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Research

Publications: Prof Qingbo Xu

Jia Y, Zhang L, Liu Z, Mao C, Ma Z, Li W, Yu F, Wang Y et al. ( 2022 ) . Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm . Cell Discovery vol. 8 , ( 1 )
Pu X, Zhu P, Zhou X, He Y, Wu H, Du L, Gong H, Sun X et al. ( 2022 ) . CD34<sup>+</sup> cell atlas of main organs implicates its impact on fibrosis . Cellular and Molecular Life Sciences vol. 79 , ( 11 )
Jia Y, Mao C, Ma Z, Huang J, Li W, Ma X, Zhang S, Li M et al. ( 2022 ) . PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing . Circulation Research vol. 131 , ( 10 ) 807 - 824 .
Ma X, Deng J, Han L, Song Y, Miao Y, Du X, Dang G, Yang D et al. ( 2022 ) . Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis . Protein and Cell vol. 13 , ( 7 ) 540 - 547 .
Wang F, Qin K, Wang K, Wang H, Liu Q, Qian M, Chen S, Sun Y et al. ( 2022 ) . Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells . Cell Reports vol. 39 , ( 12 )
Wang X, Zhu XX, Jiao SY, Qi D, Yu BQ, Xie GM, Liu Y, Song YT et al. ( 2022 ) . Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling . Acta Pharmacologica Sinica vol. 43 , ( 5 ) 1231 - 1242 .
Wang X, Wang R, Jiang L, Xu Q, Guo X ( 2022 ) . Endothelial repair by stem and progenitor cells . Journal of Molecular and Cellular Cardiology vol. 163 , 133 - 146 .
Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z et al. ( 2022 ) . Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification . Circulation Research vol. 130 , ( 2 ) 213 - 229 .
Han L, Miao Y, Zhao Y, Zhang X, Ma X, Du X, Kong W, Xu Q et al. ( 2022 ) . The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans . Blood Advances vol. 6 , ( 1 ) 46 - 61 .
Li X, Yang Y, Liang L, Fan M, Li X, Feng N, Pan Y, Tan Q et al. ( 2022 ) . Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA . International Journal of Biological Sciences vol. 18 , ( 1 ) 315 - 330 .
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP et al. ( 2021 ) . A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques . Science Translational Medicine vol. 13 , ( 623 )
Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX et al. ( 2021 ) . Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis . Science Translational Medicine vol. 13 , ( 623 )
Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP et al. ( 2021 ) . Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species . Cell Metabolism vol. 33 , ( 10 ) 2059 - 2075.e10 .
Gong H, Wang T, Xu Q ( 2021 ) . Resident stem cells in the heart . Medical Review vol. 1 , ( 1 ) 10 - 13 .
Duan Y, Qi D, Liu Y, Song Y, Wang X, Jiao S, Li H, Gonzalez FJ et al. ( 2021 ) . Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells . Biochemistry and Biophysics Reports vol. 27 ,
Jiang L, Sun X, Deng J, Hu Y, Xu Q ( 2021 ) . Different Roles of Stem/Progenitor Cells in Vascular Remodeling . Antioxidants and Redox Signaling vol. 35 , ( 3 ) 192 - 203 .
Sun X, Lyu L, Zhong X, Ni Z, Xu Q ( 2021 ) . Application of genetic cell-lineage tracing technology to study cardiovascular diseases . Journal of Molecular and Cellular Cardiology vol. 156 , 57 - 68 .
Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z et al. ( 2021 ) . Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury . Cell Research vol. 31 , ( 7 ) 773 - 790 .
Liu H, Chen J, Yang Q, Lei F, Zhang C, Qin JJ, Chen Z, Zhu L et al. ( 2021 ) . Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients . Med vol. 2 , ( 4 ) 435 - 447.e4 .
Cheng J, Gu W, Lan T, Deng J, Ni Z, Zhang Z, Hu Y, Sun X et al. ( 2021 ) . Single-cell RNA sequencing reveals cell type-and artery type-specific vascular remodelling in male spontaneously hypertensive rats . Cardiovascular Research vol. 117 , ( 4 ) 1202 - 1216 .
Lu Y, Wu J, Gu W, Huang Z, Shu Z, Huang M, Chen J, Zhou M et al. ( 2021 ) . Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure . Ecotoxicology and Environmental Safety vol. 211 ,
Wu H, Zhou X, Gong H, Ni Z, Xu Q ( 2021 ) . Perivascular tissue stem cells are crucial players in vascular disease . Free Radical Biology and Medicine vol. 165 , 324 - 333 .
Cai J, Li H, Zhang C, Chen Z, Liu H, Lei F, Qin JJ, Liu YM et al. ( 2021 ) . The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19 . Cell Metabolism vol. 33 , ( 2 ) 258 - 269.e3 .
Miao Y, Zhao Y, Han L, Ma X, Deng J, Yang J, Lü S, Shao F et al. ( 2021 ) . NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment . Cellular and Molecular Life Sciences vol. 78 , ( 4 ) 1709 - 1727 .
Jiang L, Chen T, Sun S, Wang R, Deng J, Lyu L, Wu H, Yang M et al. ( 2021 ) . Nonbone Marrow CD34<sup>+</sup>Cells Are Crucial for Endothelial Repair of Injured Artery . Circulation ResearchE146 - E165 .
Pu X, Du L, Hu Y, Fan Y, Xu Q ( 2021 ) . Stem/Progenitor Cells and Pulmonary Arterial Hypertension . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 41 , ( 1 ) 167 - 178 .
Deng J, Ni Z, Gu W, Chen Q, Nowak WN, Chen T, Issa Bhaloo S, Zhang Z et al. ( 2020 ) . Single-cell gene profiling and lineage tracing analyses revealed novel mechanisms of endothelial repair by progenitors . Cellular and Molecular Life Sciences vol. 77 , ( 24 ) 5299 - 5320 .
Zhou Y, Huang C, Hu Y, Xu Q, Hu X ( 2020 ) . Lymphatics in Cardiovascular Disease . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 40 , ( 11 ) E275 - E283 .
Cheng X, Liu YM, Li H, Zhang X, Lei F, Qin JJ, Chen Z, Deng KQ et al. ( 2020 ) . Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes . Cell Metabolism vol. 32 , ( 4 ) 537 - 547.e3 .
Qin K, Wang F, Simpson RML, Zheng X, Wang H, Hu Y, Gao Z, Xu Q et al. ( 2020 ) . Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts . Biomaterials vol. 257 ,
Qin JJ, Cheng X, Zhou F, Lei F, Akolkar G, Cai J, Zhang XJ, Blet A et al. ( 2020 ) . Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19 . Hypertension vol. 76 , ( 4 ) 1104 - 1112 .
Shao F, Miao Y, Zhang Y, Han L, Ma X, Deng J, Jiang C, Kong W et al. ( 2020 ) . B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm . Cardiovascular Research vol. 116 , ( 11 ) 1897 - 1909 .
Zhang XJ, Qin JJ, Cheng X, Shen L, Zhao YC, Yuan Y, Lei F, Chen MM et al. ( 2020 ) . In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19 . Cell Metabolism vol. 32 , ( 2 ) 176 - 187.e4 .
Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y et al. ( 2020 ) . Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis . Circulation Research
Pechlaner R, Xu Q, Kiechl S ( 2020 ) . Reply: Vascular Age Is Not Only Atherosclerosis, it Is Also Arteriosclerosis . Journal of the American College of Cardiology vol. 76 , ( 2 ) 230 - 231 .
Chen D, Li K, Festenstein S, Karegli J, Wilkinson H, Leonard H, Wei LL, Ma N et al. ( 2020 ) . Regression of atherosclerosis in apoe−/− mice via modulation of monocyte recruitment and phenotype, induced by weekly dosing of a novel “cytotopic” anti-thrombin without prolonged anticoagulation . Journal of the American Heart Association vol. 9 , ( 13 )
Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Xie J, Liu YM, Zhao YC et al. ( 2020 ) . Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality among Patients with Hypertension Hospitalized with COVID-19 . Circulation Research vol. 126 , ( 12 ) 1671 - 1681 .
Lu Y, Pechlaner R, Cai J, Yuan H, Huang Z, Yang G, Wang J, Chen Z et al. ( 2020 ) . Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women . Journal of the American College of Cardiology vol. 75 , ( 8 ) 870 - 880 .
Song Y, Qi D, Wang X, Liu Y, Xie G, Yu B, Xu Q, Gonzalez FJ et al. ( 2020 ) . Hypoxia inducible factor 2α inhibition in vascular smooth muscle cells (VSMCs) abolishes abdominal aortic aneurysm in ApoE−/− mice . Journal of Molecular and Cellular Cardiology vol. 140 ,
Zhou F, Liu YM, Xie J, Li H, Lei F, Yang H, Qin JJ, Cai J et al. ( 2020 ) . Comparative Impacts of ACE (Angiotensin-Converting Enzyme) Inhibitors Versus Angiotensin II Receptor Blockers on the Risk of COVID-19 Mortality . HypertensionE15 - E17 .
Lü SL, Dang GH, Deng JC, Liu HY, Liu B, Yang J, Ma XL, Miao YT et al. ( 2020 ) . Shikonin attenuates hyperhomocysteinemia-induced CD4<sup>+</sup> T cell inflammatory activation and atherosclerosis in ApoE<sup>−/−</sup> mice by metabolic suppression . Acta Pharmacologica Sinica vol. 41 , ( 1 ) 47 - 55 .
