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Research

Publications: Dr John Thornhill

Whitlock GG, Ahmed N, Nori A, Richardson D, Clarke E, Browne R, Doctor J, Williams A et al. ( 2022 ) . Characteristics of HIV post-exposure prophylaxis recipients at six English sexual health clinics during COVID-19 . HIV Medicine vol. 23 , ( 10 ) 1103 - 1107 .
Pace M, Ogbe A, Hurst J, Robinson N, Meyerowitz J, Olejniczak N, Thornhill JP, Jones M et al. ( 2022 ) . Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption . Frontiers in Immunology vol. 13 ,
Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A et al. ( 2022 ) . Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022 . New England Journal of Medicine vol. 387 , ( 8 ) 679 - 691 .
Marques-Gomes J, Salt MJ, Pereira-Neto R, Barteldes F, Gouveia-Barros V, Carvalho A, d’Arminio-Monforte A, De-la-Torre-Rosas A et al. ( 2022 ) . Development of the HIV360 international core set of outcome measures for adults living with HIV: A consensus process . HIV Medicine vol. 23 , ( 6 ) 639 - 649 .
Shaw J, Thornhill J ( 2022 ) . Systemic manifestations of sexually transmitted infections . Medicine vol. 50 , ( Int J STD AIDS 32 2021 ) 272 - 276 .
Reuschl AK, Mesner D, Shivkumar M, Whelan MVX, Pallett LJ, Guerra-Assunção JA, Madansein R, Dullabh KJ et al. ( 2022 ) . HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells . Cell Reports vol. 39 , ( 2 )
Dhairyawan R, Milner A, Thornhill J, Kwardem L, Matin N, Orkin C, Deane K ( 2022 ) . The acceptability of offering rapid antiretroviral therapy to people living with HIV in east London: a qualitative study . HIV MEDICINE . vol. 23 , 13 - 14 .
Lee MJ, Snell LB, Douthwaite ST, Fidler S, Fitzgerald N, Goodwin L, Hamzah L, Kulasegaram R et al. ( 2022 ) . Clinical outcomes of patients with and without HIV hospitalized with COVID-19 in England during the early stages of the pandemic: a matched retrospective multi-centre analysis (RECEDE-C19 study) . HIV Medicine vol. 23 , ( 2 ) 121 - 133 .
Reeves I, Cromarty B, Deayton J, Dhairyawan R, Kidd M, Taylor C, Thornhill J, Tickell-Painter M et al. ( 2021 ) . British HIV Association guidelines for the management of HIV-2 2021 . HIV Medicine vol. 22 , ( S4 ) 1 - 29 .
Phetsouphanh C, Phalora P, Hackstein CP, Thornhill J, Munier ML, Meyerowitz J, Murray L, Vuuren CV et al. ( 2021 ) . Human MAIT cells respond to and suppress HIV-1 . eLife vol. 10 ,
Burns JE, Stöhr W, Kinloch-De Loes S, Fox J, Clarke A, Nelson M, Thornhill J, Babiker A et al. ( 2021 ) . Tolerability of four-drug antiretroviral combination therapy in primary HIV-1 infection . HIV Medicine vol. 22 , ( 8 ) 770 - 774 .
Lee M, Fidler S, Fox J, Hamzah L, Kulasegaram R, Nori A, Palfreeman A, Thornhill J et al. ( 2021 ) . Characteristics and outcomes of respiratory bacterial co-infections in HIV-positive inpatients admitted with COVID-19 compared to a matched HIV-negative cohort (RECEDE C-19 study) . HIV MEDICINE . vol. 22 , 118 - 119 .
Lee M, Smith C, Fidler S, Goodwin L, Hamzah L, Lawrence S, Marchant R, Palfreeman A et al. ( 2021 ) . HIV and COVID-19 inpatient outcomes in England during the early pandemic: a matched retrospective multicentre analysis (RECEDE C-19 study) . HIV MEDICINE . vol. 22 , 6 - 7 .
Martin GE, Sen DR, Pace M, Robinson N, Meyerowitz J, Adland E, Thornhill JP, Jones M et al. ( 2021 ) . Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy . Frontiers in Immunology vol. 12 ,
Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB et al. ( 2021 ) . Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8<sup>+</sup> T cell antiviral responses . Cell Reports vol. 35 , ( 6 )
Thornhill J, Orkin C ( 2021 ) . Long-acting injectable HIV therapies: the next frontier: Republication . Current opinion in HIV and AIDS vol. 16 , ( 2 ) 98 - 105 .
Thornhill J, Orkin C ( 2021 ) . Long-acting injectable HIV therapies: The next frontier . Current Opinion in Infectious Diseases vol. 34 , ( 1 ) 8 - 15 .
