Publications: Dr John Thornhill
Thornhill J, Orkin C, Cevik M
(
2023
)
.
Estimating the global impact of coronavirus disease 2019 on people living with HIV
.
Current Opinion in Infectious Diseases
vol.
36
,
(
1
)
20
-
25
.
Whitlock GG, Ahmed N, Nori A, Richardson D, Clarke E, Browne R, Doctor J, Williams A et al.
(
2022
)
.
Characteristics of HIV post-exposure prophylaxis recipients at six English sexual health clinics during COVID-19
.
HIV Medicine
vol.
23
,
(
10
)
1103
-
1107
.
Pace M, Ogbe A, Hurst J, Robinson N, Meyerowitz J, Olejniczak N, Thornhill JP, Jones M et al.
(
2022
)
.
Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
.
Frontiers in Immunology
vol.
13
,
Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A et al.
(
2022
)
.
Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022
.
New England Journal of Medicine
vol.
387
,
(
8
)
679
-
691
.
Paparini S, Whitacre R, Smuk M, Thornhill J, Mwendera C, Strachan S, Nutland W, Orkin C
(
2022
)
.
Public understanding, awareness, and response to monkeypox virus outbreak: A cross-sectional survey of the most affected communities in the United Kingdom during the 2022 public health emergency
.
Marques-Gomes J, Salt MJ, Pereira-Neto R, Barteldes F, Gouveia-Barros V, Carvalho A, d’Arminio-Monforte A, De-la-Torre-Rosas A et al.
(
2022
)
.
Development of the HIV360 international core set of outcome measures for adults living with HIV: A consensus process
.
HIV Medicine
vol.
23
,
(
6
)
639
-
649
.
Shaw J, Thornhill J
(
2022
)
.
Systemic manifestations of sexually transmitted infections
.
Medicine
vol.
50
,
(
Int J STD AIDS 32 2021
)
272
-
276
.
Reuschl AK, Mesner D, Shivkumar M, Whelan MVX, Pallett LJ, Guerra-Assunção JA, Madansein R, Dullabh KJ et al.
(
2022
)
.
HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
.
Cell Reports
vol.
39
,
(
2
)
Dhairyawan R, Milner A, Thornhill J, Kwardem L, Matin N, Orkin C, Deane K
(
2022
)
.
The acceptability of offering rapid antiretroviral therapy to people living with HIV in east London: a qualitative study
.
HIV MEDICINE
.
vol.
23
,
13
-
14
.
Lee MJ, Snell LB, Douthwaite ST, Fidler S, Fitzgerald N, Goodwin L, Hamzah L, Kulasegaram R et al.
(
2022
)
.
Clinical outcomes of patients with and without HIV hospitalized with COVID-19 in England during the early stages of the pandemic: a matched retrospective multi-centre analysis (RECEDE-C19 study)
.
HIV Medicine
vol.
23
,
(
2
)
121
-
133
.
Paparini S, Whitacre R, Smuk M, Thornhill J, Mwendera C, Strachan S, Nutland W, Orkin C
(
2022
)
.
Public understanding and awareness of and response to monkeypox virus outbreak: A cross-sectional survey of the most affected communities in the United Kingdom during the 2022 public health emergency
.
HIV Medicine
Reeves I, Cromarty B, Deayton J, Dhairyawan R, Kidd M, Taylor C, Thornhill J, Tickell-Painter M et al.
(
2021
)
.
British HIV Association guidelines for the management of HIV-2 2021
.
HIV Medicine
vol.
22
,
(
S4
)
1
-
29
.
Phetsouphanh C, Phalora P, Hackstein CP, Thornhill J, Munier ML, Meyerowitz J, Murray L, Vuuren CV et al.
(
2021
)
.
Human MAIT cells respond to and suppress HIV-1
.
eLife
vol.
10
,
Burns JE, Stöhr W, Kinloch-De Loes S, Fox J, Clarke A, Nelson M, Thornhill J, Babiker A et al.
(
2021
)
.
Tolerability of four-drug antiretroviral combination therapy in primary HIV-1 infection
.
HIV Medicine
vol.
