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Research

Publications: Mrs Imogen Skene

Power H, Skene I, Murray E ( 2022 ) . The positives, the challenges and the impact; an exploration of early career nurses experiences in the Emergency Department . International Emergency Nursing vol. 64 ,
Kinley E, Skene I, Steed E, Pinnock H, McClatchey K ( 2022 ) . Delivery of supported self-management in remote asthma reviews: A systematic rapid realist review . Health Expectations vol. 25 , ( 4 ) 1200 - 1214 .
Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2022 ) . Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis . The Lancet vol. 400 , ( 10349 ) 359 - 368 .
Telfer P, Bestwick J, Elander J, Osias A, Khalid N, Skene I, Nzouakou R, Challands J et al. ( 2022 ) . A non-injected opioid analgesia protocol for acute pain crisis in adolescents and adults with sickle cell disease . British Journal of Pain vol. 16 , ( 2 ) 179 - 190 .
Stefanidis C, Bush A, Newby C, Nwokoro C, Liebeschuetz S, Skene IP, Griffiths CJ, Martineau AR ( 2022 ) . Vitamin D replacement in children with acute wheeze: a dose-escalation study . ERJ Open Research vol. 8 , ( 2 )
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10325 ) 665 - 676 .
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10320 ) 143 - 151 .
Bielicki JA, Stöhr W, Barratt S, Dunn D, Naufal N, Roland D, Sturgeon K, Finn A et al. ( 2021 ) . Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial . JAMA vol. 326 , ( 17 ) 1713 - 1724 .
Gray AJ, Roobottom C, Smith JE, Goodacre S, Oatey K, O'Brien R, Storey RF, Curzen N et al. ( 2021 ) . Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial . BMJ vol. 374 ,
Skene IP, Pfeffer PE ( 2021 ) . Improved asthma control during the COVID-19 pandemic: Are there lessons to be learnt? . Thorax vol. 76 , ( 9 ) 852 - 853 .
Roberts T, Hirst R, Sammut-Powell C, Reynard C, Daniels J, Horner D, Lyttle MD, Samuel K et al. ( 2021 ) . Psychological distress and trauma during the COVID-19 pandemic: survey of doctors practising anaesthesia, intensive care medicine, and emergency medicine in the United Kingdom and Republic of Ireland . British Journal of Anaesthesia vol. 127 , ( 2 ) e78 - e80 .
Roberts T, Daniels J, Hulme W, Hirst R, Horner D, Lyttle MD, Samuel K, Graham B et al. ( 2021 ) . Psychological distress and trauma in doctors providing frontline care during the COVID-19 pandemic in the United Kingdom and Ireland: a prospective longitudinal survey cohort study . BMJ Open vol. 11 , ( 7 )
Baker E, Battle C, Banjeri A, Carlton E, Dixon C, Ferry J, Hopkins P, Jones R et al. ( 2021 ) . Prospective observational study to examine health-related quality of life and develop models to predict long-term patient-reported outcomes 6 months after hospital discharge with blunt thoracic injuries . BMJ Open vol. 11 , ( 7 )
Skene I ( 2021 ) . The Complex Issues that Lead to Nurses Leaving the Emergency Department . The Mental Health and Wellbeing of Healthcare Practitioners ,
Roberts T, Daniels J, Hulme W, Hirst R, Horner D, Lyttle MD, Samuel K, Graham B et al. ( 2021 ) . Psychological distress during the acceleration phase of the COVID-19 pandemic: a survey of doctors practising in emergency medicine, anaesthesia and intensive care medicine in the UK and Ireland . Emerg Med J vol. 38 , ( 6 ) 450 - 459 .
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial . The Lancet vol. 397 , ( 10289 ) 2049 - 2059 .
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10285 ) 1637 - 1645 .
RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N et al. ( 2021 ) . Dexamethasone in Hospitalized Patients with Covid-19 . N Engl J Med vol. 384 , ( 8 ) 693 - 704 .
Abaleke E, Abbas M, Abbasi S, Abbott A, Abdelaziz A, Abdelbadiee S, Abdelfattah M, Abdul B et al. ( 2021 ) . Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10274 ) 605 - 612 .
