Publications: Dr James Timmons
Mcleod JC, Lim C, Stokes T, Sharif J-A, Zeynalli V, Wiens L, D’Souza AC, Colenso-Semple L et al.
(
2024
)
.
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
.
Ma S, Morris M, Hubal M, Ross L, Huffman K, Vann C, Moore N, Hauser E et al.
(
2024
)
.
Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change
.
vol.
5
,
(
09-13
)
Timmons JA, Brenner C
(
2024
)
.
The information theory of aging has not been tested
.
Cell
vol.
187
,
(
5
)
1101
-
1102
.
Stokes T, Cen HH, Kapranov P, Gallagher IJ, Pitsillides AA, Volmar C, Kraus WE, Johnson JD et al.
(
2023
)
.
Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq
.
Advanced Genetics
vol.
4
,
(
2
)
Timmons J
(
2022
)
.
Variable selection and risk prediction using a penalised modelling framework for high-dimensional data in a nested matched case-control design
.
Conference:
RSS International Conference 2022
(
Aberdeen, Scotland
)
from:
15/09/2022
to:
12/09/2022
,
Nath M, Romaine SPR, Koekemoer A, Hamby S, Webb TR, Nelson CP, Castellanos‐Uribe M, Papakonstantinou M et al.
(
2022
)
.
Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure
.
European Journal of Heart Failure
vol.
24
,
(
6
)
1009
-
1019
.
Timmons JA, Anighoro A, Brogan RJ, Stahl J, Wahlestedt C, Farquhar DG, Taylor-King J, Volmar C-H et al.
(
2022
)
.
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease
.
eLife
vol.
11
,
Dennison JL, Volmar C-H, Modarresi F, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z et al.
(
2022
)
.
JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model
.
Journal of Alzheimer's Disease
vol.
86
,
(
1
)
173
-
190
.
Cen HH, Hussein B, Botezelli JD, Wang S, Zhang JA, Noursadeghi N, Jessen N, Rodrigues B et al.
(
2021
)
.
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia‐associated insulin resistance
.
The FASEB Journal
vol.
36
,
(
1
)
Stokes T, Timmons JA, Crossland H, Tripp TR, Murphy K, McGlory C, Mitchell CJ, Oikawa SY et al.
(
2020
)
.
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
.
Cell Reports
vol.
32
,
(
5
)
Cao H, Salazar-García L, Gao F, Wahlestedt T, Wu C-L, Han X, Cai Y, Xu D et al.
(
2019
)
.
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
.
Nature Communications
vol.
10
,
(
1
)
Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE, Atherton PJ
(
2019
)
.
A statistical and biological response to an informatics appraisal of healthy aging gene signatures
.
Genome Biology
vol.
20
,
(
1
)
Timmons JA, Volmar C, Crossland H, Phillips BE, Sood S, Janczura KJ, Törmäkangas T, Kujala UM et al.
(
2019
)
.
Longevity‐related molecular pathways are subject to midlife “switch” in humans
.
Aging Cell
vol.
18
,
(
4
)
Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar C-H, Josse AR et al.
(
2018
)
.
A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
.
Nucleic Acids Research
vol.
46
,
(
15
)
Phillips BE, Kelly BM, Lilja M, Ponce-González JG, Brogan RJ, Morris DL, Gustafsson T, Kraus WE et al.
(
2017
)
.
A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes
.
Frontiers in Endocrinology
vol.
8
,
Crossland H, Timmons JA, Atherton PJ
(
2017
)
.
A dynamic ribosomal biogenesis response is not required for IGF‐1–mediated hypertrophy of human primary myotubes
.
The FASEB Journal
vol.
31
,
(
12
)
5196
-
5207
.
Dinas PC, Lahart IM, Timmons JA, Svensson P-A, Koutedakis Y, Flouris AD, Metsios GS
(
2017
)
.
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review
.
F1000Research
vol.
6
,
Pollard AS, Charlton BG, Hutchinson JR, Gustafsson T, McGonnell IM, Timmons JA, Pitsillides AA
(
2017
)
.
Limb proportions show developmental plasticity in response to embryo movement
.
Scientific Reports
vol.
7
,
(
1
)
Timmons JA
(
2016
)
.
Molecular Diagnostics of Ageing and Tackling Age-related Disease
.