22
,
(
8
)
770
-
774
.
Lee M, Fidler S, Fox J, Hamzah L, Kulasegaram R, Nori A, Palfreeman A, Thornhill J et al.
(
2021
)
.
Characteristics and outcomes of respiratory bacterial co-infections in HIV-positive inpatients admitted with COVID-19 compared to a matched HIV-negative cohort (RECEDE C-19 study)
.
HIV MEDICINE
.
vol.
22
,
118
-
119
.
Lee M, Smith C, Fidler S, Goodwin L, Hamzah L, Lawrence S, Marchant R, Palfreeman A et al.
(
2021
)
.
HIV and COVID-19 inpatient outcomes in England during the early pandemic: a matched retrospective multicentre analysis (RECEDE C-19 study)
.
HIV MEDICINE
.
vol.
22
,
6
-
7
.
Martin GE, Sen DR, Pace M, Robinson N, Meyerowitz J, Adland E, Thornhill JP, Jones M et al.
(
2021
)
.
Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy
.
Frontiers in Immunology
vol.
12
,
Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB et al.
(
2021
)
.
Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8<sup>+</sup> T cell antiviral responses
.
Cell Reports
vol.
35
,
(
6
)
Thornhill J, Orkin C
(
2021
)
.
Long-acting injectable HIV therapies: the next frontier: Republication
.
Current opinion in HIV and AIDS
vol.
16
,
(
2
)
98
-
105
.
Thornhill J, Orkin C
(
2021
)
.
Long-acting injectable HIV therapies: The next frontier
.
Current Opinion in Infectious Diseases
vol.
34
,
(
1
)
8
-
15
.
Reuschl A-K, Shivkumar M, Mesner D, Pallett L, Guerra-Assunção JA, Madansein R, Dullabh K, Sigal A et al.
(
2021
)
.
HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
.
Lee M, Smith C, Douthwaite S, Fidler S, Fitzgerald N, Goodwin L, Hamzah L, Kulasegaram R et al.
(
2021
)
.
Clinical Outcomes of Patients With and Without HIV Hospitalised with COVID-19 in England During the Early Stages of the Pandemic: A Matched Retrospective Multicentre Analysis (RECEDE-C19 Study)
.
Thornhill J, Dufaur L, Parry S, Dhairyawan R, Moir K, Cheserem E, Flanagan S, Matin N
(
2020
)
.
Use of immediate ART in late HIV presenters is feasible and efficacious in groups beyond MSM
.
HIV MEDICINE
.
vol.
21
,
22
-
23
.
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, McCoy LE, Griffith SA et al.
(
2020
)
.
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report
.
The Lancet HIV
vol.
7
,
(
5
)
e340
-
e347
.
Martin GE, Pace M, Shearer FM, Zilber E, Hurst J, Meyerowitz J, Thornhill JP, Lwanga J et al.
(
2020
)
.
Levels of human immunodeficiency virus dna are determined before art initiation and linked to CD8 T-cell activation and memory expansion
.
Journal of Infectious Diseases
vol.
221
,
(
7
)
1135
-
1145
.
Fidler S, Stöhr W, Pace M, Dorrell L, Lever A, Pett S, Kinloch-de Loes S, Fox J et al.
(
2020
)
.
Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial
.
The Lancet
vol.
395
,
(
10227
)
888
-
898
.
Thornhill JP, Lynch KD, Skelton JK, Dorner M, Khan M, Martin GE, Hoare J, Peake S et al.
(
2019
)
.
Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection
.
AIDS
vol.
33
,
(
14
)
2268
-
2271
.
Thornhill JP, Carolina H, Lewis H, Peake S, Hoare J, Fox J, Frater J, Fidler S
(
2019
)
.
HIV reservoir in gut from PHI treated individuals is stable over time and correlates with blood markers of HIV reservoir and inflammation- findings from the HEATHER gut study
.
HIV MEDICINE
.
vol.
20
,
40
-
42
.
Thornhill JP, Pace M, Martin GE, Hoare J, Peake S, Herrera C, Phetsouphanh C, Meyerowitz J et al.
