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Research

Publications: Miss Hannah Lawson

Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA ( 2022 ) . Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis . Biology open vol. 11 , ( 6 )
Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR et al. ( 2022 ) . A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells . eLife vol. 11 ,
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al. ( 2021 ) . CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation . Stem Cell Reports vol. 16 , ( 11 ) 2784 - 2797 .
Campbell KJ, Mason SM, Winder ML, Willemsen RBE, Cloix C, Lawson H, Rooney N, Dhayade S et al. ( 2021 ) . Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function . Cell Death and Differentiation vol. 28 , ( 9 ) 2589 - 2600 .
Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A et al. ( 2021 ) . JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells . Blood Advances vol. 5 , ( 3 ) 889 - 899 .
Mapperley C, Van De Lagemaat L, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al. ( 2020 ) . The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine vol. 218 , ( 3 ) 20200829 - 20200829 .
Luis TC, Lawson H, Kranc KR ( 2020 ) . Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells . Cell Stem Cell vol. 26 , ( 3 ) 299 - 301 .
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al. ( 2019 ) . Systemic silencing of Phd2 causes reversible immune regulatory dysfunction . Journal of Clinical Investigation vol. 129 , ( 9 ) 3640 - 3656 .
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al. ( 2019 ) . Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia . Cell Stem Cell vol. 25 , ( 1 ) 137 - 148.e6 .
O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR ( 2018 ) . Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions . Assay and Drug Development Technologies vol. 16 , ( 1 ) 51 - 63 .
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al. ( 2017 ) . Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions . The Journal of experimental medicine vol. 214 , ( 3 ) 719 - 735 .
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al. ( 2016 ) . Adult hematopoietic stem cells lacking Hif-1α self-renew normally . Blood vol. 127 , ( 23 ) 2841 - 2846 .