Publications: Dr James Timmons

Stokes T, Cen HH, Kapranov P, Gallagher IJ, Pitsillides AA, Volmar C, Kraus WE, Johnson JD et al. ( 2023 ) . Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq . Advanced Genetics

Timmons J ( 2022 ) . Variable selection and risk prediction using a penalised modelling framework for high-dimensional data in a nested matched case-control design . Conference: RSS International Conference 2022 ( Aberdeen, Scotland ) from: 15/09/2022 to: 12/09/2022 ,

Nath M, Romaine SPR, Koekemoer A, Hamby S, Webb TR, Nelson CP, Castellanos-Uribe M, Papakonstantinou M et al. ( 2022 ) . Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure . European Journal of Heart Failure vol. 24 , ( 6 ) 1009 - 1019 .

Timmons JA, Anighoro A, Brogan RJ, Stahl J, Wahlestedt C, Farquhar DG, Taylor-King J, Volmar CH et al. ( 2022 ) . A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease . eLife vol. 11 ,

Cen HH, Hussein B, Botezelli JD, Wang S, Zhang JA, Noursadeghi N, Jessen N, Rodrigues B et al. ( 2022 ) . Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance . FASEB Journal vol. 36 , ( 1 )

Dennison JL, Volmar C-H, Modarresi F, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z et al. ( 2022 ) . JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model . J Alzheimers Dis vol. 86 , ( 1 ) 173 - 190 .

Stokes T, Timmons JA, Crossland H, Tripp TR, Murphy K, McGlory C, Mitchell CJ, Oikawa SY et al. ( 2020 ) . Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States . Cell Reports vol. 32 , ( 5 )

Cao H, Salazar-García L, Gao F, Wahlestedt T, Wu CL, Han X, Cai Y, Xu D et al. ( 2019 ) . Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells . Nature Communications vol. 10 , ( 1 )

Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE, Atherton PJ ( 2019 ) . A statistical and biological response to an informatics appraisal of healthy aging gene signatures . Genome Biology vol. 20 , ( 1 )

Timmons JA, Volmar CH, Crossland H, Phillips BE, Sood S, Janczura KJ, Törmäkangas T, Kujala UM et al. ( 2019 ) . Longevity-related molecular pathways are subject to midlife “switch” in humans . Aging Cell vol. 18 , ( 4 )

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR et al. ( 2018 ) . A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease . Nucleic Acids Research vol. 46 , ( 15 ) 7772 - 7792 .

Phillips BE, Kelly BM, Lilja M, Ponce-González JG, Brogan RJ, Morris DL, Gustafsson T, Kraus WE et al. ( 2017 ) . A practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type II diabetes . Frontiers in Endocrinology vol. 8 , ( SEP )

Dinas PC, Lahart IM, Timmons JA, Svensson P-A, Koutedakis Y, Flouris AD, Metsios GS ( 2017 ) . Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review . F1000Research vol. 6 ,

Pollard AS, Charlton BG, Hutchinson JR, Gustafsson T, McGonnell IM, Timmons JA, Pitsillides AA ( 2017 ) . Limb proportions show developmental plasticity in response to embryo movement . Scientific Reports vol. 7 ,

Crossland H, Timmons JA, Atherton PJ ( 2017 ) . A dynamic ribosomal biogenesis response is not required for IGF-1–mediated hypertrophy of human primary myotubes . FASEB Journal vol. 31 , ( 12 ) 5196 - 5207 .

Crossland H, Atherton PJ, omberg A, Gustafsson T, Timmons JA ( 2017 ) . A reverse genetics cell-based evaluation of genes linked to healthy human tissue age . FASEB Journal vol. 31 , ( 1 ) 96 - 108 .

Dinas PC, Lahart IM, Timmons JA, Svensson PA, Koutedakis Y, Flouris AD, Metsios GS ( 2017 ) . Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review . F1000Research vol. 6 ,

Timmons JA ( 2017 ) . Molecular Diagnostics of Ageing and Tackling Age-related Disease . Trends in Pharmacological Sciences vol. 38 , ( 1 ) 67 - 80 .

Hangelbroek RWJ, Fazelzadeh P, Tieland M, Boekschoten MV, Hooiveld GJEJ, van Duynhoven JPM, Timmons JA, Verdijk LB et al. ( 2016 ) . Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness . Journal of Cachexia, Sarcopenia and Muscle vol. 7 , ( 5 ) 604 - 614 .

