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Research

Publications: Prof Kamil Kranc

Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K et al. ( 2022 ) . MYC sensitises cells to apoptosis by driving energetic demand . Nature Communications vol. 13 , ( 1 )
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al. ( 2022 ) . Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (Nature Immunology, (2022), 23, 6, (927-939), 10.1038/s41590-022-01216-z) . Nature Immunology vol. 23 , ( 9 )
Sommerkamp P, Brown JA, Haltalli MLR, Mercier FE, Vu LP, Kranc KR ( 2022 ) . m<sup>6</sup>A RNA modifications: Key regulators of normal and malignant hematopoiesis . Experimental Hematology vol. 111 , 25 - 31 .
Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA ( 2022 ) . Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis . Biology open vol. 11 , ( 6 )
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al. ( 2022 ) . Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation . Nature Immunology vol. 23 , ( 6 ) 927 - 939 .
Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR et al. ( 2022 ) . A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells . eLife vol. 11 ,
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al. ( 2021 ) . CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation . Stem Cell Reports vol. 16 , ( 11 ) 2784 - 2797 .
Adam J, Finch A, Sepulveda C, Ducker M, Torroba MB, Krell D, Kriaucionis S, Szele F et al. ( 2021 ) . Elevated 2HG does not cause features of tumorigenesis . Neuro-Oncology . vol. 23 , iv1 - iv1 .
Codino A, Turowski T, van de Lagemaat LN, Ivanova I, Tavosanis A, Much C, Auchynnikava T, Vasiliauskaitė L et al. ( 2021 ) . NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells . iScience vol. 24 , ( 7 )
Kranc KR ( 2021 ) . The essential reading list for AML: the m<sup>6</sup>A transcripts . Blood vol. 138 , ( 1 ) 6 - 7 .
Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A et al. ( 2021 ) . JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells . Blood Advances vol. 5 , ( 3 ) 889 - 899 .
Mapperley C, Van De Lagemaat L, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al. ( 2020 ) . The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine vol. 218 , ( 3 ) 20200829 - 20200829 .
Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C et al. ( 2020 ) . Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms . Leukemia vol. 34 , ( 4 ) 1062 - 1074 .
Luis TC, Lawson H, Kranc KR ( 2020 ) . Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells . Cell Stem Cell vol. 26 , ( 3 ) 299 - 301 .
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al. ( 2019 ) . Systemic silencing of Phd2 causes reversible immune regulatory dysfunction . Journal of Clinical Investigation vol. 129 , ( 9 ) 3640 - 3656 .
Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A et al. ( 2019 ) . Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia . Stem Cell Reports vol. 13 , ( 2 ) 291 - 306 .
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al. ( 2019 ) . Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia . Cell Stem Cell vol. 25 , ( 1 ) 137 - 148.e6 .
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al. ( 2019 ) . Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR . Cell vol. 177 , ( 5 ) 1201 - 1216.e19 .
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al. ( 2019 ) . Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)) . Cell vol. 178 , ( 1 ) 263 - 263 .
Van De Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D ( 2018 ) . CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands 06 Biological Sciences 0601 Biochemistry and Cell Biology 06 Biological Sciences 0604 Genetics . Epigenetics and Chromatin vol. 11 , ( 1 )
Guitart AV, Finch AJ, Kranc KR ( 2018 ) . Ca<sup>2+</sup>tapulting HSCs into action . Journal of Experimental Medicine vol. 215 , ( 8 ) 1971 - 1973 .
Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A et al. ( 2018 ) . hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival . Blood vol. 131 , ( 14 ) 1532 - 1544 .
O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR ( 2018 ) . Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions . Assay and Drug Development Technologies vol. 16 , ( 1 ) 51 - 63 .
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al. ( 2017 ) . Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions . The Journal of experimental medicine vol. 214 , ( 3 ) 719 - 735 .
Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M et al. ( 2016 ) . Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability . Genes and Development vol. 30 , ( 19 ) 2173 - 2186 .
Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR et al. ( 2016 ) . ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells . Autophagy vol. 12 , ( 6 ) 936 - 948 .
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al. ( 2016 ) . Adult hematopoietic stem cells lacking Hif-1α self-renew normally . Blood vol. 127 , ( 23 ) 2841 - 2846 .
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart AV et al. ( 2016 ) . CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells . Blood vol. 128 , ( 3 ) 371 - 383 .
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J et al. ( 2015 ) . Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance . Journal of Experimental Medicine vol. 212 , ( 13 ) 2223 - 2234 .
Guitart AV, Vukovic M, Sepulveda C, Panagopoulou T, Allen L, Pollard P, Morton N, Finch A et al. ( 2015 ) . Dual function of fumarate hydratase in haematopoietic stem cell fates . Experimental Hematology . vol. 43 ,
Kranc KR, Dzierzak E ( 2015 ) . Relieving oxidative stress in immune cells . Journal of Experimental Medicine vol. 212 , ( 8 ) 1140 - 1140 .
Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. ( 2015 ) . FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL . HAEMATOLOGICA . vol. 100 , 123 - 123 .
Vukovic M, Guitart AV, Kranc K ( 2015 ) . HIF-2A IS A TUMOUR SUPPRESSOR IN AML . HAEMATOLOGICA . vol. 100 , 10 - 10 .
