Publications: Dr Oleksandra Prysyazhna
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T et al.
(
2022
)
.
Whole-genome sequencing reveals host factors underlying critical COVID-19
.
Nature
vol.
607
,
(
7917
)
97
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103
.
Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S et al.
(
2022
)
.
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
.
Human Genetics
vol.
141
,
(
1
)
147
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173
.
Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Pathak GA, Andrews SJ et al.
(
2021
)
.
Mapping the human genetic architecture of COVID-19
.
Nature
vol.
600
,
(
7889
)
472
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477
.
Boguslavskyi A, Tokar S, Prysyazhna O, Rudyk O, Sanchez-Tatay D, Lemmey HAL, Dora KA, Garland CJ et al.
(
2021
)
.
Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans
.
Circulation
vol.
143
,
(
11
)
1123
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1138
.
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N et al.
(
2020
)
.
Genetic mechanisms of critical illness in COVID-19
.
Nature
vol.
591
,
(
7848
)
92
-
98
.
Fernandez-Caggiano M, Kamynina A, Francois AA, Prysyazhna O, Eykyn TR, Krasemann S, Crespo-Leiro MG, Vieites MG et al.
(
2020
)
.
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy
.
Nature Metabolism
vol.
2
,
(
11
)
1223
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1231
.
Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO et al.
(
2020
)
.
Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling
.
Cardiovascular Research
vol.
116
,
(
1
)
51
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62
.
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.
(
2019
)
.
Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase"
.
Circulation
vol.
140
,
(
22
)
E810
-
E811
.
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.
(
2019
)
.
Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase
.
Circulation
vol.
140
,
(
2
)
126
-
137
.
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al.
(
2019
)
.
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
.
Nature
vol.
566
,
(
7745
)
548
-
552
.
Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al.
(
2019
)
.
PKG1α oxidation negatively regulates food seeking behaviour and reward
.
Redox Biology
vol.
21
,
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al.
(
2019
)
.
Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
116
,
(
26
)
13016
-
13025
.
Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P
(
2018
)
.
61 Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome
.
Free Radical Biology and Medicine
.
vol.
128
,
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al.
(
2017
)
.
Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity
.
Scientific Reports
vol.
7
,
(
1
)
Kapil V
(
2017
)
.
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
.
BMC Pharmacol Toxicol
vol.
18
,
(
Suppl 1
)
64
-
64
.
Burgoyne JR, Prysyazhna O, Richards DA, Eaton P
(
2017
)
.
Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I (Protein Kinase G I)
.
Hypertension
vol.
70
,
(
3
)
577
-
586
.
Goetz M, Donzelli S, Schmidt K, Wolters M, Stathopoulou K, Prysyazhna O, Scotcher J, Dees C et al.
(
2017
)
.
Nitroxyl mediates vasodilation by inducing an activating intradisulfide bond in the high affinity cGMP-binding site of PKGI alpha
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
.
vol.
109
,
38
-
38
.
Rudyk O, Krasemann S, Hartmann K, Prysyazhna O, Zhang M, Weiss A, Zhao L, Schermuly R et al.
(
2017
)
.
PKGI alpha oxidation during chronic hypoxia provides an adaptive vasodilatory mechanism that limits pulmonary hypertension
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
.
vol.
109
,
9
-
9
.
Schulz S, Prysyazhna O, Eaton P, Cuello F
(
2017
)
.
Revealing transcriptomic changes in response to chronic angiotensin II infusion in atria versus ventricles of the mouse by nanostring analysis
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
.
vol.
109
,
25
-
26
.
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al.
(
2017
)
.
Distinct regulatory effects of myeloid cell and endothelial cell NAPDH oxidase 2 on blood pressure
.
Circulation
vol.
135
,
(
22
)
2163
-
2177
.
Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.
(
2016
)
.
348 Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation
.
Free Radical Biology and Medicine
.
vol.
100
,
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.
(
2016
)
.
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response
.
Nature Communications
vol.
7
,
13187
-
13187
.
Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P
(
2016
)
.
Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation
.
J Biol Chem
vol.
291
,
(
33
)
17427
-
17436
.
Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al.
(
2016
)
.
Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation
.
Biochemistry
vol.
55
,
(
5
)
751
-
761
.
Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al.
(
2016
)
.
Transcriptional regulation of cystathionine-γ-lyase in endothelial cells by NADPH oxidase 4-dependent signaling
.
Journal of Biological Chemistry
vol.
291
,
(
4
)
1774
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1788
.
Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, Santos RC, López GA, Crespo-Leiro MG, Eaton P, Doménech N
(
2016
)
.
Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability
.
Molecular and Cellular Proteomics
vol.
15
,
(
1
)
246
-
255
.
Rudyk O, Prysyazhna O, Zhao L, Eaton P
(
2015
)
.
Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension
.
BMC Pharmacology and Toxicology
vol.
16
,
(
Suppl 1
)
Prysyazhna O, Burgoyne JR, Eaton P
(
2015
)
.
Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation
.
BMC Pharmacology and Toxicology
vol.
16
,
(
Suppl 1
)
Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al.
(
2015
)
.
Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice
.
Nature Communications
vol.
6
,
Prysyazhna O, Eaton P
(
2015
)
.
Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system
.
Frontiers in Pharmacology
vol.
6
,
(
JUN
)
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al.
(
2014
)
.
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
111
,
(
22
)
8167
-
8172
.
Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P
(
2014
)
.
Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfde
.