Trends in Pharmacological Sciences
vol.
38
,
(
1
)
67
-
80
.
Crossland H, Atherton PJ, Strömberg A, Gustafsson T, Timmons JA
(
2016
)
.
A reverse genetics cell‐based evaluation of genes linked to healthy human tissue age
.
The FASEB Journal
vol.
31
,
(
1
)
96
-
108
.
Nakhuda A, Josse AR, Gburcik V, Crossland H, Raymond F, Metairon S, Good L, Atherton PJ et al.
(
2016
)
.
Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss 1 , 2
.
American Journal of Clinical Nutrition
vol.
104
,
(
3
)
557
-
565
.
Timmons JA, Gallagher IJ
(
2016
)
.
Molecular studies of exercise, skeletal muscle, and ageing
.
F1000Research
vol.
5
,
Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H et al.
(
2016
)
.
iGEMS: an integrated model for identification of alternative exon usage events
.
Nucleic Acids Research
vol.
44
,
(
11
)
e109
-
e109
.
Hangelbroek RWJ, Fazelzadeh P, Tieland M, Boekschoten MV, Hooiveld GJEJ, van Duynhoven JPM, Timmons JA, Verdijk LB et al.
(
2016
)
.
Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness
.
Journal of Cachexia Sarcopenia and Muscle
vol.
7
,
(
5
)
604
-
614
.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T et al.
(
2015
)
.
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
.
Genome Biology
vol.
16
,
(
1
)
Timmons JA, Szkop KJ, Gallagher IJ
(
2015
)
.
Multiple sources of bias confound functional enrichment analysis of global -omics data
.
Genome Biology
vol.
16
,
(
1
)
Timmons JA
(
2015
)
.
Single-Gene Genotyping and Personalized Preventive Care
.
JAMA
vol.
314
,
(
3
)
297
-
298
.
Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T
(
2013
)
.
Integrative pathway analysis of a genome-wide association study of V̇o2max response to exercise training
.
Journal of Applied Physiology
vol.
115
,
(
9
)
1343
-
1359
.
Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL et al.
(
2013
)
.
Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks
.
Diabetes
vol.
62
,
(
8
)
2717
-
2727
.
Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ et al.
(
2013
)
.
Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway
.
AJP Endocrinology and Metabolism
vol.
305
,
(
2
)
e183
-
e193
.
Phillips BE, Williams JP, Gustafsson T, Bouchard C, Rankinen T, Knudsen S, Smith K, Timmons JA et al.
(
2013
)
.
Molecular Networks of Human Muscle Adaptation to Exercise and Age
.
PLOS Genetics
vol.
9
,
(
3
)
Gburcik V, Cleasby ME, Timmons JA
(
2013
)
.
Loss of neuronatin promotes “browning” of primary mouse adipocytes while reducing Glut1-mediated glucose disposal
.
AJP Endocrinology and Metabolism
vol.
304
,
(
8
)
e885
-
e894
.
Andersen DK, Timmons JA, Cleasby ME
(
2013
)
.
High fat diet induces selective alterations in microRNA expression profile in rat skeletal muscle
.
DIABETOLOGIA
.
vol.
56
,
S251
-
S251
.
Gburcik V, Cleasby ME, Timmons JA
(
2013
)
.
Loss of neuronatin promotes 'browning' of primary mouse adipocytes
.
DIABETIC MEDICINE
.
vol.
30
,
42
-
43
.
Poulet B, Ulici V, Stone TC, Pead M, Gburcik V, Constantinou E, Palmer DB, Beier F et al.
(
2012
)
.
Time‐series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
.
Arthritis & Rheumatism
vol.
64
,
(
10
)
3256
-
3266
.
Timmons JA, Baar K, Davidsen PK, Atherton PJ
(
2012
)
.
Is irisin a human exercise gene?
.
Nature
vol.
488
,
(
7413
)
e9
-
e10
.
Gburcik V, Cawthorn WP, Nedergaard J, Timmons JA, Cannon B
(
2012
)
.
An essential role for Tbx15 in the differentiation of brown and “brite” but not white adipocytes
.
AJP Endocrinology and Metabolism
vol.
303
,
(
8
)
e1053
-
e1060
.
