Publications: Prof Claudia Langenberg

Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ et al. ( 2023 ) . Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene . Nature Communications vol. 14 , ( 1 )

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Proteogenomic links to human metabolic diseases . Nat Metab

Xu F, Yu EYW, Cai X, Yue L, Jing LP, Liang X, Fu Y, Miao Z et al. ( 2023 ) . Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility . Nature communications vol. 14 , ( 1 )

Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Li T, Twait EL, May-Wilson S et al. ( 2023 ) . Genetic mechanisms of 184 neuro-related proteins in human plasma . medRxiv

Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A et al. ( 2023 ) . Loci for insulin processing and secretion provide insight into type 2 diabetes risk . American journal of human genetics vol. 110 , ( 2 ) 284 - 299 .

Zhao J, Stewart ID, Baird D, Mason D, Wright J, Zheng J, Gaunt TR, Evans DM et al. ( 2023 ) . Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study . eBioMedicine vol. 88 ,

Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E et al. ( 2023 ) . Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults . Diabetes Care

Vernardis SI, Demichev V, Lemke O, Grüning N-M, Messner C, White M, Pietzner M, Peluso A et al. ( 2023 ) . The impact of acute nutritional interventions on the plasma proteome . J Clin Endocrinol Metab

Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH et al. ( 2023 ) . Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases . Nature Genetics vol. 55 , ( 1 ) 44 - 53 .

Kuan V, Denaxas S, Patalay P, Nitsch D, Mathur R, Gonzalez-Izquierdo A, Sofat R, Partridge L et al. ( 2023 ) . Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study . The Lancet Digital Health vol. 5 , ( 1 ) e16 - e27 .

Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ et al. ( 2022 ) . Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes . Cell Genomics vol. 2 , ( 12 )

Butler-Laporte G, Gonzalez-Kozlova E, Su CY, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals (Clinical Proteomics, (2022), 19, 1, (34), 10.1186/s12014-022-09371-z) . Clinical Proteomics vol. 19 , ( 1 )

Pietzner M, Chua RL, Wheeler E, Jechow K, Willett JDS, Radbruch H, Trump S, Heidecker B et al. ( 2022 ) . ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 . Nature Communications vol. 13 , ( 1 )

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C et al. ( 2022 ) . Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes . Clinical Epigenetics vol. 14 , ( 1 )

Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S et al. ( 2022 ) . Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses . Circulation vol. 146 , ( 20 ) 1507 - 1517 .

Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier zu Belzen J, Loock L et al. ( 2022 ) . Metabolomic profiles predict individual multidisease outcomes . Nature Medicine vol. 28 , ( 11 ) 2309 - 2320 .

Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M et al. ( 2022 ) . Proteomic signatures for identification of impaired glucose tolerance . Nature Medicine vol. 28 , ( 11 ) 2293 - 2300 .

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF et al. ( 2022 ) . Rare and common genetic determinants of metabolic individuality and their effects on human health . Nature Medicine vol. 28 , ( 11 ) 2321 - 2332 .

Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals . Clin Proteomics vol. 19 , ( 1 )

P K, ID S, RS K, M S, K M, A D, DI S, SH C et al. ( 2022 ) . Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma .

Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, Ekelund U, Aleksandrova K et al. ( 2022 ) . Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study . European journal of preventive cardiology vol. 29 , ( 12 ) 1618 - 1629 .

Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS et al. ( 2022 ) . Detection and characterization of male sex chromosome abnormalities in the UK Biobank study . Genetics in Medicine vol. 24 , ( 9 ) 1909 - 1919 .

Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S et al. ( 2022 ) . Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention . Nature Genetics vol. 54 , ( 9 ) 1332 - 1344 .

Kelly RS, Stewart ID, Bayne H, Kachroo P, Spiro A, Vokonas P, Sparrow D, Weiss ST et al. ( 2022 ) . Metabolomic differences in lung function metrics: evidence from two cohorts . Thorax vol. 77 , ( 9 ) 919 - 928 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison N, Wareham N, Pietzner M, Langenberg C ( 2022 ) . From genome to phenome via the proteome: broad capture, antibody-based proteomics to explore disease mechanisms .

