Publications: Dr Aravindan Ilangovan

Fecht S, Paracuellos P, Subramoni S, Tan CAZ, Ilangovan A, Costa TRD, Filloux A ( 2024 ) . Functionality of chimeric TssA proteins in the type VI secretion system reveals sheath docking specificity within their N-terminal domains . Nature Communications vol. 15 , ( 1 )

Pelliciari S, Bodet-Lefèvre S, Fenyk S, Stevens D, Winterhalter C, Schramm FD, Pintar S, Burnham DR et al. ( 2023 ) . The bacterial replication origin BUS promotes nucleobase capture . Nature Communications vol. 14 , ( 1 )

Najmudin S, Pan X-S, Beavil AJ, Cronin NB, Ilangovan A, Fisher LM, Sanderson MR ( 2023 ) . Higher-order cryo-EM structures of the full tetrameric type II topoisomerase with bound 18mer dsDNA . Acta Crystallographica Section A: Foundations and advances vol. 79 , ( a2 ) c702 - c702 .

Winterhalter C, Pelliciari S, Stevens D, Fenyk S, Marchand E, Cronin NB, Soultanas P, Costa TRD et al. ( 2023 ) . The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin . Nucleic Acids Research vol. 51 , ( 9 ) 4322 - 4340 .

Winterhalter C, Stevens D, Fenyk S, Pelliciari S, Marchand E, Soultanas P, Ilangovan A, Murray H ( 2022 ) . SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation . Nucleic Acids Research vol. 51 , ( 9 ) 4302 - 4321 .

Amin H, Ilangovan A, Costa TRD ( 2021 ) . Architecture of the outer-membrane core complex from a conjugative type IV secretion system . Nature Communications vol. 12 , ( 1 )

Zheng W, Peña A, Ilangovan A, Clark JN-B, Frankel G, Egelman EH, Costa TRD ( 2021 ) . Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament . Proc Natl Acad Sci U S A vol. 118 , ( 2 )

Ilangovan A, Kay CWM, Roier S, Mkami HE, Salvadori E, Zechner EL, Zanetti G, Waksman G ( 2017 ) . Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation . Cell vol. 169 , ( 4 ) 708 - 721.e12 .

Costa TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH, Waksman G ( 2016 ) . Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex . Cell vol. 166 , ( 6 ) 1436 - 1444.e10 .

Ilangovan A, Connery S, Waksman G ( 2015 ) . Structural biology of the Gram-negative bacterial conjugation systems . Trends in Microbiology vol. 23 , ( 5 ) 301 - 310 .

Ilangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, Cámara M, Truman A et al. ( 2013 ) . Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR) . PLOS Pathogens vol. 9 , ( 7 )

Redzej A, Ilangovan A, Lang S, Gruber CJ, Topf M, Zangger K, Zechner EL, Waksman G ( 2013 ) . Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems . Molecular Microbiology vol. 89 , ( 2 ) 324 - 333 .