Gallagher IJ, Stephens NA, MacDonald AJ, Skipworth RJE, Husi H, Greig CA, Ross JA, Timmons JA et al.
(
2012
)
.
Suppression of Skeletal Muscle Turnover in Cancer Cachexia: Evidence from the Transcriptome in Sequential Human Muscle Biopsies
.
Clinical Cancer Research
vol.
18
,
(
10
)
2817
-
2827
.
Poulet B, Veronica U, Stone TC, Pead M, Gburcik V, Beier F, Timmons JA, Pitsillides AA
(
2012
)
.
Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA
.
Osteoarthritis and Cartilage
.
vol.
20
,
s59
-
s60
.
Timmons JA
(
2011
)
.
Modulation of MicroRNAs During Exercise and Disease in Human Skeletal Muscle
.
Exercise and Sport Sciences Reviews
vol.
39
,
(
4
)
Timmons JA
(
2011
)
.
What happens if you pose the wrong questions?
.
The Journal of Physiology
vol.
589
,
(
19
)
4799
-
4801
.
Waldén TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J
(
2011
)
.
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
.
AJP Endocrinology and Metabolism
vol.
302
,
(
1
)
e19
-
e31
.
Bouchard C, Rankinen T, Timmons JA
(
2011
)
.
Genomics and Genetics in the Biology of Adaptation to Exercise
.
vol.
1
,
(
3
)
1603
-
1648
.
Keller P, Gburcik V, Petrovic N, Gallagher IJ, Nedergaard J, Cannon B, Timmons JA
(
2011
)
.
Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
.
BMC Endocrine Disorders
vol.
11
,
(
1
)
Timmons JA
(
2011
)
.
Genes that AKT to determine physiological heterogeneity in response to exercise
.
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences
vol.
96
,
(
3
)
259
-
260
.
Timmons JA, Helge JW
(
2010
)
.
A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism
.
Genetic and Molecular Aspects of Sport Performance
,
Wiley
Davidsen PK, Gallagher IJ, Hartman JW, Tarnopolsky MA, Dela F, Helge JW, Timmons JA, Phillips SM
(
2010
)
.
High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
.
Journal of Applied Physiology
vol.
110
,
(
2
)
309
-
317
.
Timmons JA
(
2010
)
.
Variability in training-induced skeletal muscle adaptation
.
Journal of Applied Physiology
vol.
110
,
(
3
)
846
-
853
.
Keller P, Vollaard NBJ, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C et al.
(
2010
)
.
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
.
Journal of Applied Physiology
vol.
110
,
(
1
)
46
-
59
.
Koch LG, Britton SL, Wisloff U, Kainulainen H, Timmons JA
(
2010
)
.
Development of Rat Models for Low and High Response to Exercise Training
.
Medicine & Science in Sports & Exercise
vol.
42
,
(
10
)
61
-
62
.
Shabalina IG, Petrovic N, Walden TB, Timmons JA, Cannon B, Nedergaard J
(
2010
)
.
Thermogenically competent recruitment of uncoupling protein 1 in brown preadipocytes and in a subset of cell precursors from epididymal white adipose tissue by a PPARγ agonist
.
Biochimica et Biophysica Acta (BBA) - Bioenergetics
vol.
1797
,
Samjoo I, Safdar A, Hamadeh M, Akhtar M, Raha S, Timmons J, Tarnopolsky M
(
2010
)
.
Endurance Training‐mediated Differential Regulation of miRNAs in Skeletal Muscle of Lean and Obese Men
.
The FASEB Journal
vol.
24
,
(
S1
)
806.14
-
806.14
.
Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C et al.
(
2010
)
.
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
.
Journal of Applied Physiology
vol.
108
,
(
6
)
1487
-
1496
.
Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J et al.
(
2010
)
.
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
.
Genome Medicine
vol.
2
,
(
2
)
Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC et al.
(
2010
)
.
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
.
Genome Medicine
vol.
2
,
(
1
)
Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J
(
2009
)
.
Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes*
.
Journal of Biological Chemistry
vol.
285
,
(
10
)
7153
-
7164
.
Roos A-K, Eriksson F, Timmons JA, Gerhardt J, Nyman U, Gudmundsdotter L, Bråve A, Wahren B et al.
(
2009
)
.
