Publications: Dr Rebecca Charles
Charles R, Fernandez-Caggiano M, Rudyk O, Ehteramyan M, Switzer C, Buccafusca R, Bianchi K, Morales V et al.
(
2022
)
.
A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective
.
Free Radical Biology and Medicine
vol.
192
,
Charles R, Eaton P
(
2022
)
.
Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease
.
Cells
vol.
11
,
(
12
)
Charles RL, Abis G, Fernandez BF, Guttzeit S, Buccafusca R, Conte MR, Eaton P
(
2021
)
.
A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation
.
Redox Biology102107
-
102107
.
Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P
(
2020
)
.
Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth
.
Redox Biology
vol.
29
,
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al.
(
2019
)
.
15-deoxy-Δ<sup>12,14</sup>-Prostaglandin J<inf>2</inf> inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
.
Communications Biology
vol.
2
,
(
1
)
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al.
(
2019
)
.
Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction
.
Circulation Research
vol.
124
,
(
12
)
1727
-
1746
.
Abis G, Charles RL, Eaton P, Conte MR
(
2019
)
.
Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain
.
Protein Expression and Purification
vol.
153
,
105
-
113
.
Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS
(
2017
)
.
Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
.
Journal of Biological Chemistry
vol.
292
,
(
39
)
16161
-
16173
.
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al.
(
2014
)
.
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
111
,
(
22
)
8167
-
8172
.
Charles R, Jayawardhana T, Eaton P
(
2014
)
.
Gel-based methods in redox proteomics
.
Biochimica et Biophysica Acta - General Subjects
vol.
1840
,
(
2
)
830
-
837
.
Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P
(
2013
)
.
PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy
.
Free Radical Biology and Medicine
.
vol.
65
,
Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P
(
2012
)
.
Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption
.
Free Radical Biology and Medicine
.
vol.
53
,
Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al.
(
2011
)
.
Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo
.
Arteriosclerosis, Thrombosis, and Vascular Biology
vol.
31
,
(
6
)
1368
-
1376
.
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al.
(
2011
)
.
Redox regulation of soluble epoxide hydrolase by 15-Deoxy-Δ- Prostaglandin J<inf>2</inf> Controls coronary hypoxic vasodilation
.
Circulation Research
vol.
108
,
(
3
)
324
-
334
.
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al.
(
2010
)
.
Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
299
,
(
3
)
Charles RL, Eaton P
(
2008
)
.
Redox signalling in cardiovascular disease
.
Proteomics - Clinical Applications
vol.
2
,
(
6
)
823
-
836
.
Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P
(
2007
)
.
Cysteine redox sensor in PKGIα enables oxidant-induced activation
.
Science
vol.
317
,
(
5843
)
1393
-
1397
.
Charles RL, Schröder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al.
(
2007
)
.
Protein sulfenation as a redox sensor: Proteomics studies using a novel biotinylated dimedone analogue
.
Molecular and Cellular Proteomics
vol.
6
,
(
9
)
1473
-
1484
.