Publications: Mr Christopher Mapperley

Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA ( 2022 ) . Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis . Biology Open vol. 11 , ( 6 )

Woodley K, Dillingh L, Giotopoulos G, Madrigal P, Rattigan K, Philippe C, Dembitz V, Magee AMS et al. ( 2022 ) . Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death .

Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al. ( 2021 ) . CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation . Stem Cell Reports vol. 16 , ( 11 ) 2784 - 2797 .

Young C, Russell J, Lawson H, Mapperley C, Kranc K, Christophorou M ( 2021 ) . Peptidylarginine deiminase IV (PADI4) is not essential for cell-autonomous HSC maintenance and normal haematopoiesis .

Mapperley C, Van De Lagemaat L, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al. ( 2020 ) . The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine vol. 218 , ( 3 ) 20200829 - 20200829 .

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al. ( 2019 ) . Targeting the RNA m⁶A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia . Cell Stem Cell vol. 25 , ( 1 ) 137 - 148.e6 .