Nakhuda A, Josse AR, Gburcik V, Crossland H, Raymond F, Metairon S, Good L, Atherton PJ et al. ( 2016 ) . Biomarkers of browning of white adipose tissue and their regulation during exercise- And diet-induced weight loss . American Journal of Clinical Nutrition vol. 104 , ( 3 ) 557 - 565 .

Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H et al. ( 2016 ) . iGEMS: An integrated model for identification of alternative exon usage events . Nucleic Acids Research vol. 44 , ( 11 )

Timmons JA, Gallagher IJ ( 2016 ) . Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved] . F1000Research vol. 5 ,

Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T et al. ( 2015 ) . A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status . Genome Biology vol. 16 , ( 1 )

Timmons JA, Szkop KJ, Gallagher IJ ( 2015 ) . Multiple sources of bias confound functional enrichment analysis of global -omics data . Genome Biology vol. 16 , ( 1 )

Timmons JA ( 2015 ) . Single-gene genotyping and personalized preventive care . JAMA - Journal of the American Medical Association vol. 314 , ( 3 ) 297 - 298 .

Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T ( 2013 ) . Integrative pathway analysis of a genome-wide association study of VO <inf>2max</inf> response to exercise training . Journal of Applied Physiology vol. 115 , ( 9 ) 1343 - 1359 .

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL et al. ( 2013 ) . Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks . Diabetes vol. 62 , ( 8 ) 2717 - 2727 .

Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ et al. ( 2013 ) . Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway . American Journal of Physiology - Endocrinology and Metabolism vol. 305 , ( 2 )

Gburcik V, Cleasby ME, Timmons JA ( 2013 ) . Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal . American Journal of Physiology - Endocrinology and Metabolism vol. 304 , ( 8 )

Phillips BE, Williams JP, Gustafsson T, Bouchard C, Rankinen T, Knudsen S, Smith K, Timmons JA et al. ( 2013 ) . Molecular Networks of Human Muscle Adaptation to Exercise and Age . PLoS Genetics vol. 9 , ( 3 )

Gburcik V, Cawthorn WP, Nedergaard J, Timmons JA, Cannon B ( 2012 ) . An essential role for tbx15 in the differentiation of brown and "brite" but not white adipocytes . American Journal of Physiology - Endocrinology and Metabolism vol. 303 , ( 8 )

Timmons JA, Baar K, Davidsen PK, Atherton PJ ( 2012 ) . Is irisin a human exercise gene? . Nature vol. 488 , ( 7413 )

Gallagher IJ, Stephens NA, MacDonald AJ, Skipworth RJE, Husi H, Greig CA, Ross JA, Timmons JA et al. ( 2012 ) . Suppression of skeletal muscle turnover in cancer cachexia: Evidence from the transcriptome in sequential human muscle biopsies . Clinical Cancer Research vol. 18 , ( 10 ) 2817 - 2827 .

Poulet B, Veronica U, Stone TC, Pead M, Gburcik V, Beier F, Timmons JA, Pitsillides AA ( 2012 ) . Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA . Osteoarthritis and Cartilage . vol. 20 , s59 - s60 .

Waldén TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J ( 2012 ) . Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues . American Journal of Physiology - Endocrinology and Metabolism vol. 302 , ( 1 )

Poulet B, Ulici V, Stone TC, Pead M, Gburcik V, Constantinou E, Palmer DB, Beier F et al. ( 2012 ) . Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis . Arthritis and rheumatism vol. 64 , ( 10 ) 3256 - 3266 .

Timmons JA ( 2011 ) . Modulation of MicroRNAs during exercise and disease in human skeletal muscle . Exercise and Sport Sciences Reviews vol. 39 , ( 4 )

Timmons JA ( 2011 ) . What happens if you pose the wrong questions? . Journal of Physiology vol. 589 , ( 19 ) 4799 - 4801 .

Bouchard C, Rankinen T, Timmons JA ( 2011 ) . Genomics and genetics in the biology of adaptation to exercise . Comprehensive Physiology vol. 1 , ( 3 ) 1603 - 1648 .

Keller P, Gburcik V, Petrovic N, Gallagher IJ, Nedergaard J, Cannon B, Timmons JA ( 2011 ) . Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity . BMC Endocrine Disorders vol. 11 ,

Timmons JA ( 2011 ) . Variability in training-induced skeletal muscle adaptation . Journal of Applied Physiology vol. 110 , ( 3 ) 846 - 853 .

