Publications: Dr Benjamin Jacobs
Kuri A, Vickaryous N, Awad A, Jacobs BM, Dobson R
(
2023
)
.
Vitamin D genetic risk scores in multiple sclerosis
.
Journal of Neurology
vol.
270
,
(
2
)
1030
-
1035
.
Noyce A
(
2022
)
.
The association between anti-epileptic drugs and incident Parkinson’s disease in UK Biobank
.
JAMA Neurology
Dreyer-Alster S, Achiron A, Giovannoni G, Jacobs BM, Dobson R
(
2022
)
.
No evidence for an association between alcohol consumption and Multiple Sclerosis risk: a UK Biobank study
.
Scientific Reports
vol.
12
,
(
1
)
Jacobs BM, Peter M, Giovannoni G, Noyce AJ, Morris HR, Dobson R
(
2022
)
.
Towards a global view of multiple sclerosis genetics
.
Nature Reviews Neurology
vol.
18
,
(
10
)
613
-
623
.
Hone L, Jacobs BM, Marshall C, Giovannoni G, Noyce A, Dobson R
(
2022
)
.
Age-specific effects of childhood body mass index on multiple sclerosis risk
.
Journal of Neurology
vol.
269
,
(
9
)
5052
-
5060
.
Foote IF, Jacobs BM, Mathlin G, Watson CJ, Bothongo PL, Waters S, Dobson R, Noyce AJ et al.
(
2022
)
.
The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study
.
Neurobiology of Aging
vol.
117
,
222
-
235
.
Jacobs B, Giovannoni G, Noyce A, Morris H, Dobson R
(
2022
)
.
121 The ADAMS project: protocol and baseline results
.
Journal of Neurology Neurosurgery & Psychiatry
.
vol.
93
,
Kuri A, Vickaryous N, Jacobs BM, Awad A, Dobson R
(
2022
)
.
134 Predictors of serum vitamin D level in multiple sclerosis
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
9
)
Jacobs B, Ban M, Baker A, Al-Najjar R, Else J, Sawcer S
(
2022
)
.
Single-cell profiling of MS CSF B cells highlights roles for TNFα and mTORC1 signalling
.
Journal of Neurology Neurosurgery & Psychiatry
.
vol.
93
,
Liu H, Dehestani M, Blauwendraat C, Makarious MB, Leonard H, Kim JJ, Schulte C, Noyce A et al.
(
2022
)
.
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
.
Annals of Neurology
vol.
92
,
(
2
)
270
-
278
.
Watson C, Waters S, Jacobs B, Foote I, Dey S, Noyce A, Marshall C
(
2022
)
.
003 Neuroanatomical signatures of genetic risk for Alzheimer’s disease in healthy adults
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a101.3
-
a1a102
.
Jacobs B, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R
(
2022
)
.
026 Gene-environment interactions in multiple sclerosis: a UK Biobank study
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a21.3
-
a2a22
.
Kuri A, Jacobs BM, Leddy S, Schmierer K, Turner B, Allen-Philbey K, Stennett A, Giovannoni G et al.
(
2022
)
.
091 Evaluation of remote assessments for multiple sclerosis in a real-world setting
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a129.1
-
a1a129
.
Jensen M, Jacobs B, Dobson R, Bandres-Ciga S, Blauwendraat C, Schrag A, Noyce A
(
2022
)
.
Lower lymphocyte count is associated with increased risk of Parkinson’s disease
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a94.3
-
a9a95
.
Belete D, Jacobs BM, Bestwick JP, Dobson R, Hardy J, Giovannoni G, Lees A, Schrag A et al.
(
2022
)
.
Parkinson’s disease determinants, prediction and gene-environment interac- tions: a UK Biobank study
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a7.3
-
a7a8
.
Watson CJ, Waters S, Jacobs BM, Foote IF, Dey S, Noyce AJ, Hardy CJD, Marshall CR
(
2022
)
.
Speech-in-noise perception is a marker of preclinical Alzheimer’s disease
.
Journal of Neurology Neurosurgery & Psychiatry
vol.
93
,
(
6
)
a91.1
-
a9a91
.
Simonet C, Bestwick J, Jitlal M, Waters S, Ben-Joseph A, Marshall CR, Dobson R, Marrium S et al.
(
2022
)
.
Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
.
JAMA Neurology
vol.
79
,
(
4
)
359
-
369
.
Noyce A
(
2022
)
.
