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Research

Publications: Mr Junchao Wang

Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al. ( 2021 ) . The Genomic Landscape of Actinic Keratosis . Journal of Investigative Dermatology vol. 141 , ( 7 ) 1664 - 1674.e7 .
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al. ( 2021 ) . The transcriptomic landscape of prostate cancer development and progression: An integrative analysis . Cancers vol. 13 , ( 2 ) 1 - 24 .
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al. ( 2020 ) . The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants . Nature Communications vol. 11 , ( 1 )
Larrea E, Fernandez‐mercado M, Guerra‐assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al. ( 2020 ) . Identification of recurrent mutations in the microrna‐binding sites of b‐cell lymphoma‐ associated genes in follicular lymphoma . International Journal of Molecular Sciences vol. 21 , ( 22 ) 1 - 12 .
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )
Dokal I, Tummala H, Vulliamy T, Walne A ( 2020 ) . A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure . Proceedings of the National Academy of Sciences of USA Article 32636268 ,
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al. ( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) E318 - E321 .
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) 1290 - 1290 .
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al. ( 2019 ) . Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma . Journal of Investigative Dermatology vol. 139 , ( 8 ) 1658 - 1671.e8 .
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al. ( 2019 ) . A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing . International Journal of Molecular Sciences vol. 20 , ( 14 )
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y) . Leukemia vol. 33 , ( 6 )
Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al. ( 2019 ) . Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant . Haematologica vol. 104 , ( 4 ) e174 - e177 .
Bewicke-Copley F, Arjun Kumar E, Palladino G, Korfi K, Wang J ( 2019 ) . Applications and analysis of targeted genomic sequencing in cancer studies . Computational and Structural Biotechnology Journal vol. 17 , 1348 - 1359 .
Patel MB, Wang J ( 2019 ) . The identification and interpretation of cis-regulatory noncoding mutations in cancer . High-Throughput vol. 8 , ( 1 )
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) W109 - W113 .
Wang J, Ullah AZD, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic Acids Research vol. 46 , ( 8 )
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al. ( 2018 ) . CSF1R<sup>+</sup> Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype . Cell Reports vol. 23 , ( 5 ) 1448 - 1460 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1258 - 1263 .
Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al. ( 2018 ) . GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML . Leukemia vol. 32 , ( 11 ) 2502 - 2507 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al. ( 2017 ) . Lamin B1 regulates somatic mutations and progression of B-cell malignancies . Leukemia vol. 32 , ( 2 ) 364 - 375 .
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al. ( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . Leukemia
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al. ( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al. ( 2016 ) . Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nat Genet vol. 48 , ( 6 ) 700 - 700 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .
Parry M, Rose-Zerilli MJJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al. ( 2015 ) . Genetics and prognostication in splenic marginal zone lymphoma: Revelations from deep sequencing . Clinical Cancer Research vol. 21 , ( 18 ) 4174 - 4183 .
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al. ( 2015 ) . Disease evolution and outcomes in familial AML with germline CEBPA mutations . Blood vol. 126 , ( 10 ) 1214 - 1223 .
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. ( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia . Blood vol. 123 , ( 13 ) 2066 - 2074 .
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al. ( 2013 ) . Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes . Journal of Pathology vol. 230 , ( 1 ) 107 - 117 .
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al. ( 2013 ) . Activated pancreatic stellate cells sequester CD8<sup>+</sup> T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .
Bödör C, Grossmann V, Popov N, Okosun J, O’Riain C, Tan K, Marzec J, Araf S et al. ( 2013 ) . EZH2 mutations are frequent and represent an early event in follicular lymphoma . Blood vol. 122 , ( 18 ) 3165 - 3168 .
Gilks WR, Welham SJ, Wang J, Clark SJ, King GJ ( 2012 ) . Three-point appraisal of genetic linkage maps . Theoretical and Applied Genetics vol. 125 , ( 7 ) 1393 - 1402 .
Love CG, Andongabo AE, Wang J, Carion PWC, Rawlings CJ, King GJ ( 2012 ) . InterStoreDB: A Generic Integration Resource for Genetic and Genomic Data . Journal of Integrative Plant Biology vol. 54 , ( 5 ) 345 - 355 .
Wang J, Lydiate DJ, Parkin IAP, Falentin C, Delourme R, Carion PWC, King GJ ( 2011 ) . Integration of linkage maps for the Amphidiploid Brassica napus and comparative mapping with Arabidopsis and Brassica rapa . BMC Genomics vol. 12 ,
Hammond JP, Mayes S, Bowen HC, Graham NS, Hayden RM, Love CG, Spracklen WP, Wang J et al. ( 2011 ) . Regulatory hotspots are associated with plant gene expression under varying soil phosphorus supply in brassica rapa . Plant Physiology vol. 156 , ( 3 ) 1230 - 1241 .
Wang J, Keightley PD, Halligan DL ( 2007 ) . Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites . Journal of Molecular Evolution vol. 65 , ( 6 ) 627 - 639 .
Wang J, Keightley PD, Johnson T ( 2006 ) . MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution . BMC Bioinformatics vol. 7 ,