Ludwinski FE, Patel AS, Damodaran G, Cho J, Furmston J, Xu Q, Jayasinghe SN, Smith A et al. ( 2019 ) . Encapsulation of macrophages enhances their retention and angiogenic potential . npj Regenerative Medicine vol. 4 , ( 1 )
Kelleher J, Dickinson A, Cain S, Hu Y, Bates N, Harvey A, Ren J, Zhang W et al. ( 2019 ) . Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures . Stem Cell Reports vol. 13 , ( 5 ) 817 - 831 .
Yang J, Dang G, Lü S, Liu H, Ma X, Han L, Deng J, Miao Y et al. ( 2019 ) . T-cell–derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2 . FASEB Journal vol. 33 , ( 11 ) 12780 - 12799 .
Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, Issa Bhaloo S, Lu Y et al. ( 2019 ) . Single-cell RNA-Sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 39 , ( 10 ) 2049 - 2066 .
Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y et al. ( 2019 ) . Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment . Cell Death and Disease vol. 10 , ( 8 )
JIANG L, XU Q ( 2019 ) . Current status and prospects of cardiovascular stem/progenitor cells in cardiovascular regenerative medicine . Scientia Sinica Vitae vol. 49 , ( 8 ) 965 - 976 .
Gu W, Ni Z, Tan YQ, Deng J, Zhang SJ, Lv ZC, Wang XJ, Chen T et al. ( 2019 ) . Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 39 , ( 6 ) 1055 - 1071 .
Fan Y, Chen Y, Zhang J, Yang F, Hu Y, Zhang L, Zeng C, Xu Q ( 2019 ) . Protective role of RNA helicase dead-box protein 5 in smooth muscle cell proliferation and vascular remodeling . Circulation Research vol. 124 , ( 10 ) E84 - E100 .
Cheng J, Wen J, Wang N, Wang C, Xu Q, Yang Y ( 2019 ) . Ion Channels and Vascular Diseases . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 39 , ( 5 ) E146 - E156 .
Chen T, Karamariti E, Hong X, Deng J, Wu Y, Gu W, Simpson R, Wong MM et al. ( 2019 ) . DKK3 (dikkopf-3) transdifferentiates fibroblasts into functional endothelial cells-brief report . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 39 , ( 4 ) 765 - 773 .
Ni Z, Deng J, Potter CMF, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q et al. ( 2019 ) . Recipient c-kit lineage cells repopulate smooth muscle cells of transplant arteriosclerosis in mouse models . Circulation Research vol. 125 , ( 2 ) 223 - 241 .
Chen T, Wu Y, Gu W, Xu Q ( 2018 ) . Response of vascular mesenchymal stem/progenitor cells to hyperlipidemia . Cellular and Molecular Life Sciences vol. 75 , ( 22 ) 4079 - 4091 .
Lu Y, Thavarajah T, Gu W, Cai J, Xu Q ( 2018 ) . Impact of miRNA in Atherosclerosis . Arteriosclerosis, thrombosis, and vascular biology vol. 38 , ( 9 ) e159 - e170 .
Ma B, Yao F, Xie N, Mao C, Liu F, Gong Z, Zhao G, Liu Z et al. ( 2018 ) . Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage . Journal of Molecular and Cellular Cardiology vol. 121 , 69 - 80 .
Chen Q, Yang M, Wu H, Zhou J, Wang W, Zhang H, Zhao L, Zhu J et al. ( 2018 ) . Genetic lineage tracing analysis of c-kit<sup>+</sup> stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions . Journal of Molecular and Cellular Cardiology vol. 121 , 277 - 286 .
Pan Y, Yang J, Wei Y, Wang H, Jiao R, Moraga A, Zhang Z, Hu Y et al. ( 2018 ) . Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration . Advanced Science vol. 5 , ( 8 )
Yu B, Chen Q, Le Bras A, Zhang L, Xu Q ( 2018 ) . Vascular Stem/Progenitor Cell Migration and Differentiation in Atherosclerosis . Antioxidants and Redox Signaling vol. 29 , ( 2 ) 219 - 235 .
Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X et al. ( 2018 ) . GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation . Redox Biology vol. 17 , 386 - 399 .
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L et al. ( 2018 ) . COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity . Cell Death and Disease vol. 9 , ( 6 )
Lü S, Deng J, Liu H, Liu B, Yang J, Miao Y, Li J, Wang N et al. ( 2018 ) . PKM2-dependent metabolic reprogramming in CD4<sup>+</sup> T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis . Journal of Molecular Medicine vol. 96 , ( 6 ) 585 - 600 .
Zhang L, Issa Bhaloo S, Chen T, Zhou B, Xu Q ( 2018 ) . Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis . Circulation Research vol. 122 , ( 11 ) 1608 - 1624 .
Gu W, Hong X, Le Bras A, Nowak WN, Bhaloo SI, Deng J, Xie Y, Hu Y et al. ( 2018 ) . Smooth muscle cells differentiated from mesenchymal stem cells are regulated by microRNAs and suitable for vascular tissue grafts . Journal of Biological Chemistry vol. 293 , ( 21 ) 8089 - 8102 .
Issa Bhaloo S, Wu Y, Le Bras A, Hu Y, Xu Q, Zhao Q ( 2018 ) . Abstract 479: Dickkopf-3 Binds to CXCR7 of Vascular Progenitor Cells to Enhance Degradable Graft Regeneration . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( Suppl_1 )
Gu W, Hong X, Le Bras A, Xu Q, Hu Y ( 2018 ) . Abstract 650: Stem Cell-derived SMCs Are Useful for Vascular Tissue Engineering . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( Suppl_1 )
Jain T, Nikolopoulou EA, Xu Q, Qu A ( 2018 ) . Hypoxia inducible factor as a therapeutic target for atherosclerosis . Pharmacology and Therapeutics vol. 183 , 22 - 33 .
Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML et al. ( 2018 ) . DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation into Smooth Muscle Cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 38 , ( 2 ) 425 - 437 .
Liu Y, Wang Z, Li J, Ban Y, Mao G, Zhang M, Wang M, Liu Y et al. ( 2018 ) . Inhibition of 5-Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β-Arrestin2-Mammalian Target of Rapamycin/p70S6K Pathway . J Am Heart Assoc vol. 7 , ( 3 )
Le Bras A, Yu B, Issa Bhaloo S, Hong X, Zhang Z, Hu Y, Xu Q ( 2018 ) . Adventitial Sca1+ Cells Transduced with ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling after Injury . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 38 , ( 1 ) 232 - 244 .
Bhaloo SI, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z et al. ( 2018 ) . Binding of dickkopf-3 to CXCR7 enhances vascular progenitor cell migration and degradable graft regeneration . Circulation Research vol. 123 , ( 4 ) 451 - 466 .
Zhai CG, Xu YY, Tie YY, Zhang Y, Chen WQ, Ji XP, Mao Y, Qiao L et al. ( 2018 ) . DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways . Journal of Molecular and Cellular Cardiology vol. 114 , 243 - 252 .
Li Y, He L, Huang X, Bhaloo SI, Zhao H, Zhang S, Pu W, Tian X et al. ( 2018 ) . Genetic lineage tracing of nonmyocyte population by dual recombinases . Circulation vol. 138 , ( 8 ) 793 - 805 .
Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L et al. ( 2017 ) . Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction . Circulation Research vol. 121 , ( 12 ) 1331 - 1345 .
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, Xu Q ( 2017 ) . Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration . Scientific Reports vol. 7 , ( 1 )
Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G et al. ( 2017 ) . Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia . Arterioscler Thromb Vasc Biol vol. 37 , ( 11 ) 2182 - 2194 .
Kokkinopoulos I, Wong MM, Potter CMF, Xie Y, Yu B, Warren DT, Nowak WN, Le Bras A et al. ( 2017 ) . Adventitial SCA-1<sup>+</sup> Progenitor Cell Gene Sequencing Reveals the Mechanisms of Cell Migration in Response to Hyperlipidemia . Stem Cell Reports vol. 9 , ( 2 ) 681 - 696 .
He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q et al. ( 2017 ) . Preexisting endothelial cells mediate cardiac neovascularization after injury . Journal of Clinical Investigation vol. 127 , ( 8 ) 2968 - 2981 .
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A et al. ( 2017 ) . A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective . Circulation vol. 136 , ( 11 ) 1022 - 1036 .
Wang Z, Wu Y, Wang J, Zhang C, Yan H, Zhu M, Wang K, Li C et al. ( 2017 ) . Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ϵ-caprolactone) Scaffolds . ACS Applied Materials and Interfaces vol. 9 , ( 23 ) 19541 - 19551 .
Nowak WN, Deng J, Ruan XZ, Xu Q ( 2017 ) . Reactive oxygen species generation and atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 5 ) e41 - e52 .
Cochrane A, Kelaini S, Tsifaki M, Bojdo J, Vilà-González M, Drehmer D, Caines R, Magee C et al. ( 2017 ) . Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis . Stem Cells vol. 35 , ( 4 ) 952 - 966 .
Zhang L, Xu Q ( 2017 ) . Vascular Progenitors and Smooth Muscle Cells Chicken and Egg? . Circulation Research vol. 120 , ( 2 ) 246 - 248 .
Maguire EM, Xiao Q, Xu Q ( 2017 ) . Differentiation and application of induced pluripotent stem cell?derived vascular smooth muscle cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 11 ) 2026 - 2037 .
