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Research

Publications: Dr Helen Rowe

Alkan C, Carbone L, Dennis M, Ernst J, Evrony G, Girirajan S, Leung DCY, Cheng CCY et al. ( 2022 ) . Implications of the first complete human genome assembly . Genome Research vol. 32 , ( 4 ) 595 - 598 .
Gale Hammell M, Rowe HM ( 2020 ) . Editorial Overview: Endogenous Retroviruses in Development and Disease . Viruses vol. 12 , ( 12 ) 1446 - 1446 .
Tunbak H, Enriquez-Gasca R, Tie CHC, Gould PA, Mlcochova P, Gupta RK, Fernandes L, Holt J et al. ( 2020 ) . The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s . Nature Communications vol. 11 , ( 1 )
Enriquez-Gasca R, Gould PA, Rowe HM ( 2020 ) . Host gene regulation by transposable elements: The new, the old and the ugly . Viruses vol. 12 , ( 10 )
Gould PA, Rowe HM ( 2019 ) . A nuclear licence to silence transposons . EMBO reports vol. 20 , ( 12 )
Tie CHC, Fernandes L, Conde L, Robbez‐Masson L, Sumner RP, Peacock T, Rodriguez‐Plata MT, Mickute G et al. ( 2018 ) . KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control . EMBO Reports vol. 19 , ( 10 )
Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J et al. ( 2018 ) . The hush complex cooperates with trim28 to repress young retrotransposons and new genes . Genome Research vol. 28 , ( 6 ) 836 - 845 .
Smith-Moore S, Neil SJD, Fraefel C, Linden RM, Bollen M, Rowe HM, Henckaerts E ( 2018 ) . Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome . Proceedings of the National Academy of Sciences vol. 115 , ( 15 ) E3529 - E3538 .
Robbez-Masson L, Tie CHC, Rowe HM ( 2017 ) . Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go! . Journal of Cell Biology vol. 216 , ( 11 ) 3429 - 3431 .
Tie CH, Rowe HM ( 2017 ) . Epigenetic control of retrotransposons in adult tissues: implications for immune regulation . Current Opinion in Virology vol. 25 , 28 - 33 .
Ecco G, Cassano M, Kauzlaric A, Duc J, Coluccio A, Offner S, Imbeault M, Rowe HM et al. ( 2016 ) . Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues . Dev Cell vol. 36 , ( 6 ) 611 - 623 .
Ecco G, Rowe HM, Trono D ( 2016 ) . A large-scale functional screen to identify epigenetic repressors of retrotransposon expression . Methods in Molecular Biology , vol. 1400 ,
Robbez-Masson L, Rowe HM ( 2015 ) . Retrotransposons shape species-specific embryonic stem cell gene expression . Retrovirology vol. 12 , ( 1 )
Friedli M, Turelli P, Kapopoulou A, Rauwel B, Castro-Diáz N, Rowe HM, Ecco G, Unzu C et al. ( 2014 ) . Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency . Genome Research vol. 24 , ( 8 ) 1251 - 1259 .
Rowe HM, Kapopoulou A, Corsinotti A, Fasching L, Macfarlan TS, Tarabay Y, Viville S, Jakobsson J et al. ( 2013 ) . TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells . Genome Research vol. 23 , ( 3 ) 452 - 461 .
Corsinotti A, Kapopoulou A, Gubelmann C, Imbeault M, Santoni de Sio FR, Rowe HM, Mouscaz Y, Deplancke B et al. ( 2013 ) . Global and Stage Specific Patterns of Krüppel-Associated-Box Zinc Finger Protein Gene Expression in Murine Early Embryonic Cells . PLoS ONE vol. 8 , ( 2 )
Rowe HM, Friedli M, Offner S, Verp S, Mesnard D, Marquis J, Aktas T, Trono D ( 2013 ) . De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET . Development vol. 140 , ( 3 ) 519 - 529 .
Macfarlan TS, Gifford WD, Driscoll S, Lettieri K, Rowe HM, Bonanomi D, Firth A, Singer O et al. ( 2012 ) . Embryonic stem cell potency fluctuates with endogenous retrovirus activity . Nature vol. 487 , ( 7405 ) 57 - 63 .
Rowe HM, Trono D ( 2011 ) . Dynamic control of endogenous retroviruses during development . Virology vol. 411 , ( 2 ) 273 - 287 .
Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H et al. ( 2010 ) . KAP1 controls endogenous retroviruses in embryonic stem cells . Nature vol. 463 , ( 7278 ) 237 - 240 .
Arce F, Rowe HM, Chain B, Lopes L, Collins MK ( 2009 ) . Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization . Molecular Therapy vol. 17 , ( 9 ) 1643 - 1650 .
Rowe HM, Lopes L, Brown N, Efklidou S, Smallie T, Karrar S, Kaye PM, Collins MK ( 2009 ) . Expression of vFLIP in a lentiviral vaccine vector activates NF-{kappa}B, matures dendritic cells, and increases CD8+ T-cell responses . Journal of Virology vol. 83 , ( 4 ) 1555 - 1562 .
Rowe HM, Lopes L, Ikeda Y, Bailey R, Barde I, Zenke M, Chain BM, Collins MK ( 2006 ) . Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene . Molecular Therapy vol. 13 , ( 2 ) 310 - 319 .