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al. ( 2022 ) . Author Correction: Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma (Nature Medicine, (2022), 28, 4, (814-822), 10.1038/s41591-022-01714-5) . Nature Medicine vol. 28 , ( 8 )

Li C, Imamura F, Wedekind R, Stewart ID, Pietzner M, Wheeler E, Forouhi NG, Langenberg C et al. ( 2022 ) . Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention . American Journal of Clinical Nutrition vol. 116 , ( 2 ) 511 - 522 .

Taylor K, McBride N, Zhao J, Oddie S, Azad R, Wright J, Andreassen OA, Stewart ID et al. ( 2022 ) . The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses . Journal of Cardiovascular Development and Disease vol. 9 , ( 8 )

Kuo FC, Neville MJ, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans LBL, van Dam AD, Loh NY et al. ( 2022 ) . HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution . Cell Reports vol. 40 , ( 4 )

Dam V, Onland-Moret NC, Burgess S, Chirlaque MD, Peters SAE, Schuit E, Tikk K, Weiderpass E et al. ( 2022 ) . Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization . Journal of Clinical Endocrinology and Metabolism vol. 107 , ( 7 ) E2952 - E2961 .

Bomba L, Walter K, Guo Q, Surendran P, Kundu K, Nongmaithem S, Karim MA, Stewart ID et al. ( 2022 ) . Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites . American Journal of Human Genetics vol. 109 , ( 6 ) 1038 - 1054 .

Temprano-Sagrera G, Sitlani CM, Bone WP, Martin-Bornez M, Voight BF, Morrison AC, Damrauer SM, de Vries PS et al. ( 2022 ) . Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations . Journal of Thrombosis and Haemostasis vol. 20 , ( 6 ) 1331 - 1349 .

Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N et al. ( 2022 ) . Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases . JCI Insight vol. 7 , ( 10 )

Yang Z, MacDonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N et al. ( 2022 ) . Genetic Landscape of the ACE2 Coronavirus Receptor . Circulation vol. 145 , ( 18 ) 1398 - 1411 .

LI Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Quynh Nguyen N, Scherer N et al. ( 2022 ) . MO048: Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases . Nephrology Dialysis Transplantation vol. 37 , ( Supplement_3 )

Murphy N, Song M, Papadimitriou N, Carreras-Torres R, Langenberg C, Martin RM, Tsilidis KK, Barroso I et al. ( 2022 ) . Associations between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis . Journal of the National Cancer Institute vol. 114 , ( 5 ) 740 - 752 .

John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH et al. ( 2022 ) . Genetic Associations and Architecture of Asthma-COPD Overlap . Chest vol. 161 , ( 5 ) 1155 - 1166 .

Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S et al. ( 2022 ) . Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation . Nature Genetics vol. 54 , ( 5 ) 560 - 572 .

Zhao J, Stewart I, Baird D, Mason D, Wright J, Zheng J, Gaunt T, Evans D et al. ( 2022 ) . Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study .

Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, Griffin JD, Patel S et al. ( 2022 ) . Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution . Journal of Clinical Endocrinology and Metabolism vol. 107 , ( 4 ) 1065 - 1077 .

Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al. ( 2022 ) . Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma . Nature Medicine vol. 28 , ( 4 ) 814 - 822 .

Gardner E, Kentistou K, Stankovic S, Lockhart S, Wheeler E, Day F, Kerrison N, Wareham N et al. ( 2022 ) . Damaging missense variants in <i>IGF1R</i> implicate a role for IGF-1 resistance in the aetiology of type 2 diabetes .

Warren H, Edwards T, Vaez A, Keaton J, Kamali Z, Xie T, Ani A, Evangelou E et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure .

Taylor K, McBride N, Zhao J, Oddie S, Azad R, Wright J, Andreassen O, Stewart I et al. ( 2022 ) . The relationship of maternal gestational mass spectrometry-derived metabolites with offspring congenital heart disease: results from multivariable and Mendelian randomization analyses .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen A et al. ( 2022 ) . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature

Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM ( 2022 ) . Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses . Schizophrenia Bulletin Open vol. 3 , ( 1 )

Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke S, Bhatti KF et al. ( 2021 ) . Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis .

Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke S et al. ( 2021 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids .

Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al. ( 2021 ) . Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection (Nature Communications, (2020), 11, 1, (6397), 10.1038/s41467-020-19996-z) . Nature Communications vol. 12 , ( 1 )

Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR, Allara E et al. ( 2021 ) . Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses . The Lancet Diabetes and Endocrinology vol. 9 , ( 12 ) 837 - 846 .

