Publications: Dr Vilma Dembitz

Smoljo T, Lalic H, Dembitz V, Tomic B, Batinic J, Vrhovac R, Bedalov A, Visnjic D ( 2024 ) . Bone Marrow Stromal Cells Enhance Differentiation of Acute Myeloid Leukemia Induced by Pyrimidine Synthesis Inhibitors . American Journal of Physiology: Cell Physiology

Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .

Lawson H, Holt-Martyn JP, Dembitz V, Kabayama Y, Wang LM, Bellani A, Atwal S, Saffoon N et al. ( 2024 ) . The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia . Nature Cancer vol. 5 , ( 6 ) 916 - 937 .

Dembitz V, Durko J, Campos J, James SC, Lawson H, Kranc KR, Gallipoli P ( 2024 ) . Immunodeficient NBSGW mouse strain allows chemotherapy modeling in AML patient‐derived xenografts . HemaSphere vol. 8 , ( 1 )

Smoljo T, Tomic B, Lalic H, Dembitz V, Batinic J, Bedalov A, Visnjic D ( 2023 ) . Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia . Frontiers in Pharmacology vol. 14 ,

Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al. ( 2023 ) . Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death . Nature Communications vol. 14 , ( 1 )

Sabatier M, Birsen R, Lauture L, Mouche S, Angelino P, Dehairs J, Goupille L, Boussaid I et al. ( 2023 ) . C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia . Cancer Discovery vol. 13 , ( 7 ) 1720 - 1747 .

Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .

Lawson H, Holt-Martyn J, Dembitz V, Durko J, Kabayama Y, Wang L, Van De Lagemaat L, Dubusse L et al. ( 2022 ) . Targeting HIF-Hydroxylases Compromises Disease Initiation and Propagation, and Synergises with Current Therapies to Eliminate Cancer Stem Cells in AML . Blood vol. 140 , ( Supplement 1 ) 8731 - 8732 .

Tomic B, Smoljo T, Lalic H, Dembitz V, Batinic J, Batinic D, Bedalov A, Visnjic D ( 2022 ) . Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis . Scientific Reports vol. 12 , ( 1 )

Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Tzelepis K, Philippe C, Rattigan K, Asby R et al. ( 2021 ) . Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia . Blood vol. 138 , ( Supplement 1 )

Dembitz V, Lalic H, Tomic B, Smoljo T, Batinic J, Dubravcic K, Batinic D, Bedalov A et al. ( 2021 ) . All-trans retinoic acid induces differentiation in primary acute myeloid leukemia blasts carrying an inversion of chromosome 16 . International Journal of Hematology vol. 115 , ( 1 ) 43 - 53 .

Dembitz V, Gallipoli P ( 2021 ) . The Role of Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia . Frontiers in Oncology vol. 11 ,

Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T ( 2021 ) . AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review . Cells vol. 10 , ( 5 )

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH et al. ( 2021 ) . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ . Autophagy vol. 17 , ( 1 ) 1 - 382 .

Dembitz V, Lalic H, Kodvanj I, Tomic B, Batinic J, Dubravcic K, Batinic D, Bedalov A et al. ( 2020 ) . 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts . BMC Cancer vol. 20 , ( 1 )

Dembitz V, Tomic B, Kodvanj I, Simon JA, Bedalov A, Visnjic D ( 2019 ) . The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion . Journal of Biological Chemistry vol. 294 , ( 42 ) 15257 - 15270 .

Visnjic D, Dembitz V, Lalic H ( 2019 ) . The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia . Current Medicinal Chemistry vol. 26 , ( 12 ) 2208 - 2229 .

Dembitz V, Lalic H, Visnjic D ( 2017 ) . 5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells . Cell Death Discovery vol. 3 , ( 1 )

Rozovski U, Verstovsek S, Manshouri T, Dembitz V, Bozinovic K, Newberry K, Zhang Y, Bove JE et al. ( 2016 ) . An accurate, simple prognostic model consisting of age, JAK2, CALR, and MPL mutation status for patients with primary myelofibrosis . Haematologica vol. 102 , ( 1 ) 79 - 84 .

Banfic H, Crljen V, Lukinovic-Skudar V, Dembitz V, Lalic H, Bedalov A, Visnjic D ( 2015 ) . Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length . Advances in Biological Regulation vol. 60 , 22 - 28 .

Rozovski U, Manshouri T, Dembitz V, Bozinovic K, Pierce S, Kantarjian H, Estrov Z, Verstovsek S ( 2015 ) . Prognostic model based on JAK2, CALR and MPL mutation status and age predicts the survival outcome of patients with primary myelofibrosis . Clinical Lymphoma Myeloma & Leukemia . vol. 15 ,

Dembitz V, Lalic H, Ostojic A, Vrhovac R, Banfic H, Visnjic D ( 2015 ) . The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation . International Journal of Hematology vol. 102 , ( 1 ) 12 - 24 .

Manshouri T, Estrov Z, Knez L, Zhang Y, Bozinovic K, Dembitz V, Kantarjian HM, Verstovsek S ( 2014 ) . BONE Marrow Stromal CELL Paracrine Factors from PMF Patients, but NOT Healthy Donors, Protect JAK2V617F CELLS from Ruxotinib-Induced Apoptosis . Blood . vol. 124 ,

Rozovski U, Manshouri T, Dembitz V, Bozinovic K, Pierce S, Kantarjian HM, Estrov Z, Verstovsek S ( 2014 ) . JAK2, Calr and MPL Mutation Status Predicts the Survival Outcome of Patients with Primary Myelofibrosis . Blood . vol. 124 ,

Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D ( 2014 ) . 5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells . Leukemia & Lymphoma vol. 55 , ( 10 ) 2375 - 2383 .

Višnjić D, Lalić H, Dembitz V, Banfić H ( 2014 ) . Metabolism and differentiation . Periodicum Biologorum vol. 116 , ( 1 ) 37 - 43 .

Mise J, Dembitz V, Banfic H, Visnjic D ( 2011 ) . Combined Inhibition of PI3K and mTOR Exerts Synergistic Antiproliferative Effect, but Diminishes Differentiative Properties of Rapamycin in Acute Myeloid Leukemia Cells . Pathology & Oncology Research vol. 17 , ( 3 ) 645 - 656 .