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Research

Publications: Mr Neil Dufton

Gomez-Salinero JM, Itkin T, Houghton S, Badwe C, Lin Y, Kalna V, Dufton N, Peghaire CR et al. ( 2022 ) . Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis . Nature Cardiovascular Research vol. 1 , ( 10 ) 882 - 899 .
Whiteford J, Arokiasamy S, Thompson CL, Dufton NP ( 2022 ) . Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform . In vitro models1 - 9 .
Whiteford J, Arokiasamy S, Thompson C, Alazawi W, Dufton N ( 2022 ) . FRI198 Investigating the function of Endothelial-To-Mesenchymal transition during liver fibrogenesis using a Liver-On-A-Chip platform . Journal of Hepatology vol. 77 ,
Ward E, Bert S, Fanti S, Dufton N, Malone K, Maughan R, Prin F, Volpato LK et al. ( 2022 ) . Placental inflammation leads to abnormal embryonic heart development .
Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chauhan A, Webb G, Yang Y et al. ( 2020 ) . Author Correction: Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis (Nature Communications, (2017), 8, 1, (895), 10.1038/s41467-017-01169-0) . Nature Communications vol. 11 , ( 1 )
Peghaire C, Dufton NP, Lang M, Salles-Crawley II, Ahnström J, Kalna V, Raimondi C, Pericleous C et al. ( 2019 ) . The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature . Nature Communications vol. 10 , ( 1 )
Issitt T, Bosseboeuf E, De Winter N, Dufton N, Gestri G, Senatore V, Chikh A, Randi AM et al. ( 2019 ) . Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress . iScience vol. 11 , 205 - 223 .
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO et al. ( 2018 ) . Consensus guidelines for the use and interpretation of angiogenesis assays . Angiogenesis vol. 21 , ( 3 ) 425 - 532 .
Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C et al. ( 2018 ) . Investigation of cardiac fibroblasts using myocardial slices . Cardiovascular Research vol. 114 , ( 1 ) 77 - 89 .
Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chuahan A, Webb G, Yang Y et al. ( 2017 ) . Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis . Nature Communications vol. 8 , ( 1 )
Shah AV, Birdsey GM, Peghaire C, Pitulescu ME, Dufton NP, Yang Y, Weinberg I, Osuna Almagro L et al. ( 2017 ) . The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability . Nature Communications vol. 8 ,
Beuerle MG, Dufton NP, Randi AM, Gould IR ( 2016 ) . Molecular dynamics studies on the DNA-binding process of ERG . Molecular BioSystems vol. 12 , ( 12 ) 3600 - 3610 .
Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang Y, Aspalter IM, Khan ST et al. ( 2015 ) . The endothelial transcription factor erg promotes vascular stability and growth through Wnt/β-catenin signaling . Developmental Cell vol. 32 , ( 1 ) 82 - 96 .
Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M, Wallace JL ( 2012 ) . Up-regulation of Annexin-A1 and lipoxin A<inf>4</inf> in individuals with ulcerative colitis may promote mucosal homeostasis . PLoS ONE vol. 7 , ( 6 )
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al. ( 2011 ) . Anti-inflammatory role of the murine formyl-peptide receptor 2: Ligand-specific effects on leukocyte responses and experimental in-flammation (The Journal of Immunology (2010) 184, (2611-2619)) . Journal of Immunology vol. 186 , ( 4 ) 2684 - 2685 .
Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M, Godson C ( 2010 ) . FPR2/ALX receptor expression and internalization are critical for lipoxin A<inf>4</inf>and annexin-derived peptide-stimulated phagocytosis . FASEB Journal vol. 24 , ( 11 ) 4240 - 4249 .
Dufton N, Perretti M ( 2010 ) . Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists . Pharmacology and Therapeutics vol. 127 , ( 2 ) 175 - 188 .
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al. ( 2010 ) . Anti-inflammatory role of the murine formyl-peptide receptor 2: Ligand-specific effects on leukocyte responses and experimental inflammation . Journal of Immunology vol. 184 , ( 5 ) 2611 - 2619 .
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ ( 2010 ) . Anti-allergic drugs and the annexin-A1 system . Pharmacological Reports vol. 62 , ( 3 ) 511 - 517 .
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D'Acquisto F ( 2009 ) . Interleukin 17 sustains rather than induces inflammation . Biochemical Pharmacology vol. 77 , ( 5 ) 878 - 887 .
Dufton NP, Hannon R, Perretti M, Flower R ( 2009 ) . Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse . Inflammation Research vol. 58 , ( 2 ) S252 - S255 .