Zhao Y, Stankovic S, Koprulu M, Wheeler E, Day FR, Lango Allen H, Kerrison ND, Pietzner M et al. ( 2021 ) . GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health . Nature Communications vol. 12 , ( 1 )

Bonelli R, Ansell BRE, Lotta L, Scerri T, Clemons TE, Leung I, Peto T, Bird AC et al. ( 2021 ) . Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression . Genome Medicine vol. 13 , ( 1 )

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong TV et al. ( 2021 ) . Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women . Nature Communications vol. 12 , ( 1 )

Png G, Barysenka A, Repetto L, Navarro P, Shen X, Pietzner M, Wheeler E, Wareham NJ et al. ( 2021 ) . Mapping the serum proteome to neurological diseases using whole genome sequencing . Nature Communications vol. 12 , ( 1 )

Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9) . Nature Communications vol. 12 , ( 1 )

Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, Luan J, Hingorani AD et al. ( 2021 ) . Synergistic insights into human health from aptamer- and antibody-based proteomic profiling . Nature Communications vol. 12 , ( 1 )

Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C et al. ( 2021 ) . The genomics of heart failure: design and rationale of the HERMES consortium . ESC Heart Failure vol. 8 , ( 6 ) 5531 - 5541 .

Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P et al. ( 2021 ) . MC3R links nutritional state to childhood growth and the timing of puberty . Nature vol. 599 , ( 7885 ) 436 - 441 .

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J et al. ( 2021 ) . Mapping the proteo-genomic convergence of human diseases . Science vol. 374 , ( 6569 )

Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E et al. ( 2021 ) . Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region . Diabetes vol. 70 , ( 11 ) 2706 - 2719 .

Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB et al. ( 2021 ) . Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study . The Lancet Respiratory Medicine vol. 9 , ( 11 ) 1275 - 1287 .

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, Vanderweele TJ, Higgins JPT et al. ( 2021 ) . Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement . JAMA - Journal of the American Medical Association vol. 326 , ( 16 ) 1614 - 1621 .

Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, Vanderweele TJ, Timpson NJ, Higgins JPT et al. ( 2021 ) . Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): Explanation and elaboration . The BMJ vol. 375 ,

Katsoulis M, Lai AG, Diaz-Ordaz K, Gomes M, Pasea L, Banerjee A, Denaxas S, Tsilidis K et al. ( 2021 ) . Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records . The Lancet Diabetes and Endocrinology vol. 9 , ( 10 ) 681 - 694 .

Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C et al. ( 2021 ) . Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment . Circulation. Genomic and precision medicine vol. 14 , ( 5 )

Higgins H, Mason AM, Larsson SC, Gill D, Langenberg C, Burgess S ( 2021 ) . Estimating the population benefits of blood pressure lowering: A wide-angled mendelian randomization study in uk biobank . Journal of the American Heart Association vol. 10 , ( 17 )

Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al. ( 2021 ) . 586Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis . International Journal of Epidemiology vol. 50 , ( Supplement_1 )

Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al. ( 2021 ) . Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis . INTERNATIONAL JOURNAL OF EPIDEMIOLOGY . vol. 50 ,

Cai N, Gomez-Duran A, Yonova-Doing E, Kundu K, Burgess AI, Golder ZJ, Calabrese C, Bonder MJ et al. ( 2021 ) . Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases . Nature Medicine vol. 27 , ( 9 ) 1564 - 1575 .

Guida F, Tan VY, Corbin LJ, Smith-Byrne K, Alcala K, Langenberg C, Stewart ID, Butterworth AS et al. ( 2021 ) . The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium . PLoS Medicine vol. 18 , ( 9 )

Katsoulis M, Stavola BD, Diaz-Ordaz K, Gomes M, Lai A, Lagiou P, Wannamethee G, Tsilidis K et al. ( 2021 ) . Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records . Epidemiology vol. 32 , ( 5 ) 744 - 755 .

Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L et al. ( 2021 ) . Genetic insights into biological mechanisms governing human ovarian ageing . Nature vol. 596 , ( 7872 ) 393 - 397 .