No evidence for association between polygenic risk of Multiple Sclerosis and MRI phenotypes in ~30,000 healthy adult UK Biobank participants
.
Multiple Sclerosis Journal
Noyce A
(
2022
)
.
Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
.
JAMA Neurology
Hone L, Giovannoni G, Dobson R, Jacobs BM
(
2022
)
.
Predicting Multiple Sclerosis: Challenges and Opportunities
.
Frontiers in Neurology
vol.
12
,
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR
(
2021
)
.
Speech‐in‐noise perception is a marker of preclinical Alzheimer’s disease
.
Alzheimer's & Dementia
vol.
17
,
(
S5
)
Storm CS, Kia DA, Almramhi MM, Bandres-Ciga S, Finan C, Noyce AJ, Kaiyrzhanov R, Middlehurst B et al.
(
2021
)
.
Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome
.
Nature Communications
vol.
12
,
(
1
)
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR
(
2021
)
.
Neuroanatomical signatures of genetic risk for Alzheimer's disease in healthy adults
.
Alzheimer's & Dementia
vol.
17
,
(
S4
)
Hone L, Jacobs B, Noyce A, Dobson R
(
2021
)
.
Age-specific effects of childhood BMI on multiple sclerosis risk: a Mendelian Randomisation study
.
MULTIPLE SCLEROSIS JOURNAL
.
vol.
27
,
764
-
765
.
Foote I, Jacobs B, Watson C, Bothongo P, Waters S, Dobson R, Noyce A, Bhui K et al.
(
2021
)
.
W26. A MULTIVARIATE GENOME-WIDE ASSOCIATION STUDY OF MODIFIABLE RISK FOR ALZHEIMER'S DISEASE: 269 LOCI ASSOCIATED WITH BRAIN HEALTH
.
European Neuropsychopharmacology
vol.
51
,
e159
-
e159
.
Hone L, Jacobs B, Marshall C, Giovannoni G, Noyce A, Dobson R
(
2021
)
.
Age-specific effects of childhood Body Mass Index on multiple sclerosis risk
.
Kuri A, Jacobs BM, Leddy S, Schmierer K, Turner B, Allen-Philbey K, Stennett A, Giovannoni G et al.
(
2021
)
.
Evaluation of remote assessments for multiple sclerosis in an in-home setting
.
Multiple Sclerosis and Related Disorders
vol.
54
,
Jacobs BM, Noyce AJ, Bestwick J, Belete D, Giovannoni G, Dobson R
(
2021
)
.
Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study
.
Neurology(R) neuroimmunology & neuroinflammation
vol.
8
,
(
4
)
Blauwendraat C, Iwaki H, Makarious MB, Bandres-Ciga S, Leonard HL, Grenn FP, Lake J, Krohn L et al.
(
2021
)
.
Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease
.
Annals of Neurology
vol.
90
,
(
1
)
35
-
42
.
Jacobs BM, Smets I, Giovannoni G, Noyce A, Jokubaitis V, Dobson R
(
2021
)
.
Regarding: Nicotinic acetylcholine receptors α7 and α9 modify tobacco smoke risk for multiple sclerosis
.
Multiple Sclerosis Journal
vol.
27
,
(
8
)
1311
-
1312
.
Chohan H, Senkevich K, Patel RK, Bestwick JP, Jacobs BM, Bandres Ciga S, Gan-Or Z, Noyce AJ
(
2021
)
.
Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression
.
Movement Disorders
vol.
36
,
(
6
)
1420
-
1429
.
Jensen MP, Jacobs BM, Dobson R, Bandres-Ciga S, Blauwendraat C, Schrag A, Noyce AJ
(
2021
)
.
Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease
.
Annals of Neurology
vol.
89
,
(
4
)
803
-
812
.
Foote I, Jacobs B, Mathlin G, Watson C, Bothongo PLK, Waters S, Dobson R, Noyce A et al.
(
2021
)
.
The Genetic Architecture of Alzheimer’s Disease Risk: A Genomic Structural Equation Modelling Study
.
Foote IF, Jacobs BM, Noyce AJ, Korszun A, Bhui KS, Marshall CR
(
2020
)
.
Exploring the shared genetic architecture of modifiable risk factors and related endophenotypes of Alzheimer’s disease: A genomic SEM study
.
Alzheimer's & Dementia
vol.
16
,
(
S2
)
Jacobs B, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R
(
2020
)
.
Gene-environment interactions in multiple sclerosis: a uk biobank study
.
MULTIPLE SCLEROSIS JOURNAL
.
vol.