Reuschl A-K, Shivkumar M, Mesner D, Pallett L, Guerra-Assunção JA, Madansein R, Dullabh K, Sigal A et al. ( 2021 ) . HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells .
Lee M, Smith C, Douthwaite S, Fidler S, Fitzgerald N, Goodwin L, Hamzah L, Kulasegaram R et al. ( 2021 ) . Clinical Outcomes of Patients With and Without HIV Hospitalised with COVID-19 in England During the Early Stages of the Pandemic: A Matched Retrospective Multicentre Analysis (RECEDE-C19 Study) .
Thornhill J, Dufaur L, Parry S, Dhairyawan R, Moir K, Cheserem E, Flanagan S, Matin N ( 2020 ) . Use of immediate ART in late HIV presenters is feasible and efficacious in groups beyond MSM . HIV MEDICINE . vol. 21 , 22 - 23 .
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, McCoy LE, Griffith SA et al. ( 2020 ) . Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report . The Lancet HIV vol. 7 , ( 5 ) e340 - e347 .
Martin GE, Pace M, Shearer FM, Zilber E, Hurst J, Meyerowitz J, Thornhill JP, Lwanga J et al. ( 2020 ) . Levels of human immunodeficiency virus dna are determined before art initiation and linked to CD8 T-cell activation and memory expansion . Journal of Infectious Diseases vol. 221 , ( 7 ) 1135 - 1145 .
Fidler S, Stöhr W, Pace M, Dorrell L, Lever A, Pett S, Kinloch-de Loes S, Fox J et al. ( 2020 ) . Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial . The Lancet vol. 395 , ( 10227 ) 888 - 898 .
Thornhill JP, Lynch KD, Skelton JK, Dorner M, Khan M, Martin GE, Hoare J, Peake S et al. ( 2019 ) . Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection . AIDS vol. 33 , ( 14 ) 2268 - 2271 .
Thornhill JP, Carolina H, Lewis H, Peake S, Hoare J, Fox J, Frater J, Fidler S ( 2019 ) . HIV reservoir in gut from PHI treated individuals is stable over time and correlates with blood markers of HIV reservoir and inflammation- findings from the HEATHER gut study . HIV MEDICINE . vol. 20 , 40 - 42 .
Thornhill JP, Pace M, Martin GE, Hoare J, Peake S, Herrera C, Phetsouphanh C, Meyerowitz J et al. ( 2019 ) . CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype . Mucosal Immunology vol. 12 , ( 5 ) 1212 - 1219 .
Martin GE, Pace M, Meyerowitz J, Thornhill JP, Lwanga J, Lewis H, Solano T, Bull R et al. ( 2019 ) . 8 Persistent elevation of Tim-3 and PD-1 on memory T cells despite early ART initiation during primary HIV infection . Journal of Virus Eradication vol. 5 , 7 - 8 .
Thornhill J, Pace M, Martin G, Herrera C, Hoare J, Peake S, Brown H, Nwokolo N et al. ( 2019 ) . CD32 expression identifies B cell-T cell doublets in gut-associated lymphoid tissue that are enriched for T follicular helper cells but not for HIV DNA . HIV MEDICINE . vol. 20 , 24 - 25 .
Thornhill J, Flanagan S, Moir K, Matin N ( 2019 ) . The East London Immediate ART (ELIA) survey: attitudes and barriers to immediate ART initiation . HIV MEDICINE . vol. 20 , 71 - 72 .
Lwanga J, Martin G, Hamzah L, Thornhill J, Meyerowitz J, Nwokolo N, Frater J, Fidler S et al. ( 2019 ) . The effect of time to viral suppression at primary HIV infection on long-term immunological recovery: results from the HEATHER cohort . HIV MEDICINE . vol. 20 , 7 - 8 .
Thornhill J, Herrera C, Hoare J, Peake S, Brown H, Nwokolo N, Fox J, Hanke T et al. ( 2019 ) . The impact of vorinostat and therapeutic vaccine on gut HIV DNA: the RIVER gut study . HIV MEDICINE . vol. 20 , 7 - 7 .
Martin G, Pace M, Shearer F, Zilber E, Hurst J, Meyerowitz J, Thornhill J, Lwanga J et al. ( 2019 ) . HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion .
Seers T, Vassallo P, Pollock K, Thornhill JP, Fidler S, Foster C ( 2018 ) . CD4:CD8 ratio in children with perinatally acquired HIV-1 infection . HIV Medicine vol. 19 , ( 9 ) 668 - 672 .
Thornhill JP, Martin GE, Hoare J, Peake S, Pace M, Meyerowitz J, Lwanga J, Lewis H et al. ( 2018 ) . Follicular CD8+T-cells in gut-associated lymphoid tissue are associated with lower HIV-1 reservoir in the terminal ileum after ART initiated during primary HIV infection . JOURNAL OF THE INTERNATIONAL AIDS SOCIETY . vol. 21 , 96 - 96 .
