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Research

Publications: Dr Benjamin Jacobs

Jacobs BM, Peter M, Giovannoni G, Noyce AJ, Morris HR, Dobson R ( 2022 ) . Towards a global view of multiple sclerosis genetics . Nature Reviews Neurology vol. 18 , ( 10 ) 613 - 623 .
Hone L, Jacobs BM, Marshall C, Giovannoni G, Noyce A, Dobson R ( 2022 ) . Age-specific effects of childhood body mass index on multiple sclerosis risk . Journal of Neurology vol. 269 , ( 9 ) 5052 - 5060 .
Foote IF, Jacobs BM, Mathlin G, Watson CJ, Bothongo PL, Waters S, Dobson R, Noyce AJ et al. ( 2022 ) . The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study . Neurobiology of Aging vol. 117 , 222 - 235 .
Jacobs B, Giovannoni G, Noyce A, Morris H, Dobson R ( 2022 ) . 121 The ADAMS project: protocol and baseline results . Journal of Neurology Neurosurgery & Psychiatry . vol. 93 ,
Kuri A, Vickaryous N, Jacobs BM, Awad A, Dobson R ( 2022 ) . 134 Predictors of serum vitamin D level in multiple sclerosis . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 9 )
Jacobs B, Ban M, Baker A, Al-Najjar R, Else J, Sawcer S ( 2022 ) . Single-cell profiling of MS CSF B cells highlights roles for TNFα and mTORC1 signalling . Journal of Neurology Neurosurgery & Psychiatry . vol. 93 ,
Liu H, Dehestani M, Blauwendraat C, Makarious MB, Leonard H, Kim JJ, Schulte C, Noyce A et al. ( 2022 ) . Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors . Annals of Neurology vol. 92 , ( 2 ) 270 - 278 .
Watson C, Waters S, Jacobs B, Foote I, Dey S, Noyce A, Marshall C ( 2022 ) . 003 Neuroanatomical signatures of genetic risk for Alzheimer’s disease in healthy adults . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a101.3 - a1a102 .
Jacobs B, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R ( 2022 ) . 026 Gene-environment interactions in multiple sclerosis: a UK Biobank study . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a21.3 - a2a22 .
Kuri A, Jacobs BM, Leddy S, Schmierer K, Turner B, Allen-Philbey K, Stennett A, Giovannoni G et al. ( 2022 ) . 091 Evaluation of remote assessments for multiple sclerosis in a real-world setting . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a129.1 - a1a129 .
Jensen M, Jacobs B, Dobson R, Bandres-Ciga S, Blauwendraat C, Schrag A, Noyce A ( 2022 ) . Lower lymphocyte count is associated with increased risk of Parkinson’s disease . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a94.3 - a9a95 .
Belete D, Jacobs BM, Bestwick JP, Dobson R, Hardy J, Giovannoni G, Lees A, Schrag A et al. ( 2022 ) . Parkinson’s disease determinants, prediction and gene-environment interac- tions: a UK Biobank study . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a7.3 - a7a8 .
Watson CJ, Waters S, Jacobs BM, Foote IF, Dey S, Noyce AJ, Hardy CJD, Marshall CR ( 2022 ) . Speech-in-noise perception is a marker of preclinical Alzheimer’s disease . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a91.1 - a9a91 .
Simonet C, Bestwick J, Jitlal M, Waters S, Ben-Joseph A, Marshall CR, Dobson R, Marrium S et al. ( 2022 ) . Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population . JAMA Neurology vol. 79 , ( 4 ) 359 - 369 .