Hypertension
vol.
64
,
(
6
)
1344
-
1351
.
Burgoyne JR, Rudyk O, Prysyazhna O, Schröder K, Brandes RP, Shah AM, Eaton P
(
2013
)
.
PSS132 Oxidation of Camp Dependent Protein Kinase Regulatory RIα Mediates Angiogenesis
.
Free Radical Biology and Medicine
.
vol.
65
,
Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P
(
2013
)
.
PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy
.
Free Radical Biology and Medicine
.
vol.
65
,
Prysyazhna O, Burgoyne JR, Eaton PP
(
2013
)
.
PSS167 Cys42Ser PKG Iα Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy
.
Free Radical Biology and Medicine
.
vol.
65
,
s80
-
s81
.
Rudyk O, Prysyazhna O, Eaton P
(
2013
)
.
PSS171 Redox-Dead Protein Kinase a RIα knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants
.
Free Radical Biology and Medicine
.
vol.
65
,
Stubbert D, Prysyazhna O, Rudyk O, Burgoyne JR, Eaton P
(
2013
)
.
PSS176 The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G Iα
.
Free Radical Biology and Medicine
.
vol.
65
,
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar R, Eaton P
(
2013
)
.
Protein kinase G oxidation contribute to hypotension and organ injury during sepsis
.
BMC Pharmacology and Toxicology
vol.
14
,
(
Suppl 1
)
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P
(
2013
)
.
Protein kinase G oxidation is a major cause of injury during sepsis
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
110
,
(
24
)
9909
-
9913
.
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P
(
2012
)
.
CGMP-dependent activation of protein kinase g precludes disulfide activation: Implications for blood pressure control
.
Hypertension
vol.
60
,
(
5
)
1301
-
1308
.
Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P
(
2012
)
.
Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption
.
Free Radical Biology and Medicine
.
vol.
53
,
Prysyazhna O, Cuello F, Eaton P
(
2012
)
.
Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice
.
Free Radical Biology and Medicine
.
vol.
53
,
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P
(
2012
)
.
cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation
.
Free Radical Biology and Medicine
.
vol.
53
,
Burgoyne⁎ JR, Prysyazhna O, Eaton P
(
2012
)
.
Dynamic interplay between classical and oxidative activation of PKG1α - implications for blood pressure control
.
Free Radical Biology and Medicine
.
vol.
53
,
s129
-
s130
.
Rudyk⁎ O, Prysyazhna O, Eaton P
(
2012
)
.
Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse
.
Free Radical Biology and Medicine
.
vol.
53
,
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P
(
2012
)
.
Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse
.
Circulation
vol.
126
,
(
3
)
287
-
295
.
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P
(
2012
)
.
Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1α knock-in mouse
.
Nitric Oxide
.
vol.
27
,
s13
-
s14
.
Prysyazhna O, Rudyk O, Eaton P
(
2012
)
.
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
.
Nature Medicine
vol.
18
,
(
2
)
286
-
290
.
Prysyazhna O, Rudyk O, Eaton P
(
2012
)
.
ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGI alpha KNOCK-IN MOUSE
.
JOURNAL OF VASCULAR RESEARCH
.
vol.
49
,
39
-
39
.
Prysyazhna O, Rudyk O, Eaton P
(
2011
)
.
Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension
.
Free Radical Biology and Medicine
.
vol.
51
,
Rudyk O, Prysyazhna O, Burgoyne J, Eaton P
(
2011
)
.
Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation
.
Free Radical Biology and Medicine
.
vol.
51
,
Prysyazhna O, Rudyk O, Eaton P
(
2011
)
.
High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse
.
BMC Pharmacology
vol.
11
,
(
Suppl 1
)
Korkach JP, Dudchenko NO, Kotsuruba AV, Prysyazhna OD, Sagach VF
(
2008
)
.
Role of non-haem iron in protecting effect of ecdysterone on development of streptozotocine-induced hyperglycaemia in rats
.
Ukrain'skyi Biokhimichnyi Zhurnal
vol.
80
,
(
1
)
46
-
51
.
Prysyazhna OD, Sagach VF
(
2007
)
.
UCP blockade decreases disturbances of contractive reactions of heart and vessels with type 1 experimental diabetes mellitus
.
DIABETOLOGIA
.
vol.
50
,
S91
-
S91
.
Prysyazhna OD, Sagach VF
(
2007
)
.
The role of oxidative stress in the development of myocardial diastolic dysfunction with diabetes mellitus
.
Journal of Molecular and Cellular Cardiology
vol.
42
,
(
6
)
Sagach VF, Prysyazhna OD
(
2006
)
.
Myocardial diastolic dysfunction at experimental diabetes mellitus—the role of nitric oxide
.
Journal of Molecular and Cellular Cardiology
vol.
40
,
(
6
)
Prysyazhna OD, Sagach VF
(
2006
)
.
Infringement of NO-dependent regulation of contractive reactions of heart and vessels at experimental diabetes mellitus
.
JOURNAL OF VASCULAR RESEARCH
.
vol.
43
,
556
-
556
.
Prysyazhna OD, Sagach VF, Kotsyuruba AV, Tkachenko MN
(
2003
)
.
Endothelium-Dependent Stretch-Induced Contractile Responses of Vascular Smooth Muscles in Experimental Diabetes Mellitus, and the Nitric Oxide System
.
Neurophysiology
vol.
35
,
(
3-4
)
339
-
339
.