Publications: Dr Mark van Breugel

Carden S, Vitiello E, Rosa E Silva I, Holder J, Quarantotti V, Kishore K, Roamio Franklin VN, D'Santos C et al. ( 2023 ) . Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method . Developmental Cell vol. 58 , ( 21 ) 2393 - 2410.e9 .

van Breugel M, Rosa e Silva I, Andreeva A ( 2022 ) . Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes . Communications Biology vol. 5 , ( 1 )

Rosa e Silva I, Binó L, Johnson CM, Rutherford TJ, Neuhaus D, Andreeva A, Čajánek L, van Breugel M ( 2021 ) . Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies . Structure vol. 30 , ( 1 ) 114 - 128.e9 .

Ochi T, Quarantotti V, Lin H, Jullien J, Rosa e Silva I, Boselli F, Barnabas DD, Johnson CM et al. ( 2020 ) . CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions . Structure vol. 28 , ( 6 ) 674 - 689.e11 .

Liu Y, Kim J, Philip R, Sridhar V, Chandrashekhar M, Moffat J, van Breugel M, Pelletier L ( 2020 ) . Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration . Journal of Cell Science vol. 133 , ( 8 )

Joseph N, Al-Jassar C, Johnson CM, Andreeva A, Barnabas DD, Freund SMV, Gergely F, van Breugel M ( 2018 ) . Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis . Cell Reports vol. 23 , ( 9 ) 2805 - 2818 .

Liu Y, Gupta GD, Barnabas DD, Agircan FG, Mehmood S, Wu D, Coyaud E, Johnson CM et al. ( 2018 ) . Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly . Nature Communications vol. 9 , ( 1 )

Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M ( 2016 ) . The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase . Structure vol. 25 , ( 1 ) 146 - 156 .

van Breugel M, Wilcken R, McLaughlin SH, Rutherford TJ, Johnson CM ( 2014 ) . Structure of the SAS-6 cartwheel hub from Leishmania major . eLife vol. 3 ,

Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM et al. ( 2013 ) . Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly . eLife vol. 2 , e01071 - e01071 .

van Breugel M, Hirono M, Andreeva A, Yanagisawa H-A, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M et al. ( 2011 ) . Structures of SAS-6 Suggest Its Organization in Centrioles . Science vol. 331 , ( 6021 ) 1196 - 1199 .