Deng J, Lü S, Liu H, Liu B, Jiang C, Xu Q, Feng J, Wang X ( 2017 ) . Homocysteine activates B cells via regulating PKM2-dependent metabolic reprogramming . Journal of Immunology vol. 198 , ( 1 ) 170 - 183 .
Xie Y, Potter CMF, Le Bras A, Nowak WN, Gu W, Bhaloo SI, Zhang Z, Hu Y et al. ( 2017 ) . Leptin induces sca-1<sup>+</sup> progenitor cell migration enhancing neointimal lesions in vessel-injury mouse models . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 11 ) 2114 - 2127 .
Gu W, Hong X, Potter C, Qu A, Xu Q ( 2017 ) . Mesenchymal stem cells and vascular regeneration . Microcirculation vol. 24 , ( 1 )
Hong X, Le Bras A, Margariti A, Xu Q ( 2016 ) . Reprogramming towards endothelial cells for vascular regeneration . Genes and Diseases vol. 3 , ( 3 ) 186 - 197 .
Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y et al. ( 2016 ) . Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification . Circulation Research vol. 119 , ( 2 ) 261 - 276 .
Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D et al. ( 2016 ) . Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation . Stem Cells vol. 34 , ( 9 ) 2368 - 2380 .
Zhao Y, Li Y, Luo P, Gao Y, Yang J, Lao KH, Wang G, Cockerill G et al. ( 2016 ) . XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles . Scientific Reports vol. 6 ,
Karamariti E, Zhai C, Yu B, Niehrs C, Hu Y, Zhang C, Xu Q ( 2016 ) . B DKK3 Stabilises Atherosclerotic Plaque via Promoting Vascular Progenitor and Fibroblast Differentiation to Smooth Muscle Cells . Heart vol. 102 , ( Suppl 6 )
Simpson RML, Hong X, Wong MM, Karamariti E, Bhaloo SI, Warren D, Kong W, Hu Y et al. ( 2016 ) . Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage . Stem Cells vol. 34 , ( 5 ) 1225 - 1238 .
Xie Y, Fan Y, Xu Q ( 2016 ) . Vascular regeneration by stem/progenitor cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 36 , ( 5 ) e33 - e40 .
Luo Y, Feng J, Xu Q, Wang W, Wang X ( 2016 ) . NSun2 deficiency protects endothelium from inflammation via mRNA methylation of ICAM-1 . Circulation Research vol. 118 , ( 6 ) 944 - 956 .
Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu SS, Xu Q et al. ( 2016 ) . Microsomal Prostaglandin e Synthase-1-Derived PGE<sup>2</sup> Inhibits Vascular Smooth Muscle Cell Calcification . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 36 , ( 1 ) 108 - 121 .
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X et al. ( 2015 ) . XBP 1-deficiency abrogates neointimal lesion of injured vessels via cross talk with the PDGF signaling . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( 10 ) 2134 - 2144 .
Lao KH, Zeng L, Xu Q ( 2015 ) . Endothelial and smooth muscle cell transformation in atherosclerosis . Current Opinion in Lipidology vol. 26 , ( 5 ) 449 - 456 .
Wang X, Karamariti E, Simpson R, Wang W, Xu Q ( 2015 ) . Dickkopf homolog 3 induces stem cell differentiation into smooth muscle lineage via ATF6 signalling . Journal of Biological Chemistry vol. 290 , ( 32 ) 19844 - 19852 .
Campagnolo P, Tsai TN, Hong X, Kirton JP, So PW, Margariti A, Di Bernardini E, Wong MM et al. ( 2015 ) . C-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway . Biomaterials vol. 60 , 53 - 61 .
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J et al. ( 2015 ) . Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells . Cell Death and Differentiation vol. 22 , ( 7 ) 1170 - 1180 .
Hong X, Margariti A, Jacquet L, Le Bras A, Hu Y, Xu Q ( 2015 ) . 222 Generation of Functional Endothelial-Like Cells Enabling Therapeutic Angiogenesis from Human Smooth Muscle Cells . Heart vol. 101 , ( Suppl 4 )
Wang Z, Lu Y, Qin K, Wu Y, Tian Y, Wang J, Zhang J, Hou J et al. ( 2015 ) . Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug . Journal of Controlled Release vol. 210 , 179 - 188 .
Campagnolo P, Hong X, Di Bernardini E, Smyrnias I, Hu Y, Xu Q ( 2015 ) . Resveratrol-induced vascular progenitor differentiation towards endothelial lineage via miR-21/Akt/β-catenin is protective in vessel graft models . PLoS ONE vol. 10 , ( 5 )
Yu B, Wong MM, Wang W, Hu Y, Xu Q ( 2015 ) . Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( suppl_1 )
Yu B, Wong MM, Potter C, Hu Y, Wang W, Xu Q ( 2015 ) . Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( suppl_1 )
Chen T, Margariti A, Kelaini S, Cochrane A, Guha ST, Hu Y, Stitt AW, Zhang L et al. ( 2015 ) . MicroRNA-199b modulates vascular cell fate during ips cell differentiation by targeting the notch ligand jagged1 and enhancing VEGF signaling . Stem Cells vol. 33 , ( 5 ) 1405 - 1418 .
Wong MM, Xu Q ( 2015 ) . Stem Cell Therapeutics . Atherosclerosis: Risks, Mechanisms, and Therapies ,
Wong MM, Hong X, Karamariti E, Hu Y, Xu Q ( 2015 ) . Generation and grafting of tissue-engineered vessels in a mouse model . Journal of Visualized Experiments vol. 2015 , ( 97 )
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M et al. ( 2015 ) . ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1 . Circulation vol. 131 , ( 13 ) 1191 - 1201 .
Chen D, Xia M, Hayford C, Tham EL, Semik V, Hurst S, Chen Y, Tam HH et al. ( 2015 ) . Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE<sup>-/-</sup> mice . Circulation vol. 131 , ( 15 ) 1350 - 1360 .
Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W et al. ( 2015 ) . Genetic targeting of sprouting angiogenesis using Apln-CreER . Nature Communications vol. 6 ,
Wang G, Jacquet L, Karamariti E, Xu Q ( 2015 ) . Origin and differentiation of vascular smooth muscle cells . Journal of Physiology vol. 593 , ( 14 ) 3013 - 3030 .
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J et al. ( 2014 ) . Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells . Cell Death and Differentiation
Martin D, Li Y, Yang J, Wang G, Margariti A, Jiang Z, Yu H, Zampetaki A et al. ( 2014 ) . Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3 . Journal of Biological Chemistry vol. 289 , ( 44 ) 30625 - 30634 .
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Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W et al. ( 2009 ) . Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow . Proceedings of the National Academy of Sciences of the United States of America vol. 106 , ( 20 ) 8326 - 8331 .
Xiao Q, Xu Q ( 2009 ) . Caspase-8, a double-edged sword for EPC functioning . Arterioscler Thromb Vasc Biol. vol. 29 , ( 4 ) 444 - 446 .
Xiao Q, Luo Z, Pepe AE, Margariti A, Zeng L, Xu Q ( 2009 ) . Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2 . Am J Physiol Cell Physiol. vol. 296 , ( 4 ) C711 - C723 .
Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu Q, Zhu Y, Wang N et al. ( 2009 ) . ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries . Circulation Research vol. 104 , ( 5 ) 688 - 698 .
Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Martin D, Hu Y, Zeng L et al. ( 2009 ) . Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells . Journal of Cell Science vol. 122 , ( 4 ) 460 - 470 .
Zampetaki A, Xu Q ( 2009 ) . Vascular remodeling in diabetes don't leave without your STAT5 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 29 , ( 1 ) 10 - 11 .
Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM et al. ( 2009 ) . Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts . Journal of Molecular and Cellular Cardiology vol. 46 , ( 2 ) 268 - 277 .
Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q et al. ( 2009 ) . Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures . Circ Res. vol. 104 , ( 1 ) 32 - 40 .
Laxton RC, Hu YH, Duchene J, Zhang F, Zhang ZY, Leung KY, Xiao QZ, Scotland RS et al. ( 2009 ) . A Role of Matrix Metalloproteinase-8 in Atherosclerosis . Circ.Res. vol. 105 , ( 9 ) 921 - U231 .
Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ et al. ( 2009 ) . Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: Results from the Bruneck study . European Heart Journal vol. 30 , ( 1 ) 107 - 115 .
Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N et al. ( 2009 ) . Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures . Blood vol. 114 , ( 3 ) 723 - 732 .
Dai J, Wang X, Feng J, Kong W, Xu Q, Shen X, Wang X ( 2008 ) . Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages . FEBS Letters vol. 582 , ( 28 ) 3893 - 3898 .
Wang QQ, Ping BH, Xu QB, Wang W ( 2008 ) . Rheological effects of blood in a nonplanar distal end-to-side anastomosis . Journal of Biomechanical Engineering vol. 130 , ( 5 )
Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Hu Y, Zeng L, Xu Q ( 2008 ) . HISTONE DEACETYLASE 7 IS ESSENTIAL FOR STEM CELL DIFFERENTIATION INTO SMOOTH MUSCLE CELLS . Atherosclerosis . vol. 199 ,
Hu Y, Foteinos G, Xiao Q, Xu Q ( 2008 ) . RAPID ENDOTHELIAL TURNOVER IN ATHEROSCLEROSIS-PRONE AREAS COINCIDES WITH STEM CELL REPAIR IN APOE-DEFICIENT MICE . Atherosclerosis . vol. 199 ,
Zeng L, Zampetaki A, Margariti A, Li H, Zhang Z, Xiao Q, Hu Y, Xu Q ( 2008 ) . XBP1 IS A KEY PROTEIN INDUCING ENDOTHELIAL CELL DEATH IN VIVO AND IN VITRO . Atherosclerosis . vol. 199 , 465 - 466 .
