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Research

Publications: Mr Edoardo Prediletto

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .
Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 52.2 - 5253 .
Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .
Corsiero E, Caliste M, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2022 ) . POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 456.1 - 45456 .
Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 470.1 - 47470 .
Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2022 ) . POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 474.2 - 47475 .
Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 475.2 - 47476 .
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2022 ) . Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression . Cell Reports vol. 39 , ( 5 )
El Shikh MEM, El Sayed R, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Front Med (Lausanne) vol. 9 ,
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .
Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .
Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Derrac Soria A, Jones SA et al. ( 2020 ) . Impaired Interleukin-27–Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome . Arthritis and Rheumatology vol. 72 , ( 9 ) 1559 - 1570 .
Rivellese F, Prediletto E ( 2020 ) . ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia . Autoimmunity Reviews vol. 19 , ( 6 )
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 59 ,
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome . Rheumatology . vol. 59 ,
Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M ( 2019 ) . Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 791 - 791 .
Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. ( 2019 ) . OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN’S SYNDROME . Conference: Oral Presentations220.1 - 22220 .
Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .
Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,
Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin . Annals of the Rheumatic Diseases . Conference: Autoimmune inflammation vol. 76 ,
Corsiero E, Pratesi F, Prediletto E, Bombardieri M, Migliorini P ( 2016 ) . NETosis as Source of Autoantigens in Rheumatoid Arthritis . Front Immunol vol. 7 , 485 - 485 .
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 116 - 117 .
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 ,
Capecchi R, Prediletto E, Pratesi F, Italiani P, Puxeddu I, Panza F, Migliorini P ( 2015 ) . A6.10 Anti citrullinated peptides/proteins antibodies induce secretion of CCL5/rantes by fibroblast like synoviocytes . Annals of the Rheumatic Diseases . vol. 74 , a59 - a59 .