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Publications: Prof Philip Eaton

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Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J et al. ( 2023 ) . Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation . Circulation Research vol. 133 , ( 12 ) 966 - 988 .
Caggiano MF, Charles R, Prysyazhna O, Eaton P ( 2023 ) . UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2 . Free Radical Biology and Medicine vol. 208 ,
Heusch G, Andreadou I, Bell R, Bertero E, Botker H-E, Davidson SM, Downey J, Eaton P et al. ( 2023 ) . Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection . Redox Biology vol. 67 ,
Switzer CH, Kasamatsu S, Ihara H, Eaton P ( 2023 ) . SOD1 is an essential H2S detoxifying enzyme . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 3 )
Kamynina A, Guttzeit S, Eaton P, Cuello F ( 2022 ) . Blood pressure lowering by nitroxyl donor CXL-1020 is mediated by oxidation of Protein Kinase G I . Journal of Molecular and Cellular Cardiology vol. 173 , 96 - 97 .
Varadarajan S, Abdelsaid K, Boatwright H, McMenamin M, Eaton P, Ushio-Fukai M, Fukai T ( 2022 ) . Abstract 9930: Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G . Circulation vol. 146 , ( Suppl_1 ) a9930 - a9930 .
Charles R, Fernandez-Caggiano M, Rudyk O, Ehteramyan M, Switzer C, Buccafusca R, Bianchi K, Morales V et al. ( 2022 ) . A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective . Free Radical Biology and Medicine vol. 192 ,
Francois AA, Yin X, Mayr M, Eaton P ( 2022 ) . Identification of Cardiac Proteins that Sense Oxidants by Intra-disulfide Formation . Free Radical Biology and Medicine vol. 192 , 60 - 61 .
Baidanoff FM, Trebucq LL, Plano SA, Eaton P, Golombek DA, Chiesa JJ ( 2022 ) . Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 . Biomolecules vol. 12 , ( 7 )
Charles R, Eaton P ( 2022 ) . Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease . Cells vol. 11 , ( 12 )
Switzer CH, Cho H-J, Eykyn TR, Lavender P, Eaton P ( 2022 ) . NOS2 and <i>S</i>-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 21 )
Switzer CH, Cho H-J, Eykyn TR, Lavender P, Eaton P ( 2022 ) . NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 21 )
Kamynina A, Guttzeit S, Eaton P, Cuello F ( 2022 ) . Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I . Hypertension vol. 79 , ( 5 ) 946 - 956 .
Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H et al. ( 2022 ) . Redox-dependent internalization ofthe purinergic P2Y6 receptor limits colitis progression . Science Signaling vol. 15 , ( 716 )
Varadarajan S, Abdelsaid K, Boatwright H, McMenamin M, Eaton P, Ushio-Fukai M, Fukai T ( 2022 ) . Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G . CIRCULATION . vol. 146 ,
Queiroz RF, Stanley CP, Wolhuter K, Kong SMY, Rajivan R, McKinnon N, Nguyen GTH, Roveri A et al. ( 2021 ) . Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation . Nature Communications vol. 12 , ( 1 )
Switzer CH, Guttzeit S, Eykyn TR, Eaton P ( 2021 ) . Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells . Redox Biology vol. 47 ,
Islam MMT, Tarnowski D, Zhang M, Trum M, Lebek S, Mustroph J, Daniel H, Moellencamp J et al. ( 2021 ) . Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice . Journal of the American Heart Association vol. 10 , ( 19 )
Charles RL, Abis G, Fernandez BF, Guttzeit S, Buccafusca R, Conte MR, Eaton P ( 2021 ) . A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation . Redox Biology102107 - 102107 .
Fernandez-Caggiano M, Eaton P ( 2021 ) . Heart failure—emerging roles for the mitochondrial pyruvate carrier . Cell Death & Differentiation vol. 28 , ( 4 ) 1149 - 1158 .
Simon JN, VRELLAKU B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2020 ) . Abstract 14219: Oxidation of PKA-RIα Protects Against Ischemia-reperfusion Injury by Inhibiting Lysosomal-triggered Calcium Release . Circulation vol. 142 , ( Suppl_3 )
Simon JN, Vrellaku B, Monterisi S, Chu SM, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2020 ) . Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release . Circulation vol. 143 , ( 5 ) 449 - 465 .