Davidsen PK, Gallagher IJ, Hartman JW, Tarnopolsky MA, Dela F, Helge JW, Timmons JA, Phillips SM ( 2011 ) . High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression . Journal of Applied Physiology vol. 110 , ( 2 ) 309 - 317 .

Keller P, Vollaard NBJ, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C et al. ( 2011 ) . A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype . Journal of Applied Physiology vol. 110 , ( 1 ) 46 - 59 .

Timmons JA ( 2011 ) . Genes that AKT to determine physiological heterogeneity in response to exercise . Experimental Physiology vol. 96 , ( 3 ) 259 - 260 .

Timmons JA, Helge JW ( 2010 ) . A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism . Genetic and Molecular Aspects of Sport Performance ,

Koch LG, Britton SL, Wisloff U, Kainulainen H, Timmons JA ( 2010 ) . Development of Rat Models for Low and High Response to Exercise Training . Medicine & Science in Sports & Exercise vol. 42 , ( 10 ) 61 - 62 .

Shabalina IG, Petrovic N, Walden TB, Timmons JA, Cannon B, Nedergaard J ( 2010 ) . Thermogenically competent recruitment of uncoupling protein 1 in brown preadipocytes and in a subset of cell precursors from epididymal white adipose tissue by a PPARγ agonist . Biochimica et Biophysica Acta (BBA) - Bioenergetics vol. 1797 ,

Samjoo I, Safdar A, Hamadeh M, Akhtar M, Raha S, Timmons J, Tarnopolsky M ( 2010 ) . Endurance Training‐mediated Differential Regulation of miRNAs in Skeletal Muscle of Lean and Obese Men . The FASEB Journal vol. 24 , ( S1 ) 806.14 - 806.14 .

Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J ( 2010 ) . Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes . Journal of Biological Chemistry vol. 285 , ( 10 ) 7153 - 7164 .

Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J et al. ( 2010 ) . Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes . Genome Medicine vol. 2 , ( 2 )

Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC et al. ( 2010 ) . Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia . Genome Medicine vol. 2 , ( 1 )

Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C et al. ( 2010 ) . Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans . Journal of Applied Physiology vol. 108 , ( 6 ) 1487 - 1496 .

Roos AK, Eriksson F, Timmons JA, Gerhardt J, Nyman U, Gudmundsdotter L, Bråve A, Wahren B et al. ( 2009 ) . Skin electroporation: Effects on transgene expression, DNA persistence and local tissue environment . PLoS ONE vol. 4 , ( 9 )

Timmons JA, Pedersen BK ( 2009 ) . The importance of brown adipose tissue . New England Journal of Medicine vol. 361 , ( 4 ) 415 - 421 .

Scheele C, Larsson O, Timmons JA ( 2009 ) . Chapter 12 Using Functional Genomics to Study PINK1 and Metabolic Physiology . vol. 457 ,

Vollaard NBJ, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ ( 2009 ) . Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance . Journal of Applied Physiology vol. 106 , ( 5 ) 1479 - 1486 .

Walden TB, Timmons JA, Keller P, Nedergaard J, Cannon B ( 2009 ) . Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes . Journal of Cellular Physiology vol. 218 , ( 2 ) 444 - 449 .

Babraj JA, Vollaard NBJ, Keast C, Guppy FM, Cottrell G, Timmons JA ( 2009 ) . Extremely short duration high intensity interval training substantially improves insulin action in young healthy males . BMC Endocrine Disorders vol. 9 ,

Fredriksson K, Tjäder I, Keller P, Petrovic N, Ahlman B, Schéele C, Wernerman J, Timmons JA et al. ( 2008 ) . Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure . PLoS ONE vol. 3 , ( 11 )

Petrovic N, Shabalina IG, Timmons JA, Cannon B, Nedergaard J ( 2008 ) . Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist . American Journal of Physiology - Endocrinology and Metabolism vol. 295 , ( 2 )

Timmons JA ( 2008 ) . Commentary on Viewpoint: Perspective on the future use of genomics in exercise prescription . Journal of Applied Physiology vol. 104 , ( 4 )

Franks PW, Scheele C, Loos RJF, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ et al. ( 2008 ) . Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites . FASEB Journal vol. 22 , ( 9 ) 3135 - 3145 .

