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Research

Publications: Dr Mark van Breugel

Ochi T, Quarantotti V, Lin H, Jullien J, Rosa E Silva I, Boselli F, Barnabas DD, Johnson CM et al. ( 2020 ) . CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions . Structure vol. 28 , ( 6 ) 674 - 689.e11 .
Liu Y, Kim J, Philip R, Sridhar V, Chandrashekhar M, Moffat J, van Breugel M, Pelletier L ( 2020 ) . Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration . Journal of Cell Science vol. 133 , ( 8 )
Joseph N, Al-Jassar C, Johnson CM, Andreeva A, Barnabas DD, Freund SMV, Gergely F, van Breugel M ( 2018 ) . Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis . Cell Rep vol. 23 , ( 9 ) 2805 - 2818 .
Liu Y, Gupta GD, Barnabas DD, Agircan FG, Mehmood S, Wu D, Coyaud E, Johnson CM et al. ( 2018 ) . Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly . Nat Commun vol. 9 , ( 1 )
Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M ( 2017 ) . The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase . Structure vol. 25 , ( 1 ) 146 - 156 .
van Breugel M, Wilcken R, McLaughlin SH, Rutherford TJ, Johnson CM ( 2014 ) . Structure of the SAS-6 cartwheel hub from Leishmania major . Elife vol. 3 ,
Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM et al. ( 2013 ) . Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly . eLife vol. 2 , e01071 - e01071 .
van Breugel M, Hirono M, Andreeva A, Yanagisawa H-A, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M et al. ( 2011 ) . Structures of SAS-6 suggest its organization in centrioles . Science vol. 331 , ( 6021 ) 1196 - 1199 .