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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Alex Clark

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Scaber J, Thomas-Wright I, Clark AJ, Xu Y, Vahsen BF, Carcolé M, Dafinca R, Farrimond L et al. ( 2024 ) . Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons . Stem Cell Reports vol. 19 , ( 7 ) 957 - 972 .
Van Lent J, Prior R, Pérez Siles G, Cutrupi AN, Kennerson ML, Vangansewinkel T, Wolfs E, Mukherjee-Clavin B et al. ( 2024 ) . Advances and challenges in modeling inherited peripheral neuropathies using iPSCs . Experimental & Molecular Medicine vol. 56 , ( 6 ) 1348 - 1364 .
Perez-Sanchez J, Middleton SJ, Pattison LA, Hilton H, Awadelkareem MA, Zuberi SR, Renke MB, Hu H et al. ( 2023 ) . A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons . Science Translational Medicine vol. 15 , ( 716 ) eadh3839 - eadh3839 .
Clark AJ, Kugathasan U, Baskozos G, Priestman DA, Fugger N, Lone MA, Othman A, Chu KH et al. ( 2021 ) . An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions . Cell Reports Medicine vol. 2 , ( 7 )
( 2021 ) . Corrigendum to: Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth . Brain vol. 144 , ( 5 ) e49 - e49 .
Baskozos G, Sandy-Hindmarch O, Clark AJ, Windsor K, Karlsson P, Weir GA, McDermott LA, Burchall J et al. ( 2020 ) . Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth . Brain vol. 143 , ( 7 ) 2009 - 2026 .
Clark AJ ( 2020 ) . Establishing Myelinating Cocultures Using Human iPSC-Derived Sensory Neurons to Investigate Axonal Degeneration and Demyelination . Axon Degeneration , vol. 2143 , Springer Nature
McDermott LA, Weir GA, Themistocleous AC, Segerdahl AR, Blesneac I, Baskozos G, Clark AJ, Millar V et al. ( 2019 ) . Defining the Functional Role of NaV1.7 in Human Nociception . Neuron vol. 101 , ( 5 ) 905 - 919.e8 .
Baskozos G, Dawes JM, Austin JS, Antunes-Martins A, McDermott L, Clark AJ, Trendafilova T, Lees JG et al. ( 2018 ) . Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury . Pain vol. 160 , ( 2 ) 463 - 485 .
Wilson ER, Kugathasan U, Abramov AY, Clark AJ, Bennett DLH, Reilly MM, Greensmith L, Kalmar B ( 2018 ) . Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro . Neurobiology of Disease vol. 117 , 1 - 14 .
Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J et al. ( 2018 ) . Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability . Neuron vol. 97 , ( 4 ) 806 - 822.e10 .
Clark AJ, Menendez G, AlQatari M, Patel N, Arstad E, Schiavo G, Koltzenburg M ( 2018 ) . Functional imaging in microfluidic chambers reveals sensory neuron sensitivity is differentially regulated between neuronal regions . Pain vol. 159 , ( 7 ) 1413 - 1425 .
Weir GA, Middleton SJ, Clark AJ, Daniel T, Khovanov N, McMahon SB, Bennett DL ( 2017 ) . Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source . Brain vol. 140 , ( 10 ) 2570 - 2585 .
Clark AJ, Kaller MS, Galino J, Willison HJ, Rinaldi S, Bennett DLH ( 2017 ) . Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination . Brain vol. 140 , ( 4 ) 898 - 913 .
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