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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Ivan Kadurin

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Kadurin I, Dahimene S, Page KM, Ellaway JIJ, Chaggar K, Troeberg L, Nagase H, Dolphin AC ( 2022 ) . ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement . Function vol. 3 , ( 3 )
Dahimene S, von Elsner L, Holling T, Mattas LS, Pickard J, Lessel D, Pilch KS, Kadurin I et al. ( 2022 ) . Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy . Brain vol. 145 , ( 8 ) 2721 - 2729 .
Dolphin AC, Kadurin I ( 2020 ) . Fight or flight: The culprit is lurking in the neighbourhood . Cell Calcium vol. 87 ,
Meyer JO, Dahimene S, Page KM, Ferron L, Kadurin I, Ellaway JIJ, Zhao P, Patel T et al. ( 2019 ) . Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking . Cell Reports vol. 29 , ( 1 ) 22 - 33.e5 .
Dahimene S, Page KM, Kadurin I, Ferron L, Ho DY, Powell GT, Pratt WS, Wilson SW et al. ( 2018 ) . The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1 . Cell Reports vol. 25 , ( 6 ) 1610 - 1621.e5 .
Ferron L, Kadurin I, Dolphin AC ( 2018 ) . Proteolytic maturation of α2δ controls the probability of synaptic vesicular release . eLife vol. 7 ,
Kadurin I, Rothwell SW, Lana B, Nieto-Rostro M, Dolphin AC ( 2017 ) . LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit . Scientific Reports vol. 7 , ( 1 )
Kadurin I, Ferron L, Rothwell SW, Meyer JO, Douglas LR, Bauer CS, Lana B, Margas W et al. ( 2016 ) . Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels . eLife vol. 5 ,
Lana B, Page KM, Kadurin I, Ho S, Nieto-Rostro M, Dolphin AC ( 2016 ) . Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed . Scientific Reports vol. 6 , ( 1 )
Cassidy JS, Ferron L, Kadurin I, Pratt WS, Dolphin AC ( 2014 ) . Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 24 ) 8979 - 8984 .
Alvarez-Laviada A, Kadurin I, Senatore A, Chiesa R, Dolphin AC ( 2014 ) . The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways . Biochemical Journal vol. 458 , ( 2 ) 365 - 374 .
Kadurin I, Alvarez-Laviada A, Ng SFJ, Walker-Gray R, D'Arco M, Fadel MG, Pratt WS, Dolphin AC ( 2012 ) . Calcium Currents Are Enhanced by α2δ-1 Lacking Its Membrane Anchor* . Journal of Biological Chemistry vol. 287 , ( 40 ) 33554 - 33566 .
Kadurin I, Bauer C, Lana B, Alvarez-Laviada A, Nieto-Rostro M, Douglas L, Troeberg L, Nagase H et al. ( 2012 ) . Voltage-Gated Calcium Channel α2δ Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into α2 and δ . Biophysical Journal . vol. 102 ,
Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM ( 2011 ) . Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses . Nature Neuroscience vol. 14 , ( 4 ) 478 - 486 .
Bauer CS, Tran-Van-Minh A, Kadurin I, Dolphin AC ( 2010 ) . A new look at calcium channel α2δ subunits . Current Opinion in Neurobiology vol. 20 , ( 5 ) 563 - 571 .
Davies A, Kadurin I, Alvarez-Laviada A, Douglas L, Nieto-Rostro M, Bauer CS, Pratt WS, Dolphin AC ( 2010 ) . The α2δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function . Proceedings of the National Academy of Sciences of the United States of America vol. 107 , ( 4 ) 1654 - 1659 .
Bauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin I, Ranjan YS et al. ( 2009 ) . The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin . Journal of Neuroscience vol. 29 , ( 13 ) 4076 - 4088 .
Kadurin I, Huber S, Gründer S ( 2009 ) . A single conserved proline residue determines the membrane topology of stomatin . Biochemical Journal vol. 418 , ( 3 ) 587 - 594 .
Kadurin I, Golubovic A, Leisle L, Schindelin H, Gründer S ( 2008 ) . Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b . Biochemical Journal vol. 412 , ( 3 ) 469 - 475 .
Chen X, Polleichtner G, Kadurin I, Gründer S ( 2007 ) . Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H+ * . Journal of Biological Chemistry vol. 282 , ( 42 ) 30406 - 30413 .
Chen X, Paukert M, Kadurin I, Pusch M, Gründer S ( 2006 ) . Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium . Neuropharmacology vol. 50 , ( 8 ) 964 - 974 .
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