Scheele C, Nielsen AR, Walden TB, Sewell DA, Fischer CP, Brogan RJ, Petrovic N, Larsson O et al. ( 2007 ) . Altered regulation of the PINK1 locus: A link between type 2 diabetes and neurodegeneration? . FASEB Journal vol. 21 , ( 13 ) 3653 - 3665 .

Keller P, Vollaard N, Babraj J, Ball D, Sewell DA, Timmons JA ( 2007 ) . Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training . Biochemical Society Transactions . vol. 35 , 1306 - 1309 .

Timmons JA, Scheele C, Wahlestedt C ( 2007 ) . Do mitochondria provide a common link between diabetes and Parkinson's disease? . Practical Diabetes International vol. 24 , ( 7 ) 337 - 339 .

Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L et al. ( 2007 ) . The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function . BMC Genomics vol. 8 ,

Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE et al. ( 2007 ) . Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages . Proceedings of the National Academy of Sciences of the United States of America vol. 104 , ( 11 ) 4401 - 4406 .

Timmons JA, Good L ( 2006 ) . Does everything now make (anti)sense? . Biochemical Society Transactions . vol. 34 , 1148 - 1150 .

Baker DJ, Constantin-Teodosiu D, Jones SW, Timmons JA, Greenhaff PL ( 2006 ) . Chronic treatment with the β<inf>2</inf>-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype . Journal of Pharmacology and Experimental Therapeutics vol. 319 , ( 1 ) 439 - 446 .

Baker DJ, Greenhaff PL, MacInnes A, Timmons JA ( 2006 ) . The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction . Diabetes vol. 55 , ( 6 ) 1855 - 1861 .

Baker DJ, Greenhaff PL, Timmons JA ( 2006 ) . Glycogen phosphorylase inhibition as a therapeutic target: A review of the recent patent literature . Expert Opinion on Therapeutic Patents vol. 16 , ( 4 ) 459 - 466 .

Timmons JA, Norrbom J, Schéele C, Thonberg H, Wahlestedt C, Tesch P ( 2006 ) . Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes . Genomics vol. 87 , ( 1 ) 165 - 172 .

Timmons JA, Sundberg CJ ( 2006 ) . Oligonucleotide microarray expression profiling: Human skeletal muscle phenotype and aerobic exercise training . IUBMB Life vol. 58 , ( 1 ) 15 - 24 .

Timmons JA, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J, Sundberg CJ ( 2005 ) . Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans . BMC Biology vol. 3 ,

Baker DJ, Timmons JA, Greenhaff PL ( 2005 ) . Glycogen phosphorylase inhibition in type 2 diabetes therapy: A systematic evaluation of metabolic and functional effects in rat skeletal muscle . Diabetes vol. 54 , ( 8 ) 2453 - 2459 .

MacInnes A, Timmons JA ( 2005 ) . Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle . BMC Physiology vol. 5 ,

Gustafsson T, Ameln H, Fischer H, Sundberg CJ, Timmons JA, Jansson E ( 2005 ) . VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise . Journal of Applied Physiology vol. 98 , ( 6 ) 2137 - 2146 .

Larsson O, Wahlestedt C, Timmons JA ( 2005 ) . Considerations when using the significance analysis of microarrays (SAM) algorithm . BMC Bioinformatics vol. 6 ,

Timmons JA, Larsson O, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J et al. ( 2005 ) . Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy . FASEB Journal vol. 19 , ( 7 ) 750 - 760 .

Timmons JA, Jones AM, Koppo K ( 2005 ) . Chasing the "ghost" of the acetyl group deficit [1] (multiple letters) . Medicine and Science in Sports and Exercise vol. 37 , ( 1 ) 162 - 163 .

Timmons JA, Constantin-Teodosiu D, Poucher SM, Greenhaff PL ( 2004 ) . Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction . Journal of Physiology vol. 561 , ( 3 ) 851 - 859 .

Jones SW, Baker DJ, Gardiner SM, Bennett T, Timmons JA, Greenhaff PL ( 2004 ) . The effect of the β<inf>2</inf>-adrenoceptor agonist prodrug BRL-47672 on cardiovascular function, skeletal muscle myosin heavy chain, and MyoD expression in the rat . Journal of Pharmacology and Experimental Therapeutics vol. 311 , ( 3 ) 1225 - 1231 .