Noyce A ( 2022 ) . No evidence for association between polygenic risk of Multiple Sclerosis and MRI phenotypes in ~30,000 healthy adult UK Biobank participants . Multiple Sclerosis Journal
Noyce A ( 2022 ) . Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population . JAMA Neurology
Hone L, Giovannoni G, Dobson R, Jacobs BM ( 2022 ) . Predicting Multiple Sclerosis: Challenges and Opportunities . Frontiers in Neurology vol. 12 ,
Kuri A, Vickaryous N, Awad A, Jacobs BM, Dobson R ( 2022 ) . Vitamin D genetic risk scores in multiple sclerosis . Journal of Neurology
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR ( 2021 ) . Speech‐in‐noise perception is a marker of preclinical Alzheimer’s disease . Alzheimer's & Dementia vol. 17 , ( S5 )
Storm CS, Kia DA, Almramhi MM, Bandres-Ciga S, Finan C, Noyce AJ, Kaiyrzhanov R, Middlehurst B et al. ( 2021 ) . Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome . Nature Communications vol. 12 , ( 1 )
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR ( 2021 ) . Neuroanatomical signatures of genetic risk for Alzheimer's disease in healthy adults . Alzheimer's & Dementia vol. 17 , ( S4 )
Hone L, Jacobs B, Noyce A, Dobson R ( 2021 ) . Age-specific effects of childhood BMI on multiple sclerosis risk: a Mendelian Randomisation study . MULTIPLE SCLEROSIS JOURNAL . vol. 27 , 764 - 765 .
Foote I, Jacobs B, Watson C, Bothongo P, Waters S, Dobson R, Noyce A, Bhui K et al. ( 2021 ) . W26. A MULTIVARIATE GENOME-WIDE ASSOCIATION STUDY OF MODIFIABLE RISK FOR ALZHEIMER'S DISEASE: 269 LOCI ASSOCIATED WITH BRAIN HEALTH . European Neuropsychopharmacology vol. 51 , e159 - e159 .
Kuri A, Jacobs BM, Leddy S, Schmierer K, Turner B, Allen-Philbey K, Stennett A, Giovannoni G et al. ( 2021 ) . Evaluation of remote assessments for multiple sclerosis in an in-home setting . Multiple Sclerosis and Related Disorders vol. 54 ,
Jacobs BM, Noyce AJ, Bestwick J, Belete D, Giovannoni G, Dobson R ( 2021 ) . Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study . Neurology(R) neuroimmunology & neuroinflammation vol. 8 , ( 4 )
Blauwendraat C, Iwaki H, Makarious MB, Bandres-Ciga S, Leonard HL, Grenn FP, Lake J, Krohn L et al. ( 2021 ) . Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease . Annals of Neurology vol. 90 , ( 1 ) 35 - 42 .
Jacobs BM, Smets I, Giovannoni G, Noyce A, Jokubaitis V, Dobson R ( 2021 ) . Regarding: Nicotinic acetylcholine receptors α7 and α9 modify tobacco smoke risk for multiple sclerosis . Multiple Sclerosis Journal vol. 27 , ( 8 ) 1311 - 1312 .
Chohan H, Senkevich K, Patel RK, Bestwick JP, Jacobs BM, Bandres Ciga S, Gan-Or Z, Noyce AJ ( 2021 ) . Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression . Movement Disorders vol. 36 , ( 6 ) 1420 - 1429 .
Jensen MP, Jacobs BM, Dobson R, Bandres-Ciga S, Blauwendraat C, Schrag A, Noyce AJ ( 2021 ) . Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease . Annals of Neurology vol. 89 , ( 4 ) 803 - 812 .
Foote I, Jacobs B, Mathlin G, Watson C, Bothongo PLK, Waters S, Dobson R, Noyce A et al. ( 2021 ) . The Genetic Architecture of Alzheimer’s Disease Risk: A Genomic Structural Equation Modelling Study .
Foote IF, Jacobs BM, Noyce AJ, Korszun A, Bhui KS, Marshall CR ( 2020 ) . Exploring the shared genetic architecture of modifiable risk factors and related endophenotypes of Alzheimer’s disease: A genomic SEM study . Alzheimer's & Dementia vol. 16 , ( S2 )
Jacobs B, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R ( 2020 ) . Gene-environment interactions in multiple sclerosis: a uk biobank study . MULTIPLE SCLEROSIS JOURNAL . vol. 26 , 367 - 367 .