(
2019
)
.
CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype
.
Mucosal Immunology
vol.
12
,
(
5
)
1212
-
1219
.
Martin GE, Pace M, Meyerowitz J, Thornhill JP, Lwanga J, Lewis H, Solano T, Bull R et al.
(
2019
)
.
8 Persistent elevation of Tim-3 and PD-1 on memory T cells despite early ART initiation during primary HIV infection
.
Journal of Virus Eradication
vol.
5
,
7
-
8
.
Thornhill J, Pace M, Martin G, Herrera C, Hoare J, Peake S, Brown H, Nwokolo N et al.
(
2019
)
.
CD32 expression identifies B cell-T cell doublets in gut-associated lymphoid tissue that are enriched for T follicular helper cells but not for HIV DNA
.
HIV MEDICINE
.
vol.
20
,
24
-
25
.
Thornhill J, Flanagan S, Moir K, Matin N
(
2019
)
.
The East London Immediate ART (ELIA) survey: attitudes and barriers to immediate ART initiation
.
HIV MEDICINE
.
vol.
20
,
71
-
72
.
Lwanga J, Martin G, Hamzah L, Thornhill J, Meyerowitz J, Nwokolo N, Frater J, Fidler S et al.
(
2019
)
.
The effect of time to viral suppression at primary HIV infection on long-term immunological recovery: results from the HEATHER cohort
.
HIV MEDICINE
.
vol.
20
,
7
-
8
.
Thornhill J, Herrera C, Hoare J, Peake S, Brown H, Nwokolo N, Fox J, Hanke T et al.
(
2019
)
.
The impact of vorinostat and therapeutic vaccine on gut HIV DNA: the RIVER gut study
.
HIV MEDICINE
.
vol.
20
,
7
-
7
.
Martin G, Pace M, Shearer F, Zilber E, Hurst J, Meyerowitz J, Thornhill J, Lwanga J et al.
(
2019
)
.
HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
.
Seers T, Vassallo P, Pollock K, Thornhill JP, Fidler S, Foster C
(
2018
)
.
CD4:CD8 ratio in children with perinatally acquired HIV-1 infection
.
HIV Medicine
vol.
19
,
(
9
)
668
-
672
.
Thornhill JP, Martin GE, Hoare J, Peake S, Pace M, Meyerowitz J, Lwanga J, Lewis H et al.
(
2018
)
.
Follicular CD8+T-cells in gut-associated lymphoid tissue are associated with lower HIV-1 reservoir in the terminal ileum after ART initiated during primary HIV infection
.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
.
vol.
21
,
96
-
96
.
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N et al.
(
2018
)
.
CD32-expressing CD4 T cells are phenotypically diverse and can contain proviral HIV DNA
.
Frontiers in Immunology
vol.
9
,
(
MAY
)
Thornhill J, Martin G, Pace M, Lewis H, Brown H, Peake S, Hoare J, Fidler S et al.
(
2018
)
.
CD32 is enriched on CD4(+) T-cells with a T-follicular
.
HIV MEDICINE
.
vol.
19
,
S10
-
S10
.
Thornhill J, Hoare J, Peake S, Khan M, Williamson K, Murray C, Frater J, Kinloch S et al.
(
2018
)
.
Two case reports on safety and impact of alpha 4 beta 7 integrin monoclonal antibody in treated primary HIV infection on HIV reservoirs OVERRIDE
.
HIV MEDICINE
.
vol.
19
,
S41
-
S41
.
Fidler S, Lewis H, Meyerowitz J, Kuldanek K, Thornhill J, Muir D, Bonnissent A, Timson G et al.
(
2017
)
.
A pilot evaluation of whole blood finger-prick sampling for point-of-care HIV viral load measurement: The UNICORN study
.
Scientific Reports
vol.
7
,
(
1
)
Martin G, Pace M, Thornhill J, Phetsouphanh C, Meyerowitz J, Gossez M, Hopkins E, Brown H et al.
(
2017
)
.
Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue
.
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Hopkins E, Meyerowitz J, Nwokolo N, Fox J et al.
(
2017
)
.