Fernandez-Caggiano M, Kamynina A, Francois AA, Prysyazhna O, Eykyn TR, Krasemann S, Crespo-Leiro MG, Vieites MG et al. ( 2020 ) . Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy . Nature Metabolism vol. 2 , ( 11 ) 1223 - 1231 .
Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, Maier LS, Wagner S ( 2020 ) . Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart . AJP Heart and Circulatory Physiology vol. 319 , ( 6 ) h1347 - h1357 .
Simon JN, Vrellaku B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2020 ) . B Oxidized PKARIα protects against ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release . Heart vol. 106 , ( Suppl 2 ) a111 - a111 .
Wack G, Eaton P, Schmidtko A, Kallenborn-Gerhardt W ( 2020 ) . Redox regulation of soluble epoxide hydrolase does not affect pain behavior in mice . Neuroscience Letters vol. 721 ,
Cho H-J, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P ( 2019 ) . Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth . Redox Biology vol. 29 ,
Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HAT, Hill‐Eubanks D et al. ( 2019 ) . “A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG . Physiological Reports vol. 7 , ( 22 )
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Response by Prysyazhna et al to Letter Regarding Article, “Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase” . Circulation vol. 140 , ( 22 ) e810 - e811 .
Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO et al. ( 2019 ) . Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling . Cardiovascular Research vol. 116 , ( 1 ) 51 - 62 .
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al. ( 2019 ) . Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 26 ) 13016 - 13025 .
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Blood Pressure-Lowering by the Antioxidant Resveratrol is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase . Circulation vol. 140 , ( 2 ) 126 - 137 .
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al. ( 2019 ) . 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism . Communications Biology vol. 2 , ( 1 )
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al. ( 2019 ) . Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction . Circulation Research vol. 124 , ( 12 ) 1727 - 1746 .
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al. ( 2019 ) . Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation . Nature vol. 566 , ( 7745 ) 548 - 552 .
Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al. ( 2018 ) . PKG1α oxidation negatively regulates food seeking behaviour and reward . Redox Biology vol. 21 ,
Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P ( 2018 ) . 61 Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome . Free Radical Biology and Medicine . vol. 128 ,
Cuello F, Eaton P ( 2018 ) . Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System . Annual Reviews
Abis G, Charles RL, Eaton P, Conte MR ( 2018 ) . Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain . Protein Expression and Purification vol. 153 , 105 - 113 .
Cuello F, Wittig I, Lorenz K, Eaton P ( 2018 ) . Oxidation of cardiac myofilament proteins: Priming for dysfunction? . Molecular Aspects of Medicine vol. 63 , 47 - 58 .
De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED et al. ( 2018 ) . The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules . JCI Insight vol. 3 , ( 16 )
Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P ( 2018 ) . Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation . Molecular Cell vol. 69 , ( 3 ) 438 - 450.e5 .
Kapil V ( 2017 ) . Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 . BMC Pharmacol Toxicol vol. 18 , ( Suppl 1 ) 64 - 64 .
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al. ( 2017 ) . Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity . Scientific Reports vol. 7 , ( 1 )
Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS ( 2017 ) . Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 . Journal of Biological Chemistry vol. 292 , ( 39 ) 16161 - 16173 .
Burgoyne JR, Prysyazhna O, Richards DA, Eaton P ( 2017 ) . Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I&agr; (Protein Kinase G I&agr;) . Hypertension vol. 70 , ( 3 ) 577 - 586 .
Rudyk O, Eaton P ( 2017 ) . Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity . Free Radical Biology and Medicine vol. 110 , 390 - 398 .
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al. ( 2017 ) . Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure . Circulation vol. 135 , ( 22 ) 2163 - 2177 .
Wolhuter K, Eaton P ( 2017 ) . How widespread is stable protein S-nitrosylation as an end-effector of protein regulation? . Free Radical Biology and Medicine vol. 109 , 156 - 166 .
Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I ( 2016 ) . Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain . Redox Biology vol. 11 , 176 - 191 .
Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . 348 Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation . Free Radical Biology and Medicine . vol. 100 ,
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response . Nature Communications vol. 7 , 13187 - 13187 .
