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Research

Publications: Mr Christopher Mapperley

Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA ( 2022 ) . Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis . Biology open vol. 11 , ( 6 )
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al. ( 2021 ) . CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation . Stem Cell Reports vol. 16 , ( 11 ) 2784 - 2797 .
Mapperley C, Van De Lagemaat L, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al. ( 2020 ) . The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine vol. 218 , ( 3 ) 20200829 - 20200829 .
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al. ( 2019 ) . Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia . Cell Stem Cell vol. 25 , ( 1 ) 137 - 148.e6 .