Publications: Dr Emma Chambers
Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F et al.
(
2022
)
.
Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study
.
The Journal of infectious diseases
vol.
226
,
(
11
)
1903
-
1908
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Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C et al.
(
2022
)
.
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial
.
Nutrients
vol.
14
,
(
18
)
Fiard G, Stavrinides V, Chambers ES, Heavey S, Freeman A, Ball R, Akbar AN, Emberton M
(
2021
)
.
Cellular senescence as a possible link between prostate diseases of the ageing male
.
Nature Reviews Urology
vol.
18
,
(
10
)
597
-
610
.
Zou J, Thornton C, Chambers ES, Rosser EC, Ciurtin C
(
2021
)
.
Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease
.
Frontiers in Immunology
vol.
11
,
Chambers E, Vukmanovic-Stejic M, Shih B, Subramanian P, Devine OP, Glanville J, Gilroy D, Rustin M et al.
(
2021
)
.
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
.
Nature Aging101
-
113
.
Chambers E
(
2020
)
.
The impact of ageing on monocytes and macrophages
.
Immunology Letters
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, Tsaliki E, Rustin M et al.
(
2020
)
.
Vitamin D3 replacement enhances antigen-specific immunity in older adults
.
Immunotherapy Advances
Article
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,
1
-
1
.
Chambers ES, Akbar AN
(
2020
)
.
Reply
.
vol.
146
,
is.
4
,
pp.
922
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923
.
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Chambers ES, Vukmanovic-Stejic M
(
2020
)
.
Skin barrier immunity and ageing
.
Immunology
vol.
160
,
(
2
)
116
-
125
.
Chambers ES, Akbar AN
(
2020
)
.
Can blocking inflammation enhance immunity during aging?
.
Journal of Allergy and Clinical Immunology
vol.
145
,
(
5
)
1323
-
1331
.
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E et al.
(
2020
)
.
Sestrins induce natural killer function in 1 senescent-like CD8+ T cells
.
Nature Immunology
Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ et al.
(
2019
)
.
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8<sup>+</sup> T cell inhibition
.
Nature Communications
vol.
10
,
(
1
)
Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR et al.
(
2019
)
.
Circulating senescent T cells are linked to systemic inflammation and lesion size during human cutaneous leishmaniasis
.
Frontiers in Immunology
vol.
10
,
(
JAN
)
Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA et al.
(
2018
)
.
Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge
.
J Infect Dis
vol.
218
,
(
suppl_2
)
S88
-
S98
.
Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE et al.
(
2018
)
.
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation
.
Journal of Allergy and Clinical Immunology
vol.
142
,
(
3
)
844
-
856
.
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM
(
2018
)
.
Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids
.
Clinical and Experimental Allergy
vol.
48
,
(
1
)
13
-
22
.
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM
(
2017
)
.
Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK
.
Aging Cell
Mann EH, Chambers ES, Chen YH, Richards DF, Hawrylowicz CM
(
2015
)
.
1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4<sup>+</sup> Foxp3<sup>-</sup> T cells
.
Immunology
vol.
146
,
(
3
)
423
-
431
.
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al.
(
2015
)
.
Distinct endotypes of steroid-resistant asthma characterized by IL-17A<sup>high</sup> and IFN-γ<sup>high</sup> immunophenotypes: Potential benefits of calcitriol
.
Journal of Allergy and Clinical Immunology
vol.
136
,
(
3
)
628
-
637.e4
.
Mann EH, Chambers ES, Nanzer AM, Richards DF, Hawrylowicz CM
(
2014
)
.
Corticosteroids enhance potentially pathogenic IL-17A+CD4+T cells
.
IMMUNOLOGY
.
vol.
143
,
83
-
84
.
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, Hawrylowicz CM
(
2014
)
.
Vitamin D influences asthmatic pathology through its action on diverse immunological pathways
.
Annals of the American Thoracic Society
vol.
11
,
S314
-
S321
.
Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, Hawrylowicz CM
(
2014
)
.
1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3<sup>+</sup> regulatory T cells through preferential expansion and usage of interleukin-2
.
Immunology
vol.
143
,
(
1
)
52
-
60
.
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E et al.
(
2014
)
.
Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma
.
Thorax
vol.
69
,
(
6
)
508
-
515
.
Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM
(
2014
)
.
Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma
.
Annals of the New York Academy of Sciences
vol.
1317
,
(
1
)
57
-
69
.
Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR et al.
(
2014
)
.
The effects of calcitriol treatment in glucocorticoid-resistant asthma
.
Journal of Allergy and Clinical Immunology
Nanzer A, Chambers E, Richards D, Martineau A, Griffiths C, Corrigan C, Hawrylowicz C
(
2013
)
.
P193 A role for active Vitamin D in steroid resistant asthma patients who have enhanced production of IL-17A and reduced IL-10
.
Thorax
.
vol.
68
,
Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ et al.
(
2013
)
.
Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion
.
Journal of Allergy and Clinical Immunology
vol.
132
,
(
2
)
Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A et al.
(
2012
)
.
The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3<sup>+</sup>and IL-10<sup>+</sup> CD4<sup>+</sup> T cells
.
European Journal of Immunology
vol.
42
,
(
10
)
2697
-
2708
.
Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ et al.
(
2012
)
.
Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma
.
J Allergy Clin Immunol
vol.
130
,
(
2
)
542
-
544
.
Nanzer AM, Chambers ES, Ryanna K, Richards DF, Freeman A, Martineau AR, Xystrakis E, Corrigan CJ et al.
(
2011
)
.
Differential production of IL-17 expression in peripheral blood cultures of steroid refractory versus steroid sensitive asthmatics
.
IMMUNOLOGY
.
vol.
135
,
188
-
188
.
Chambers ES, Nanzer AM, Richards DF, Freeman A, Ryanna K, Griffiths C, Corrigan CJ, Hawrylowicz CM
(
2011
)
.
Serum 25(OH)D levels can predict Foxp3+treg frequency and steroid responsiveness in severe asthmatics
.
IMMUNOLOGY
.
vol.
135
,
201
-
201
.
Nanzer AM, Chambers ES, Richards DF, Timms PM, Martineau AR, Corrigan CJ, Griffiths CJ, Hawrylowicz CM
(
2011
)
.
Steroid refractory asthma patients express lower levels of the immunomodulatory transcription factor FoxP3 and have lower levels of serum vitamin D
.
CLINICAL AND EXPERIMENTAL ALLERGY
.
vol.
41
,
1840
-
1840
.
Chambers ES, Hawrylowicz CM
(
2011
)
.
The impact of vitamin D on regulatory T cells
.
Current Allergy and Asthma Reports
vol.
11
,
(
1
)
29
-
36
.
Chambers ES, Nanzer A, Richards DF, Freeman A, Ryanna K, Dimeloe SK, Griffiths C, Corrigan C et al.
(
2010
)
.
The frequency of CD4(+) Foxp3(+) T cells is lower in the peripheral blood of steroid-refractory than steroid-sensitive asthmatics
.
IMMUNOLOGY
.
vol.
131
,
88
-
88
.