26
,
367
-
367
.
Vickaryous N, Jitlal M, Jacobs BM, Middleton R, Chandran S, MacDougall NJJ, Giovannoni G, Dobson R
(
2020
)
.
Remote testing of vitamin D levels across the UK MS population—A case control study
.
PLoS ONE
vol.
15
,
(
12 December
)
Vickaryous N, Garjani A, Jacobs B, Jitlal M, Middleton R, Das Nair R, Tuite-Dalton K, Hunter R et al.
(
2020
)
.
Vitamin D levels in the UK MS population and COVID-19 susceptibility
.
MULTIPLE SCLEROSIS JOURNAL
.
vol.
26
,
55
-
55
.
Voormolen DC, Polinder S, von Steinbuechel N, Feng Y, Wilson L, Oppe M, Haagsma JA, Åkerlund C et al.
(
2020
)
.
Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom
.
Quality of Life Research
vol.
29
,
(
11
)
3095
-
3107
.
Vickaryous N, Jitlal M, Jacobs BM, Middleton R, Chandran S, MacDougall NJJ, Giovannoni G, Dobson R
(
2020
)
.
Remote testing of vitamin D levels across the UK MS population – a case control study
.
Auger SD, Jacobs BM, Dobson R, Marshall CR, Noyce AJ
(
2020
)
.
Big data, machine learning and artificial intelligence: a neurologist's guide
.
Pract Neurol
vol.
21
,
(
1
)
4
-
11
.
Auger S, Jacobs B, Dobson R, MARSHALL C, Noyce A
(
2020
)
.
Navigating a world of big data, machine learning and artificial intelligence: a neurologist's guide
.
Practical Neurology
Jacobs B, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, International Parkinson’s Disease Genomics Consortium (IPDGC) et al.
(
2020
)
.
Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank
.
Journal of Neurology, Neurosurgery and Psychiatry
vol.
91
,
1046
-
1054
.
Belete D, Jacobs B, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, Nalls M et al.
(
2020
)
.
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank
.
MOVEMENT DISORDERS
.
vol.
35
,
S74
-
S74
.
Jacobs B, Taylor T, Awad A, Baker D, Giovannoni G, Noyce A, Dobson R
(
2020
)
.
Summary-data-based mendelian randomisation prioritises potential druggable targets for Multiple Sclerosis
.
Brain Communications
Taylor TR, Jacobs BM, Giovannoni G, Petrushkin H, Dobson R
(
2020
)
.
Prevalence and demographics of multiple sclerosis-associated uveitis: a UK biobank study
.
Multiple Sclerosis and Related Disorders
vol.
43
,
Kuri A, Jacobs BM, Vickaryous N, Pakpoor J, Middeldorp J, Giovannoni G, Dobson R
(
2020
)
.
Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom
.
BMC Public Health
vol.
20
,
(
1
)
Leddy S, Jacobs BM, Giovannoni G, Dobson R
(
2020
)
.
To examine the impact of Multiple Sclerosis on bone health and explore mechanisms for this association
.
EUROPEAN JOURNAL OF NEUROLOGY
.
vol.
27
,
981
-
981
.
Leddy S, Jacobs B, Giovannoni G, Dobson R
(
2020
)
.
Bone health, fracture risk, and Multiple Sclerosis: a UK Biobank study
.
NEUROLOGY
.
vol.
94
,
Jacobs B, Giovannoni G, Dobson R
(
2020
)
.
Environmental exposures associated with Multiple Sclerosis: a UK Biobank study
.
NEUROLOGY
.
vol.
94
,
Belete D, Jacobs B, Schrag A, Noyce A
(
2020
)
.
Exploring the Parkinson's disease phenome in the UK Biobank population
.
NEUROLOGY
.
vol.
94
,
Jacobs BM, Sarathchandra N, Karela M, Daniels LE, Purkayastha N
(
2020
)
.
STREAMLINING PRIMARY CARE REFERRALS TO AN EARLY INFLAMMATORY ARTHRITIS (EIA) CLINIC: DISTINGUISHING BETWEEN PATIENTS WITH OSTEOARTHRITIS AND INFLAMMATORY ARTHRITIS
.
RHEUMATOLOGY
.
vol.
59
,
Dobson R, Jacobs B, Giovannoni G, Cuzick J
(
2020
)
.
Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factors
.
Multiple Sclerosis Journal
Jacobs BM, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R
(
2020
)
.
Gene-environment interactions in Multiple Sclerosis: a UK Biobank study
.