Metzler B, Xu Q, Mayr M ( 2008 ) . Letter by Metzler et al regarding article, "Intracoronary KAI-9803 as an adjunct to primary coronary intervention for acute ST-segment elevation myocardial infarction" . Circulation vol. 118 , ( 4 )
Zeng L, Xu Q ( 2008 ) . eNOS-ERα Complex goes to telomerase . Circulation Research vol. 103 , ( 1 ) 10 - 12 .
Afzal AR, Kiechl S, Daryani YP, Weerasinghe A, Zhang Y, Reindl M, Mayr A, Weger S et al. ( 2008 ) . Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the bruneck population . Stroke vol. 39 , ( 7 ) 1972 - 1978 .
Metzler B, Haubner B, Conci E, Voelkl J, Jehle J, Bauer M, Wolf D, Pachinger O et al. ( 2008 ) . Myocardial ischaemia-reperfusion injury in haematopoietic cell-restricted beta1 integrin knockout mice . Exp.Physiol. vol. 93 , ( 7 ) 825 - 833 .
Zampetaki A, Kirton JP, Xu Q ( 2008 ) . Vascular repair by endothelial progenitor cells . Cardiovascular Research vol. 78 , ( 3 ) 413 - 421 .
Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B et al. ( 2008 ) . Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice . Circulation Research vol. 102 , ( 9 ) 1046 - 1056 .
Xu Q ( 2008 ) . Stem cells and transplant arteriosclerosis . Circulation Research vol. 102 , ( 9 ) 1011 - 1024 .
Afzal AR, Mandal K, Nyamweya S, Foteinos G, Poloniecki J, Camm AJ, Jahangiri M, Xu Q ( 2008 ) . Association of Met439Thr substitution in heat shock protein 70 gene with postoperative atrial fibrillation and serum HSP70 protein levels . Cardiology vol. 110 , ( 1 ) 45 - 52 .
Foteinos G, Hu Y, Xiao Q, Metzler B, Xu Q ( 2008 ) . Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice . Circulation vol. 117 , ( 14 ) 1856 - 1863 .
Hu Y, Xu Q ( 2008 ) . Vessel graft atherosclerosis in murine models . Current Drug Targets vol. 9 , ( 3 ) 239 - 250 .
Mayr M, Yusuf S, Weir G, Chung YL, Mayr U, Yin X, Ladroue C, Madhu B et al. ( 2008 ) . Combined Metabolomic and Proteomic Analysis of Human Atrial Fibrillation . Journal of the American College of Cardiology vol. 51 , ( 5 ) 585 - 594 .
YE S, WILLEIT J, KRONENBERG F, XU Q, KIECHL S ( 2008 ) . Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis - A population-based, prospective study . J Am Coll Cardiol vol. 52 , ( 5 ) 378 - 384 .
Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S, Xu Q ( 2008 ) . SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study . PLoS One vol. 3 , ( 12 )
Mandal K, Jahangiri M, Xu Q ( 2007 ) . Progenitor Cells and Vascular Repair . Cardiovascular Regeneration and Stem Cell Therapy ,
Xu Q ( 2007 ) . The role of stem cells in vein graft remodelling . Biochemical Society Transactions . vol. 35 , 895 - 899 .
Adams B, Xiao Q, Xu Q ( 2007 ) . Vascular progenitor cells and atherosclerosis . Future Cardiology vol. 3 , ( 6 ) 635 - 645 .
Qi XW, Liu HF, Xue YZ, Kong XQ, Xu QB, Xiao QZ ( 2007 ) . Changes of endothelial progenitor cells and vascular endothelial growth factor in patients with coronary artery disease . Journal of Clinical Rehabilitative Tissue Engineering Research vol. 11 , ( 42 ) 8439 - 8443 .
Simper D, Mayr U, Benbow U, Newby A, Xu Q, Mayr M ( 2007 ) . Abstract 1162: Proteomic Characterization of the Secretome of Peripheral Blood-derived Smooth Muscle Progenitors . Circulation vol. 116 , ( suppl_16 )
Margariti A, Xiao Q, Zampetaki A, Hu Y, Zeng L, Xu Q ( 2007 ) . Abstract 433: HDAC7 is Essential for Stem Cell Differentiation into Smooth Muscle Cells . Circulation vol. 116 , ( suppl_16 )
Xiao Q, Kiechi S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M et al. ( 2007 ) . Endothelial progenitor cells, cardiovascular risk factors, cytokine levels and atherosclerosis - Results from a large population-based study . PLoS ONE vol. 2 , ( 10 )
Zampetaki A, Zeng L, Xiao Q, Margariti A, Hu Y, Xu Q ( 2007 ) . Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-α is rescued by HDAC inhibitor trichostatin A . American Journal of Physiology - Cell Physiology vol. 293 , ( 4 )
Xu Q ( 2007 ) . Progenitor cells in vascular repair . Current Opinion in Lipidology vol. 18 , ( 5 ) 534 - 539 .
Adams B, Xiao Q, Xu Q ( 2007 ) . Stem Cell Therapy for Vascular Disease . Trends in Cardiovascular Medicine vol. 17 , ( 7 ) 246 - 251 .
Xiao Q, Kiechl S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M et al. ( 2007 ) . Endothelial progenitor cells, cardiovascular risk factors, cytokines levels and atherosclerosis-results from a large population-based study . Atherosclerosis . vol. 193 ,
Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S et al. ( 2007 ) . Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 Activity, and 10-year cardiovascular outcomes: Prospective results from the bruneck study . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 27 , ( 8 ) 1788 - 1795 .
Kiechl S, Schett G, Schwaiger J, Seppi K, Eder P, Egger G, Santer P, Mayr A et al. ( 2007 ) . Soluble receptor activator of nuclear factor-κB ligand and risk for cardiovascular disease . Circulation vol. 116 , ( 4 ) 385 - 391 .
Li C, Xu Q ( 2007 ) . Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo . Cellular Signalling vol. 19 , ( 5 ) 881 - 891 .
Torsney E, Mandal K, Halliday A, Jahangiri M, Xu Q ( 2007 ) . Characterisation of progenitor cells in human atherosclerotic vessels . Atherosclerosis vol. 191 , ( 2 ) 259 - 264 .
Roberts N, Xiao Q, Weir G, Xu Q, Jahangiri M ( 2007 ) . Endothelial Progenitor Cells are Mobilized After Cardiac Surgery . Annals of Thoracic Surgery vol. 83 , ( 2 ) 598 - 605 .
Mayr M, Madhu B, Xu Q ( 2007 ) . Proteomics and Metabolomics Combined in Cardiovascular Research . Trends in Cardiovascular Medicine vol. 17 , ( 2 ) 43 - 48 .
Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M ( 2007 ) . Integrated membrane protein analysis of mature and embryonic stem cell-derived smooth muscle cells using a novel combination of cydye/biotin labeling . Molecular and Cellular Proteomics vol. 6 , ( 10 ) 1788 - 1797 .
Xiao Q, Zeng L, Zhang Z, Hu Y, Xu Q ( 2007 ) . Stem cell-derived Sca-1<sup>+</sup> progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α<inf>1</inf>/ β<inf>1</inf>/α<inf>v</inf> and PDGF receptor pathways . American Journal of Physiology - Cell Physiology vol. 292 , ( 1 )
Xu QB, Wang X ( 2007 ) . Updates on atherogenesis: the stem/progenitor cells hypothesis . Zhonghua bing li xue za zhi Chinese journal of pathology vol. 36 , ( 12 ) 793 - 795 .
Yin X, Mayr M, Xiao Q, Wang W, Xu Q ( 2006 ) . Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells . Proteomics vol. 6 , ( 24 ) 6437 - 6446 .
Bhoday J, De Silva S, Xu Q ( 2006 ) . The molecular mechanisms of vascular restenosis: Which genes are crucial? . Current Vascular Pharmacology vol. 4 , ( 3 ) 269 - 275 .
Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V et al. ( 2006 ) . Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems . Vascular Pharmacology vol. 45 , ( 5 ) 281 - 301 .
Xiao Q, Zeng L, Zhang Z, Margariti A, Ali ZA, Channon KM, Xu Q, Hu Y ( 2006 ) . Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 26 , ( 10 ) 2244 - 2251 .
Zeng L, Xiao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y et al. ( 2006 ) . HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells . Journal of Cell Biology vol. 174 , ( 7 ) 1059 - 1069 .
Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q ( 2006 ) . Combining proteomics and metabolomics in vascular research . Vascular Pharmacology vol. 45 , ( 3 )
Markus HS, Labrum R, Bevan S, Reindl M, Egger G, Wiedermann CJ, Xu Q, Kiechl S et al. ( 2006 ) . Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis . Stroke vol. 37 , ( 9 ) 2253 - 2259 .