Meddens SFW, de Vlaming R, Bowers P, Burik CAP, Linnér RK, Lee C, Okbay A, Turley P et al. ( 2021 ) . Genomic analysis of diet composition finds novel loci and associations with health and lifestyle . Molecular Psychiatry vol. 26 , ( 6 ) 2056 - 2069 .

Zuber V, Gill D, Ala-Korpela M, Langenberg C, Butterworth A, Bottolo L, Burgess S ( 2021 ) . High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease . International Journal of Epidemiology vol. 50 , ( 3 ) 893 - 901 .

Cheng TS, Day FR, Perry JRB, Luan J, Langenberg C, Forouhi NG, Wareham NJ, Ong KK ( 2021 ) . Prepubertal dietary and plasma phospholipid fatty acids related to puberty timing: Longitudinal cohort and mendelian randomization analyses . Nutrients vol. 13 , ( 6 )

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x) . Nature Genetics vol. 53 , ( 5 )

Klaric L, Gisby JS, Papadaki A, Muckian MD, Macdonald-Dunlop E, Zhao JH, Tokolyi A, Persyn E et al. ( 2021 ) . Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19 .

Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M et al. ( 2021 ) . A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity . Nature Medicine vol. 27 , ( 4 ) 659 - 667 .

Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar SK et al. ( 2021 ) . Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 . Nature Medicine vol. 27 , ( 4 ) 668 - 676 .

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M et al. ( 2021 ) . Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory . International Journal of Obesity vol. 45 , ( 4 ) 758 - 765 .

Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D et al. ( 2021 ) . Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations with Risks of Psychosis and Depression in Young Adults . JAMA Psychiatry vol. 78 , ( 4 ) 416 - 425 .

Lotta L, Langenberg C, Wareham NJ, Farooqi IS ( 2021 ) . Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R . Cell vol. 184 , ( 7 ) 1652 - 1653 .

Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M ( 2021 ) . Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study . Neurology vol. 96 , ( 13 ) E1732 - E1742 .

Perry BI, Burgess S, Jones HJ, Zammit S, Upthegrove R, Mason AM, Day FR, Langenberg C et al. ( 2021 ) . The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study . PLoS Medicine vol. 18 , ( 3 )

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M et al. ( 2021 ) . Correction: Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory (International Journal of Obesity, (2021), 10.1038/s41366-020-00735-9) . International Journal of Obesity vol. 45 , ( 3 )

Pietzner M, Stewart ID, Raffler J, Khaw KT, Michelotti GA, Kastenmüller G, Wareham NJ, Langenberg C ( 2021 ) . Plasma metabolites to profile pathways in noncommunicable disease multimorbidity . Nature Medicine vol. 27 , ( 3 ) 471 - 479 .

Higgins H, Mason A, Larsson S, Gill D, Langenberg C, Burgess S ( 2021 ) . Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank .

Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK et al. ( 2021 ) . A cross-platform approach identifies genetic regulators of human metabolism and health . Nature Genetics vol. 53 , ( 1 ) 54 - 64 .

Stankovic S, Day FR, Zhao Y, Langenberg C, Wareham NJ, Me Research Team, Perry JRB, Ong KK ( 2021 ) . Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk .

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Agbessi M, Ahsan H, Alves I et al. ( 2021 ) . Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour . Nature Human Behaviour

Zheng JS, Luan J, Sofianopoulou E, Imamura F, Stewart ID, Day FR, Pietzner M, Wheeler E et al. ( 2021 ) . Plasma Vitamin C and type 2 diabetes: Genome-wide association study and mendelian randomization analysis in European populations . Diabetes Care vol. 44 , ( 1 ) 98 - 106 .

Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P et al. ( 2021 ) . rs641738C&gt;T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis . Journal of Hepatology vol. 74 , ( 1 ) 20 - 30 .

Powell R, De Lucia Rolfe E, Day F, Perry JRB, Griffin S, Forouhi N, Brage S, Wareham N et al. ( 2020 ) . Development and validation of total and regional body composition prediction equations from anthropometry and single frequency segmental bioelectrical impedance with DEXA .

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al. ( 2020 ) . Genetic architecture of host proteins involved in SARS-CoV-2 infection . Nature Communications vol. 11 , ( 1 )

Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS et al. ( 2020 ) . Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity . Diabetes vol. 69 , ( 12 ) 2806 - 2818 .

Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E et al. ( 2020 ) . Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study . Scientific Data vol. 7 , ( 1 )

Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB et al. ( 2020 ) . Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure . Nature Communications vol. 11 , ( 1 )

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Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al. ( 2011 ) . Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 . American Journal of Human Genetics vol. 89 , ( 5 ) 619 - 627 .

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Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME et al. ( 2011 ) . Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes . Diabetes vol. 60 , ( 10 ) 2624 - 2634 .

Pfister R, Barnes D, Luben R, Forouhi NG, Bochud M, Khaw KT, Wareham NJ, Langenberg C ( 2011 ) . No evidence for a causal link between uric acid and type 2 diabetes: A Mendelian randomisation approach . Diabetologia vol. 54 , ( 10 ) 2561 - 2569 .

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM et al. ( 2011 ) . The Lin28/let-7 axis regulates glucose metabolism . Cell vol. 147 , ( 1 ) 81 - 94 .

Langenberg C, Sharp S, Forouhi NG, Franks PW, Schulze MB, Kerrison N, Ekelund U, Barroso I et al. ( 2011 ) . Design and cohort description of the InterAct Project: An examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study . Diabetologia vol. 54 , ( 9 ) 2272 - 2282 .

Pfister R, Barnes D, Luben RN, Khaw KT, Wareham NJ, Langenberg C ( 2011 ) . Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease . Diabetologia vol. 54 , ( 9 ) 2283 - 2287 .

Kanoni S, Nettleton JA, Hivert MF, Ye Z, Van Rooij FJA, Shungin D, Sonestedt E, Ngwa JS et al. ( 2011 ) . Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: A 14-cohort meta-analysis . Diabetes vol. 60 , ( 9 ) 2407 - 2416 .

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS et al. ( 2011 ) . Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile . Nature Genetics vol. 43 , ( 8 ) 753 - 760 .

Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S et al. ( 2011 ) . Association of genetic loci with glucose levels in childhood and adolescence: A meta-analysis of over 6,000 children . Diabetes vol. 60 , ( 6 ) 1805 - 1812 .

Small KS, Hedman AK, Grundberg E, Nica AC, Thorleifsson G, Kong A, Thorsteindottir U, Shin SY et al. ( 2011 ) . Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes . Nature Genetics vol. 43 , ( 6 ) 561 - 564 .

Jensen AC, Barker A, Kumari M, Brunner EJ, Kivimäki M, Hingorani AD, Wareham NJ, Tabák AG et al. ( 2011 ) . Associations of common genetic variants with age-related changes in fasting and postload glucose: Evidence from 18 years of follow-up of the whitehall II cohort . Diabetes vol. 60 , ( 5 ) 1617 - 1623 .

Langenberg C, Savage DB ( 2011 ) . An amino acid profile to predict diabetes? . Nature Medicine vol. 17 , ( 4 ) 418 - 420 .

Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, Wareham NJ, Loos RJF ( 2011 ) . Genetic predisposition to obesity leads to increased risk of type 2 diabetes . Diabetologia vol. 54 , ( 4 ) 776 - 782 .

Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C et al. ( 2011 ) . Common variants at 10 genomic loci influence hemoglobin A<inf>1C</inf> levels via glycemic and nonglycemic pathways (Diabetes (2010) 59, (3229-3239)) . Diabetes vol. 60 , ( 3 )

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G et al. ( 2011 ) . Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits . PLoS Genetics vol. 7 , ( 3 )

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, Van Rooij FJA, Sonestedt E et al. ( 2011 ) . Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies (Diabetes Care (2010) 33 (2684-2691)) . Diabetes Care vol. 34 , ( 3 ) 785 - 786 .

De Silva NMG, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN et al. ( 2011 ) . Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance . Diabetes vol. 60 , ( 3 ) 1008 - 1018 .

Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C et al. ( 2011 ) . Erratum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis . Nature Genetics vol. 43 , ( 4 )

Pfister R, Sharp S, Luben R, Welsh P, Barroso I, Salomaa V, Meirhaeghe A, Khaw KT et al. ( 2011 ) . Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: Evidence of causal association from population studies . PLoS Medicine vol. 8 , ( 10 )

Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C et al. ( 2010 ) . Common variants at 10 genomic loci influence hemoglobin A<inf>1C</inf> levels via glycemic and nonglycemic pathways . Diabetes vol. 59 , ( 12 ) 3229 - 3239 .