Sepulveda C, Guitart A, Vukovic M, Panagopoulou TI, Allen L, Lengelling A, Ratcliffe PJ, Kranc KR ( 2015 ) . THE ROLE OF 2-OXOGLUTARATE DEPENDENT DIOXYGENASES IN NORMAL HAEMATOPOIESIS AND ACUTE MYELOID LEUKEMIA . HAEMATOLOGICA . vol. 100 , 9 - 9 .
Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H et al. ( 2015 ) . Acute loss of Cited2 impairs nanog expression and decreases self-renewal of mouse embryonic stem cells . Stem Cells vol. 33 , ( 3 ) 699 - 712 .
Gezer D, Vukovic M, Soga T, Pollard PJ, Kranc KR ( 2014 ) . Concise review: Genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells . Stem Cells vol. 32 , ( 6 ) 1390 - 1397 .
Yang M, Su H, Soga T, Kranc KR, Pollard PJ ( 2014 ) . Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism . Hypoxia (Auckl) vol. 2 , 127 - 142 .
Sinclair A, Calaminus S, Pellicano F, Guitart A, Graham S, Poncz M, Graham G, Sansom O et al. ( 2013 ) . CHEMOKINE SIGNALLING REGULATES HAEMOPOIETIC STEM CELL SURVIVAL . HAEMATOLOGICA . vol. 98 , 391 - 392 .
Guitart A, Pollard P, Holyoake T, Enver T, Ratcliffe P, Kranc K ( 2013 ) . HIF-1ALPHA AND HIF-2APLPHA ARE NOT ESSENTIAL FOR STEADY-STATE HEMATOPOIETIC STEM CELL MAINTENANCE . HAEMATOLOGICA . vol. 98 , 493 - 493 .
Calaminus SDJ, Guitart AV, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM ( 2013 ) . Correction: Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny (PLoS ONE 7, 12, (e51361) DOI:10.1371/journal.pone.0051361) . PLoS ONE vol. 8 , ( 5 )
Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K et al. ( 2013 ) . Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance . Blood vol. 122 , ( 10 ) 1741 - 1745 .
Calaminus SDJ, Guitart A, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM ( 2012 ) . Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny . PLoS ONE vol. 7 , ( 12 )
Sinclair A, Pellicano P, Graham SM, Kinstrie R, Kranc K, Graham G, Holyoake TL ( 2012 ) . An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence . BRITISH JOURNAL OF HAEMATOLOGY . vol. 157 , 26 - 27 .
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al. ( 2011 ) . The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance . Journal of Experimental Medicine vol. 208 , ( 3 ) 455 - 467 .
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al. ( 2011 ) . The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance . Journal of Cell Biology vol. 192 , ( 5 ) i5 - i5 .
Pollard PJ, Kranc KR ( 2010 ) . Hypoxia signaling in hematopoietic stem cells: A double-edged sword . Cell Stem Cell vol. 7 , ( 3 ) 276 - 278 .
Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M et al. ( 2009 ) . Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells . Cell Stem Cell vol. 5 , ( 6 ) 659 - 665 .
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al. ( 2009 ) . T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides (DOI:10.1016/j.immuni.2009.01.009) . Immunity vol. 30 , ( 4 )
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al. ( 2009 ) . T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides . Immunity vol. 30 , ( 3 ) 348 - 357 .
Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI et al. ( 2006 ) . Functional epistasis on a common MHC haplotype associated with multiple sclerosis . Nature vol. 443 , ( 7111 ) 574 - 577 .
Kranc KR, Taylor AM, Willcox N, Fugger L ( 2005 ) . Control of autoimmunity by 'epitope theft' . Trends in Molecular Medicine vol. 11 , ( 1 ) 1 - 4 .
Kranc KR, Bamforth SD, Bragança J, Norbury C, Van Lohuizen M, Bhattacharya S ( 2003 ) . Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF . Molecular and Cellular Biology vol. 23 , ( 21 ) 7658 - 7666 .
HURST HC, Murdoch JN, Eloranta JJ, Braganca J, Bhattacharya S, Henderson DJ, Kranc KR, Marques FIR et al. ( 2001 ) . Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator . Nature Genetics vol. 29 , ( 4 ) 469 - 474 .
Clark JF, Pyne GJ, Tao LM, Claridge T, Harris D, Kranc K, Cadoux-Hudson T, Turnbull J et al. ( 2001 ) . Oxidative degradation of bilirubin produces vasoactive compounds in subarachnoid hemorrhage patients with cerebral vasospasm . FASEB JOURNAL . vol. 15 , A112 - A112 .
Kranc KR, Pyne GJ, Tao L, Claridge TDW, Harris DA, Cadoux-Hudson TAD, Turnbull JJ, Schofield CJ et al. ( 2000 ) . Oxidative degradation of bilirubin produces vasoactive compounds . European Journal of Biochemistry vol. 267 , ( 24 ) 7094 - 7101 .
Clark JF, Kranc KR ( 1999 ) . The role of the mitochondrion in smooth muscle cell fate choices of proliferation versus apoptosis during vascular and cardiovascular diseases . Expert Opinion on Therapeutic Targets vol. 3 , ( 4 ) 513 - 525 .