Mayr M, Kiechl S, Tsimikas S, Willeit J, Witztum JL, Xu Q ( 2006 ) . Oxidized LDL autoantibodies, chronic infections and carotid atherosclerosis . Vascular Pharmacology vol. 45 , ( 3 )
Yin X, Xiao Q, Mayr U, Mayr M, Xu Q ( 2006 ) . Proteomic analysis of embryonic stem cell-derived smooth muscle cells . Vascular Pharmacology vol. 45 , ( 3 )
Zeng L, Xiao Q, Margariti A, Xu Q ( 2006 ) . Shear stress-induced stem cell differentiation toward endothelial cells is regulated by HDAC-P53-P21 pathways . Vascular Pharmacology vol. 45 , ( 3 )
Zampetaki A, Xiao Q, Zeng L, Xu Q ( 2006 ) . TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications . Vascular Pharmacology vol. 45 , ( 3 )
Zampetaki A, Xiao Q, Zeng L, Hu Y, Xu Q ( 2006 ) . TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications . Biochemical and Biophysical Research Communications vol. 347 , ( 1 ) 89 - 99 .
Castier Y, Lehoux S, Hu Y, Fonteinos G, Tedgui A, Xu Q ( 2006 ) . Characterization of neointima lesions associated with arteriovenous fistulas in a mouse model . Kidney International vol. 70 , ( 2 ) 315 - 320 .
Edfeldt K, Agerberth B, Rottenberg ME, Gudmundsson GH, Wang XB, Mandal K, Xu Q, Yan ZQ ( 2006 ) . Involvement of the antimicrobial peptide LL-37 in human atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 26 , ( 7 ) 1551 - 1557 .
Margariti A, Zeng L, Xu Q ( 2006 ) . Stem cells, vascular smooth muscle cells and atherosclerosis . Histology and Histopathology vol. 21 , ( 7-9 ) 979 - 985 .
Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q ( 2006 ) . Oxidized Low-Density Lipoprotein Autoantibodies, Chronic Infections, and Carotid Atherosclerosis in a Population-Based Study . Journal of the American College of Cardiology vol. 47 , ( 12 ) 2436 - 2443 .
Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C et al. ( 2006 ) . Oxidized Phospholipids Predict the Presence and Progression of Carotid and Femoral Atherosclerosis and Symptomatic Cardiovascular Disease. Five-Year Prospective Results From the Bruneck Study . Journal of the American College of Cardiology vol. 47 , ( 11 ) 2219 - 2228 .
Mandal K, Afzal AR, Brecker SJD, Poloniecki J, Xu Q, Jahangiri M ( 2006 ) . Association of serum soluble heat shock protein 60 with toll-like receptor 4 polymorphism and severity of coronary artery disease . Heart vol. 92 , ( 5 ) 683 - 685 .
Mayr U, Zou Y, Zhang Z, Dietrich H, Hu Y, Xu Q ( 2006 ) . Accelerated arteriosclerosis of vein grafts in inducible NO synthase <sup>-/-</sup> mice is related to decreased endothelial progenitor cell repair . Circulation Research vol. 98 , ( 3 ) 412 - 420 .
Xu Q ( 2006 ) . The impact of progenitor cells in atherosclerosis . Nature Clinical Practice Cardiovascular Medicine vol. 3 , ( 2 ) 94 - 101 .
Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q ( 2005 ) . Proteomic dataset of mouse aortic smooth muscle cells . Proteomics vol. 5 , ( 17 ) 4546 - 4557 .
XIAO Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S et al. ( 2005 ) . Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study . Stroke vol. 36 , ( 12 ) Article PMID: 16254226 , 2571 - 2576 .
Mandal K, Foteinos G, Jahangiri M, Xu Q ( 2005 ) . Role of antiheat shock protein 60 autoantibodies in atherosclerosis . Lupus vol. 14 , ( 9 ) 742 - 746 .
Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y et al. ( 2005 ) . Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 25 , ( 10 ) 2135 - 2142 .
Püntmann VO, Hussain MB, Mayr M, Xu Q, Singer DRJ ( 2005 ) . Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease . Vascular Pharmacology vol. 43 , ( 4 ) 277 - 282 .
Ali ZA, Bursill CA, Hu Y, Choudhury RP, Xu Q, Greaves DR, Channon KM ( 2005 ) . Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice . Circulation vol. 112 , ( 9 SUPPL. )
Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q ( 2005 ) . Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage . Circulation vol. 112 , ( 8 ) 1206 - 1213 .
Zampetaki A, Zhang Z, Hu Y, Xu Q ( 2005 ) . Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-κB signaling pathways . American Journal of Physiology - Heart and Circulatory Physiology vol. 288 , ( 6 57-6 )
Torsney E, Hu Y, Xu Q ( 2005 ) . Adventitial progenitor cells contribute to arteriosclerosis . Trends in Cardiovascular Medicine vol. 15 , ( 2 ) 64 - 68 .
Mandal K, Torsney E, Poloniecki J, Camm AJ, Xu Q, Jahangiri M ( 2005 ) . Association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fibrillation . Annals of Thoracic Surgery vol. 79 , ( 3 ) 865 - 871 .
Mandal K, Jahangiri M, Xu Q ( 2005 ) . Autoimmune mechanisms of atherosclerosis . Handbook of Experimental Pharmacology vol. 170 , 723 - 743 .
Xu QB ( 2005 ) . Endothelial progenitor cells in angiogenesis . Sheng li xue bao : [Acta physiologica Sinica] vol. 57 , ( 1 ) 1 - 6 .
Roberts N, Jahangiri M, Xu Q ( 2005 ) . Progenitor cells in vascular disease . Journal of Cellular and Molecular Medicine vol. 9 , ( 3 ) 583 - 591 .
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ, Tarelli E ( 2005 ) . Proteomic dataset of Sca-1+ progenitor cells . Proteomics vol. 5 , ( 17 ) 4533 - 4545 .
Xu Q ( 2005 ) . The role of stem cells in atherosclerosis . Archives des maladies du coeur et des vaisseaux vol. 98 , ( 6 ) 672 - 676 .
Xu Q, Wick G ( 2004 ) . The Pathogenic Role of Heat Shock Proteins in Atherosclerosis . Infection and Autoimmunity, 2nd edition ,
Mayr M, Mayr U, Chung YL, Yin X, Griffiths JR, Xu Q ( 2004 ) . Vascular proteomics: Linking proteomic and metabolomic changes . Proteomics vol. 4 , ( 12 ) 3751 - 3761 .
Mandal K, Jahangiri M, Mukhin M, Poloniecki J, Camm AJ, Xu Q ( 2004 ) . Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation . Circulation vol. 110 , ( 17 ) 2588 - 2590 .
Mayr M, Metzler B, Chung YL, McGregor E, Mayr U, Troy H, Hu Y, Leitges M et al. ( 2004 ) . Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice . American Journal of Physiology - Heart and Circulatory Physiology vol. 287 , ( 2 56-2 )
Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ et al. ( 2004 ) . Loss of PKC-δ alters cardiac metabolism . American Journal of Physiology - Heart and Circulatory Physiology vol. 287 , ( 2 56-2 )
Torsney E, Mayr U, Zou Y, Thompson WD, Hu Y, Xu Q ( 2004 ) . Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection . Circulation Research vol. 94 , ( 11 ) 1466 - 1473 .
Melhus H, Schett G, Redlich K, Pietschmann P, Smolen J, Kiechl S, Willeit J, Oberhollenzer F et al. ( 2004 ) . Soluble RANKL and risk of nontraumatic fracture [3] . JAMA vol. 291 , ( 22 ) 2703 - 2704 .
Wick G, Knoflach M, Xu Q ( 2004 ) . Autoimmune and inflammatory mechanisms in atherosclerosis .
Mayr M, Siow R, Chung Y-L, Mayr U, Griffiths JR, Xu Q ( 2004 ) . A PROTEOMIC AND METABOLOMIC ANALYSIS: ROLE OF PKCDELTA IN VASCULAR SMOOTH MUSCLE CELLS . Cardiovascular Pathology vol. 13 , ( 3 )
Hu Y, Zhang Z, Torsney E, Davison F, Xu Q ( 2004 ) . ANGIOGENESIS WITHIN ATHEROSCLEROTIC LESIONS BY STEM/PROGENITOR CELLS . Cardiovascular Pathology vol. 13 , ( 3 )
Torsney E, Hu Y, Zou Y, Xu Q ( 2004 ) . ENDOTHELIAL DAMAGE AND THROMBOSIS IN VEIN GRAFT ATHEROSCLEROSIS ARE INHIBITED BY ASPIRIN . Cardiovascular Pathology vol. 13 , ( 3 ) 177 - 178 .
Mayr M, Kiechl S, Tsimikas S, Miller E, Willeit J, Witztum JL, Xu Q ( 2004 ) . INFECTIONS, IMMUNITY AND ATHEROSCLEROSIS: ASSOCIATIONS OF ANTIBODIES TO OXIDIZED LDL AND INFECTIOUS AGENTS IN THE BRUNECK STUDY . Cardiovascular Pathology vol. 13 , ( 3 )
Zal B, Kaski JC, Arno G, Akiyu JP, Xu Q, Cole D, Whelan M, Russell N et al. ( 2004 ) . Heat-Shock Protein 60-Reactive CD4<sup>+</sup>CD28<sup>null</sup> T Cells in Patients with Acute Coronary Syndromes . Circulation vol. 109 , ( 10 ) 1230 - 1235 .
Schett G, Kiechl S, Redlich K, Oberhollenzer F, Weger S, Egger G, Mayr A, Jocher J et al. ( 2004 ) . Soluble RANKL and Risk of Nontraumatic Fracture . JAMA vol. 291 , ( 9 ) 1108 - 1113 .
Mandal K, Jahangiri M, Xu Q ( 2004 ) . Autoimmunity to heat shock proteins in atherosclerosis . Autoimmunity Reviews vol. 3 , ( 2 ) 31 - 37 .
