Publications: Dr Matthew Traylor
Shen X, Howard DM, Adams MJ, Hill WD, Clarke TK, Adams MJ, Clarke TK, McIntosh AM et al.(2020).
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications
vol. 11,
(1)
Persyn E, Hanscombe KB, Howson JMM, Lewis CM, Traylor M, Markus HS(2020).
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants. Nature Communications
vol. 11,
(1)
Taylor KM, Hanscombe KB, Prescott NJ, Iniesta R, Traylor M, Taylor NS, Fong S, Powell N et al.(2020).
Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn's Disease. Clinical Gastroenterology and Hepatology
vol. 18,
(4)
908-916.e13.
Harshfield EL, Sims MC, Traylor M, Ouwehand WH, Markus HS(2020).
The role of haematological traits in risk of ischaemic stroke and its subtypes. Brain
vol. 143,
(1)
210-221.
Traylor M, Amin Al Olama A, Lyytikäinen LP, Marini S, Chung J, Malik R, Dichgans M, Kähönen M et al.(2019).
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke. Hypertension
vol. 75,
(2)
365-371.
Wahab KW, Tiwari HK, Ovbiagele B, Sarfo F, Akinyemi R, Traylor M, Rotimi C, Markus HS et al.(2019).
Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions. Journal of the Neurological Sciences
vol. 407,
Tan RYY, Traylor M, Megy K, Duarte D, Deevi SVV, Shamardina O, Mapeta RP, Ouwehand WH et al.(2019).
How common are single gene mutations as a cause for lacunar stroke?: A targeted gene panel study. Neurology
vol. 93,
(22)
E2007-E2020.
Brown RB, Traylor M, Burgess S, Sawcer S, Markus HS(2019).
Do Cerebral Small Vessel Disease and Multiple Sclerosis Share Common Mechanisms of White Matter Injury?: A Genetic Study. Stroke
vol. 50,
(8)
1968-1972.
Traylor M, Anderson CD, Rutten-Jacobs LCA, Falcone GJ, Comeau ME, Ay H, Sudlow CLM, Xu H et al.(2019).
Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls. Circulation: Genomic and Precision Medicine
vol. 12,
(7)
307-314.
Hanscombe KB, Coleman JRI, Traylor M, Lewis CM(2019).
UKBTools: An R package to manage and query UK Biobank data. PLoS ONE
vol. 14,
(5)
Larsson SC, Traylor M, Markus HS(2019).
Homocysteine and small vessel stroke: A mendelian randomization analysis. Annals of Neurology
vol. 85,
(4)
495-501.
Söderholm M, Pedersen A, Lorentzen E, Stanne TM, Bevan S, Olsson M, Cole JW, Fernandez-Cadenas I et al.(2019).
Genome-wide association meta-analysis of functional outcome after ischemic stroke. Neurology
vol. 92,
(12)
E1271-E1283.
Newnham M, South K, Bleda M, Auger WR, Barberà JA, Bogaard H, Bunclark K, Cannon JE et al.(2019).
The ADAMTS13–VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension. European Respiratory Journal
vol. 53,
(3)
Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS, Malik R et al.(2019).
Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. Neurology
vol. 92,
(9)
E944-E950.
Traylor M, Tozer DJ, Croall ID, Lisiecka Ford DM, Olorunda AO, Boncoraglio G, Dichgans M, Lemmens R et al.(2019).
Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226). Neurology
vol. 92,
(8)
E749-E757.
Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S et al.(2019).
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology
vol. 92,
(5)
E486-E503.
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC et al.(2019).
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1. Circulation
vol. 139,
(2)
256-268.
Drazyk AM, Tan RYY, Tay J, Traylor M, Das T, Markus HS(2019).
Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Patients. Stroke
vol. 50,
(2)
283-290.
Traylor M, Knevel R, Cui J, Taylor J, Harm-Jan W, Conaghan PG, Cope AP, Curtis C et al.(2019).
Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases. PLoS ONE
vol. 14,
(10)
Chung J, Marini S, Pera J, Norrving B, Jimenez-Conde J, Roquer J, Fernandez-Cadenas I, Tirschwell DL et al.(2019).
Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Brain
vol. 142,
(10)
3176-3189.
Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM et al.(2018).
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications
vol. 9,
(1)
Malik R, Rannikmäe K, Traylor M, Georgakis MK, Sargurupremraj M, Markus HS, Hopewell JC, Debette S et al.(2018).
Genome-wide meta-analysis identifies 3 novel loci associated with stroke. Annals of Neurology
vol. 84,
(6)
934-939.
Larsson SC, Traylor M, Markus HS(2018).
Circulating vitamin K<inf>1</inf> levels in relation to ischemic stroke and its subtypes: A mendelian randomization study. Nutrients
vol. 10,
(11)
Cole JW, Xu H, Ryan K, Jaworek T, Dueker N, McArdle P, Gaynor B, Cheng YC et al.(2018).
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. PLoS ONE
vol. 13,
(11)
Larsson SC, Traylor M, Markus HS, Michaëlsson K(2018).
Serum parathyroid hormone, 25-hydroxyvitamin D, and risk of Alzheimer’s disease: A mendelian randomization study. Nutrients
vol. 10,
(9)
Traylor M, Walker JL, Corrigan AA, Hernandez MA, Newhouse SJ, Folarin AA, Patel H, Ross PJ et al.(2018).
Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer. PLoS ONE
vol. 13,
(5)
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK et al.(2018).
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics
vol. 50,
(4)
524-537.
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK et al.(2018).
Publisher correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes(Nature Genetics, (2018) 50, 4, (524-537), 10.1038/s41588-018-0058-3). Nature Genetics
vol. 51,
(7)
1192-1193.
Hindy G, Engström G, Larsson SC, Traylor M, Markus HS, Melander O, Orho-Melander M(2018).
Role of blood lipids in the development of ischemic stroke and its subtypes: A mendelian randomization study. Stroke
vol. 49,
(4)
820-827.
Liu J, Rutten-Jacobs L, Liu M, Markus HS, Traylor M(2018).
Causal impact of type 2 diabetes mellitus on cerebral small vessel disease: A mendelian randomization analysis. Stroke
vol. 49,
(6)
1325-1331.
Rutten-Jacobs LCA, Larsson SC, Malik R, Rannikmäe K, Sudlow CL, Dichgans M, Markus HS, Traylor M(2018).
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: Cohort study of 306 473 UK Biobank participants. BMJ (Online)
vol. 363,
Rutten-Jacobs LCA, Tozer DJ, Duering M, Malik R, Dichgans M, Markus HS, Traylor M(2018).
Genetic study of white matter integrity in UK Biobank (N=8448) and the overlap with stroke, depression, and dementia. Stroke
vol. 49,
(6)
1340-1347.
Larsson SC, Traylor M, Mishra A, Howson JMM, Michaëlsson K, Markus HS(2018).
Serum 25-hydroxyvitamin D concentrations and ischemic stroke and its subtypes a Mendelian randomization study. Stroke
vol. 49,
(10)
2508-2511.
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS(2017).
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis. BMJ (Clinical research ed.)
vol. 359,
Rannikme K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ et al.(2017).
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology
vol. 89,
(17)
1829-1839.
Maguire JM, Bevan S, Stanne TM, Lorenzen E, Fernandez-Cadenas I, Hankey GJ, Jimenez-Conde J, Jood K et al.(2017).
GISCOME – Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study. European Stroke Journal
vol. 2,
(3)
229-237.
Traylor M, Curtis C, Patel H, Breen G, Lee SH, Xu X, Newhouse S, Dobson R et al.(2017).
Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: The GENRA case-control study. Rheumatology (United Kingdom)
vol. 56,
(8)
1282-1292.