Khavandi K, Baylie RA, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD et al. ( 2016 ) . Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels . Science Signaling vol. 9 , ( 449 )
Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P ( 2016 ) . Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation . J Biol Chem vol. 291 , ( 33 ) 17427 - 17436 .
Fernandez-Caggiano M, Schröder E, Cho H-J, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P ( 2016 ) . Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2* . Journal of Biological Chemistry vol. 291 , ( 19 ) 10399 - 10410 .
Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F et al. ( 2016 ) . S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure . The FASEB Journal vol. 30 , ( 5 ) 1849 - 1864 .
Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al. ( 2016 ) . Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S‑Guanylation . Biochemistry vol. 55 , ( 5 ) 751 - 761 .
Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE ( 2015 ) . Intensity matters: Ryanodine receptor regulation during exercise . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 50 ) 15271 - 15272 .
Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al. ( 2015 ) . Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling* . Journal of Biological Chemistry vol. 291 , ( 4 ) 1774 - 1788 .
Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, CalviñoSantos R, Aldama López G, Generosa Crespo-Leiro M, Eaton P, Doménech N ( 2015 ) . Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability* . Molecular & Cellular Proteomics vol. 15 , ( 1 ) 246 - 255 .
Rudyk O, Prysyazhna O, Zhao L, Eaton P ( 2015 ) . Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )
Prysyazhna O, Burgoyne JR, Eaton P ( 2015 ) . Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )
Burgoyne JR, Rudyk O, Cho H-J, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al. ( 2015 ) . Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice . Nature Communications vol. 6 , ( 1 )
Prysyazhna O, Eaton P ( 2015 ) . Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system . Frontiers in Pharmacology vol. 6 ,
Cameron JM, Gabrielsen M, Chim YH, Munro J, McGhee EJ, Sumpton D, Eaton P, Anderson KI et al. ( 2015 ) . Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation . Current Biology vol. 25 , ( 11 ) 1520 - 1525 .
Nakamura T, Ranek MJ, Lee DI, Hahn VS, Kim C, Eaton P, Kass DA ( 2015 ) . Prevention of PKG1α oxidation augments cardioprotection in the stressed heart . Journal of Clinical Investigation vol. 125 , ( 6 ) 2468 - 2472 .
Eaton P ( 2015 ) . OP7 Thiol redox sensing and signalling and the control of blood pressure . Nitric Oxide . vol. 47 , s6 - s7 .
Sawa T, Ahmed A, Ono K, Ida T, Fujii S, Eaton P, Akaike T ( 2014 ) . P179 Persistent activation of protein kinase G by a nitrated cyclic nucleotide via site specific S-guanylation and its implication for vascular hyporeactivity in endotoxin shock . Nitric Oxide . vol. 42 ,
Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P ( 2014 ) . Protein Kinase G I&agr; Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide . Hypertension vol. 64 , ( 6 ) 1344 - 1351 .
Rudyk O, Eaton P ( 2014 ) . Biochemical methods for monitoring protein thiol redox states in biological systems . Redox Biology vol. 2 , 803 - 813 .
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al. ( 2014 ) . Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 22 ) 8167 - 8172 .
Eaton P, Shah AM ( 2014 ) . Preface for redox signalling in the cardiovascular system . Journal of Molecular and Cellular Cardiology vol. 73 ,
Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KMJ, Eaton P, Geisslinger G, Schmidtko A ( 2014 ) . Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury . Antioxidants & Redox Signaling vol. 21 , ( 10 ) 1504 - 1515 .
Bassi R, Rudyk O, Burgoyne J, Eaton P, Marber MS ( 2014 ) . 3 Can Redox-Sensitive Cysteines in P38A-MAPK Modulate Activation During Stress? . Heart . vol. 100 ,
Islam T, Dantz C, Daniel H, Moellencamp J, El-Armouche A, Eaton P, Maier LS, Wagner S ( 2014 ) . Disruption of oxidative PKA activation contributes to ventricular remodeling upon increased afterload . EUROPEAN HEART JOURNAL . vol. 35 , 330 - 330 .
Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T et al. ( 2013 ) . Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research . European Journal of Heart Failure vol. 16 , ( 1 ) 6 - 14 .