Xu Q, Wick G ( 2004 ) . 56 The Pathogenic Role of Heat Shock Proteins in Atherosclerosis . Infection and Autoimmunity ,
Hu Y, Zhang Z, Torsney E, Afzal AR, Davison F, Metzler B, Xu Q ( 2004 ) . Abundant progenitor cells in the adventitia contribute to atheroscleroses of vein grafts in ApoE-deficient mice . Journal of Clinical Investigation vol. 113 , ( 9 ) 1258 - 1265 .
Xu Q ( 2004 ) . Mouse models of arteriosclerosis: From arterial injuries to vascular grafts . American Journal of Pathology vol. 165 , ( 1 ) 1 - 10 .
Xu Q ( 2004 ) . Mouse models of vein grafts . Arteriosclerosis, thrombosis, and vascular biology vol. 24 , ( 11 )
Mayr M, Mandal K, Xu Q ( 2004 ) . Pitfalls of proteomics . Circulation vol. 110 , ( 12 )
Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q ( 2004 ) . Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta . Circulation research vol. 94 , ( 10 )
Hu Y, Davison F, Zhang Z, Xu Q ( 2003 ) . Endothelial Replacement and Angiogenesis in Arteriosclerotic Lesions of Allografts Are Contributed by Circulating Progenitor Cells . Circulation vol. 108 , ( 25 ) 3122 - 3127 .
Schett G, Steiner CW, Xu Q, Smolen JS, Steiner G ( 2003 ) . TNFα mediates susceptibility to heat-induced apoptosis by protein phosphatase-mediated inhibition of the HSF1/hsp70 stress response . Cell Death and Differentiation vol. 10 , ( 10 ) 1126 - 1136 .
Xu Q ( 2003 ) . Infections, heat shock proteins, and atherosclerosis . Current Opinion in Cardiology vol. 18 , ( 4 ) 245 - 252 .
Perschinka H, Mayr M, Millonig G, Mayerl C, Van Der Zee R, Morrison SG, Morrison RP, Xu Q et al. ( 2003 ) . Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 23 , ( 6 ) 1060 - 1065 .
Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu Y, Xu Q ( 2003 ) . Activation of heat shock transcription factor 1 in atherosclerosis . American Journal of Pathology vol. 162 , ( 5 ) 1669 - 1676 .
Wernig F, Mayr M, Xu Q ( 2003 ) . Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by β<inf>1</inf>-integrin signaling pathways . Hypertension vol. 41 , ( 4 ) 903 - 911 .
Mayr M, Kiechl S, Mendall MA, Willeit J, Wick G, Xu Q ( 2003 ) . Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: Prospective results from the Bruneck study . Stroke vol. 34 , ( 3 ) 610 - 615 .
Shaw A, Xu Q ( 2003 ) . Biomechanical stress-induced signaling in smooth muscle cells: an update . Current vascular pharmacology vol. 1 , ( 1 ) 41 - 58 .
Xu Q, Zhang Z, Davison F, Hu Y ( 2003 ) . Circulating progenitor cells regenerate endothelium of vein graft atherosclerosis, which is diminished in ApoE-deficient mice . Circulation research vol. 93 , ( 8 )
Li C, Wernig F, Leitges M, Hu Y, Xu Q ( 2003 ) . Mechanical stress-activated PKCdelta regulates smooth muscle cell migration . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 17 , ( 14 ) 2106 - 2108 .
Metzler B, Hammerer-Lercher A, Jehle J, Dietrich H, Pachinger O, Xu Q, Mair J ( 2002 ) . Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction . Clinica Chimica Acta vol. 325 , ( 1-2 ) 87 - 90 .
Lardenoye JHP, De Vries MR, Löwik CWGM, Xu Q, Dhore CR, Cleutjens JPM, Van Hinsbergh VWM, Van Bockel JH et al. ( 2002 ) . Accelerated atherosclerosis and calcification in vein grafts: A study in APOE*3 Leiden transgenic mice . Circulation Research vol. 91 , ( 7 ) 577 - 584 .
Xu Q ( 2002 ) . Role of heat shock proteins in atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 22 , ( 10 ) 1547 - 1559 .
Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, Xu Q ( 2002 ) . Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells . Circulation vol. 106 , ( 14 ) 1834 - 1839 .
Kiechl S, Werner P, Egger G, Oberhollenzer F, Mayr M, Xu Q, Poewe W, Willeit J ( 2002 ) . Active and passive smoking, chronic infections, and the risk of carotid atherosclerosis: Prospective results from the Bruneck Study . Stroke vol. 33 , ( 9 ) 2170 - 2176 .
Mayr U, Mayr M, Li C, Wernig F, Dietrich H, Hu Y, Xu Q ( 2002 ) . Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice . Circulation Research vol. 90 , ( 2 ) 197 - 204 .
Wernig F, Xu Q ( 2002 ) . Mechanical stress-induced apoptosis in the cardiovascular system . Progress in Biophysics and Molecular Biology vol. 78 , ( 2-3 ) 105 - 137 .
Hu Y, Mayr M, Metzler B, Erdel M, Davison F, Xu Q ( 2002 ) . Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions . Circulation research vol. 91 , ( 7 )
Mayr M, Hu Y, Hainaut H, Xu Q ( 2002 ) . Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 16 , ( 11 ) 1423 - 1425 .
Hu Y, Xu Q ( 2002 ) . New mouse model of vein bypass graft atherosclerosis . Heart Lung and Circulation vol. 11 , ( 3 ) 182 - 188 .
Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G et al. ( 2001 ) . Exacerbated vein graft arteriosclerosis in protein kinase Cδ-null mice . Journal of Clinical Investigation vol. 108 , ( 10 ) 1505 - 1512 .
Schett G, Hayer S, Tohidast-Akrad M, Schmid BJ, Lang S, Türk B, Kainberger F, Haralambous S et al. ( 2001 ) . Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor α transgenic mice . Arthritis and Rheumatism vol. 44 , ( 12 ) 2888 - 2898 .
Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, Wick G ( 2001 ) . Erratum: Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65 (Arteriosclerosis, Thrombosis and Vascular Biology (1998) 19 (1905-1911)) . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 21 , ( 10 )
Mayr M, Xu Q ( 2001 ) . Smooth muscle cell apoptosis in arteriosclerosis . Experimental Gerontology vol. 36 , ( 7 ) 969 - 987 .
Schett G, Hayer S, Tohidast-Akrad M, Xu Q, Kollias G, Steiner G, Smolen J ( 2001 ) . FRI0074 Adenoviral-based overexpression of timp-1 reduces tissue damage in the joints of tnf-a-transgenic mice . Conference: Speaker abstracts 2001a476.1 - a4a476 .
Xu Q ( 2001 ) . Heat shock proteins and atherosclerosis . European Journal of Clinical Investigation vol. 31 , ( 4 ) 283 - 284 .
Schett G, Hayer S, Tohidast-Akrad M, Jahn-Schmid B, Lang S, Kainberger F, Kollias G, Newby A et al. ( 2001 ) . Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints of TNF-alpha transgenic mice . Arthritis Research & Therapy vol. 3 , ( Suppl 1 )
Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F, Muggeo M, Xu Q et al. ( 2001 ) . Chronic infections and the risk of carotid atherosclerosis: Prospective results from a large population study . Circulation vol. 103 , ( 8 ) 1064 - 1070 .
Metzler B, Mair J, Lercher A, Schaber C, Hintringer F, Pachinger O, Xu Q ( 2001 ) . Mouse model of myocardial remodelling after ischemia: Role of intercellular adhesion molecule-1 . Cardiovascular Research vol. 49 , ( 2 ) 399 - 407 .
Schett G, Hayer S, Xu Q, Tohidast-Akrad M, Kollias G, Steiner G, Smolen J ( 2001 ) . Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints TNF-transgenic mice . Arthritis Research & Therapy vol. 3 , ( Suppl 2 )
Hu Y, Baker AH, Zou Y, Newby AC, Xu Q ( 2001 ) . Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 21 , ( 8 ) 1275 - 1280 .
Wick G, Millonig G, Xu Q ( 2001 ) . The Autoimmune Pathogenesis of Atherosclerosis—An Evolutionary-Darwinian Concept . Atherosclerosis and Autoimmunity ,
Xu Q ( 2000 ) . Biomechanical-stress-induced signaling and gene expression in the development of arteriosclerosis . Trends in Cardiovascular Medicine vol. 10 , ( 1 ) 35 - 41 .
Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, Zenz P, Redlich K et al. ( 2000 ) . Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis . Arthritis and Rheumatism vol. 43 , ( 11 ) 2501 - 2512 .
Dunzendorfer S, Meierhofer C, Xu Q, Wiedermann CJ ( 2000 ) . Pentoxifylline-augmented antiproliferative effects of adrenomedullin on vascular smooth muscle cells . European Journal of Heart Failure vol. 2 , ( 3 ) 257 - 260 .
Mayr M, Kiechl S, Willeit J, Wick G, Xu Q ( 2000 ) . Infections, immunity, and atherosclerosis: Associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis . Circulation vol. 102 , ( 8 ) 833 - 839 .
Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S et al. ( 2000 ) . Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population . Circulation vol. 102 , ( 1 ) 14 - 20 .
Hu Y, Li C, Sturm G, Wick G, Xu Q ( 2000 ) . Mechanical stress-induced HSP70 expression in SMC via RAS/RAC G-proteins, but not MAPK . Atherosclerosis vol. 151 , ( 1 )
Li C, Xu Q ( 2000 ) . Mechanical stress-initiated signal transductions in vascular smooth muscle cells . Cellular Signalling vol. 12 , ( 7 ) 435 - 445 .
