Publications: Dr Christopher Harry Switzer
Switzer CH, Kasamatsu S, Ihara H, Eaton P
(
2023
)
.
SOD1 is an essential H<inf>2</inf>S detoxifying enzyme
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
120
,
(
3
)
Switzer CH, Fukuto JM
(
2022
)
.
The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species
.
Redox Biology
vol.
57
,
Switzer CH, Cho HJ, Eykyn TR, Lavender P, Eaton P
(
2022
)
.
NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
119
,
(
21
)
Switzer CH, Cho H-J, Eykyn TR, Lavender P, Eaton P
(
2022
)
.
NOS2 and <i>S</i>-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
119
,
(
21
)
Switzer CH, Guttzeit S, Eykyn TR, Eaton P
(
2021
)
.
Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells
.
Redox Biology
vol.
47
,
Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P
(
2020
)
.
Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth
.
Redox Biology
vol.
29
,
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.
(
2019
)
.
Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase"
.
Circulation
vol.
140
,
(
22
)
E810
-
E811
.
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.
(
2019
)
.
Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase
.
Circulation
vol.
140
,
(
2
)
126
-
137
.
Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P
(
2018
)
.
Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation
.
Molecular Cell
vol.
69
,
(
3
)
438
-
450.e5
.
Wink DA, Ridnour LA, Cheng R, Switzer CW, Glynn S, Ambs S
(
2015
)
.
The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer
.
Redox biology
vol.
5
,
Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD et al.
(
2015
)
.
Signaling and stress: The redox landscape in NOS2 biology
.
Free Radical Biology and Medicine
vol.
87
,
204
-
225
.
Cheng RYS, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S et al.
(
2014
)
.
Gene expression profiles of NO- and HNO-donor treated breast cancer cells: Insights into tumor response and resistance pathways
.
Nitric Oxide - Biology and Chemistry
vol.
43
,
17
-
28
.
Heinecke JL, Ridnour LA, Cheng RYS, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP et al.
(
2014
)
.
Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
111
,
(
17
)
6323
-
6328
.
Heinrich TA, Da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM
(
2013
)
.
Biological nitric oxide signalling: Chemistry and terminology
.
British Journal of Pharmacology
vol.
169
,
(
7
)
1417
-
1429
.
Ridnour LA, Cheng RYS, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G et al.
(
2013
)
.
Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity
.
Clinical Cancer Research
vol.
19
,
(
6
)
1340
-
1346
.
Switzer CH, Miller TW, Farmer PJ, Fukuto JM
(
2013
)
.
Synthesis and characterization of lithium oxonitrate (LiNO)
.
Journal of Inorganic Biochemistry
vol.
118
,
128
-
133
.
Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA
(
2012
)
.
S-nitrosation mediates multiple pathways, that lead to tumor progression in estrogen receptor - Negative breast cancer
.
Forum on Immunopathological Diseases and Therapeutics
.
vol.
3
,
117
-
124
.
Switzer CH, Cheng RYS, Ridnour LA, Glynn SA, Ambs S, Wink DA
(
2012
)
.
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
.
Breast Cancer Research
vol.
14
,
(
5
)
Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH et al.
(
2012
)
.
Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation
.
PLoS ONE
vol.
7
,
(
9
)
Switzer CH, Glynn SA, Cheng RYS, Ridnour LA, Green JE, Ambs S, Wink DA
(
2012
)
.
S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer
.
Molecular Cancer Research
vol.
10
,
(
9
)
1203
-
1215
.
Switzer CH, Cheng RYS, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB et al.
(
2012
)
.
Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer
.
Cancer Research
vol.
72
,
(
9
)
2394
-
2404
.
Switzer CH, Glynn SA, Ridnour LA, Cheng RYS, Vitek MP, Ambs S, Wink DA
(
2011
)
.
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer
.
Trends in Pharmacological Sciences
vol.
32
,
(
11
)
644
-
651
.
Switzer CH, Cheng RYS, Vitek TM, Christensen DJ, Wink DA, Vitek MP
(
2011
)
.
Targeting SET/I<inf>2</inf> PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy
.
Oncogene
vol.
30
,
(
22
)
2504
-
2513
.
