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Research

Publications: Dr Rebecca Charles

Charles RL, Abis G, Fernandez BF, Guttzeit S, Buccafusca R, Conte MR, Eaton P ( 2021 ) . A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation . Redox Biology102107 - 102107 .
Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P ( 2020 ) . Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth . Redox Biology vol. 29 ,
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al. ( 2019 ) . 15-deoxy-Δ<sup>12,14</sup>-Prostaglandin J<inf>2</inf> inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism . Communications Biology vol. 2 , ( 1 )
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al. ( 2019 ) . Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction . Circulation Research vol. 124 , ( 12 ) 1727 - 1746 .
Abis G, Charles RL, Eaton P, Conte MR ( 2019 ) . Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain . Protein Expression and Purification vol. 153 , 105 - 113 .
Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS ( 2017 ) . Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 . Journal of Biological Chemistry vol. 292 , ( 39 ) 16161 - 16173 .
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al. ( 2014 ) . Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 22 ) 8167 - 8172 .
Charles R, Jayawardhana T, Eaton P ( 2014 ) . Gel-based methods in redox proteomics . Biochimica et Biophysica Acta - General Subjects vol. 1840 , ( 2 ) 830 - 837 .
Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P ( 2013 ) . PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy . Free Radical Biology and Medicine . vol. 65 ,
Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P ( 2012 ) . Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption . Free Radical Biology and Medicine . vol. 53 ,
Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al. ( 2011 ) . Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 6 ) 1368 - 1376 .
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al. ( 2011 ) . Redox regulation of soluble epoxide hydrolase by 15-Deoxy-Δ- Prostaglandin J<inf>2</inf> Controls coronary hypoxic vasodilation . Circulation Research vol. 108 , ( 3 ) 324 - 334 .
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al. ( 2010 ) . Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury . American Journal of Physiology - Heart and Circulatory Physiology vol. 299 , ( 3 )
Charles RL, Eaton P ( 2008 ) . Redox signalling in cardiovascular disease . Proteomics - Clinical Applications vol. 2 , ( 6 ) 823 - 836 .
Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P ( 2007 ) . Cysteine redox sensor in PKGIα enables oxidant-induced activation . Science vol. 317 , ( 5843 ) 1393 - 1397 .
Charles RL, Schröder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al. ( 2007 ) . Protein sulfenation as a redox sensor: Proteomics studies using a novel biotinylated dimedone analogue . Molecular and Cellular Proteomics vol. 6 , ( 9 ) 1473 - 1484 .