Vickaryous N, Jitlal M, Jacobs BM, Middleton R, Chandran S, MacDougall NJJ, Giovannoni G, Dobson R ( 2020 ) . Remote testing of vitamin D levels across the UK MS population—A case control study . PLoS ONE vol. 15 , ( 12 December )
Vickaryous N, Garjani A, Jacobs B, Jitlal M, Middleton R, Das Nair R, Tuite-Dalton K, Hunter R et al. ( 2020 ) . Vitamin D levels in the UK MS population and COVID-19 susceptibility . MULTIPLE SCLEROSIS JOURNAL . vol. 26 , 55 - 55 .
Voormolen DC, Polinder S, von Steinbuechel N, Feng Y, Wilson L, Oppe M, Haagsma JA, Åkerlund C et al. ( 2020 ) . Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom . Quality of Life Research vol. 29 , ( 11 ) 3095 - 3107 .
Vickaryous N, Jitlal M, Jacobs BM, Middleton R, Chandran S, MacDougall NJJ, Giovannoni G, Dobson R ( 2020 ) . Remote testing of vitamin D levels across the UK MS population – a case control study .
Auger SD, Jacobs BM, Dobson R, Marshall CR, Noyce AJ ( 2020 ) . Big data, machine learning and artificial intelligence: a neurologist's guide . Pract Neurol vol. 21 , ( 1 ) 4 - 11 .
Auger S, Jacobs B, Dobson R, MARSHALL C, Noyce A ( 2020 ) . Navigating a world of big data, machine learning and artificial intelligence: a neurologist's guide . Practical Neurology
Jacobs B, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, International Parkinson’s Disease Genomics Consortium (IPDGC) et al. ( 2020 ) . Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank . Journal of Neurology, Neurosurgery and Psychiatry vol. 91 , 1046 - 1054 .
Belete D, Jacobs B, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, Nalls M et al. ( 2020 ) . Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank . MOVEMENT DISORDERS . vol. 35 , S74 - S74 .
Jacobs B, Taylor T, Awad A, Baker D, Giovannoni G, Noyce A, Dobson R ( 2020 ) . Summary-data-based mendelian randomisation prioritises potential druggable targets for Multiple Sclerosis . Brain Communications
Taylor TR, Jacobs BM, Giovannoni G, Petrushkin H, Dobson R ( 2020 ) . Prevalence and demographics of multiple sclerosis-associated uveitis: a UK biobank study . Multiple Sclerosis and Related Disorders vol. 43 ,
Kuri A, Jacobs BM, Vickaryous N, Pakpoor J, Middeldorp J, Giovannoni G, Dobson R ( 2020 ) . Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom . BMC Public Health vol. 20 , ( 1 )
Leddy S, Jacobs BM, Giovannoni G, Dobson R ( 2020 ) . To examine the impact of Multiple Sclerosis on bone health and explore mechanisms for this association . EUROPEAN JOURNAL OF NEUROLOGY . vol. 27 , 981 - 981 .
Leddy S, Jacobs B, Giovannoni G, Dobson R ( 2020 ) . Bone health, fracture risk, and Multiple Sclerosis: a UK Biobank study . NEUROLOGY . vol. 94 ,
Jacobs B, Giovannoni G, Dobson R ( 2020 ) . Environmental exposures associated with Multiple Sclerosis: a UK Biobank study . NEUROLOGY . vol. 94 ,
Belete D, Jacobs B, Schrag A, Noyce A ( 2020 ) . Exploring the Parkinson's disease phenome in the UK Biobank population . NEUROLOGY . vol. 94 ,
Jacobs BM, Sarathchandra N, Karela M, Daniels LE, Purkayastha N ( 2020 ) . STREAMLINING PRIMARY CARE REFERRALS TO AN EARLY INFLAMMATORY ARTHRITIS (EIA) CLINIC: DISTINGUISHING BETWEEN PATIENTS WITH OSTEOARTHRITIS AND INFLAMMATORY ARTHRITIS . RHEUMATOLOGY . vol. 59 ,
Dobson R, Jacobs B, Giovannoni G, Cuzick J ( 2020 ) . Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factors . Multiple Sclerosis Journal
Jacobs B, Noyce A, Hardy CJD, Warren J, Marshall C ( 2020 ) . Estimating the causal effect of hearing loss on Alzheimer’s disease: a Mendelian randomisation study .