Jacobs B, Noyce A, Hardy CJD, Warren J, Marshall C
(
2020
)
.
Estimating the causal effect of hearing loss on Alzheimer’s disease: a Mendelian randomisation study
.
Jacobs B, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, Nalls M et al.
(
2020
)
.
Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank
.
Kuri A, Jacobs BM, Vickaryous N, Pakpoor J, Middeldorp J, Giovannoni G, Dobson R
(
2020
)
.
Epidemiology of Epstein-Barr Virus infection and Infectious Mononucleosis in the United Kingdom
.
Jacobs BM, Taylor T, Awad A, Baker D, Giovanonni G, Noyce A, Dobson R
(
2020
)
.
Summary-data-based mendelian randomisation reveals druggable targets for multiple sclerosis
.
Dobson R, Noyce A, Giovannoni G, jacobs B
(
2020
)
.
BMI and low serum vitamin D are causal risk factors for Multiple Sclerosis: a Mendelian Randomisation study
.
Neurology, Neuroimmunology and Neuroinflammation
Baker D, Jacobs BM, Gnanapavan S, Schmierer K, Giovannoni G
(
2019
)
.
Plasma cell and B cell-targeted treatments for use in advanced multiple sclerosis
.
Multiple Sclerosis and Related Disorders
vol.
35
,
19
-
25
.
Jacobs BM, Giovannoni G, Cuzick J, Dobson R
(
2019
)
.
Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factors
.
medRxiv19007450
-
19007450
.
Bell JS, Spencer JI, Yates RL, Yee SA, Jacobs BM, DeLuca GC
(
2019
)
.
Invited Review: From nose to gut – the role of the microbiome in neurological disease
.
Neuropathology and Applied Neurobiology
vol.
45
,
(
3
)
195
-
215
.
Jacobs BM, Ammoscato F, Giovannoni G, Baker D, Schmierer K
(
2018
)
.
Cladribine: mechanisms and mysteries in multiple sclerosis
.
Journal of Neurology, Neurosurgery and Psychiatry
vol.
89
,
(
12
)
1266
-
1271
.
Jacobs B, Ammoscato F, Ceronie B, Xenakis T, Baker D, Giovannoni G, Schmierer K
(
2018
)
.
Explaining long-term depletion of memory B lymphocytes after cladribine treatment
.
MULTIPLE SCLEROSIS JOURNAL
.
vol.
24
,
894
-
894
.
Jacobs B, Jawad A, Fattah Z
(
2018
)
.
Pneumatosis intestinalis and intestinal perforation in a patient receiving tocilizumab
.
Archives of Rheumatology
vol.
33
,
(
3
)
372
-
375
.
Jacobs BM, Giovannoni G, Schmierer K
(
2018
)
.
No Evident Disease Activity-More Than a Risky Ambition?
.
JAMA Neurol
Ceronie B, Jacobs BM, Baker D, Dubuisson N, Mao Z, Ammoscato F, Lock H, Longhurst HJ et al.
(
2018
)
.
Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells
.
Journal of Neurology
vol.
265
,
(
5
)
1199
-
1209
.
Ceronie B, Dubuisson N, Jacobs BM, Mao Z, Ammoscato F, Lock H, Longhurst H, Giovannoni G et al.
(
2018
)
.
Cladribine for the Effective Control of Multiple Sclerosis via Memory B Cell Depletion
.
NEUROLOGY
.
vol.
90
,
Yates RL, Esiri MM, Palace J, Jacobs B, Perera R, DeLuca GC
(
2017
)
.
Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex
.
Annals of Neurology
vol.
82
,
(
2
)
259
-
270
.
Jacobs BM
(
2015
)
.
A dangerous method? The use of induced pluripotent stem cells as a model for schizophrenia
.
Schizophrenia Research
vol.
168
,
(
1-2
)
563
-
568
.
Wei W-C, Jacobs B, Becker EBE, Glitsch MD
(
2015
)
.
Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H
.
Proc Natl Acad Sci U S A
vol.
112
,
(
34
)
10738
-
10743
.
Jacobs BM
(
2015
)
.
Is there a moral obligation to select healthy children?
.
Journal of Medical Ethics
vol.
41
,
(
8
)
696
-
700
.
Jacobs BM
(
2014
)
.
Stemming the Hype: What can we learn from iPSC models of parkinson's disease and how can we learn it?
.
Journal of Parkinson's Disease
vol.
4
,
(
1
)
15
-
27
.