Larsson SC, Scott RA, Traylor M, Langenberg CC, Hindy G, Melander O, Orho-Melander M, Seshadri S et al.(2017).
Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study. Neurology
vol. 89,
(5)
454-460.
Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL et al.(2017).
Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Stroke
vol. 48,
(6)
1451-1456.
Tan R, Traylor M, Rutten-Jacobs L, Markus H(2017).
New insights into mechanisms of small vessel disease stroke from genetics. Clinical Science
vol. 131,
(7)
515-531.
Vassos E, Di Forti M, Coleman J, Iyegbe C, Prata D, Euesden J, O'Reilly P, Curtis C et al.(2017).
An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis. Biological Psychiatry
vol. 81,
(6)
470-477.
Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C et al.(2017).
Genetic variation at 16q24.2 is associated with small vessel stroke. Annals of Neurology
vol. 81,
(3)
383-394.
Larsson SC, Traylor M, Burgess S, Markus HS(2017).
Genetically-Predicted Adult Height and Alzheimer's Disease. Journal of Alzheimer's Disease
vol. 60,
(2)
691-698.
Traylor M, Rutten-Jacobs L, Curtis C, Patel H, Breen G, Newhouse S, Lewis CM, Markus HS(2017).
Genetics of stroke in a UK African ancestry case-control study: South London ethnicity and stroke study. Neurology: Genetics
vol. 3,
(2)
Lu M, Lewis CM, Traylor M(2017).
Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe. BMC Medical Genomics
vol. 1,
(1)
MUNROE PB(2016).
Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Genetics
Traylor M, Lewis CM(2016).
Genetic discovery in multi-ethnic populations. European Journal of Human Genetics
vol. 24,
(8)
1097-1098.
Chauhan G, Arnold CR, Chu AY, Fornage M, Reyahi A, Bis JC, Havulinna AS, Sargurupremraj M et al.(2016).
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet Neurology
vol. 15,
(7)
695-707.
Traylor M, Rutten-Jacobs LCA, Thijs V, Holliday EG, Levi C, Bevan S, Malik R, Boncoraglio G et al.(2016).
Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke. Stroke
vol. 47,
(5)
1174-1179.
Traylor M, Adib-Samii P, Harold D, Dichgans M, Williams J, Lewis CM, Markus HS, Fornage M et al.(2016).
Shared genetic contribution to ischemic stroke and Alzheimer's disease. Annals of Neurology
vol. 79,
(5)
739-747.
Malik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, Zhao W, Abrantes P et al.(2016).
Low-frequency and common genetic variation in ischemic stroke. Neurology
vol. 86,
(13)
1217-1226.
Rutten-Jacobs LCA, Traylor M, Adib-Samii P, Thijs V, Sudlow C, Rothwell PM, Boncoraglio G, Dichgans M et al.(2016).
Association of MTHFR C677T Genotype with Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype. Stroke
vol. 47,
(3)
646-651.
Traylor M, Bevan S, Baron JC, Hassan A, Lewis CM, Markus HS(2016).
Erratum: Genetic architecture of lacunar stroke (Stroke (2015) 46 (2407-2412) DOI: 10.1161/STROKEAHA.115.009485). Stroke
vol. 47,
(3)
Harris SE, Malik R, Marioni R, Campbell A, Seshadri S, Worrall BB, Sudlow CLM, Hayward C et al.(2016).
Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology
vol. 86,
(7)
611-618.
Cheng YC, Stanne TM, Giese AK, Ho WK, Traylor M, Amouyel P, Holliday EG, Malik R et al.(2016).
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke
vol. 47,
(2)
307-316.
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L et al.(2016).
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology
vol. 86,
(2)
146-153.
Traylor M, Anderson CD, Hurford R, Bevan S, Markus HS(2016).
Oxidative phosphorylation and lacunar stroke. Neurology
vol. 86,
(2)
141-145.