Skin Electroporation: Effects on Transgene Expression, DNA Persistence and Local Tissue Environment
.
PLOS ONE
vol.
4
,
(
9
)
Timmons JA, Pedersen BK
(
2009
)
.
The Importance of Brown Adipose Tissue
.
New England Journal of Medicine
vol.
361
,
(
4
)
415
-
421
.
Vollaard NBJ, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ
(
2009
)
.
Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance
.
Journal of Applied Physiology
vol.
106
,
(
5
)
1479
-
1486
.
Babraj JA, Vollaard NB, Keast C, Guppy FM, Cottrell G, Timmons JA
(
2009
)
.
Extremely short duration high intensity interval training substantially improves insulin action in young healthy males
.
BMC Endocrine Disorders
vol.
9
,
(
1
)
Scheele C, Larsson O, Timmons JA
(
2009
)
.
Chapter 12 Using Functional Genomics to Study PINK1 and Metabolic Physiology
.
Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases
,
vol.
457
,
Elsevier
Fredriksson K, Tjäder I, Keller P, Petrovic N, Ahlman B, Schéele C, Wernerman J, Timmons JA et al.
(
2008
)
.
Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure
.
PLOS ONE
vol.
3
,
(
11
)
Walden TB, Timmons JA, Keller P, Nedergaard J, Cannon B
(
2008
)
.
Distinct expression of muscle‐specific MicroRNAs (myomirs) in brown adipocytes
.
Journal of Cellular Physiology
vol.
218
,
(
2
)
444
-
449
.
Franks PW, Scheele C, Loos RJF, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ et al.
(
2008
)
.
Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites
.
The FASEB Journal
vol.
22
,
(
9
)
3135
-
3145
.
Petrovic N, Shabalina IG, Timmons JA, Cannon B, Nedergaard J
(
2008
)
.
Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist
.
AJP Endocrinology and Metabolism
vol.
295
,
(
2
)
e287
-
e296
.
Timmons JA
(
2008
)
.
Commentary on Viewpoint: Perspective on the future use of genomics in exercise prescription
.
Journal of Applied Physiology
vol.
104
,
(
4
)
1250
-
1250
.
Timmons JA, Sundberg CJ
(
2008
)
.
Oligonucleotide microarray expression profiling: Human skeletal muscle phenotype and aerobic exercise training
.
IUBMB Life
vol.
58
,
(
1
)
15
-
24
.
Keller P, Vollaard N, Babraj J, Ball D, Sewell DA, Timmons JA
(
2007
)
.
Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training
.
Biochemical Society Transactions
.
vol.
35
,
1306
-
1309
.
Timmons J, Scheele C, Wahlestedt C
(
2007
)
.
Do mitochondria provide a common link between diabetes and Parkinson's disease?
.
Practical Diabetes
vol.
24
,
(
7
)
337
-
339
.
Scheele C, Nielsen AR, Walden TB, Sewell DA, Fischer CP, Brogan RJ, Petrovic N, Larsson O et al.
(
2007
)
.
Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?
.
The FASEB Journal
vol.
21
,
(
13
)
3653
-
3665
.
Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L et al.
(
2007
)
.
The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
.
BMC Genomics
vol.
8
,
(
1
)
Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE et al.
(
2007
)
.
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
104
,
(
11
)
4401
-
4406
.
Unnithan V, Timmons J, Paton J, Rowland T
(
2007
)
.
Physiologic Correlates to Running Performance in Pre-Pubertal Distance Runners
.
International Journal of Sports Medicine
vol.
16
,
(
08
)
528
-
533
.
Nedergaard J, Petrovic N, Timmons JA, Cannon B
(
2007
)
.
Food constituents and quantity as determinants of differentiation of adipose progenitor cells
.
ANNALS OF NUTRITION AND METABOLISM
.
vol.
51
,
17
-
18
.
Franks PW, Scheele C, Loos RJF, Nielsen AR, Pedersen BK, Wareham NJ, Timmons JA
(
2007
)
.
Gene expression and genetic association studies suggest a role for the Parkinson's gene <i>PINK1</i> in the pathogenesis of type 2 diabetes
.
DIABETOLOGIA
.
vol.
50
,
S134
-
S134
.
Timmons JA, Good L
(
2006
)
.
Does everything now make (anti)sense?
.