Dobson R, Noyce A, Giovannoni G, jacobs B ( 2020 ) . BMI and low serum vitamin D are causal risk factors for Multiple Sclerosis: a Mendelian Randomisation study . Neurology, Neuroimmunology and Neuroinflammation
Baker D, Jacobs BM, Gnanapavan S, Schmierer K, Giovannoni G ( 2019 ) . Plasma cell and B cell-targeted treatments for use in advanced multiple sclerosis . Multiple Sclerosis and Related Disorders vol. 35 , 19 - 25 .
Jacobs BM, Giovannoni G, Cuzick J, Dobson R ( 2019 ) . Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factors . medRxiv19007450 - 19007450 .
Bell JS, Spencer JI, Yates RL, Yee SA, Jacobs BM, DeLuca GC ( 2019 ) . Invited Review: From nose to gut – the role of the microbiome in neurological disease . Neuropathology and Applied Neurobiology vol. 45 , ( 3 ) 195 - 215 .
Jacobs BM, Ammoscato F, Giovannoni G, Baker D, Schmierer K ( 2018 ) . Cladribine: mechanisms and mysteries in multiple sclerosis . Journal of Neurology, Neurosurgery and Psychiatry vol. 89 , ( 12 ) 1266 - 1271 .
Jacobs B, Ammoscato F, Ceronie B, Xenakis T, Baker D, Giovannoni G, Schmierer K ( 2018 ) . Explaining long-term depletion of memory B lymphocytes after cladribine treatment . MULTIPLE SCLEROSIS JOURNAL . vol. 24 , 894 - 894 .
Jacobs B, Jawad A, Fattah Z ( 2018 ) . Pneumatosis intestinalis and intestinal perforation in a patient receiving tocilizumab . Archives of Rheumatology vol. 33 , ( 3 ) 372 - 375 .
Jacobs BM, Giovannoni G, Schmierer K ( 2018 ) . No Evident Disease Activity-More Than a Risky Ambition? . JAMA Neurol
Ceronie B, Jacobs BM, Baker D, Dubuisson N, Mao Z, Ammoscato F, Lock H, Longhurst HJ et al. ( 2018 ) . Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells . Journal of Neurology vol. 265 , ( 5 ) 1199 - 1209 .
Ceronie B, Dubuisson N, Jacobs BM, Mao Z, Ammoscato F, Lock H, Longhurst H, Giovannoni G et al. ( 2018 ) . Cladribine for the Effective Control of Multiple Sclerosis via Memory B Cell Depletion . NEUROLOGY . vol. 90 ,
Yates RL, Esiri MM, Palace J, Jacobs B, Perera R, DeLuca GC ( 2017 ) . Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex . Annals of Neurology vol. 82 , ( 2 ) 259 - 270 .
Jacobs BM ( 2015 ) . A dangerous method? The use of induced pluripotent stem cells as a model for schizophrenia . Schizophrenia Research vol. 168 , ( 1-2 ) 563 - 568 .
Wei W-C, Jacobs B, Becker EBE, Glitsch MD ( 2015 ) . Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H . Proc Natl Acad Sci U S A vol. 112 , ( 34 ) 10738 - 10743 .
Jacobs BM ( 2015 ) . Is there a moral obligation to select healthy children? . Journal of Medical Ethics vol. 41 , ( 8 ) 696 - 700 .
Jacobs BM ( 2014 ) . Stemming the Hype: What can we learn from iPSC models of parkinson's disease and how can we learn it? . Journal of Parkinson's Disease vol. 4 , ( 1 ) 15 - 27 .