Brenner A, Belli A, Chaudhri R, Coats T, Frimley L, Jamaluddin SF, Jooma R, Mansukhani R et al. ( 2020 ) . Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial . Critical Care vol. 24 , ( 1 )
RECOVERY Collaborative Group, Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M et al. ( 2020 ) . Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 . N Engl J Med vol. 383 , ( 21 ) 2030 - 2040 .
French C, Pinnock H, Forbes G, Skene I, Taylor S ( 2020 ) . Process evaluation within pragmatic randomised controlled trials: what is it, why is it done, and can we find it? – a systematic review . Trials vol. 21 , Article 916 ,
Roberts I, Shakur-Still H, Afolabi A, Akere A, Arribas M, Brenner A, Chaudhri R, Gilmore I et al. ( 2020 ) . Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial . The Lancet vol. 395 , ( 10241 ) 1927 - 1936 .
Roberts I, Shakur-Still H, Aeron-Thomas A, Belli A, Brenner A, Chaudary MA, Chaudhri R, Jamaluddin SFB et al. ( 2019 ) . Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): A randomised, placebo-controlled trial . The Lancet vol. 394 , ( 10210 ) 1713 - 1723 .
Brunsdon D, Biesty L, Brocklehurst P, Brueton V, Devane D, Elliott J, Galvin S, Gamble C et al. ( 2019 ) . What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: The PRioRiTy II (Prioritising Retention in Randomised Trials) study . Trials vol. 20 , ( 1 )
Gillies K, Brunsdon D, Biesty L, Brocklehurst P, Brueton V, Devane D, Elliott J, Galvin S et al. ( 2019 ) . Identifying trial retention uncertainties using a James Lind Alliance Priority Setting Partnership - The PRioRiTy II (Prioritising Retention in Randomised Trials) Study . TRIALS . vol. 20 ,
Lyttle MD, Rainford NEA, Gamble C, Messahel S, Humphreys A, Hickey H, Woolfall K, Roper L et al. ( 2019 ) . Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial . The Lancet vol. 393 , ( 10186 ) 2125 - 2134 .
Bath PM, Scutt P, Anderson CS, Appleton JP, Berge E, Cala L, Dixon M, England TM et al. ( 2019 ) . Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial . The Lancet vol. 393 , ( 10175 ) 1009 - 1020 .
Telfer P, Kaya B, Barroso F, Nzouakou R, Osias A, Bloom B, Skene I, Boulton O et al. ( 2019 ) . A Phase 1 study to determine maximum tolerated dose of sublingual fentanyl in combination with oral oxycodone for hospital management of an acute painful crisis in adolescents and adults with sickle cell disease . BRITISH JOURNAL OF HAEMATOLOGY . vol. 185 , 113 - 114 .
Skene I, Pott J, McKeown E ( 2017 ) . Patients’ experience of trauma care in the emergency department of a major trauma centre in the UK . International Emergency Nursing vol. 35 , 1 - 6 .
Naumann DN, Mellis C, Smith IM, Mamuza J, Skene I, Harris T, Midwinter MJ, Hutchings SD ( 2016 ) . Safety and feasibility of sublingual microcirculation assessment in the emergency department for civilian and military patients with traumatic haemorrhagic shock: A prospective cohort study . BMJ Open vol. 6 , ( 12 )
Smith JE, Rockett M, Creanor S, Squire R, Hayward C, Ewings P, Barton A, Pritchard C et al. ( 2015 ) . PAin SoluTions In the Emergency Setting (PASTIES)--patient controlled analgesia versus routine care in emergency department patients with non-traumatic abdominal pain: randomised trial . BMJ vol. 350 ,
Smith JE, Rockett M, S SC, Squire R, Hayward C, Ewings P, Barton A, Pritchard C et al. ( 2015 ) . PAin SoluTions In the Emergency Setting (PASTIES)--patient controlled analgesia versus routine care in emergency department patients with pain from traumatic injuries: randomised trial . BMJ vol. 350 ,
Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE et al. ( 2015 ) . Trial of early, goal-directed resuscitation for septic shock . N Engl J Med vol. 372 , ( 14 ) 1301 - 1311 .