Biochemical Society Transactions
.
vol.
34
,
1148
-
1150
.
Baker DJ, Constantin-Teodosiu D, Jones SW, Timmons JA, Greenhaff PL
(
2006
)
.
Chronic Treatment with the β2-Adrenoceptor Agonist Prodrug BRL-47672 Impairs Rat Skeletal Muscle Function by Inducing a Comprehensive Shift to a Faster Muscle Phenotype
.
Journal of Pharmacology and Experimental Therapeutics
vol.
319
,
(
1
)
439
-
446
.
Baker DJ, Greenhaff PL, MacInnes A, Timmons JA
(
2006
)
.
The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction
.
Diabetes
vol.
55
,
(
6
)
1855
-
1861
.
Baker DJ, Greenhaff PL, Timmons JA
(
2006
)
.
Glycogen phosphorylase inhibition as a therapeutic target: a review of the recent patent literature
.
Expert Opinion on Therapeutic Patents
vol.
16
,
(
4
)
459
-
466
.
Timmons JA, Sundberg CJ
(
2006
)
.
Oligonucleotide microarray expression profiling: Human skeletal muscle phenotype and aerobic exercise training (vol 58, pg 15, 2006)
.
IUBMB LIFE
vol.
58
,
(
2
)
117
-
117
.
Timmons JA, Norrbom J, Schéele C, Thonberg H, Wahlestedt C, Tesch P
(
2005
)
.
Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes
.
Genomics
vol.
87
,
(
1
)
165
-
172
.
Timmons JA, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J, Sundberg CJ
(
2005
)
.
Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans
.
BMC Biology
vol.
3
,
(
1
)
Baker DJ, Timmons JA, Greenhaff PL
(
2005
)
.
Glycogen Phosphorylase Inhibition in Type 2 Diabetes Therapy A Systematic Evaluation of Metabolic and Functional Effects in Rat Skeletal Muscle
.
Diabetes
vol.
54
,
(
8
)
2453
-
2459
.
MacInnes A, Timmons JA
(
2005
)
.
Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle
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BMC Physiology
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Larsson O, Wahlestedt C, Timmons JA
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Considerations when using the significance analysis of microarrays (SAM) algorithm
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BMC Bioinformatics
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6
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Timmons JA, Larsson O, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J et al.
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Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy
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The FASEB Journal
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19
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7
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750
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760
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Gustafsson T, Ameln H, Fischer H, Sundberg CJ, Timmons JA, Jansson E
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2005
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VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise
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Journal of Applied Physiology
vol.
98
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6
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2137
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Timmons JA
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2005
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CHASING THE “GHOST” OF THE ACETYL GROUP DEFICIT
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Medicine & Science in Sports & Exercise
vol.
37
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1
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Timmons JA, Constantin‐Teodosiu D, Poucher SM, Greenhaff PL
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Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
.
The Journal of Physiology
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561
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3
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851
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859
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Jones SW, Baker DJ, Gardiner SM, Bennett T, Timmons JA, Greenhaff PL
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The Effect of the β2-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat
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Journal of Pharmacology and Experimental Therapeutics
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311
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Greenhaff PL, Campbell‐O’Sullivan SP, Constantin‐Teodosiu D, Poucher SM, Roberts PA, Timmons JA
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Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease
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British Journal of Clinical Pharmacology
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Timmons JA
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2002
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Can we “switch” the emphasis please?
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Journal of Applied Physiology
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92
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2221
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2221
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Greenhaff PL, Campbell-O'Sullivan SP, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA
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2002
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An acetyl group deficit limits mitochondrial ATP production at the onset of exercise
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Biochemical Society Transactions
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Greenhaff PL, Campbell S, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA
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The acetyl-group deficit limits mitochondrial ATP production at the onset of exercise
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Biochemical Society Transactions
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a10
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MacInnes A, Timmons JA
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2002
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PDE inhibition by UK-114,542 does not alter skeletal muscle function during partial ischaemia in the anaesthetised dog
.
JOURNAL OF PHYSIOLOGY-LONDON
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539
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47P
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Timmons JA, MacInnes A
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The effects of the PDE inhibitor UK-114,542 on skeletal muscle glucose uptake in the anaesthetised dog
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JOURNAL OF PHYSIOLOGY-LONDON
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26P
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26P
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MacInnes A, Hogan MC, Hepple RT, Timmons JA
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2000
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Is there a role for neutrophil plugging in canine skeletal muscle contractile dysfunction during partial ischaemia?