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N et al. ( 2018 ) . CD32-expressing CD4 T cells are phenotypically diverse and can contain proviral HIV DNA . Frontiers in Immunology vol. 9 , ( MAY )
Thornhill J, Martin G, Pace M, Lewis H, Brown H, Peake S, Hoare J, Fidler S et al. ( 2018 ) . CD32 is enriched on CD4(+) T-cells with a T-follicular . HIV MEDICINE . vol. 19 , S10 - S10 .
Thornhill J, Hoare J, Peake S, Khan M, Williamson K, Murray C, Frater J, Kinloch S et al. ( 2018 ) . Two case reports on safety and impact of alpha 4 beta 7 integrin monoclonal antibody in treated primary HIV infection on HIV reservoirs OVERRIDE . HIV MEDICINE . vol. 19 , S41 - S41 .
Fidler S, Lewis H, Meyerowitz J, Kuldanek K, Thornhill J, Muir D, Bonnissent A, Timson G et al. ( 2017 ) . A pilot evaluation of whole blood finger-prick sampling for point-of-care HIV viral load measurement: The UNICORN study . Scientific Reports vol. 7 , ( 1 )
Martin G, Pace M, Thornhill J, Phetsouphanh C, Meyerowitz J, Gossez M, Hopkins E, Brown H et al. ( 2017 ) . Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue .
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Hopkins E, Meyerowitz J, Nwokolo N, Fox J et al. ( 2017 ) . Enrichment of the HIV reservoir in CD32+CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression . JOURNAL OF THE INTERNATIONAL AIDS SOCIETY . vol. 20 , 103 - 103 .
Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Hopkins E, Meyerowitz J, Nwokolo N, Fox J et al. ( 2017 ) . OA1-2 Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression . Journal of Virus Eradication vol. 3 , 1 - 2 .
Thornhill J, Fidler S, Martin G, Meyerowitz J, Jones M, Frater J, Porter K, Nwokolo N et al. ( 2017 ) . Diagnosis of primary HIV infection with rapid ART in the HEATHER cohort: towards zero infections . HIV MEDICINE . vol. 18 , 23 - 24 .
Thornhill J, Herrera C, Olejniczak N, Fidler S, Frater J, Martin G, Hopkins E ( 2017 ) . Impact of ART in primary HIV infection on T cell immune exhaustion in gut-associated lymphoid tissue: implications for HIV persistence . HIV MEDICINE . vol. 18 , 6 - 6 .
Fidler S, Olson AD, Bucher HC, Fox J, Thornhill J, Morrison C, Muga R, Phillips A et al. ( 2017 ) . Virological blips and predictors of post treatment viral control after stopping ART started in primary HIV infection . Journal of Acquired Immune Deficiency Syndromes vol. 74 , ( 2 ) 126 - 133 .
Thornhill JP, Fidler S, Klenerman P, Frater J, Phetsouphanh C ( 2017 ) . The role of CD4+ T follicular helper cells in HIV infection: From the germinal center to the periphery . Frontiers in Immunology vol. 8 , ( JAN )
Thornhill J, Inshaw J, Kaleebu P, Cooper D, Ramjee G, Schechter M, Tambussi G, Fox J et al. ( 2016 ) . Brief Report: Enhanced Normalization of CD4/CD8 Ratio with Earlier Antiretroviral Therapy at Primary HIV Infection . Journal of Acquired Immune Deficiency Syndromes vol. 73 , ( 1 ) 69 - 73 .
Thornhill J, Underwood J, Kuldanek K, Mahay K, Fidler S, Frater J, Hopkins E, Meyerowitz J et al. ( 2016 ) . Impact of timing of ART on HIV DNA; findings from HEATHER, an observational cohort study . HIV MEDICINE . vol. 17 , 11 - 11 .
Thornhill J, Frater J, Fidler S ( 2015 ) . Post-treatment control: A functional cure for HIV . Future Virology vol. 10 , ( 11 ) 1245 - 1256 .
Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C et al. ( 2015 ) . Immunological biomarkers predict HIV-1 viral rebound after treatment interruption . Nature Communications vol. 6 ,
Fidler S, Thornhill J, Malatinkova E, Reinhard R, Lamplough R, Ananworanich J, Chahroudi A ( 2015 ) . IAS Towards an HIV Cure Symposium: people focused, science driven: 18-19 July 2015, Vancouver, Canada . J Virus Erad vol. 1 , ( 4 ) 276 - 281 .
Thornhill J, Sivaramakrishnan A, Orkin C ( 2015 ) . Pneumococcal vaccination in people living with HIV . Vaccine vol. 33 , ( 28 ) 3159 - 3160 .