Burgoyne JR, Rudyk O, Prysyazhna O, Schröder K, Brandes RP, Shah AM, Eaton P ( 2013 ) . PSS132 Oxidation of Camp Dependent Protein Kinase Regulatory RIα Mediates Angiogenesis . Free Radical Biology and Medicine . vol. 65 ,
Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P ( 2013 ) . PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy . Free Radical Biology and Medicine . vol. 65 ,
Prysyazhna O, Burgoyne JR, Eaton PP ( 2013 ) . PSS167 Cys42Ser PKG Iα Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy . Free Radical Biology and Medicine . vol. 65 , s80 - s81 .
Rudyk O, Prysyazhna O, Eaton P ( 2013 ) . PSS171 Redox-Dead Protein Kinase a RIα knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants . Free Radical Biology and Medicine . vol. 65 ,
Stubbert D, Prysyazhna O, Rudyk O, Burgoyne JR, Eaton P ( 2013 ) . PSS176 The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G Iα . Free Radical Biology and Medicine . vol. 65 ,
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar R, Eaton P ( 2013 ) . Protein kinase G oxidation contribute to hypotension and organ injury during sepsis . BMC Pharmacology and Toxicology vol. 14 , ( Suppl 1 )
Burgoyne JR, Oviosu O, Eaton P ( 2013 ) . The PEG-switch assay: A fast semi-quantitative method to determine protein reversible cysteine oxidation . Journal of Pharmacological and Toxicological Methods vol. 68 , ( 3 ) 297 - 301 .
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P ( 2013 ) . Protein kinase G oxidation is a major cause of injury during sepsis . Proceedings of the National Academy of Sciences of the United States of America vol. 110 , ( 24 ) 9909 - 9913 .
Burgoyne JR, Eaton P ( 2013 ) . Approaches for Monitoring PKG1α Oxidative Activation . Methods in Molecular Biology vol. 1020 , 163 - 173 .
Charles R, Jayawardhana T, Eaton P ( 2013 ) . Gel-based methods in redox proteomics . Biochimica et Biophysica Acta vol. 1840 , ( 2 ) 830 - 837 .
Burgoyne JR, Din HM, Eaton P, Shah AM ( 2013 ) . Response to Detailed Aspects of Redox Signaling in Cardiac Physiology and Pathology . Circulation Research vol. 112 , ( 1 )
Burgoyne JR, Eaton P ( 2013 ) . Chapter Seven Detecting Disulfide-Bound Complexes and the Oxidative Regulation of Cyclic Nucleotide-Dependent Protein Kinases by H2O2 . Methods in Enzymology vol. 528 , 111 - 128 .
Fernandez-Caggiano M, Schroder E, Burgoyne J, Eaton P ( 2012 ) . Characterization of Redox Changes in Cardiac DJ-1 during Oxidant Stress . Free Radical Biology and Medicine . vol. 53 , s159 - s160 .
Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P ( 2012 ) . Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption . Free Radical Biology and Medicine . vol. 53 ,
Prysyazhna O, Cuello F, Eaton P ( 2012 ) . Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice . Free Radical Biology and Medicine . vol. 53 ,
Burgoyne JR, Rudyk O, Eaton P ( 2012 ) . Protein Kinase a Regulatory RI Oxidation Mediates Angiogenesis . Free Radical Biology and Medicine . vol. 53 ,
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation . Free Radical Biology and Medicine . vol. 53 ,
Burgoyne JR, Mongue-Din H, Eaton P, Shah AM ( 2012 ) . Redox Signaling in Cardiac Physiology and Pathology . Circulation Research vol. 111 , ( 8 ) 1091 - 1106 .
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation . Hypertension vol. 60 , ( 5 ) 1301 - 1308 .
Burgoyne JR, Oka S-I, Ale-Agha N, Eaton P ( 2012 ) . Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System . Antioxidants & Redox Signaling vol. 18 , ( 9 ) 1042 - 1052 .
Burgoyne⁎ JR, Rudyk O, Eaton P ( 2012 ) . A potential role for PKA oxidation in growth factor mediated angiogenesis . Free Radical Biology and Medicine . vol. 53 ,
Fernandez-Caggiano⁎ M, Schroder E, Eaton P ( 2012 ) . Dynamic and Complex Redox-Dependent Modifications of DJ-1 in Cardiac Cells and Tissue During Oxidative Stress . Free Radical Biology and Medicine . vol. 53 , s61 - s62 .
