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Research

Publications: Dr Vilma Dembitz

Tomic B, Smoljo T, Lalic H, Dembitz V, Batinic J, Batinic D, Bedalov A, Visnjic D ( 2022 ) . Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis . Scientific Reports vol. 12 , ( 1 )
Dembitz V, Lalic H, Tomic B, Smoljo T, Batinic J, Dubravcic K, Batinic D, Bedalov A et al. ( 2022 ) . All-trans retinoic acid induces differentiation in primary acute myeloid leukemia blasts carrying an inversion of chromosome 16 . International Journal of Hematology vol. 115 , ( 1 ) 43 - 53 .
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Tzelepis K, Philippe C, Rattigan K, Asby R et al. ( 2021 ) . Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia . Blood vol. 138 , ( Supplement 1 ) 508 - 508 .
Dembitz V, Gallipoli P ( 2021 ) . The Role of Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia . Frontiers in Oncology vol. 11 ,
Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T ( 2021 ) . Aicar, a widely used ampk activator with important ampk-independent effects: A systematic review . Cells vol. 10 , ( 5 )
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH et al. ( 2021 ) . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup> . Autophagy vol. 17 , ( 1 ) 1 - 382 .
Dembitz V, Lalic H, Kodvanj I, Tomic B, Batinic J, Dubravcic K, Batinic D, Bedalov A et al. ( 2020 ) . 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts . BMC Cancer vol. 20 , ( 1 )
Dembitz V, Tomic B, Kodvanj I, Simon JA, Bedalov A, Visnjic D ( 2019 ) . The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion . Journal of Biological Chemistry vol. 294 , ( 42 ) 15257 - 15270 .
Visnjic D, Dembitz V, Lalic H ( 2019 ) . The role of AMPK/mTOR modulators in the therapy of acute myeloid leukemia . Current Medicinal Chemistry vol. 26 , ( 12 ) 2208 - 2229 .
Dembitz V, Lalic H, Visnjic D ( 2017 ) . 5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells . Cell Death Discovery vol. 3 , ( 1 )
Rozovski U, Verstovsek S, Manshouri T, Dembitz V, Bozinovic K, Newberry K, Zhang Y, Bove JE et al. ( 2017 ) . An accurate, simple prognostic model consisting of age, JAK2, CALR, and MPL mutation status for patients with primary myelofibrosis . Haematologica vol. 102 , ( 1 ) 79 - 84 .
Banfic H, Crljen V, Lukinovic-Skudar V, Dembitz V, Lalic H, Bedalov A, Visnjic D ( 2016 ) . Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length . Advances in Biological Regulation vol. 60 , 22 - 28 .
Dembitz V, Lalic H, Ostojic A, Vrhovac R, Banfic H, Visnjic D ( 2015 ) . The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation . International Journal of Hematology vol. 102 , ( 1 ) 12 - 24 .
Rozovski U, Manshouri T, Dembitz V, Bozinovic K, Pierce S, Kantarjian H, Estrov Z, Verstovsek S ( 2015 ) . Prognostic model based on JAK2, CALR and MPL mutation status and age predicts the survival outcome of patients with primary myelofibrosis . Clinical Lymphoma Myeloma & Leukemia . vol. 15 ,
Manshouri T, Estrov Z, Knez L, Zhang Y, Bozinovic K, Dembitz V, Kantarjian HM, Verstovsek S ( 2014 ) . BONE Marrow Stromal CELL Paracrine Factors from PMF Patients, but NOT Healthy Donors, Protect JAK2V617F CELLS from Ruxotinib-Induced Apoptosis . Blood . vol. 124 , 1872 - 1872 .
Rozovski U, Manshouri T, Dembitz V, Bozinovic K, Pierce S, Kantarjian HM, Estrov Z, Verstovsek S ( 2014 ) . JAK2, Calr and MPL Mutation Status Predicts the Survival Outcome of Patients with Primary Myelofibrosis . Blood . vol. 124 , 1829 - 1829 .
Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D ( 2014 ) . 5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells . Leukemia and Lymphoma vol. 55 , ( 10 ) 2375 - 2383 .
Višnjić D, Lalić H, Dembitz V, Banfić H ( 2014 ) . Metabolism and differentiation . Periodicum Biologorum vol. 116 , ( 1 ) 37 - 43 .
Mise J, Dembitz V, Banfic H, Visnjic D ( 2011 ) . Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells . Pathology and Oncology Research vol. 17 , ( 3 ) 645 - 656 .