Publications: Prof Claudia Langenberg
Gharibzadeh S, Routen A, Razieh C, Zaccardi F, Lawson C, Gillies C, Heller S, Davies M et al.
(
2025
)
.
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study
.
EClinicalMedicine
vol.
79
,
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J et al.
(
2024
)
.
Genetic basis of early onset and progression of type 2 diabetes in South Asians
.
Nature Medicine1
-
9
.
Hamilton F, Schurz H, Yates TA, Gilchrist JJ, Möller M, Naranbhai V, Ghazal P, Timpson NJ et al.
(
2024
)
.
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
.
The Lancet Microbe
Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F et al.
(
2024
)
.
Incidence of diabetes mellitus following hospitalisation for COVID‐19 in the United Kingdom: A prospective observational study
.
Diabetes Obesity and Metabolism
Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K et al.
(
2024
)
.
Genetic architecture of routinely acquired blood tests in a British South Asian cohort
.
Nature Communications
vol.
15
,
(
1
)
Gordillo-Marañón M, Schmidt AF, Warwick A, Tomlinson C, Ytsma C, Engmann J, Torralbo A, Maclean R et al.
(
2024
)
.
Disease coverage of human genome-wide association studies and pharmaceutical research and development
.
Communications Medicine
vol.
4
,
(
1
)
Carrasco-Zanini J, Wheeler E, Uluvar B, Kerrison N, Koprulu M, Wareham NJ, Pietzner M, Langenberg C
(
2024
)
.
Mapping biological influences on the human plasma proteome beyond the genome
.
Nature Metabolism
vol.
6
,
(
10
)
2010
-
2023
.
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J et al.
(
2024
)
.
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health
.
Nature Metabolism
vol.
6
,
(
10
)
1922
-
1938
.
Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Feng X, Li T, Yao Y et al.
(
2024
)
.
The genetic landscape of neuro-related proteins in human plasma
.
Nature Human Behaviour
vol.
8
,
(
11
)
2222
-
2234
.
Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M
(
2024
)
.
Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization
.
EBioMedicine
vol.
107
,
Chen Y, Butler-Laporte G, Liang KYH, Ilboudo Y, Yasmeen S, Sasako T, Langenberg C, Greenwood CMT et al.
(
2024
)
.
The performance of AlphaMissense to identify genes influencing disease
.
Human Genetics and Genomics Advances
vol.
5
,
(
4
)
Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O et al.
(
2024
)
.
An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections
.
Blood
vol.
144
,
(
4
)
420
-
434
.
(
2024
)
.
Blood proteins predict the risk of many diseases years before onset
.
Nature Medicine
vol.
30
,
(
9
)
2419
-
2420
.
Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al.
(
2024
)
.
Proteomic signatures improve risk prediction for common and rare diseases
.
Nature Medicine
vol.
30
,
(
9
)
2489
-
2498
.
Lim SS, Semnani-Azad Z, Morieri ML, Ng AH, Ahmad A, Fitipaldi H, Boyle J, Collin C et al.
(
2024
)
.
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist
.
Nature Medicine
vol.
30
,
(
7
)
1874
-
1881
.
Pietzner M, Denaxas S, Yasmeen S, Ulmer MA, Nakanishi T, Arnold M, Kastenmüller G, Hemingway H et al.
(
2024
)
.
Complex patterns of multimorbidity associated with severe COVID-19 and long COVID
.
Communications Medicine
vol.
4
,
(
1
)
Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C
(
2024
)
.
Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study
.
The Lancet Digital Health
vol.
6
,
(
7
)
e470
-
e479
.
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE et al.
(
2024
)
.
SMIM1 absence is associated with reduced energy expenditure and excess weight
.
Med
vol.
5
,
(
9
)
1083
-
1095.e6
.
Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al.
(
2024
)
.
Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
.
EBioMedicine
vol.
105
,
Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al.
(
2024
)
.
RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats
.
Nature Communications
vol.
15
,
(
1
)
Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al.
(
2024
)
.
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
.
Nature Genetics
vol.
56
,
(
5
)
778
-
791
.
Smith-Byrne K, Hedman Å, Dimitriou M, Desai T, Sokolov AV, Schioth HB, Koprulu M, Pietzner M et al.
(
2024
)
.
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
.
Nature Communications
vol.
15
,
(
1
)
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA et al.
(
2024
)
.
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
.
Nature Genetics
vol.
56
,
(
5
)
1032
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1033
.
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S et al.
(
2024
)
.
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
.
Nature Immunology
vol.
25
,
(
4
)
607
-
621
.
Elneima O, Hurst JR, Echevarria C, Quint JK, Walker S, Siddiqui S, Novotny P, Pfeffer PE et al.
(
2024
)
.
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID
.
ERJ Open Research
vol.
10
,
(
4
)
00982
-
02023
.
Desai TA, Hedman AK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al.
(
2024
)
.
Abstract 7330: Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using mendelian randomization and tumor spatial transcriptomics
.
Cancer Research
vol.
84
,
(
6_Supplement
)
7330
-
7330
.
Ganji-Arjenaki M, Kamali Z, Pressure ICOB, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N et al.
(
2024
)
.
Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
.
Kidney International Reports
vol.
9
,
(
6
)
1849
-
1859
.
Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS et al.
