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Research

Publications: Dr Emma Chambers

Fiard G, Stavrinides V, Chambers ES, Heavey S, Freeman A, Ball R, Akbar AN, Emberton M ( 2021 ) . Cellular senescence as a possible link between prostate diseases of the ageing male . Nature Reviews Urology vol. 18 , ( 10 ) 597 - 610 .
Zou J, Thornton C, Chambers ES, Rosser EC, Ciurtin C ( 2021 ) . Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease . Frontiers in Immunology vol. 11 ,
Chambers E, Vukmanovic-Stejic M, Shih B, Subramanian P, Devine OP, Glanville J, Gilroy D, Rustin M et al. ( 2021 ) . Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging . Nature Aging101 - 113 .
Chambers E ( 2020 ) . The impact of ageing on monocytes and macrophages . Immunology Letters
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, Tsaliki E, Rustin M et al. ( 2020 ) . Vitamin D3 replacement enhances antigen-specific immunity in older adults . Immunotherapy Advances Article ltaa008 , 1 - 1 .
Chambers ES, Akbar AN ( 2020 ) . Reply . vol. 146 , is. 4 , pp. 922 - 923 . Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
Chambers ES, Vukmanovic-Stejic M ( 2020 ) . Skin barrier immunity and ageing . Immunology vol. 160 , ( 2 ) 116 - 125 .
Chambers ES, Akbar AN ( 2020 ) . Can blocking inflammation enhance immunity during aging? . Journal of Allergy and Clinical Immunology vol. 145 , ( 5 ) 1323 - 1331 .
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E et al. ( 2020 ) . Sestrins induce natural killer function in 1 senescent-like CD8+ T cells . Nature Immunology
Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ et al. ( 2019 ) . Senescent cells evade immune clearance via HLA-E-mediated NK and CD8<sup>+</sup> T cell inhibition . Nature Communications vol. 10 , ( 1 )
Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR et al. ( 2019 ) . Circulating senescent T cells are linked to systemic inflammation and lesion size during human cutaneous leishmaniasis . Frontiers in Immunology vol. 10 , ( JAN )
Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA et al. ( 2018 ) . Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge . J Infect Dis vol. 218 , ( suppl_2 ) S88 - S98 .
Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE et al. ( 2018 ) . Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation . Journal of Allergy and Clinical Immunology vol. 142 , ( 3 ) 844 - 856 .
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM ( 2018 ) . Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids . Clinical and Experimental Allergy vol. 48 , ( 1 ) 13 - 22 .
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM ( 2017 ) . Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK . Aging Cell
Mann EH, Chambers ES, Chen YH, Richards DF, Hawrylowicz CM ( 2015 ) . 1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4<sup>+</sup> Foxp3<sup>-</sup> T cells . Immunology vol. 146 , ( 3 ) 423 - 431 .
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al. ( 2015 ) . Distinct endotypes of steroid-resistant asthma characterized by IL-17A<sup>high</sup> and IFN-γ<sup>high</sup> immunophenotypes: Potential benefits of calcitriol . Journal of Allergy and Clinical Immunology vol. 136 , ( 3 ) 628 - 637.e4 .
Mann EH, Chambers ES, Nanzer AM, Richards DF, Hawrylowicz CM ( 2014 ) . Corticosteroids enhance potentially pathogenic IL-17A+CD4+T cells . IMMUNOLOGY . vol. 143 , 83 - 84 .
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, Hawrylowicz CM ( 2014 ) . Vitamin D influences asthmatic pathology through its action on diverse immunological pathways . Annals of the American Thoracic Society vol. 11 , S314 - S321 .
Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, Hawrylowicz CM ( 2014 ) . 1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3<sup>+</sup> regulatory T cells through preferential expansion and usage of interleukin-2 . Immunology vol. 143 , ( 1 ) 52 - 60 .
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E et al. ( 2014 ) . Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma . Thorax vol. 69 , ( 6 ) 508 - 515 .
Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM ( 2014 ) . Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma . Annals of the New York Academy of Sciences vol. 1317 , ( 1 ) 57 - 69 .
Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR et al. ( 2014 ) . The effects of calcitriol treatment in glucocorticoid-resistant asthma . Journal of Allergy and Clinical Immunology
Nanzer A, Chambers E, Richards D, Martineau A, Griffiths C, Corrigan C, Hawrylowicz C ( 2013 ) . P193 A role for active Vitamin D in steroid resistant asthma patients who have enhanced production of IL-17A and reduced IL-10 . Thorax . vol. 68 ,
Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ et al. ( 2013 ) . Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion . Journal of Allergy and Clinical Immunology vol. 132 , ( 2 )
Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A et al. ( 2012 ) . The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3<sup>+</sup>and IL-10<sup>+</sup> CD4<sup>+</sup> T cells . European Journal of Immunology vol. 42 , ( 10 ) 2697 - 2708 .
Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ et al. ( 2012 ) . Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma . J Allergy Clin Immunol vol. 130 , ( 2 ) 542 - 544 .
Nanzer AM, Chambers ES, Ryanna K, Richards DF, Freeman A, Martineau AR, Xystrakis E, Corrigan CJ et al. ( 2011 ) . Differential production of IL-17 expression in peripheral blood cultures of steroid refractory versus steroid sensitive asthmatics . IMMUNOLOGY . vol. 135 , 188 - 188 .
Chambers ES, Nanzer AM, Richards DF, Freeman A, Ryanna K, Griffiths C, Corrigan CJ, Hawrylowicz CM ( 2011 ) . Serum 25(OH)D levels can predict Foxp3+treg frequency and steroid responsiveness in severe asthmatics . IMMUNOLOGY . vol. 135 , 201 - 201 .
Nanzer AM, Chambers ES, Richards DF, Timms PM, Martineau AR, Corrigan CJ, Griffiths CJ, Hawrylowicz CM ( 2011 ) . Steroid refractory asthma patients express lower levels of the immunomodulatory transcription factor FoxP3 and have lower levels of serum vitamin D . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 41 , 1840 - 1840 .
Chambers ES, Hawrylowicz CM ( 2011 ) . The impact of vitamin D on regulatory T cells . Current Allergy and Asthma Reports vol. 11 , ( 1 ) 29 - 36 .
Chambers ES, Nanzer A, Richards DF, Freeman A, Ryanna K, Dimeloe SK, Griffiths C, Corrigan C et al. ( 2010 ) . The frequency of CD4(+) Foxp3(+) T cells is lower in the peripheral blood of steroid-refractory than steroid-sensitive asthmatics . IMMUNOLOGY . vol. 131 , 88 - 88 .