Wallis E, Thornhill J, Saunders J, Orkin C ( 2015 ) . Introducing opt-out HIV testing in an acute medical admissions unit: Does it improve testing uptake in those with lobar pneumonia? . Sexually Transmitted Infections vol. 91 , ( 3 )
Mahay K, Kuldanek K, Thornhill J, Fidler S ( 2015 ) . Approaches to recruitment of patients presenting with Primary HIV Infection (PHI) into clinical studies . HIV MEDICINE . vol. 16 , 69 - 69 .
Thornhill J, Haidari G, Entwistle OH, Mahay K, Kuldanek K, Fidler S, Dosekun O, Mackie N et al. ( 2015 ) . Uptake of immediate antiretroviral therapy in primary HIV infection: To treat or not to treat? . HIV MEDICINE . vol. 16 , 36 - 36 .
Thornhill J, Fidler S, Frater J ( 2015 ) . Advancing the HIV cure agenda: The next 5 years . Current Opinion in Infectious Diseases vol. 28 , ( 1 ) 1 - 9 .
Thornhill J, Mandersloot G, Bath R, Orkin C ( 2014 ) . Opt-out HIV testing in adult critical care units (vol 383, pg 1460, 2014) . LANCET vol. 383 , ( 9930 ) 1720 - 1720 .
Thornhill J, Inshaw J, Oomeer S, Kaleebu P, Cooper D, Ramjee G, Schechter M, Tambussi G et al. ( 2014 ) . Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection . J Int AIDS Soc vol. 17 , ( 4 Suppl 3 )
Thornhill J, Mandersloot G, Bath R, Orkin C ( 2014 ) . Erratum: Opt-out HIV testing in adult critical care units (Lancet (2014) 383 (1460)) . The Lancet vol. 383 , ( 9930 )
Thornhill J, Mandersloot G, Bath R, Orkin C ( 2014 ) . Opt-out HIV testing in adult critical care units . The Lancet vol. 383 , ( 9927 )
Fidler S, Olson A, Fox J, Phillips A, Morrison C, Thornhill J, Bucher H, Muga R et al. ( 2014 ) . The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART . J Int AIDS Soc vol. 17 , ( 4 Suppl 3 )
Thornhill J, Wallis E, Cho S, Khan P, Sivaramakrishnan A, Amin A, Orkin C ( 2013 ) . Cross-sectional analysis of invasive pneumococcal disease in a London HIV-positive cohort . HIV MEDICINE . vol. 14 , 67 - 67 .
Wijeyekoon S, Thornhill J, Nathan M ( 2013 ) . 49. 1-, 5- and 10-year high-grade disease-free survival after laser ablation of biopsy proven AIN2/3: outcomes from a single centre prospective cohort . Sexual Health . vol. 10 ,
Cresswell F, Gothard A, Cevik M, Haidari G, Alexander H, Katsarolis I, McGinty T, Wolujewic A et al. ( 2013 ) . Safety and efficacy of rilpivirine-tenofovir-emtricitabine (Eviplera (R)) in hepatitis C-HIV coinfection . ANTIVIRAL THERAPY . vol. 18 , A61 - A61 .
Thornhill J, Aboud M ( 2012 ) . Letter to the editors . International Journal of STD and AIDS vol. 23 , ( 10 )
Thornhill J, Reeves I ( 2012 ) . A question of potency? reasons for switching from atazanavir to darunavir in a London HIV cohort . HIV MEDICINE . vol. 13 , 75 - 75 .
Thornhill J, Browne R, Nageswaran A ( 2012 ) . Management of stable HIV patients in a community based satellite outpatient HIV service - an appropriate model of care . HIV MEDICINE . vol. 13 , 18 - 18 .
Thornhill J, Jit M, Klein K, Hickey N, Awosika D, Singh N, Sheaff M, Nathan M ( 2012 ) . Treatment of anal intraepithelial neoplasia and prevention of anal carcinoma . HIV MEDICINE . vol. 13 , 32 - 32 .
Thornhill J, Kazi S, Aboud M ( 2010 ) . Timing of antiretrovirals in opportunistic infections - how are we doing? . HIV MEDICINE . vol. 11 , 60 - 60 .
Jackson A, O'Shea D, de Barra E, Farrell G, Thornhill J, Mulcahy F, Bergin C ( 2008 ) . Continuing Evidence Supporting the Role of Early Kinetic Monitoring (RVR) in Predicting SVR for HIV/HCV Coinfected Patients . International Journal of Infectious Diseases . vol. 12 ,
Colevas AD, Read R, Thornhill J, Adak S, Tishler R, Busse P, Li Y, Posner M ( 2001 ) . Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck . Int J Radiat Oncol Biol Phys vol. 51 , ( 3 ) 599 - 604 .