Burgoyne⁎ JR, Prysyazhna O, Eaton P ( 2012 ) . Dynamic interplay between classical and oxidative activation of PKG1α - implications for blood pressure control . Free Radical Biology and Medicine . vol. 53 , s129 - s130 .
Rudyk⁎ O, Prysyazhna O, Eaton P ( 2012 ) . Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse . Free Radical Biology and Medicine . vol. 53 ,
Zhang M, Takimoto E, Lee D-I, Santos CXC, Nakamura T, Hsu S, Jiang A, Nagayama T et al. ( 2012 ) . Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling . Circulation vol. 126 , ( 8 ) 942 - 951 .
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1α knock-in mouse . Nitric Oxide . vol. 27 , s13 - s14 .
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1&agr; Knock-In Mouse . Circulation vol. 126 , ( 3 ) 287 - 295 .
Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension . Nature Medicine vol. 18 , ( 2 ) 286 - 290 .
Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGIα KNOCK-IN MOUSE . JOURNAL OF VASCULAR RESEARCH . vol. 49 , 39 - 39 .
Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension . Free Radical Biology and Medicine . vol. 51 ,
Rudyk O, Prysyazhna O, Burgoyne J, Eaton P ( 2011 ) . Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation . Free Radical Biology and Medicine . vol. 51 ,
Burgoyne JR, Eaton P ( 2011 ) . Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation . Biochemical Society Transactions vol. 39 , ( 5 ) 1260 - 1267 .
Shao D, Oka S-I, Brady CD, Haendeler J, Eaton P, Sadoshima J ( 2011 ) . Redox modification of cell signaling in the cardiovascular system . Journal of Molecular and Cellular Cardiology vol. 52 , ( 3 ) 550 - 558 .
Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse . BMC Pharmacology vol. 11 , ( Suppl 1 )
Akaike T, van der Vliet A, Eaton P ( 2011 ) . Frontiers in nitric oxide and redox signaling . Nitric Oxide vol. 25 , ( 2 ) 57 - 58 .
Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al. ( 2011 ) . Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo . Arteriosclerosis Thrombosis and Vascular Biology vol. 31 , ( 6 ) 1368 - 1376 .
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al. ( 2010 ) . Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-&Dgr;-Prostaglandin J2 Controls Coronary Hypoxic Vasodilation . Circulation Research vol. 108 , ( 3 ) 324 - 334 .
Burgoyne JR, Rudyk O, Mayr M, Eaton P ( 2010 ) . Nitrosative protein oxidation is modulated during early endotoxemia . Nitric Oxide vol. 25 , ( 2 ) 118 - 124 .
Maller C, Schröder E, Eaton P ( 2010 ) . Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody . Antioxidants & Redox Signaling vol. 14 , ( 1 ) 49 - 60 .
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al. ( 2010 ) . Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury . AJP Heart and Circulatory Physiology vol. 299 , ( 3 ) h827 - h836 .
Burgoyne JR, Eaton P ( 2010 ) . Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation . Sensors vol. 10 , ( 4 ) 2731 - 2751 .
Burgoyne JR, Eaton P ( 2010 ) . Chapter 15 A Rapid Approach for the Detection, Quantification, and Discovery of Novel Sulfenic Acid or S-Nitrosothiol Modified Proteins Using a Biotin-Switch Method . Thiol Redox Transitions in Cell Signaling, Part A: Chemistry and Biochemistry of Low Molecular Weight and Protein Thiols , vol. 473 , Elsevier
Burgoyne JR, Eaton P ( 2009 ) . Transnitrosylating Nitric Oxide Species Directly Activate Type I Protein Kinase A, Providing a Novel Adenylate Cyclase-independent Cross-talk to β-Adrenergic-like Signaling* . Journal of Biological Chemistry vol. 284 , ( 43 ) 29260 - 29268 .
Schröder E, Eaton P ( 2009 ) . Hydrogen Peroxide and Cysteine Protein Signaling Pathways . Redox Signaling and Regulation in Biology and Medicine , Wiley
Burgoyne JR, Eaton P ( 2009 ) . Beating the silent killer: A new way to relax . Biologist vol. 56 , ( 1 ) 40 - 45 .