Hu Y, Dietrich H, Zou Y, Wick G, Xu Q ( 2000 ) . Mouse model of transplant arteriosclerosis: Role of ICAM-1 . Atherosclerosis vol. 151 , ( 1 )
Hu Y, Dietrich H, Zou Y, Huemer U, Li C, Mayr M, Xu Q ( 2000 ) . Rapid development of vein graft atheroma in apoe-deficient mice: Implication for gene transfer study . Atherosclerosis vol. 151 , ( 1 )
Hu Y, Zou Y, Hala M, Dietrich H, Wick G, Xu Q ( 2000 ) . Prolonged survival of heart allografts from p53-deficient mice . Transplantation vol. 69 , ( 12 ) 2634 - 2640 .
Xu Q, Schett G, Li C, Hu Y, Wick G ( 2000 ) . Mechanical stress-induced heat shock protein 70 expression in vascular smooth muscle cells is regulated by rac and ras small G proteins but not mitogen-activated protein kinases . Circulation Research vol. 86 , ( 11 ) 1122 - 1128 .
Zou Y, Hu Y, Mayr M, Dietrich H, Wick G, Xu Q ( 2000 ) . Reduced neointima hyperplasia of vein bypass grafts in intercellular adhesion molecule-1-deficient mice . Circulation Research vol. 86 , ( 4 ) 434 - 440 .
Li C, Hu Y, Sturm G, Wick G, Xu Q ( 2000 ) . Ras/Rac-Dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress . Arterioscler Thromb Vasc Biol vol. 20 , ( 3 ) E1 - E9 .
Mayr M, Li C, Zou Y, Huemer U, Hu Y, Xu Q ( 2000 ) . Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases . FASEB Journal vol. 14 , ( 2 ) 261 - 270 .
Hochleitner BW, Hochleitner EO, Obrist P, Eberl T, Amberger A, Xu Q, Margreiter R, Wick G ( 2000 ) . Fluid shear stress induces heat shock protein 60 expression in endothelial cells in vitro and in vivo . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 20 , ( 3 ) 617 - 623 .
Hu Y, Dietrich H, Metzler B, Wick G, Xu Q ( 2000 ) . Hyperexpression and activation of extracellular signal-regulated kinases (ERK1/2) in atherosclerotic lesions of cholesterol-fed rabbits . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 20 , ( 1 ) 18 - 26 .
Metzler B, Hu Y, Dietrich H, Xu Q ( 2000 ) . Increased expression and activation of stress-activated protein kinases/c-Jun NH<inf>2</inf>-terminal protein kinases in atherosclerotic lesions coincide with p53 . American Journal of Pathology vol. 156 , ( 6 ) 1875 - 1886 .
Dietrich H, Hu Y, Zou Y, Dirnhofer S, Kleindienst R, Wick G, Xu Q ( 2000 ) . Mouse model of transplant arteriosclerosis: Role of intercellular adhesion molecule-1 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 20 , ( 2 ) 343 - 352 .
Kiechl S, Willeit J, Bonora E, Schwarz S, Xu Q ( 2000 ) . No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study) . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 20 , ( 4 ) 1094 - 1100 .
Dietrich H, Hu Y, Zou Y, Huemer U, Metzler B, Li C, Mayr M, Xu Q ( 2000 ) . Rapid development of vein graft atheroma in apoE-deficient mice . American Journal of Pathology vol. 157 , ( 2 ) 659 - 669 .
Schett G, Steiner CW, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G ( 2000 ) . [Reciprocal modification of Fas activation and stress protein response decides apoptosis or resistance development of cells] . Acta Med Austriaca vol. 27 , ( 3 ) 94 - 98 .
Mayr M, Xu Q, Wick G ( 1999 ) . Atherogenic effects of chronic infections: The role of heat shock protein 60 in autoimmunity . Israel Medical Association Journal vol. 1 , ( 4 ) 272 - 277 .
Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, Wick G ( 1999 ) . Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: Clinical significance determined in a follow-up study . Circulation vol. 100 , ( 11 ) 1169 - 1174 .
Li C, Hu Y, Mayr M, Xu Q ( 1999 ) . Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways . Journal of Biological Chemistry vol. 274 , ( 36 ) 25273 - 25280 .
Hu Y, Zou Y, Dietrich H, Wick G, Xu Q ( 1999 ) . Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin . Circulation vol. 100 , ( 8 ) 861 - 868 .
Schett G, Metzler B, Kleindienst R, Amberger A, Recheis H, Xu Q, Wick G ( 1999 ) . Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response . Cardiovascular Research vol. 42 , ( 3 ) 685 - 695 .
Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Q, Wick G ( 1999 ) . Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: Immune reactions to heat shock proteins as a possible link between infection and atherosclerosis . Circulation vol. 99 , ( 12 ) 1560 - 1566 .
Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G ( 1999 ) . Activation of Fas inhibits heat-induced activation of HSF1 and up- regulation of hsp70 . FASEB Journal vol. 13 , ( 8 ) 833 - 842 .
Wick G, Xu Q ( 1999 ) . Atherosclerosis - An autoimmune disease . Experimental Gerontology vol. 34 , ( 4 ) 559 - 566 .
Wick G, Perschinka H, Xu Q ( 1999 ) . Autoimmunity and atherosclerosis . American Heart Journal . vol. 138 ,
Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, Wick G ( 1999 ) . Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 19 , ( 8 ) 1905 - 1911 .
Metzler B, Li C, Hu Y, Sturm G, Ghaffari-Tabrizi N, Xu Q ( 1999 ) . LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 19 , ( 8 ) 1862 - 1871 .
Amberger A, Hala M, Saurwein-Teissl M, Metzler B, Grubeck-Loebenstein B, Xu Q, Wick G ( 1999 ) . Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins . Molecular Medicine vol. 5 , ( 2 ) 117 - 128 .
Metzier B, Hu Y, Sturm G, Wick G, Xu Q ( 1998 ) . Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells . Journal of Biological Chemistry vol. 273 , ( 50 ) 33320 - 33326 .
Schett G, Redlich K, Xu Q, Bizan P, Gröger M, Tohidast-Akrad M, Kiener H, Smolen J et al. ( 1998 ) . Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue: Differential regulation of HSP 70 expression and HSF1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs . Journal of Clinical Investigation vol. 102 , ( 2 ) 302 - 311 .
Metzler B, Xu Q, Wick G ( 1998 ) . The role of (auto-) immunity in atherogenesis . Wiener Klinische Wochenschrift vol. 110 , ( 10 ) 350 - 355 .
Hu Y, Schett G, Zou Y, Dietrich H, Xu Q ( 1998 ) . Abundance of platelet-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age . Molecular Brain Research vol. 53 , ( 1-2 ) 251 - 258 .
Hu Y, Böck G, Wick G, Xu Q ( 1998 ) . Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress . FASEB Journal vol. 12 , ( 12 ) 1135 - 1142 .
Hu Y, Hochleitner BW, Wick G, Xu Q ( 1998 ) . Decline of shear stress-induced activation of extracellular signal-regulated kinases, but not stress-activated protein kinases, in in vitro propagated endothelial cells . Experimental Gerontology vol. 33 , ( 6 ) 601 - 613 .
Zou Y, Dietrich H, Hu Y, Metzler B, Wick G, Xu Q ( 1998 ) . Mouse model of venous bypass graft arteriosclerosis . American Journal of Pathology vol. 153 , ( 4 ) 1301 - 1310 .
Melrose J, Whitelock J, Xu Q, Ghosh P ( 1998 ) . Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells . Journal of Vascular Surgery vol. 28 , ( 4 ) 676 - 686 .
Zou Y, Hu Y, Metzler B, Xu Q ( 1998 ) . Signal transduction in arteriosclerosis: mechanical stress-activated MAP kinases in vascular smooth muscle cells (review) . International journal of molecular medicine vol. 1 , ( 5 ) 827 - 834 .
Hu Y, Cheng L, Hochleitner B-W, Xu Q ( 1997 ) . 3.P.211 Activation of mitogen-activated protein kinases and activator protein-1 in rat arteries after balloon injury . Atherosclerosis vol. 134 , ( 1-2 )
Hu Y, Hochleitner B-W, Wick G, Xu Q ( 1997 ) . 3.P.317 Age-related decline in activation of mitogen-activated protein kinases in shear-stressed endothelial cells . Atherosclerosis vol. 134 , ( 1-2 )
Xu Q, Hu Y, Kleindienst R, Wick G ( 1997 ) . Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1 . Journal of Clinical Investigation vol. 100 , ( 5 ) 1089 - 1097 .
Amberger A, Maczek C, Jürgens G, Michaelis D, Schett G, Trieb K, Eberl T, Jindal S et al. ( 1997 ) . Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins . Cell Stress and Chaperones vol. 2 , ( 2 ) 94 - 103 .
Fawcett TW, Xu Q, Holbrook NJ ( 1997 ) . Potentiation of heat stress induced hsp70 expression in vivo by aspirin . Cell Stress and Chaperones vol. 2 , ( 2 ) 104 - 109 .
Hu Y, Metzler B, Xu Q ( 1997 ) . Discordant activation of stress-activated protein kinases or c-Jun NH<inf>2</inf>- terminal protein kinases in tissues of heat-stressed mice . Journal of Biological Chemistry vol. 272 , ( 14 ) 9113 - 9119 .
