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Research

Publications: Dr Christopher Harry Switzer

Switzer CH, Fukuto JM ( 2022 ) . The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species . Redox Biology vol. 57 ,
Switzer CH, Cho HJ, Eykyn TR, Lavender P, Eaton P ( 2022 ) . NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 21 )
Switzer CH, Guttzeit S, Eykyn TR, Eaton P ( 2021 ) . Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells . Redox Biology vol. 47 ,
Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P ( 2020 ) . Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth . Redox Biology vol. 29 ,
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase" . Circulation vol. 140 , ( 22 ) E810 - E811 .
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase . Circulation vol. 140 , ( 2 ) 126 - 137 .
Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P ( 2018 ) . Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation . Molecular Cell vol. 69 , ( 3 ) 438 - 450.e5 .
Wink DA, Ridnour LA, Cheng R, Switzer CW, Glynn S, Ambs S ( 2015 ) . The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer . Redox biology vol. 5 ,
Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD et al. ( 2015 ) . Signaling and stress: The redox landscape in NOS2 biology . Free Radical Biology and Medicine vol. 87 , 204 - 225 .
Cheng RYS, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S et al. ( 2014 ) . Gene expression profiles of NO- and HNO-donor treated breast cancer cells: Insights into tumor response and resistance pathways . Nitric Oxide - Biology and Chemistry vol. 43 , 17 - 28 .
Heinecke JL, Ridnour LA, Cheng RYS, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP et al. ( 2014 ) . Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 17 ) 6323 - 6328 .
Heinrich TA, Da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM ( 2013 ) . Biological nitric oxide signalling: Chemistry and terminology . British Journal of Pharmacology vol. 169 , ( 7 ) 1417 - 1429 .
Ridnour LA, Cheng RYS, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G et al. ( 2013 ) . Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity . Clinical Cancer Research vol. 19 , ( 6 ) 1340 - 1346 .
Switzer CH, Miller TW, Farmer PJ, Fukuto JM ( 2013 ) . Synthesis and characterization of lithium oxonitrate (LiNO) . Journal of Inorganic Biochemistry vol. 118 , 128 - 133 .
Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA ( 2012 ) . S-nitrosation mediates multiple pathways, that lead to tumor progression in estrogen receptor - Negative breast cancer . Forum on Immunopathological Diseases and Therapeutics . vol. 3 , 117 - 124 .
Switzer CH, Cheng RYS, Ridnour LA, Glynn SA, Ambs S, Wink DA ( 2012 ) . Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer . Breast Cancer Research vol. 14 , ( 5 )
Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH et al. ( 2012 ) . Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation . PLoS ONE vol. 7 , ( 9 )
Switzer CH, Glynn SA, Cheng RYS, Ridnour LA, Green JE, Ambs S, Wink DA ( 2012 ) . S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer . Molecular Cancer Research vol. 10 , ( 9 ) 1203 - 1215 .
Switzer CH, Cheng RYS, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB et al. ( 2012 ) . Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer . Cancer Research vol. 72 , ( 9 ) 2394 - 2404 .
Switzer CH, Glynn SA, Ridnour LA, Cheng RYS, Vitek MP, Ambs S, Wink DA ( 2011 ) . Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer . Trends in Pharmacological Sciences vol. 32 , ( 11 ) 644 - 651 .
Switzer CH, Cheng RYS, Vitek TM, Christensen DJ, Wink DA, Vitek MP ( 2011 ) . Targeting SET/I<inf>2</inf> PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy . Oncogene vol. 30 , ( 22 ) 2504 - 2513 .
Wink DA, Hines HB, Cheng RYS, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA ( 2011 ) . Nitric oxide and redox mechanisms in the immune response . Journal of Leukocyte Biology vol. 89 , ( 6 ) 873 - 891 .
Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA et al. ( 2011 ) . The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems . Antioxidants and Redox Signaling vol. 14 , ( 9 ) 1659 - 1674 .
Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH et al. ( 2010 ) . Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients . Journal of Clinical Investigation vol. 120 , ( 11 ) 3843 - 3854 .
Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A et al. ( 2010 ) . Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells . Lung Cancer vol. 68 , ( 2 ) 154 - 160 .
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA ( 2010 ) . Chapter 1 Determinants of Nitric Oxide Chemistry Impact of Cell Signaling Processes . Nitric Oxide ,
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA ( 2010 ) . Determinants of Nitric Oxide Chemistry. Impact of Cell Signaling Processes . Nitric Oxide ,
Cheng R, Glynn S, Flores-Santana W, Switzer C, Ridnour L, Wink DA ( 2010 ) . Nitric oxide and redox inflammation in cancer . Advances in Molecular Toxicology vol. 4 , ( C ) 157 - 182 .
Switzer CH, Ridnour LA, Cheng RYS, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD et al. ( 2009 ) . Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity . Oncogene vol. 28 , ( 43 ) 3837 - 3846 .
Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM et al. ( 2009 ) . Comparing the chemical biology of NO and HNO . Archives of Pharmacal Research vol. 32 , ( 8 ) 1139 - 1153 .
Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM et al. ( 2009 ) . The emergence of nitroxyl (HNO) as a pharmacological agent . Biochimica et Biophysica Acta - Bioenergetics vol. 1787 , ( 7 ) 835 - 840 .
Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB et al. ( 2008 ) . Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine . Free Radical Biology and Medicine vol. 45 , ( 5 ) 578 - 584 .
Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA ( 2008 ) . Molecular mechanisms for discrete nitric oxide levels in cancer . Nitric Oxide - Biology and Chemistry vol. 19 , ( 2 ) 73 - 76 .
Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C et al. ( 2008 ) . The chemical biology of nitric oxide: Implications in cellular signaling . Free Radical Biology and Medicine vol. 45 , ( 1 ) 18 - 31 .
Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD ( 2007 ) . Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake . Journal of Biological Chemistry vol. 282 , ( 21 ) 15404 - 15415 .
Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB et al. ( 2006 ) . The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling . Antioxidants and Redox Signaling vol. 8 , ( 7-8 ) 1363 - 1371 .
Fukuto JM, Switzer CH, Miranda KM, Wink DA ( 2005 ) . Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology .
Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA et al. ( 2002 ) . The reduction potential of nitric oxide (NO) and its importance to NO biochemistry . Proceedings of the National Academy of Sciences of the United States of America vol. 99 , ( 17 ) 10958 - 10963 .
Shinyashiki M, Pan CJG, Switzer CH, Fukuto JM ( 2001 ) . Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: An examination of the copper-responsive yeast transcription factor ace1 . Chemical Research in Toxicology vol. 14 , ( 12 ) 1584 - 1589 .
Chiang KT, Switzer CH, Akali KO, Fukuto JM ( 2000 ) . The role of oxygen and reduced oxygen species in nitric oxide-mediated cytotoxicity: Studies in the yeast Saccharomyces cerevisiae model system . Toxicology and Applied Pharmacology vol. 167 , ( 1 ) 30 - 36 .
Chiang KT, Shinyashiki M, Switzer CH, Valentine JS, Gralla EB, Thiele DJ, Fukuto JM ( 2000 ) . Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: Cytotoxic and cytoprotective actions of nitric oxide . Archives of Biochemistry and Biophysics vol. 377 , ( 2 ) 296 - 303 .
Shinyashiki M, Chiang KT, Switzer CH, Gralla EB, Valentine JS, Thiele DJ, Fukuto JM ( 2000 ) . The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 6 ) 2491 - 2496 .