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Research

Publications: Dr Roberto Bellelli

Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L et al. ( 2021 ) . Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD . Molecular Cell
Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H et al. ( 2020 ) . RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions . Cell Reports vol. 33 , ( 12 )
Bellelli R, Boulton SJ ( 2020 ) . Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases . Trends in Genetics
Bellelli R, Youds J, Borel V, Svendsen J, Pavicic-Kaltenbrunner V, Boulton SJ ( 2020 ) . Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication . Cell Reports vol. 31 , ( 8 )
Logan CV, Murray JE, Parry DA, Robertson A, Bellelli R, Tarnauskait¿ Ž, Challis R, Cleal L et al. ( 2018 ) . DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency . American Journal of Human Genetics vol. 103 , ( 6 ) 1038 - 1044 .
Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G et al. ( 2018 ) . POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication . Molecular Cell vol. 72 , ( 1 ) 112 - 126.e5 .
Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM et al. ( 2018 ) . Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis . Molecular Cell vol. 70 , ( 4 ) 707 - 721.e7 .
Margalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton SJ ( 2018 ) . Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe . Cell vol. 172 , ( 3 ) 439 - 453.e14 .
Bellelli R, Vitagliano D, Federico G, Marotta P, Tamburrino A, Salerno P, Paciello O, Papparella S et al. ( 2018 ) . Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia . Molecular and Cellular Endocrinology vol. 460 , 24 - 35 .
Federico G, Bellelli R, Nai A, Silvestri L, Camaschella C, Iolascon A, Santoro M, Carlomagno F ( 2017 ) . NCOA4 Links Iron Bioavailability to DNA Metabolism . BLOOD . vol. 130 ,
Stingele J, Bellelli R, Boulton SJ ( 2017 ) . Mechanisms of DNA-protein crosslink repair . Nature Reviews Molecular Cell Biology vol. 18 , ( 9 ) 563 - 573 .
Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A et al. ( 2016 ) . Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN . Molecular Cell vol. 64 , ( 4 ) 688 - 703 .
Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L et al. ( 2016 ) . NCOA4 Deficiency Impairs Systemic Iron Homeostasis . Cell Reports vol. 14 , ( 3 ) 411 - 421 .
Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind JS ( 2015 ) . Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma . Oncogene vol. 34 , ( 13 ) 1679 - 1687 .
Castellone MD, Langella A, Cantara S, Laurila JP, Laatikainen LE, Bellelli R, Pacini F, Salvatore M et al. ( 2014 ) . Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis . Antioxidants and Redox Signaling vol. 21 , ( 10 ) 1460 - 1474 .
Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A et al. ( 2014 ) . NCOA4 transcriptional coactivator inhibits activation of DNA replication origins . Molecular Cell vol. 55 , ( 1 ) 123 - 137 .
Bellelli R, Castellone MD, Garcia-Rostan G, Ugolini C, Nucera C, Sadow PM, Nappi TC, Salerno P et al. ( 2012 ) . FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma . Endocrine-Related Cancer vol. 19 , ( 5 ) 695 - 710 .
Faraonio R, Salerno P, Passaro F, Sedia C, Iaccio A, Bellelli R, Nappi TC, Comegna M et al. ( 2012 ) . A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts . Cell Death and Differentiation vol. 19 , ( 4 ) 713 - 721 .
Castellone MD, De Falco V, Rao DM, Bellelli R, Muthu M, Basolo F, Fusco A, Gutkind JS et al. ( 2009 ) . The β-Catenin axis integrates multiple signals downstream from RET/Papillary thyroid carcinoma leading to cell proliferation . Cancer Research vol. 69 , ( 5 ) 1867 - 1876 .