Eaton P, Clements‐Jewery H ( 2009 ) . Peroxynitrite: in vivo cardioprotectant or arrhythmogen? . British Journal of Pharmacology vol. 155 , ( 7 ) 972 - 973 .
Charles RL, Eaton P ( 2008 ) . Redox signalling in cardiovascular disease . Proteomics Clinical Applications vol. 2 , ( 6 ) 823 - 836 .
Schröder E, Brennan JP, Eaton P ( 2008 ) . Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress . AJP Heart and Circulatory Physiology vol. 295 , ( 1 ) h425 - h433 .
Schröder E, Eaton P ( 2008 ) . Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations . Current Opinion in Pharmacology vol. 8 , ( 2 ) 153 - 159 .
Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia L-G, Tucker AL et al. ( 2007 ) . Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity . AJP Heart and Circulatory Physiology vol. 294 , ( 2 ) h613 - h621 .
Bell JR, Eaton P, Shattock MJ ( 2007 ) . ROLE OF p38-MITOGEN-ACTIVATED PROTEIN KINASE IN ISCHAEMIC PRECONDITIONING IN RAT HEART . Clinical and Experimental Pharmacology and Physiology vol. 0 , ( 0 ) 070924173348001 - ??? .
Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P ( 2007 ) . Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation . Science vol. 317 , ( 5843 ) 1393 - 1397 .
Charles RL, Schröder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al. ( 2007 ) . Protein Sulfenation as a Redox Sensor Proteomics Studies Using a Novel Biotinylated Dimedone Analogue* . Molecular & Cellular Proteomics vol. 6 , ( 9 ) 1473 - 1484 .
Brennan JP, Eaton P ( 2006 ) . Oxidized Proteins in Cardiac Ischemia and Reperfusion . Redox Proteomics , Wiley
Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schröder E, Wait R, Begum S, Kentish JC et al. ( 2006 ) . Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation* . Journal of Biological Chemistry vol. 281 , ( 31 ) 21827 - 21836 .
Eaton P ( 2006 ) . Protein thiol oxidation in health and disease: Techniques for measuring disulfides and related modifications in complex protein mixtures . Free Radical Biology and Medicine vol. 40 , ( 11 ) 1889 - 1899 .
EATON P, SHATTOCK MJ ( 2002 ) . Purification of Proteins Susceptible to Oxidation at Cysteine Residues: Identification of Malate Dehydrogenase as a Target for S‐Glutathiolation . Annals of the New York Academy of Sciences . vol. 973 , 529 - 532 .
Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schroder E, Wait R, Begum S, Kentish JC et al. ( 2006 ) . Direct activation of type I protein kinase a (PKA) by oxidants independently of cAMP is mediated by RI subunit interprotein disulphide bond formation . CIRCULATION . vol. 114 , 1 - 2 .
Brennan JP, Miller JIA, Fuller W, Wait R, Begum S, Dunn MJ, Eaton P ( 2005 ) . The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation* . Molecular & Cellular Proteomics vol. 5 , ( 2 ) 215 - 225 .
Eaton P, Bell RM, Cave AC, Shattock MJ ( 2005 ) . Ischemic Preconditioning: A Potential Role for Protein S-Thiolation? . Antioxidants & Redox Signaling vol. 7 , ( 7-8 ) 882 - 888 .
Eaton P, Shattock MJ ( 2005 ) . Protein S-Thiolation: Emphasis on Cell Signaling and Gene Expression . Antioxidants & Redox Signaling vol. 7 , ( 7-8 ) 839 - 840 .
Silverman BDZ, Fuller W, Eaton P, Deng J, Moorman JR, Cheung JY, James AF, Shattock MJ ( 2005 ) . Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase . Cardiovascular Research vol. 65 , ( 1 ) 93 - 103 .
Saurin AT, Neubert H, Brennan JP, Eaton P ( 2004 ) . Widespread sulfenic acid formation in tissues in response to hydrogen peroxide . Proceedings of the National Academy of Sciences of the United States of America vol. 101 , ( 52 ) 17982 - 17987 .