Enrichment of the HIV reservoir in CD32+CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression
.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
.
vol.
20
,
103
-
103
.
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Hopkins E, Meyerowitz J, Nwokolo N, Fox J et al.
(
2017
)
.
OA1-2 Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression
.
Journal of Virus Eradication
vol.
3
,
1
-
2
.
Thornhill J, Fidler S, Martin G, Meyerowitz J, Jones M, Frater J, Porter K, Nwokolo N et al.
(
2017
)
.
Diagnosis of primary HIV infection with rapid ART in the HEATHER cohort: towards zero infections
.
HIV MEDICINE
.
vol.
18
,
23
-
24
.
Thornhill J, Herrera C, Olejniczak N, Fidler S, Frater J, Martin G, Hopkins E
(
2017
)
.
Impact of ART in primary HIV infection on T cell immune exhaustion in gut-associated lymphoid tissue: implications for HIV persistence
.
HIV MEDICINE
.
vol.
18
,
6
-
6
.
Fidler S, Olson AD, Bucher HC, Fox J, Thornhill J, Morrison C, Muga R, Phillips A et al.
(
2017
)
.
Virological blips and predictors of post treatment viral control after stopping ART started in primary HIV infection
.
Journal of Acquired Immune Deficiency Syndromes
vol.
74
,
(
2
)
126
-
133
.
Thornhill JP, Fidler S, Klenerman P, Frater J, Phetsouphanh C
(
2017
)
.
The role of CD4+ T follicular helper cells in HIV infection: From the germinal center to the periphery
.
Frontiers in Immunology
vol.
8
,
(
JAN
)
Thornhill J, Inshaw J, Kaleebu P, Cooper D, Ramjee G, Schechter M, Tambussi G, Fox J et al.
(
2016
)
.
Brief Report: Enhanced Normalization of CD4/CD8 Ratio with Earlier Antiretroviral Therapy at Primary HIV Infection
.
Journal of Acquired Immune Deficiency Syndromes
vol.
73
,
(
1
)
69
-
73
.
Thornhill J, Underwood J, Kuldanek K, Mahay K, Fidler S, Frater J, Hopkins E, Meyerowitz J et al.
(
2016
)
.
Impact of timing of ART on HIV DNA; findings from HEATHER, an observational cohort study
.
HIV MEDICINE
.
vol.
17
,
11
-
11
.
Thornhill J, Frater J, Fidler S
(
2015
)
.
Post-treatment control: A functional cure for HIV
.
Future Virology
vol.
10
,
(
11
)
1245
-
1256
.
Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C et al.
(
2015
)
.
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
.
Nature Communications
vol.
6
,
Fidler S, Thornhill J, Malatinkova E, Reinhard R, Lamplough R, Ananworanich J, Chahroudi A
(
2015
)
.
IAS Towards an HIV Cure Symposium: people focused, science driven: 18-19 July 2015, Vancouver, Canada
.
J Virus Erad
vol.
1
,
(
4
)
276
-
281
.
Thornhill J, Sivaramakrishnan A, Orkin C
(
2015
)
.
Pneumococcal vaccination in people living with HIV
.
Vaccine
vol.
33
,
(
28
)
3159
-
3160
.
Wallis E, Thornhill J, Saunders J, Orkin C
(
2015
)
.
Introducing opt-out HIV testing in an acute medical admissions unit: Does it improve testing uptake in those with lobar pneumonia?
.
Sexually Transmitted Infections
vol.
91
,
(
3
)
Mahay K, Kuldanek K, Thornhill J, Fidler S
(
2015
)
.
Approaches to recruitment of patients presenting with Primary HIV Infection (PHI) into clinical studies
.
HIV MEDICINE
.
vol.
16
,
69
-
69
.
Thornhill J, Haidari G, Entwistle OH, Mahay K, Kuldanek K, Fidler S, Dosekun O, Mackie N et al.
(
2015
)
.
Uptake of immediate antiretroviral therapy in primary HIV infection: To treat or not to treat?
.
HIV MEDICINE
.
vol.
16
,
36
-
36
.