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, Van Rooij FJA, Sonestedt E et al. ( 2010 ) . Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies . Diabetes Care vol. 33 , ( 12 ) 2684 - 2691 .

Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK, Gokulakrishnan K et al. ( 2010 ) . Differential white blood cell count and type 2 diabetes: Systematic review and meta-analysis of cross-sectional and prospective studies . PLoS ONE vol. 5 , ( 10 )

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S et al. ( 2010 ) . Biological, clinical and population relevance of 95 loci for blood lipids . Nature vol. 466 , ( 7307 ) 707 - 713 .

Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C et al. ( 2010 ) . Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis . Nature Genetics vol. 42 , ( 7 ) 579 - 589 .

Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE et al. ( 2010 ) . Analysis of TBC1D4 in patients with severe insulin resistance . Diabetologia vol. 53 , ( 6 ) 1239 - 1242 .

Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S et al. ( 2010 ) . Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans . Diabetes vol. 59 , ( 5 ) 1266 - 1275 .

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) . Nature Genetics vol. 42 , ( 5 )

Elks CE, Loos RJF, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, Ness AR, Smith GD et al. ( 2010 ) . Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth . PLoS Medicine vol. 7 , ( 5 )

Liu C, Wu Y, Li H, Qi Q, Langenberg C, Loos RJF, Lin X ( 2010 ) . MTNR1B rs10830963 is associated with fasting plasma glucose, HbA<inf>1C </inf>and impaired beta-cell function in Chinese Hans from Shanghai . BMC Medical Genetics vol. 11 , ( 1 )

Bouatia-Naji N, Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow J, Vollenweider P, Lyssenko V et al. ( 2010 ) . O10 Une méta-analyse GWA de la glycémie après 2 h d’HGPO révèle que GIPR est associé avec la sécrétion de l’insuline en réponse au glucose et que ADCY5 est un nouveau gène de susceptibilité au diabète de type 2 . Diabetes & Metabolism vol. 36 ,

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N et al. ( 2010 ) . Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge . Nature Genetics vol. 42 , ( 2 ) 142 - 148 .

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . Nature Genetics vol. 42 , ( 2 ) 105 - 116 .

Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A et al. ( 2009 ) . Parental origin of sequence variants associated with complex diseases . Nature vol. 462 , ( 7275 ) 868 - 874 .

Brent Richards J, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ et al. ( 2009 ) . A genome-wide association study reveals variants in ARL15 that influence adiponectin levels . PLoS Genetics vol. 5 , ( 12 )

Kelliny C, Ekelund U, Andersen LB, Brage S, Loos RJF, Wareham NJ, Langenberg C ( 2009 ) . Common genetic determinants of glucose homeostasis in healthy children the european youth heart study . Diabetes vol. 58 , ( 12 ) 2939 - 2945 .

Perry JRB, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H et al. ( 2009 ) . Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes . Human Molecular Genetics vol. 19 , ( 3 ) 535 - 544 .

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM et al. ( 2009 ) . Underlying genetic models of inheritance in established type 2 diabetes associations . American Journal of Epidemiology vol. 170 , ( 5 ) 537 - 545 .

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF et al. ( 2009 ) . Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response . Diabetologia vol. 52 , ( 8 ) 1537 - 1542 .

Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CSS, Soos MA, Clark J et al. ( 2009 ) . A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia . Proceedings of the National Academy of Sciences of the United States of America vol. 106 , ( 23 ) 9350 - 9355 .

Perry J, Zeggini E, Scott L, Saxena R, Voight B, Ferrucci L, Maggio M, Paolisso G et al. ( 2009 ) . Mendelian Randomization Studies of the Role of Biomarkers in Type 2 Diabetes . DIABETES . vol. 58 , A311 - A311 .

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJF, Manning AK et al. ( 2009 ) . Variants in MTNR1B influence fasting glucose levels . Nature Genetics vol. 41 , ( 1 ) 77 - 81 .

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PIW, Abecasis GR et al. ( 2008 ) . Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes . Nature Genetics vol. 40 , ( 5 ) 638 - 645 .