Brennan JP, Wait R, Begum S, Bell JR, Dunn MJ, Eaton P ( 2004 ) . Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis* . Journal of Biological Chemistry vol. 279 , ( 40 ) 41352 - 41360 .
Fuller W, Eaton P, Bell JR, Shattock MJ ( 2003 ) . Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase . The FASEB Journal vol. 18 , ( 1 ) 197 - 199 .
THOMAS JD, EATON P ( 2003 ) . Accumulation of free amino acids and humic substances in a freshwater modular system and their ecological significance . Freshwater Biology vol. 35 , ( 2 ) 323 - 338 .
Fuller W, Parmar V, Eaton P, Bell JR, Shattock MJ ( 2003 ) . Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress . Cardiovascular Research vol. 57 , ( 4 ) 1044 - 1051 .
LEUNG K, Shattock MJ, Pratt JR, Ward MA, Byers HL, Leeds N, McGregor E, Eaton P et al. ( 2003 ) . Reversible cysteine-targeted oxidation of proteins during renal oxidative stress . J Am Soc Nephrol . vol. 3 , S290 - 296 .
Eaton P, Wright N, Hearse DJ, Shattock MJ ( 2002 ) . Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion . Journal of Molecular and Cellular Cardiology vol. 34 , ( 11 ) 1549 - 1560 .
Eaton P, Fuller W, Shattock MJ ( 2002 ) . S-Thiolation of HSP27 Regulates Its Multimeric Aggregate Size Independently of Phosphorylation* . Journal of Biological Chemistry vol. 277 , ( 24 ) 21189 - 21196 .
Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ ( 2002 ) . Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion* . Journal of Biological Chemistry vol. 277 , ( 12 ) 9806 - 9811 .
Eaton P, Fuller W, Bell JR, Shattock MJ ( 2001 ) . α B Crystallin Translocation and Phosphorylation: Signal Transduction Pathways and Preconditioning in the Isolated Rat Heart . Journal of Molecular and Cellular Cardiology vol. 33 , ( 9 ) 1659 - 1671 .
Eaton P, Hearse DJ, Shattock MJ ( 2001 ) . Lipid hydroperoxide modification of proteins during myocardial ischaemia . Cardiovascular Research vol. 51 , ( 2 ) 294 - 303 .
Fuller W, Eaton P, Medina RA, Bell J, Shattock MJ ( 2001 ) . Differential Centrifugation Separates Cardiac Sarcolemmal and Endosomal Membranes from Langendorff-Perfused Rat Hearts . Analytical Biochemistry vol. 293 , ( 2 ) 216 - 223 .
Eaton P, Awad WI, Miller JI, Hearse DJ, Shattock MJ ( 2000 ) . Ischemic Preconditioning: a Potential Role for Constitutive Low Molecular Weight Stress Protein Translocation and Phosphorylation? . Journal of Molecular and Cellular Cardiology vol. 32 , ( 6 ) 961 - 971 .
Eaton P, Thomas JD ( 1999 ) . The accumulation and metabolism of amino acids by Biomphalaria glabrata, a freshwater pulmonate snail . Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology vol. 122 , ( 4 ) 421 - 428 .
Eaton P, Li J-M, Hearse DJ, Shattock MJ ( 1999 ) . Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart . American Journal of Physiology vol. 276 , ( 3 ) h935 - h943 .
Thomas JD, Eaton P ( 1998 ) . The Origins, Fate, and Ecological Significance of Free Amino Compounds Released by Freshwater Pulmonate Snails . Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology . vol. 119 , 341 - 349 .
Thomas JD, Eaton P ( 1996 ) . The accumulation of amino-acids and humic substances in media conditioned by axenic and non-axenic duckweed (Lemna minor L.) and their possible ecological significance . Hydrobiologia vol. 333 , ( 2 ) 121 - 128 .
Thomas JD, Eaton P ( 1996 ) . The spatio-temporal patterns and ecological significance of free amino acids and humic substances in contrasting oligotrophic and eutrophic freshwater ecosystems . Hydrobiologia vol. 332 , ( 3 ) 183 - 211 .
Thomas JD, Eaton P ( 1993 ) . Amino acid medleys of snail origin as possible sources of information for conspecifics, schistosome miracidia and predators . Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology vol. 106 , ( 3 ) 781 - 796 .
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