation device during migraine attacks: A real‐life randomized controlled trial . Pain Practice vol. 21 , ( 8 ) 850 - 858 .

Bharde S, Caxaria S, Dell’Accio F, Sikandar S ( 2021 ) . Update on pain in arthritis . Current Opinion in Supportive and Palliative Care vol. 15 , ( 2 ) 99 - 107 .

MacDonald DI, Sikandar S, Weiss J, Pyrski M, Luiz AP, Millet Q, Emery EC, Mancini F et al. ( 2021 ) . A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7 . Neuron vol. 109 , ( 9 ) 1497 - 1512.e6 .

de Clauser L, Luiz AP, Santana-Varela S, Wood JN, Sikandar S ( 2020 ) . Sensitization of Cutaneous Primary Afferents in Bone Cancer Revealed by In Vivo Calcium Imaging . Cancers vol. 12 , ( 12 )

de Clauser L, Santana‐Varela S, Wood JN, Sikandar S ( 2020 ) . Physiologic osteoclasts are not sufficient to induce skeletal pain in mice . European Journal of Pain vol. 25 , ( 1 ) 199 - 212 .

Marchetti Calônego MA, Sikandar S, Ferris FD, Moreira de Barros GA ( 2020 ) . Spread the Word: There Are Two Opioid Crises! . Drugs vol. 80 , ( 12 ) 1147 - 1154 .

Sikandar S, Sommer C ( 2019 ) . Neurotrophins, Cytokines, and Pain . The Oxford Handbook of the Neurobiology of Pain , Oxford University Press (OUP)

Luiz AP, MacDonald DI, Santana-Varela S, Millet Q, Sikandar S, Wood JN, Emery EC ( 2019 ) . Cold sensing by NaV1.8-positive and NaV1.8-negative sensory neurons . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 9 ) 3811 - 3816 .

Bangash MA, Alles SRA, Santana-Varela S, Millet Q, Sikandar S, de Clauser L, ter Heegde F, Habib A et al. ( 2018 ) . Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions .

Bangash MA, Alles SRA, Santana-Varela S, Millet Q, Sikandar S, de Clauser L, Ter Heegde F, Habib AM et al. ( 2018 ) . Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved] . Wellcome Open Research vol. 3 ,

Sikandar S, Minett MS, Millet Q, Santana-Varela S, Lau J, Wood JN, Zhao J ( 2018 ) . Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain . Brain vol. 141 , ( 4 ) 1028 - 1039 .

Sikandar S, Sommer C ( 2018 ) . Neurotrophins, cytokines, and pain 771 . The Oxford Handbook of the Neurobiology of Pain ,

Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, Emery EC, Bogdanov YD et al. ( 2017 ) . A novel human pain insensitivity disorder caused by a point mutation in ZFHX2 . Brain vol. 141 , ( 2 ) 365 - 376 .

Sikandar S, West SJ, McMahon SB, Bennett DL, Dickenson AH ( 2017 ) . Sensory processing of deep tissue nociception in the rat spinal cord and thalamic ventrobasal complex . Physiological Reports vol. 5 , ( 14 )

Dalmolin GD, Bannister K, Gonçalves L, Sikandar S, Patel R, do Nascimento Cordeiro M, Gomez MV, Ferreira J et al. ( 2017 ) . Effect of the spider toxin Tx3-3 on spinal processing of sensory information in naive and neuropathic rats . PAIN Reports vol. 2 , ( 4 )

Sikandar S, Minett MS, Lau J, Millet Q, Santana-Varela S, Wood JN, Zhao J ( 2017 ) . Brain-derived neurotrophic factor derived from peripheral sensory neurons plays a critical role in pain chronification .

Emery EC, Luiz AP, Sikandar S, Magnúsdóttir R, Dong X, Wood JN ( 2016 ) . In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP . Science Advances vol. 2 , ( 11 )

Sikandar S ( 2016 ) . SP0066 Peripheral Processing and Central Modulation of Pain . Annals of the Rheumatic Diseases . vol. 75 ,

Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R ( 2016 ) . Effects of intraplantar botulinum toxin‐B on carrageenan‐induced changes in nociception and spinal phosphorylation of GluA1 and Akt . European Journal of Neuroscience vol. 44 , ( 1 ) 1714 - 1722 .

Sikandar S, Aasvang EK, Dickenson AH ( 2016 ) . Scratching the surface: the processing of pain from deep tissues . Pain Management vol. 6 , ( 2 ) 95 - 102 .

Minett MS, Pereira V, Sikandar S, Matsuyama A, Lolignier S, Kanellopoulos AH, Mancini F, Iannetti GD et al. ( 2015 ) . Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 . Nature Communications vol. 6 , ( 1 )

O'Neill J, Sikandar S, McMahon SB, Dickenson AH ( 2015 ) . Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models . The Journal of Physiology vol. 593 , ( 17 ) 4029 - 4042 .

Sikandar S, Dickenson AH ( 2013 ) . II. No need for translation when the same language is spoken . British Journal of Anaesthesia vol. 111 , ( 1 ) 3 - 6 .

Sikandar S, Ronga I, Iannetti GD, Dickenson AH ( 2013 ) . Neural coding of nociceptive stimuli—from rat spinal neurones to human perception . Pain vol. 154 , ( 8 ) 1263 - 1273 .

Sikandar S, Patel R, Patel S, Sikander S, Bennett DLH, Dickenson AH ( 2013 ) . Genes, molecules and patients—Emerging topics to guide clinical pain research . European Journal of Pharmacology vol. 716 , ( 1-3 ) 188 - 202 .

Sikandar S, Bannister K, Dickenson AH ( 2012 ) . Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats . Neuroscience Letters vol. 519 , ( 1 ) 31 - 36 .

Sikandar S, Dickenson AH ( 2012 ) . Visceral pain . Current Opinion in Supportive and Palliative Care vol. 6 , ( 1 ) 17 - 26 .

Sikandar S, Dickenson AH ( 2012 ) . 315 PREGABALIN MODULATION OF VISCERAL NOCICEPTION INVOLVES BRAINSTEM (RVM) PROCESSING . European Journal of Pain vol. 13 , ( S1 ) s97 - s97 .

Sikandar S, Dickenson AH ( 2011 ) . Pregabalin modulation of spinal and brainstem visceral nociceptive processing . Pain vol. 152 , ( 10 ) 2312 - 2322 .

Bannister K, Sikandar S, Bauer CS, Dolphin AC, Porreca F, Dickenson AH ( 2011 ) . Pregabalin Suppresses Spinal Neuronal Hyperexcitability and Visceral Hypersensitivity in the Absence of Peripheral Pathophysiology . Anesthesiology vol. 115 , ( 1 ) 144 - 152 .

SUZUKI R, SIKANDAR S, DICKENSON AH ( 2010 ) . Nociception: basic principles . Cancer Pain , Cambridge University Press (CUP)

Rahman W, Sikandar S, Suzuki R, Hunt SP, Dickenson AH ( 2008 ) . Corrigendum to “Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABAA receptors” [Neurosci. Lett. 419 (2007) 278–283] . Neuroscience Letters vol. 434 , ( 3 )

Rahman W, Sikander S, Suzuki R, Hunt SP, Dickenson AH ( 2007 ) . Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABAA receptors . Neuroscience Letters vol. 419 , ( 3 ) 278 - 283 .