Jassal SK, Langenberg C, von Mühlen D, Bergstrom J, Barrett-Connor E ( 2008 ) . Usefulness of Microalbuminuria Versus the Metabolic Syndrome as a Predictor of Cardiovascular Disease in Women and Men &gt;40 Years of Age (from the Rancho Bernardo Study) . American Journal of Cardiology vol. 101 , ( 9 ) 1275 - 1280 .

Batty GD, Gale CR, Mortensen LH, Langenberg C, Shipley MJ, Deary IJ ( 2008 ) . Pre-morbid intelligence, the metabolic syndrome and mortality: The Vietnam Experience Study . Diabetologia vol. 51 , ( 3 ) 436 - 443 .

Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E ( 2008 ) . Prevalence of angina in women versus men: A systematic review and meta-analysis of international variations across 31 countries . Circulation vol. 117 , ( 12 ) 1526 - 1536 .

Laughlin GA, Barrett-Connor E, May S, Langenberg C ( 2007 ) . Association of adiponectin with coronary heart disease and mortality: The Rancho Bernardo study . American Journal of Epidemiology vol. 165 , ( 2 ) 164 - 174 .

Langenberg C, Araneta MRG, Bergstrom J, Marmot M, Barrett-Connor E ( 2007 ) . Diabetes and coronary heart disease in Filipino-American women: Role of growth and life-course socioeconomic factors . Diabetes Care vol. 30 , ( 3 ) 535 - 541 .

Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ ( 2007 ) . Life course body size and lipid levels at 53 years in a British birth cohort . Journal of Epidemiology and Community Health vol. 61 , ( 3 ) 215 - 220 .

Ferrie JE, Langenberg C, Shipley MJ, Marmot MG ( 2006 ) . Birth weight, components of height and coronary heart disease: Evidence from the Whitehall II study . International Journal of Epidemiology vol. 35 , ( 6 ) 1532 - 1542 .

Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M ( 2006 ) . Household wealth and the metabolic syndrome in the Whitehall II study . Diabetes Care vol. 29 , ( 12 ) 2694 - 2700 .

Langenberg C, Kuh D, Wadsworth MEJ, Brunner E, Hardy R ( 2006 ) . Social circumstances and education: Life course origins of social inequalities in metabolic risk in a prospective national birth cohort . American Journal of Public Health vol. 96 , ( 12 ) 2216 - 2221 .

Batty GD, Gunnell D, Langenberg C, Smith GD, Marmot MG, Shipley MJ ( 2006 ) . Adult height and lung function as markers of life course exposures: Associations with risk factors and cause-specific mortality . European Journal of Epidemiology vol. 21 , ( 11 ) 795 - 801 .

Langenberg C, Barrett-Connor E, Damant J, Hemingway H ( 2006 ) . Sex differences in angina pectoris: meta-analysis of international variations in 53 studies in 23 countries . European Journal of Preventive Cardiology vol. 13 , ( Supplement 1 )

Batty GD, Shipley MJ, Langenberg C, Marmot MG, Davey Smith G ( 2006 ) . Adult height in relation to mortality from 14 cancer sites in men in London (UK): Evidence from the original Whitehall study . Annals of Oncology vol. 17 , ( 1 ) 157 - 166 .

Langenberg C, Bergstrom J, Scheidt-Nave C, Pfeilschifter J, Barrett-Connor E ( 2006 ) . Cardiovascular death and the metabolic syndrome: Role of adiposity-signaling hormones and inflammatory markers . Diabetes Care vol. 29 , ( 6 ) 1363 - 1369 .

Weiss LA, Langenberg C, Barrett-Connor E ( 2006 ) . Ghrelin and bone: Is there an association in older adults?: The Rancho Bernardo Study . Journal of Bone and Mineral Research vol. 21 , ( 5 ) 752 - 757 .

Langenberg C, Hardy R, Breeze E, Kuh D, Wadsworth MEJ ( 2005 ) . Influence of short stature on the change in pulse pressure, systolic and diastolic blood pressure from age 36 to 53 years: An analysis using multilevel models . International Journal of Epidemiology vol. 34 , ( 4 ) 905 - 913 .

Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M ( 2005 ) . 211-S: Household Wealth and the Metabolic Syndrome in the Whitehall II Cohort . American Journal of Epidemiology vol. 161 , ( Supplement_1 ) s53 - s53 .

