Publications: Dr Rebecca Charles

de Jesus DS, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al. ( 2024 ) . Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension . Free Radical Biology and Medicine vol. 224 ,

Faulkes CG, Eykyn TR, Miljkovic JL, Gilbert JD, Charles RL, Prag HA, Patel N, Hart DW et al. ( 2024 ) . Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles . Nature Communications vol. 15 , ( 1 )

Caggiano MF, Charles R, Prysyazhna O, Eaton P ( 2023 ) . UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2 . Free Radical Biology and Medicine vol. 208 ,

Charles R, Fernandez-Caggiano M, Rudyk O, Ehteramyan M, Switzer C, Buccafusca R, Bianchi K, Morales V et al. ( 2022 ) . A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective . Free Radical Biology and Medicine vol. 192 ,

Charles R, Eaton P ( 2022 ) . Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease . Cells vol. 11 , ( 12 )

Charles RL, Abis G, Fernandez BF, Guttzeit S, Buccafusca R, Conte MR, Eaton P ( 2021 ) . A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation . Redox Biology102107 - 102107 .

Cho H-J, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P ( 2019 ) . Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth . Redox Biology vol. 29 ,

Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al. ( 2019 ) . 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism . Communications Biology vol. 2 , ( 1 )

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al. ( 2019 ) . Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction . Circulation Research vol. 124 , ( 12 ) 1727 - 1746 .

Abis G, Charles RL, Eaton P, Conte MR ( 2018 ) . Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain . Protein Expression and Purification vol. 153 , 105 - 113 .

Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS ( 2017 ) . Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 . Journal of Biological Chemistry vol. 292 , ( 39 ) 16161 - 16173 .

Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al. ( 2014 ) . Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 22 ) 8167 - 8172 .

Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P ( 2013 ) . PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy . Free Radical Biology and Medicine . vol. 65 ,

Charles R, Jayawardhana T, Eaton P ( 2013 ) . Gel-based methods in redox proteomics . Biochimica et Biophysica Acta vol. 1840 , ( 2 ) 830 - 837 .

Charles R, Yin X, Mayr M, Eaton P ( 2012 ) . Detection and Identification of Cardiac Proteins Modified by the Dietary Flavanol Curcumin . Free Radical Biology and Medicine . vol. 53 , s157 - s158 .

Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P ( 2012 ) . Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption . Free Radical Biology and Medicine . vol. 53 ,

Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al. ( 2011 ) . Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo . Arteriosclerosis Thrombosis and Vascular Biology vol. 31 , ( 6 ) 1368 - 1376 .

Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al. ( 2010 ) . Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-&Dgr;-Prostaglandin J2 Controls Coronary Hypoxic Vasodilation . Circulation Research vol. 108 , ( 3 ) 324 - 334 .

Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al. ( 2010 ) . Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury . AJP Heart and Circulatory Physiology vol. 299 , ( 3 ) h827 - h836 .

Charles RL, Burgoyne J, Mayr M, Landar A, Eaton P ( 2009 ) . 15-deoxy-Δ 12, 14-prostaglandin J₂ Adducts to Soluble Epoxide Hydrolase at Cys521 Resulting in its Inhibition which Couples to Coronary Vasodilation . FREE RADICAL BIOLOGY AND MEDICINE . vol. 47 , S56 - S56 .

Charles RL, Eaton P ( 2008 ) . Redox signalling in cardiovascular disease . Proteomics Clinical Applications vol. 2 , ( 6 ) 823 - 836 .

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P ( 2007 ) . Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation . Science vol. 317 , ( 5843 ) 1393 - 1397 .

Charles RL, Schröder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al. ( 2007 ) . Protein Sulfenation as a Redox Sensor Proteomics Studies Using a Novel Biotinylated Dimedone Analogue* . Molecular & Cellular Proteomics vol. 6 , ( 9 ) 1473 - 1484 .

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schroeder E, Eaton P ( 2007 ) . H2O2 operates as an endothelium-derived hyperpolarizing factor by directly activating protein kinase G (PKG) Iα independently of cGMP via disulfide formation . CIRCULATION . vol. 116 , 8 - 8 .