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Research

Publications: Mr Ian Sealy

Pini V, Weisburd B, Merteroglu M, Sealy I, White R, Busch-Nentwich E, Muntoni F ( 2022 ) . VP.81 In vivo modulation of novel genetic modifiers for LAMA2-RD . Neuromuscular Disorders vol. 32 , s124 - s125 .
Tuschl K, White RJ, Trivedi C, Valdivia LE, Niklaus S, Bianco IH, Dadswell C, González-Méndez R et al. ( 2022 ) . Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish . Disease Models and Mechanisms vol. 15 , ( 6 )
Sheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV et al. ( 2022 ) . Translational relevance of forward genetic screens in animal models for the study of psychiatric disease . Neuroscience and Biobehavioral Reviews vol. 135 ,
Mech AM, Merteroglu M, Sealy IM, Teh MT, White RJ, Havelange W, Brennan CH, Busch-Nentwich EM ( 2022 ) . Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish . Frontiers in Psychiatry vol. 12 ,
Collins JE, White RJ, Staudt N, Sealy IM, Packham I, Wali N, Tudor C, Mazzeo C et al. ( 2019 ) . Common and distinct transcriptional signatures of mammalian embryonic lethality . Nature Communications vol. 10 , ( 1 )
Dooley CM, Wali N, Sealy IM, White RJ, Stemple DL, Collins JE, Busch-Nentwich EM ( 2019 ) . The gene regulatory basis of genetic compensation during neural crest induction . PLoS Genetics vol. 15 , ( 6 )
Young RM, Hawkins TA, Cavodeassi F, Stickney HL, Schwarz Q, Lawrence LM, Wierzbicki C, Cheng BYL et al. ( 2019 ) . Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification . eLife vol. 8 ,
Radloff A, Breckpot J, Hoff K, Kramer HH, Pan?kov? D, Mercks A, Devriendt K, Gewillig M et al. ( 2018 ) . CAPZB: A Potential Novel Key Player in Cardiac Development and Congenital Heart Defects . The Thoracic and Cardiovascular Surgeon . Conference: 50th Annual Meeting of the German Society for Pediatric Cardiology (DGPK) vol. 66 , s111 - s138 .
Scahill CM, Digby Z, Sealy IM, White RJ, Wali N, Collins JE, Stemple DL, Busch-Nentwich EM ( 2018 ) . The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish [version 2; referees: 2 approved] . Wellcome Open Research vol. 2 ,
White RJ, Collins JE, Sealy IM, Wali N, Dooley CM, Digby Z, Stemple DL, Murphy DN et al. ( 2017 ) . A high-resolution mRNA expression time course of embryonic development in zebrafish . eLife vol. 6 ,
Scahill CM, Digby Z, Sealy IM, White RJ, Collins JE, Busch-Nentwich EM ( 2017 ) . The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish . Wellcome Open Research vol. 2 ,
Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T et al. ( 2017 ) . Loss of the chromatin modifier Kdm2aa causes Braf<sup>V600E</sup>-independent spontaneous melanoma in zebrafish . PLoS Genetics vol. 13 , ( 8 )
White R, Collins J, Sealy I, Wali N, Dooley C, Digby Z, Stemple D, Murphy D et al. ( 2017 ) . A high-resolution mRNA expression time course of embryonic development in zebrafish .
Chow W, Brugger K, Caccamo M, Sealy I, Torrance J, Howe K ( 2016 ) . GEVAL - A web-based browser for evaluating genome assemblies . Bioinformatics vol. 32 , ( 16 ) 2508 - 2510 .
Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S, van Eeden FJ ( 2015 ) . Genome-wide mapping of Hif-1aα binding sites in zebrafish . BMC Genomics vol. 16 , ( 1 )
Patrick J, Wali N, Sealy I, Collins J, Busch-Nentwich E, Stemple D ( 2015 ) . G.P.239 Zebrafish models of inherited skeletal muscle disorders . Neuromuscular Disorders vol. 25 ,
Collins JE, Wali N, Sealy IM, Morris JA, White RJ, Leonard SR, Jackson DK, Jones MC et al. ( 2015 ) . High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping . BMC Genomics vol. 16 , ( 1 )
Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN et al. ( 2015 ) . Identification of a plant isoflavonoid that causes biliary atresia . Science Translational Medicine vol. 7 , ( 286 )
Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S et al. ( 2014 ) . Erratum: The zebrafish reference genome sequence and its relationship to the human genome (Nature (2013) 496 (498-503) DOI: 10.1038/nature12111) . Nature vol. 505 , ( 7482 )
Harvey SA, Sealy I, Kettleborough R, Fenyes F, White R, Stemple D, Smith JC ( 2013 ) . Identification of the zebrafish maternal and paternal transcriptomes . Development (Cambridge) vol. 140 , ( 13 ) 2703 - 2710 .
Kettleborough RNW, Busch-Nentwich EM, Harvey SA, Dooley CM, De Bruijn E, Van Eeden F, Sealy I, White RJ et al. ( 2013 ) . A systematic genome-wide analysis of zebrafish protein-coding gene function . Nature vol. 496 , ( 7446 ) 494 - 497 .
Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S et al. ( 2013 ) . The zebrafish reference genome sequence and its relationship to the human genome . Nature vol. 496 , ( 7446 ) 498 - 503 .
Flicek P, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G et al. ( 2008 ) . Ensembl 2008 . Nucleic Acids Research vol. 36 , ( SUPPL. 1 )
Kikuta H, Laplante M, Navratilova P, Komisarczuk AZ, Engström PG, Fredman D, Akalin A, Caccamo M et al. ( 2007 ) . Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates . Genome Research vol. 17 , ( 5 ) 545 - 555 .
Hubbard TJP, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G et al. ( 2007 ) . Ensembl 2007 . Nucleic Acids Research vol. 35 , ( SUPPL. 1 )
Birney E, Andrews D, Caccamo M, Chen Y, Clarke L, Coates G, Cox T, Cunningham F et al. ( 2006 ) . Ensembl 2006 . Nucleic acids research vol. 34 , ( Database issue )