Publications: Dr Manikandan Subramanian

Singhal A, Dhawan U, Bhutia K, Wilson H, Velasco G, Kiss-Toth E, Subramanian M ( 2024 ) . Lipid-induced ATF4 signalling impairs macrophage efferocytosis and promotes atherosclerotic plaque necrosis . Atherosclerosis vol. 395 ,

Bhattacharya P, Dhawan UK, Hussain MT, Singh P, Bhagat KK, Singhal A, Austin-Williams S, Sengupta S et al. ( 2023 ) . Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling . Cell Reports vol. 42 , ( 7 )

Perretti M, Subramanian M ( 2022 ) . Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases . Seminars in Immunology vol. 65 ,

Dhawan UK, Margraf A, Lech M, Subramanian M ( 2022 ) . Hypercholesterolemia promotes autoantibody production and a lupus‐like pathology via decreased DNase‐mediated clearance of DNA . Journal of Cellular and Molecular Medicine vol. 26 , ( 20 ) 5267 - 5276 .

Bhattacharya P, Kanagasooriyan R, Subramanian M ( 2022 ) . Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond? . Current Opinion in Pharmacology vol. 66 ,

Manickam V, Dhawan UK, Singh D, Gupta M, Subramanian M ( 2022 ) . Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe -/- Mice . Frontiers in Pharmacology vol. 13 ,

Dhawan UK, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A, Subramanian M ( 2021 ) . Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression . Arteriosclerosis, Thrombosis and Vascular BiologyATVBAHA120316389 - ATVBAHA120316389 .

Subramanian M, Marelli-Berg FM ( 2021 ) . CD36 pumps fat to defang killer T cells in tumors . Cell Metabolism vol. 33 , ( 8 ) 1509 - 1511 .

Dhawan UK, Singhal A, Subramanian M ( 2021 ) . Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolution . Pharmacological Research vol. 170 ,

Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S et al. ( 2021 ) . Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2 . eLife vol. 10 ,

DeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I, Thorp EB ( 2021 ) . Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction . Journal of Clinical Investigation vol. 131 , ( 6 )

Yurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC et al. ( 2020 ) . Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury . Cell Metabolism vol. 31 , ( 3 ) 518 - 533.e10 .

Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC et al. ( 2018 ) . Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution . Immunity vol. 49 , ( 4 ) 666 - 677.e6 .

Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G et al. ( 2018 ) . Hypercholesterolemia induces T cell expansion in humanized immune mice . Journal of Clinical Investigation vol. 128 , ( 6 ) 2370 - 2375 .

Singhal A, Subramanian M ( 2017 ) . Colony stimulating factors (CSFs): Complex roles in atherosclerosis . Cytokine vol. 122 ,

Wang Y, Subramanian M, Yurdagul A, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M et al. ( 2017 ) . Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages . Cell vol. 171 , ( 2 ) 331 - 345.e22 .

Subramanian M, Proto JD, Matsushima GK, Tabas I ( 2016 ) . Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression . Scientific Reports vol. 6 , ( 1 )

Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin C-S, Spite M, Fredman G et al. ( 2016 ) . MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation . Proceedings of the National Academy of Sciences of the United States of America vol. 113 , ( 23 ) 6526 - 6531 .

Kamaly N, Fredman G, Fojas JJR, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M et al. ( 2016 ) . Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis . ACS Nano vol. 10 , ( 5 ) 5280 - 5292 .

Proto JD, Sozen E, Subramanian M, Tabas I ( 2016 ) . Expansion of Regulatory T Cells Promotes the Clearance of Apoptotic Cells by Macrophages in Murine Atherosclerotic Plaques . The FASEB Journal vol. 30 , ( S1 )

Subramanian M, Ozcan L, Ghorpade DS, Ferrante AW, Tabas I ( 2015 ) . Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity . PLOS ONE vol. 10 , ( 8 )

Proto J, Subramanian M, Islam M, Hook J, Gusarova G, Bhattacharya J, Tabas I ( 2015 ) . A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung Injury . The FASEB Journal vol. 29 , ( S1 )

Subramanian M, Thorp E, Tabas I ( 2015 ) . Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling . Circ Res vol. 116 , ( 2 ) e13 - e24 .

Ash D, Subramanian M, Surolia A, Shaha C ( 2015 ) . Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells . American Journal of Cancer Research vol. 5 , ( 2 ) 481 - 497 .

Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I et al. ( 2014 ) . Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( 5 ) 976 - 984 .

Subramanian M, Tabas I ( 2014 ) . A new RIDDle in DC-mediated cross-presentation . Nature Immunology vol. 15 , ( 3 ) 213 - 215 .

Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K et al. ( 2014 ) . An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo . Journal of Clinical Investigation vol. 124 , ( 3 ) 1296 - 1308 .

Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS, Bhattacharya J ( 2014 ) . Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity . Nature vol. 506 , ( 7489 ) 503 - 506 .

Subramanian M, Tabas I ( 2013 ) . Dendritic cells in atherosclerosis . Seminars in Immunopathology vol. 36 , ( 1 ) 93 - 102 .

Kamaly N, Fredman G, Subramanian M, Gadde S, Pesic A, Cheung L, Fayad ZA, Langer R et al. ( 2013 ) . Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles . Proceedings of the National Academy of Sciences of the United States of America vol. 110 , ( 16 ) 6506 - 6511 .

Subramanian M, Thorp E, Hansson GK, Tabas I ( 2012 ) . Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs . Journal of Clinical Investigation vol. 123 , ( 1 ) 179 - 188 .

Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J et al. ( 2012 ) . Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis . Cell Metabolism vol. 15 , ( 4 ) 545 - 553 .

Thorp E, Subramanian M, Tabas I ( 2011 ) . The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis . European Journal of Immunology vol. 41 , ( 9 ) 2515 - 2518 .

Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C, Tabas I ( 2011 ) . Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK) . Journal of Biological Chemistry vol. 286 , ( 38 ) 33335 - 33344 .

Subramanian M, Shaha C ( 2009 ) . Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor‐α and β . Journal of Cellular and Molecular Medicine vol. 13 , ( 8b ) 2317 - 2329 .

Subramanian M, Shaha C ( 2009 ) . Oestrogen modulates human macrophage apoptosis <i>via</i> differential signalling through oestrogen receptor-α and β . JOURNAL OF CELLULAR AND MOLECULAR MEDICINE vol. 13 , ( 8B ) 2317 - 2329 .

Subramanian M, Shaha C ( 2007 ) . Up-Regulation of Bcl-2 through ERK Phosphorylation Is Associated with Human Macrophage Survival in an Estrogen Microenvironment . The Journal of Immunology vol. 179 , ( 4 ) 2330 - 2338 .