Hardy R, Kuh D, Langenberg C, Wadsworth MEJ ( 2005 ) . Erratum: Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort (Lancet (2003) 362 (1178-1183)) . Lancet vol. 365 , ( 9471 )

Langenberg C, Shipley MJ, Batty GD, Marmot MG ( 2005 ) . Adult socioeconomic position and the association between height and coronary heart disease mortality: Findings from 33 years of follow-up in the Whitehall Study . American Journal of Public Health vol. 95 , ( 4 ) 628 - 632 .

Kuh D, Langenberg C, Hardy R, Kok H, Cooper R, Butterworth S, Wadsworth MEJ ( 2005 ) . Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: A prospective British birth cohort study . BJOG: An International Journal of Obstetrics and Gynaecology vol. 112 , ( 4 ) 476 - 485 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Ghrelin and the metabolic syndrome in older adults . Journal of Clinical Endocrinology and Metabolism vol. 90 , ( 12 ) 6448 - 6453 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: Longitudinal analysis of the Rancho Bernardo Cohort . American Journal of Epidemiology vol. 162 , ( 12 ) 1189 - 1197 .

Hardy R, Wadsworth MEJ, Langenberg C, Kuh D ( 2004 ) . Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort . International Journal of Epidemiology vol. 33 , ( 1 ) 121 - 129 .

Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ ( 2004 ) . Birth Weight and Lipids in a National Birth Cohort Study . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 24 , ( 3 ) 588 - 594 .

Hardy R, Langenberg C ( 2003 ) . Commentary: The association between height growth and cholesterol levels during puberty: Implications for adult health . International Journal of Epidemiology vol. 32 , ( 6 ) 1110 - 1111 .

Hardy R, Kuh D, Langenberg C, Wadsworth MEJ ( 2003 ) . Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort . Lancet vol. 362 , ( 9391 ) 1178 - 1183 .

Langenberg C, Hardy R, Kuh D, Brunner E, Wadsworth M ( 2003 ) . Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: Evidence from a national birth cohort . Journal of Epidemiology and Community Health vol. 57 , ( 10 ) 816 - 822 .

Langenberg C, Marmot M ( 2003 ) . Commentary: Disentangling the association between short height and cardiovascular risk - Genes or environment? . International Journal of Epidemiology vol. 32 , ( 4 ) 614 - 616 .

Asif AR, Grunewald RW, Langenberg C, Metten M, Jarry H, Muller GA, Burckhardt G, Hagos Y ( 2003 ) . Human organic anion transporter 3 (hOAT3) in human adrenocortical cells transports cortisol . FASEB JOURNAL . vol. 17 , A477 - A477 .

Langenberg C, Hardy R, Kuh D, Wadsworth MEJ ( 2003 ) . Influence of height, leg and trunk length on pulse pressure, systolic and diastolic blood pressure . Journal of Hypertension vol. 21 , ( 3 ) 537 - 543 .

Wadsworth MEJ, Butterworth SL, Hardy RJ, Kuh DJ, Richards M, Langenberg C, Hilder WS, Connor M ( 2003 ) . The life course prospective design: An example of benefits and problems associated with study longevity . Social Science and Medicine vol. 57 , ( 11 ) 2193 - 2205 .

Kuh D, Hardy R, Langenberg C, Richards M, Wadsworth MEJ ( 2002 ) . Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: Post war birth cohort study . British Medical Journal vol. 325 , ( 7372 ) 1076 - 1080 .

Pritsche L, Donner-Banzhoff N, Druck G, Kunz R, Langenberg C, Lelgemann M, Pientka L, Von Maxen A et al. ( 2001 ) . EbM-courses for hospital and practise settings - Current models in Germany . Zeitschrift fur Arztliche Fortbildung und Qualitatssicherung vol. 95 , ( 4 ) 297 - 298 .

Helou A, Perleth M, Lühmann D, Langenberg C, Busse R ( 2001 ) . Evidence-based medicine: What kind of competencies should medical education provide? . Medizinische Ausbildung . vol. 18 , 31 - 37 .

Raspe H, Langenberg C ( 1999 ) . Final and causal foundations of medical practice--two achievements of evidence-based medicine . Zeitschrift für ärztliche Fortbildung und Qualitätssicherung : in Zusammenarbeit mit der Kaiserin-Friedrich-Stiftung für das ärztliche Fortbildungswesen vol. 93 , ( 4 )