Traylor M, Rutten-Jacobs LCA, Holliday EG, Malik R, Sudlow C, Rothwell PM, Maguire JM, Koblar SA et al.(2015).
Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex. Stroke
vol. 46,
(11)
3042-3047.
Traylor M, Bevan S, Baron JC, Hassan A, Lewis CM, Markus HS(2015).
Genetic Architecture of Lacunar Stroke. Stroke
vol. 46,
(9)
2407-2412.
Hanscombe KB, Traylor M, Hysi PG, Bevan S, Dichgans M, Rothwell PM, Worrall BB, Seshadri S et al.(2015).
Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. Stroke; a journal of cerebral circulation
vol. 46,
(8)
2069-2074.
Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, De Vries B, Holliday EG et al.(2015).
Shared genetic basis for migraine and ischemic stroke. Neurology
vol. 84,
(21)
2132-2145.
Achterberg S, Kappelle LJ, De Bakker PIW, Traylor M, Algra A, Van Der Graaf Y, Grobbee DE, Rutten GEHM et al.(2015).
No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study. PLoS ONE
vol. 10,
(4)
Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD et al.(2015).
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology
vol. 84,
(9)
918-926.
Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, Cheng YC, Cotlarciuc I et al.(2015).
Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke
vol. 46,
(3)
615-619.
Adib-Samii P, Devan W, Traylor M, Lanfranconi S, Zhang CR, Cloonan L, Falcone GJ, Radmanesh F et al.(2015).
Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. Stroke
vol. 46,
(2)
348-353.
Rutten-Jacobs LCA, Traylor M, Adib-Samii P, Thijs V, Sudlow C, Rothwell PM, Boncoraglio G, Dichgans M et al.(2015).
Common NOTCH3 Variants and Cerebral Small-Vessel Disease. Stroke
vol. 46,
(6)
1482-1487.
Traylor M, Markus H, Lewis CM(2015).
Homogeneous case subgroups increase power in genetic association studies. European Journal of Human Genetics
vol. 23,
(6)
863-869.
Verhaaren BFJ, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB et al.(2015).
Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Circulation: Cardiovascular Genetics
vol. 8,
(2)
398-409.
Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, Sturm J, Hankey GJ et al.(2014).
Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke
vol. 45,
(12)
3508-3513.
Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P et al.(2014).
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology
vol. 83,
(8)
678-685.
Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, Wiggins KL, Zhao W et al.(2014).
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach. PLoS Genetics
vol. 10,
(7)
Mäkelä KM, Traylor M, Oksala N, Kleber ME, Seppälä I, Lyytikäinen LP, Hernesniemi JA, Kähönen M et al.(2014).
Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events. Atherosclerosis
vol. 234,
(1)
214-217.
Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S et al.(2014).
Erratum: Ischemic stroke is associated with the ABO locus: The EuroCLOT study (Annals of Neurology (2013) 73 (16-31)). Annals of Neurology
vol. 75,
(1)
166-167.
Traylor M, Bevan S, Rothwell PM, Sudlow C, Dichgans M, Markus HS, Lewis CM(2013).
Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes. Genetic Epidemiology
vol. 37,
(5)
495-503.
Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, Fitzpatrick K, Bevan S et al.(2013).
17q25 locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status. Stroke
vol. 44,
(6)
1609-1615.
Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S et al.(2013).
Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Annals of neurology
vol. 73,
(1)
16-31.
Bevan S, Traylor M, Adib-Samii P, Malik R, Paul NLM, Jackson C, Farrall M, Rothwell PM et al.(2012).
Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke
vol. 43,
(12)
3161-3167.
Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA et al.(2012).
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies. The Lancet Neurology
vol. 11,
(11)
951-962.
Holliday EG, Maguire JM, Evans TJ, Koblar SA, Jannes J, Sturm JW, Hankey GJ, Baker R et al.(2012).
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nature Genetics
vol. 44,
(10)
1147-1151.
Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, Jackson CA, Traylor M et al.(2012).
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics
vol. 44,
(3)
328-333.