Schett G, Metzler B, Mayr M, Amberger A, Niederwieser D, Gupta RS, Mizzen L, Xu Q et al. ( 1997 ) . Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60 . Atherosclerosis vol. 128 , ( 1 ) 27 - 38 .
Hu Y, Cheng L, Hochleitner BW, Xu Q ( 1997 ) . Activation of mitogen-activated protein kinases (ERK/JNK) and AP-1 transcription factor in rat carotid arteries after balloon injury . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 17 , ( 11 ) 2808 - 2816 .
Wick G, Romen M, Amberger A, Metzler B, Mayr M, Falkensammer G, Xu Q ( 1997 ) . Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue . FASEB Journal vol. 11 , ( 13 ) 1199 - 1207 .
Metzler B, Schett G, Kleindienst R, Van Zee RD, Ottenhoff T, Hajeer A, Bernstein R, Xu Q et al. ( 1997 ) . Epitope specificity of anti-heat shock protein 65/60 serum antibodies in atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 17 , ( 3 ) 536 - 541 .
Xu Q, Fawcett TW, Gorospe M, Guyton KZ, Liu Y, Holbrook NJ ( 1997 ) . Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension . Hypertension vol. 30 , ( 1 ) 106 - 111 .
Schett G, Metzler B, Kleindienst R, Moschèn I, Hattmannsdorfer R, Wolf H, Ottenhoff T, Xu Q et al. ( 1997 ) . Salivary Anti-hsp65 Antibodies as a Diagnostic Marker for Gingivitis and a Possible Link to Atherosclerosis . International Archives of Allergy and Immunology vol. 114 , ( 3 ) 246 - 250 .
Schett G, Metzler B, Amberger A, Michaelis D, Romen M, Xu Q, Wick G ( 1997 ) . The Influence of Heat Shock Proteins in Atherogenesis . Heat Shock Proteins and the Cardiovascular System , vol. 192 ,
Metzler B, Xu Q ( 1997 ) . The Role of Mast Cells in Atherosclerosis . International Archives of Allergy and Immunology vol. 114 , ( 1 ) 10 - 14 .
Guyton KZ, Xu Q, Holbrook NJ ( 1996 ) . Induction of the mammalian stress response gene GADD153 by oxidative stress: Role of AP-1 element . Biochemical Journal vol. 314 , ( 2 ) 547 - 554 .
Guyton KZ, Liu Y, Gorospe M, Xu Q, Holbrook NJ ( 1996 ) . Activation of mitogen-activated protein kinase by H<inf>2</inf>O<inf>2</inf>: Role in cell survival following oxidant injury . Journal of Biological Chemistry vol. 271 , ( 8 ) 4138 - 4142 .
Liu Y, Guyton KZ, Gorospe M, Xu Q, Kokkonen GC, Mock YD, Roth GS, Holbrook NJ ( 1996 ) . Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes . Journal of Biological Chemistry vol. 271 , ( 7 ) 3604 - 3607 .
Xu Q, Liu Y, Gorospe M, Udelsman R, Holbrook NJ ( 1996 ) . Acute hypertension activates mitogen-activated protein kinases in arterial wall . Journal of Clinical Investigation vol. 97 , ( 2 ) 508 - 514 .
Xu Q, Fawcett TW, Udelsman R, Holbrook NJ ( 1996 ) . Activation of heat shock transcription factor 1 in rat aorta in response to high blood pressure . Hypertension vol. 28 , ( 1 ) 53 - 57 .
Seitz CS, Kleindienst R, Xu Q, Wick G ( 1996 ) . Coexpression of Heat-shock Protein 60 and Intercellular-adhesion Molecule-1 Is Related to Increased Adhesion of Monocytes and T cells to Aortic Endothelium of Rats in Response to Endotoxin . Laboratory Investigation vol. 74 , ( 1 ) 241 - 252 .
Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ ( 1996 ) . Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite . Free Radical Biology and Medicine vol. 21 , ( 6 ) 771 - 781 .
Gorospe M, Liu Y, Xu Q, Chrest FJ, Holbrook NJ ( 1996 ) . Inhibition of G<inf>1</inf> cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A<inf>2</inf> . Molecular and Cellular Biology vol. 16 , ( 3 ) 762 - 770 .
Xu Q, Kleindienst R, Schett G, Waitz W, Jindal S, Gupta RS, Dietrich H, Wick G ( 1996 ) . Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits . Atherosclerosis vol. 123 , ( 1-2 ) 145 - 155 .
Xu Q, Wick G ( 1996 ) . The role of heat shock proteins in protection and pathophysiology of the arterial wall . Molecular Medicine Today vol. 2 , ( 9 ) 372 - 379 .
Xu Q, Ganju L, Fawcett TW, Holbrook NJ ( 1996 ) . Vasopressin-induced heat shock protein expression in renal tubular cells . Laboratory Investigation vol. 74 , ( 1 ) 178 - 187 .
Xu Q, Li DG, Holbrook NJ, Udelsman R ( 1995 ) . Acute hypertension induces heat-shock protein 70 gene expression in rat aorta . Circulation vol. 92 , ( 5 ) 1223 - 1229 .
Kleindienst R, Xu Q, Schett G, Dietrich H, Wick G ( 1995 ) . Heat — Shock protein 65 — But not cholesterol-induced arteriosclerotic lesions regress in rabbit aortae . Atherosclerosis vol. 115 ,
Kleindienst R, Schett G, Amberger A, Seitz CS, Michaelis D, Metzler B, Dietrich H, Xu Q et al. ( 1995 ) . Atherosclerosis as an autoimmune condition . Israel Journal of Medical Sciences vol. 31 , ( 10 ) 596 - 599 .
Schett G, Xu Q, Amberger A, Van Der Zee R, Recheis H, Willeit J, Wick G ( 1995 ) . Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity . Journal of Clinical Investigation vol. 96 , ( 6 ) 2569 - 2577 .
Wick G, Schett G, Amberger A, Kleindienst R, Xu Q ( 1995 ) . Is atherosclerosis an immunologically mediated disease? . Immunology Today vol. 16 , ( 1 ) 27 - 33 .
Wick G, Kleindienst R, Schett G, Amberger A, Xu Q ( 1995 ) . Role of heat shock protein 65/60 in the pathogenesis of atherosclerosis . Int Arch Allergy Immunol vol. 107 , ( 1-3 ) 130 - 131 .
Xu Q, Wick G, Wachter H, Reibnegger G ( 1994 ) . Relationship among Serum hsp65 Antibodies, Neopterin, Autoantibodies and Atherosclerosis . Pteridines vol. 5 , ( 4 ) 139 - 141 .
Xu Q, Schett G, Seitz CS, Hu Y, Gupta RS, Wick G ( 1994 ) . Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells . Circulation Research vol. 75 , ( 6 ) 1078 - 1085 .
Kleindienst R, Xu Q, Willeit J, Waldenberger FR, Weimann S, Wick G ( 1993 ) . Immunology of atherosclerosis: Demonstration of heat shock protein 60 expression and T lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions . American Journal of Pathology vol. 142 , ( 6 ) 1927 - 1937 .
Xu Q, Wick G, Willeit J, Marosi M, Kiechl S, Luef G, Kleindienst R, Stulnig T et al. ( 1993 ) . Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis . The Lancet vol. 341 , ( 8840 ) 255 - 259 .
Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick G ( 1993 ) . Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65 . Journal of Clinical Investigation vol. 91 , ( 6 ) 2693 - 2702 .
Xu Q, Luef G, Weimann S, Gupta RS, Wolf H, Wick G ( 1993 ) . Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 13 , ( 12 ) 1763 - 1769 .
Xu Q, Buhler E, Steinmetz A, Schonitzer D, Bock G, Jurgens G, Wick G ( 1992 ) . A high-density-lipoprotein receptor appears to mediate the transfer of essential fatty acids from high-density lipoprotein to lymphocytes . Biochemical Journal vol. 287 , ( 2 ) 395 - 401 .
Xu Q, Dietrich H, Steiner HJ, Gown AM, Schoel B, Mikuz G, Kaufmann SHE, Wick G ( 1992 ) . Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 12 , ( 7 ) 789 - 799 .
Wick G, Kleindienst R, Dietrich H, Xu Q ( 1992 ) . Is atherosclerosis an autoimmune disease? . Trends in Food Science and Technology vol. 3 , ( C ) 114 - 119 .
Xu Q, Jurgens G, Huber LA, Bock G, Wolf H, Wick G ( 1992 ) . Lipid utilization by human lymphocytes is correlated with high-density-lipoprotein binding site activity . Biochemical Journal vol. 285 , ( 1 ) 105 - 112 .
Huber LA, Xu Q, Jürgens G, Böck G, Bühler E, Fred Gey K, Schönitzer D, Traill KN et al. ( 1991 ) . Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged . European Journal of Immunology vol. 21 , ( 11 ) 2761 - 2765 .
Xu Q, Oberhuber G, Gruschwitz M, Wick G ( 1990 ) . Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens . Clinical Immunology and Immunopathology vol. 56 , ( 3 ) 344 - 359 .
Jurgens G, Xu Q, Huber LA, Bock G, Howanietz H, Wick G, Traill KN ( 1989 ) . Promotion of lymphocyte growth by high density lipoproteins (HDL). Physiological significance of the HDL binding site . Journal of Biological Chemistry vol. 264 , ( 15 ) 8549 - 8556 .