.
JOURNAL OF PHYSIOLOGY-LONDON
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vol.
523
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242P
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243P
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Timmons JA
(
1999
)
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A conflicting role for the pyruvate dehydrogenase complex in resting versus contracting skeletal muscle?
.
AMERICAN ZOOLOGIST
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vol.
39
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6A
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Timmons JA, Poucher SM, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL
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1998
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Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction
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American Journal of Physiology
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274
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5
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Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Greenhaff PL
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1998
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Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise
.
American Journal of Physiology
vol.
274
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2
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e377
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e380
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Greenhaff PL, Timmons JA
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1998
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1 Interaction Between Aerobic and Anaerobic Metabolism During Intense Muscle Contraction
.
Exercise and Sport Sciences Reviews
vol.
26
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1
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Timmons JA, Poucher SM, Greenhaff PL
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Inhibition of lipolysis and mitochondrial lipid uptake during contraction in ischaemic skeletal muscle
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JOURNAL OF PHYSIOLOGY-LONDON
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40P
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Greenhaff PL, Timmons JA
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1998
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Pyruvate Dehydrogenase Complex Activation Status and Acetyl Group Availability as a Site of Interchange between Anaerobic and Oxidative Metabolism during Intense Exercise
.
Advances in Experimental Medicine and Biology
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vol.
441
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Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Hultman E, Kaijser L, Chwalbinska-Moneta J, Constantin-Teodosiu D et al.
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1998
)
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Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise
.
Journal of Clinical Investigation
vol.
101
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1
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79
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85
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Timmons JA, Greenhaff PL, Poucher SM
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1998
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The effects of asparagine infusion on ischaemic contractile function in canine skeletal muscle
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JOURNAL OF PHYSIOLOGY-LONDON
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41P
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41P
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Timmons JA, Poucher SM, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL
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1997
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Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle
.
American Journal of Physiology
vol.
273
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2
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e233
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e238
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Greenhaff PL, Casey A, ConstantinTeodosiu D, Green AL, Hultman E, Soderlund K, Timmons JA
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1997
)
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Biochemical aspects of muscle fatigue
.
PHYSIOLOGY, STRESS, AND MALNUTRITION
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463
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481
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Hultman E, Soderlund K, Timmons JA, Cederblad G, Greenhaff PL
(
1996
)
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Muscle creatine loading in men
.
Journal of Applied Physiology
vol.
81
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1
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232
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237
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Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, MacDonald IA, Greenhaff PL
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1996
)
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Metabolic responses of canine gracilis muscle during contraction with partial ischemia
.
American Journal of Physiology
vol.
270
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3
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e400
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e406
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Unnithan VB, Timmons JA, Brogan RT, Paton JY, Rowland TW
(
1996
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Submaximal running economy in run-trained pre-pubertal boys
.
The Journal of Sports Medicine and Physical Fitness
vol.
36
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1
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16
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23
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Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA, Greenhaff PL
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1996
)
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Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia
.
Journal of Clinical Investigation
vol.
97
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3
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879
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883
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Timmons JA, Constantin-Teodosiu D, Poucher SM, Worrall V, Greenhaff PL
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1995
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DICHLOROACETATE ENHANCES SKELETAL MUSCLE PERFORMANCE DURING ISCHAEMIC WORK: 17
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Medicine & Science in Sports & Exercise
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27
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Unnithan VB, Murray LA, Timmons JA, Buchanan D, Paton JY
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Reproducibility of cardiorespiratory measurements during submaximal and maximal running in children
.
British Journal of Sports Medicine
vol.
29
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Unnithan VB, Wilson J, Buchanan D, Timmons JA, Paton JY
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Validation of the Sensormedics (S2900Z) Metabolic Cart for Pediatric Exercise Testing
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Applied Physiology Nutrition and Metabolism
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472
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479
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Timmons J, Poucher S, Constantin-Teodosiu D, Worrall V, Macdonald I, Greenhaff P
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An in vivo Technique for Modelling the Metabolic Responses of Skeletal Muscle to Ischaemic Work
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Clinical Science
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