Greenhaff PL, Campbell-O'Sullivan SP, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA ( 2004 ) . Metabolic inertia in contracting skeletal muscle: A novel approach for pharmacological intervention in peripheral vascular disease . British Journal of Clinical Pharmacology vol. 57 , ( 3 ) 237 - 243 .

Greenhaff PL, Campbell S, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA ( 2002 ) . The acetyl-group deficit limits mitochondrial ATP production at the onset of exercise . Biochemical Society Transactions vol. 30 , ( 1 ) a10 - a10 .

Greenhaff PL, Campbell-O'Sullivan SP, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA ( 2002 ) . An acetyl group deficit limits mitochondrial ATP production at the onset of exercise . Biochemical Society transactions . vol. 30 , 275 - 280 .

Timmons JA ( 2002 ) . Can we "switch" the emphasis please? [1] . Journal of Applied Physiology vol. 92 , ( 5 )

Greenhaff PL, Timmons JA ( 1998 ) . 1 interaction between aerobic and anaerobic metabolism during intense muscle contraction . Exercise and Sport Sciences Reviews vol. 26 , ( 1 ) 1 - 30 .

Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Greenhaff PL ( 1998 ) . Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise . American Journal of Physiology - Endocrinology and Metabolism vol. 274 , ( 2 37-2 )

Greenhaff PL, Timmons JA ( 1998 ) . Pyruvate dehydrogenase complex activation status and acetyl group availability as a site of interchange between anaerobic and oxidative metabolism during intense exercise . Advances in Experimental Medicine and Biology . vol. 441 , 287 - 298 .

Timmons JA, Poucher SM, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL ( 1998 ) . Regulation of skeletal muscle carbohydrate oxidation during steady- state contraction . American Journal of Physiology - Regulatory Integrative and Comparative Physiology vol. 274 , ( 5 43-5 )

Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Hultman E, Kaijser L, Chwalbinska-Moneta J, Constantin-Teodosiu D et al. ( 1998 ) . Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise . Journal of Clinical Investigation vol. 101 , ( 1 ) 79 - 85 .

Timmons JA, Poucher SM, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL ( 1997 ) . Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle . American Journal of Physiology - Endocrinology and Metabolism vol. 273 , ( 2 36-2 )

Unnithan VB, Timmons JA, Brogan RT, Paton JY, Rowland TW ( 1996 ) . Submaximal running economy in run-trained pre-pubertal boys . Journal of Sports Medicine and Physical Fitness vol. 36 , ( 1 ) 16 - 23 .

Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA, Greenhaff PL ( 1996 ) . Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia . Journal of Clinical Investigation vol. 97 , ( 3 ) 879 - 883 .

Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA, Greenhaff PL ( 1996 ) . Metabolic responses of canine gracilis muscle during contraction with partial ischemia . American Journal of Physiology - Endocrinology and Metabolism vol. 270 , ( 3 33-3 )

Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL ( 1996 ) . Muscle creatine loading in men . Journal of Applied Physiology vol. 81 , ( 1 ) 232 - 237 .

Unnithan VB, Timmons JA, Paton JY, Rowland TW ( 1995 ) . Physiologic correlates to running performance in pre-pubertal distance runners . International Journal of Sports Medicine vol. 16 , ( 8 ) 528 - 533 .

Timmons JA, Constantin-Teodosiu D, Poucher SM, Worrall V, Greenhaff PL ( 1995 ) . DICHLOROACETATE ENHANCES SKELETAL MUSCLE PERFORMANCE DURING ISCHAEMIC WORK: 17 . Medicine & Science in Sports & Exercise vol. 27 , ( 5 )

Unnithan VB, Murray LA, Timmons JA, Buchanan D, Paton JY ( 1995 ) . Reproducibility of cardiorespiratory measurements during submaximal and maximal running in children . British Journal of Sports Medicine vol. 29 , ( 1 ) 66 - 71 .

Timmons J, Poucher S, Constantin-Teodosiu D, Worrall V, Macdonald I, Greenhaff P ( 1994 ) . An in vivo Technique for Modelling the Metabolic Responses of Skeletal Muscle to Ischaemic Work . Clinical Science vol. 87 , ( s1 ) 55 - 56 .

Unnithan VB, Wilson J, Buchanan D, Timmons JA, Paton JY ( 1994 ) . Validation of the sensormedics (S2900Z) metabolic cart for pediatric exercise testing . Canadian journal of applied physiology = Revue canadienne de physiologie appliquée vol. 19 , ( 4 ) 472 - 479 .