Thornhill J, Fidler S, Frater J
(
2015
)
.
Advancing the HIV cure agenda: The next 5 years
.
Current Opinion in Infectious Diseases
vol.
28
,
(
1
)
1
-
9
.
Thornhill J, Mandersloot G, Bath R, Orkin C
(
2014
)
.
Opt-out HIV testing in adult critical care units (vol 383, pg 1460, 2014)
.
LANCET
vol.
383
,
(
9930
)
1720
-
1720
.
Thornhill J, Inshaw J, Oomeer S, Kaleebu P, Cooper D, Ramjee G, Schechter M, Tambussi G et al.
(
2014
)
.
Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection
.
J Int AIDS Soc
vol.
17
,
(
4 Suppl 3
)
Thornhill J, Mandersloot G, Bath R, Orkin C
(
2014
)
.
Erratum: Opt-out HIV testing in adult critical care units (Lancet (2014) 383 (1460))
.
The Lancet
vol.
383
,
(
9930
)
Thornhill J, Mandersloot G, Bath R, Orkin C
(
2014
)
.
Opt-out HIV testing in adult critical care units
.
The Lancet
vol.
383
,
(
9927
)
Fidler S, Olson A, Fox J, Phillips A, Morrison C, Thornhill J, Bucher H, Muga R et al.
(
2014
)
.
The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART
.
J Int AIDS Soc
vol.
17
,
(
4 Suppl 3
)
Thornhill J, Wallis E, Cho S, Khan P, Sivaramakrishnan A, Amin A, Orkin C
(
2013
)
.
Cross-sectional analysis of invasive pneumococcal disease in a London HIV-positive cohort
.
HIV MEDICINE
.
vol.
14
,
67
-
67
.
Wijeyekoon S, Thornhill J, Nathan M
(
2013
)
.
49. 1-, 5- and 10-year high-grade disease-free survival after laser ablation of biopsy proven AIN2/3: outcomes from a single centre prospective cohort
.
Sexual Health
.
vol.
10
,
Cresswell F, Gothard A, Cevik M, Haidari G, Alexander H, Katsarolis I, McGinty T, Wolujewic A et al.
(
2013
)
.
Safety and efficacy of rilpivirine-tenofovir-emtricitabine (Eviplera (R)) in hepatitis C-HIV coinfection
.
ANTIVIRAL THERAPY
.
vol.
18
,
A61
-
A61
.
Thornhill J, Aboud M
(
2012
)
.
Letter to the editors
.
International Journal of STD and AIDS
vol.
23
,
(
10
)
Thornhill J, Reeves I
(
2012
)
.
A question of potency? reasons for switching from atazanavir to darunavir in a London HIV cohort
.
HIV MEDICINE
.
vol.
13
,
75
-
75
.
Thornhill J, Browne R, Nageswaran A
(
2012
)
.
Management of stable HIV patients in a community based satellite outpatient HIV service - an appropriate model of care
.
HIV MEDICINE
.
vol.
13
,
18
-
18
.
Thornhill J, Jit M, Klein K, Hickey N, Awosika D, Singh N, Sheaff M, Nathan M
(
2012
)
.
Treatment of anal intraepithelial neoplasia and prevention of anal carcinoma
.
HIV MEDICINE
.
vol.
13
,
32
-
32
.
Thornhill J, Kazi S, Aboud M
(
2010
)
.
Timing of antiretrovirals in opportunistic infections - how are we doing?
.
HIV MEDICINE
.
vol.
11
,
60
-
60
.
Jackson A, O'Shea D, de Barra E, Farrell G, Thornhill J, Mulcahy F, Bergin C
(
2008
)
.
Continuing Evidence Supporting the Role of Early Kinetic Monitoring (RVR) in Predicting SVR for HIV/HCV Coinfected Patients
.
International Journal of Infectious Diseases
.
vol.
12
,
Colevas AD, Read R, Thornhill J, Adak S, Tishler R, Busse P, Li Y, Posner M
(
2001
)
.
Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck
.
Int J Radiat Oncol Biol Phys
vol.
51
,
(
3
)
599
-
604
.