Wink DA, Hines HB, Cheng RYS, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA
(
2011
)
.
Nitric oxide and redox mechanisms in the immune response
.
Journal of Leukocyte Biology
vol.
89
,
(
6
)
873
-
891
.
Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA et al.
(
2011
)
.
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems
.
Antioxidants and Redox Signaling
vol.
14
,
(
9
)
1659
-
1674
.
Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH et al.
(
2010
)
.
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
.
Journal of Clinical Investigation
vol.
120
,
(
11
)
3843
-
3854
.
Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A et al.
(
2010
)
.
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells
.
Lung Cancer
vol.
68
,
(
2
)
154
-
160
.
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA
(
2010
)
.
Chapter 1 Determinants of Nitric Oxide Chemistry Impact of Cell Signaling Processes
.
Nitric Oxide
,
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA
(
2010
)
.
Determinants of Nitric Oxide Chemistry. Impact of Cell Signaling Processes
.
Nitric Oxide
,
Cheng R, Glynn S, Flores-Santana W, Switzer C, Ridnour L, Wink DA
(
2010
)
.
Nitric oxide and redox inflammation in cancer
.
Advances in Molecular Toxicology
vol.
4
,
(
C
)
157
-
182
.
Switzer CH, Ridnour LA, Cheng RYS, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD et al.
(
2009
)
.
Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity
.
Oncogene
vol.
28
,
(
43
)
3837
-
3846
.
Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM et al.
(
2009
)
.
Comparing the chemical biology of NO and HNO
.
Archives of Pharmacal Research
vol.
32
,
(
8
)
1139
-
1153
.
Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM et al.
(
2009
)
.
The emergence of nitroxyl (HNO) as a pharmacological agent
.
Biochimica et Biophysica Acta - Bioenergetics
vol.
1787
,
(
7
)
835
-
840
.
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA
(
2009
)
.
Determinants of Nitric Oxide Chemistry
.
Nitric Oxide: Biology and Pathobiology
,
Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB et al.
(
2008
)
.
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine
.
Free Radical Biology and Medicine
vol.
45
,
(
5
)
578
-
584
.
Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA
(
2008
)
.
Molecular mechanisms for discrete nitric oxide levels in cancer
.
Nitric Oxide - Biology and Chemistry
vol.
19
,
(
2
)
73
-
76
.
Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C et al.
(
2008
)
.
The chemical biology of nitric oxide: Implications in cellular signaling
.
Free Radical Biology and Medicine
vol.
45
,
(
1
)
18
-
31
.
Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD
(
2007
)
.
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake
.
Journal of Biological Chemistry
vol.
282
,
(
21
)
15404
-
15415
.
Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB et al.
(
2006
)
.
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling
.
Antioxidants and Redox Signaling
vol.
8
,
(
7-8
)
1363
-
1371
.
Fukuto JM, Switzer CH, Miranda KM, Wink DA
(
2005
)
.
Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology
.
Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA et al.
(
2002
)
.
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
99
,
(
17
)
10958
-
10963
.
Shinyashiki M, Pan CJG, Switzer CH, Fukuto JM
(
2001
)
.
Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: An examination of the copper-responsive yeast transcription factor ace1
.
Chemical Research in Toxicology
vol.
14
,
(
12
)
1584
-
1589
.
Chiang KT, Switzer CH, Akali KO, Fukuto JM
(
2000
)
.
The role of oxygen and reduced oxygen species in nitric oxide-mediated cytotoxicity: Studies in the yeast Saccharomyces cerevisiae model system
.
Toxicology and Applied Pharmacology
vol.
167
,
(
1
)
30
-
36
.
Chiang KT, Shinyashiki M, Switzer CH, Valentine JS, Gralla EB, Thiele DJ, Fukuto JM
(
2000
)
.
Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: Cytotoxic and cytoprotective actions of nitric oxide
.
Archives of Biochemistry and Biophysics
vol.
377
,
(
2
)
296
-
303
.
Shinyashiki M, Chiang KT, Switzer CH, Gralla EB, Valentine JS, Thiele DJ, Fukuto JM
(
2000
)
.
The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
97
,
(
6
)
2491
-
2496
.