(
2024
)
.
Systemic proteome adaptions to 7-day complete caloric restriction in humans
.
Nature Metabolism
vol.
6
,
(
4
)
764
-
777
.
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A et al.
(
2024
)
.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
.
Nature
vol.
627
,
(
8003
)
347
-
357
.
Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O et al.
(
2024
)
.
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
.
Nature Communications
vol.
15
,
(
1
)
Lord JM, Veenith T, Sullivan J, Sharma-Oates A, Richter AG, Greening NJ, McAuley HJC, Evans RA et al.
(
2024
)
.
Accelerated immune ageing is associated with COVID-19 disease severity
.
Immunity & Ageing
vol.
21
,
(
1
)
Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Ghasemi-Semeskandeh D, Coassin S et al.
(
2023
)
.
Genetic determinants of complement activation in the general population
.
Cell Reports
vol.
43
,
(
1
)
Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho L-P, Marks M, Poinasamy K et al.
(
2023
)
.
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
.
International Journal of Epidemiology
vol.
53
,
(
1
)
Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw K, Langenberg C et al.
(
2023
)
.
Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New‐Onset Type 2 Diabetes: Analyses in the Fenland and EPIC‐Norfolk Studies, United Kingdom
.
Molecular Nutrition & Food Research
vol.
68
,
(
1
)
Collaboration ERFCE-CVDS, Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR et al.
(
2023
)
.
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
.
The Lancet Diabetes & Endocrinology
vol.
12
,
(
1
)
e2
-
e11
.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al.
(
2023
)
.
Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
.
Nature Communications
vol.
14
,
(
1
)
Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I et al.
(
2023
)
.
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
.
Communications Biology
vol.
6
,
(
1
)
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al.
(
2023
)
.
INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE
.
Canadian Journal of Diabetes
vol.
47
,
(
7
)
Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ
(
2023
)
.
Multi-omic prediction of incident type 2 diabetes
.
Diabetologia
vol.
67
,
(
1
)
102
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112
.
Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
(
2023
)
.
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
.
Wellcome Open Research
vol.
8
,
Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
(
2023
)
.
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
.
Wellcome open research
vol.
8
,
Hingorani AD, Gratton J, Finan C, Schmidt AF, Patel R, Sofat R, Kuan V, Langenberg C et al.
(
2023
)
.
Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
.
BMJ Medicine
vol.
2
,
(
1
)
Brightling CE, Evans RA, Singapuri A, Smith N, Wain LV, Brightling CE, Evans RA, Wain LV et al.
(
2023
)
.
Long COVID research: an update from the PHOSP-COVID Scientific Summit
.
The Lancet Respiratory Medicine
vol.
11
,
(
11
)
e93
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e94
.
Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ, Hemingway H et al.
(
2023
)
.
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon
.
Nature Communications
vol.
14
,
(
1
)
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett JDS, Su C-Y et al.
(
2023
)
.
THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis
.
Journal of the Endocrine Society
vol.
7
,
(
Supplement_1
)
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al.
(
2023
)
.
INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE
.
Canadian Journal of Cardiology
vol.
39
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10
)
s209
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s210
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Fethnou E, Qafoud F, Alkhayat E, Afifi N, Tomei S, Liu W, Lorenz S, Syed N et al.
(
2023
)
.
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
.
Nature Genetics
vol.
55
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(
10
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1778
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1779
.
Brightling CE, Evans RA, Wain LV, Chalmers JD, Harris VC, Ho LP, Horsley A, Marks M et al.
(
2023
)
.
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
.
The Lancet Respiratory Medicine
vol.
11
,
(
11
)
1003
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1019
.
Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al.
(
2023
)
.
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
.
Nature Genetics
vol.
55
,
(
9
)
1448
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1461
.
Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Coassin S, Fuchsberger C et al.
(
2023
)
.
176 A genome-wide association screening of complement activation from a general population study
.
Immunobiology
vol.
228
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5
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Alwan H, Luan J, Williamson A, Steward I, Wareham N, Langenberg C, Pietzner M
(
2023
)
.
Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study
.
Endocrine Abstracts
Zhou S, Sosina OA, Bovijn J, Laurent L, Sharma V, Akbari P, Forgetta V, Jiang L et al.
(
2023
)
.
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
.
Nature Genetics
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55
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8
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1277
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1287
.
Carland C, Png G, Malarstig A, Kho PF, Gustafsson S, Michaelsson K, Lind L, Tsafantakis E et al.
(
2023
)
.
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
.
Clinical Proteomics
vol.
20
,
(
1
)
Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H et al.
(
2023
)
.
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization
.
Arthritis & Rheumatology
vol.
75
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(
10
)
1781
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1792
.
van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S et al.
(
2023
)
.
Circulating metabolites modulated by diet are associated with depression
.
Molecular Psychiatry
vol.
28
,
(
9
)
3874
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3887
.
Langenberg C, Hingorani AD, Whitty CJM
(
2023
)
.
Biological and functional multimorbidity—from mechanisms to management
.
Nature Medicine
vol.
29
,
(
7
)
1649
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1657
.
Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al.
(
2023
)
.
Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
.
Nature Communications
vol.
14
,
(
1
)
Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S et al.
(
2023
)
.
Causal associations between cardiorespiratory fitness and type 2 diabetes
.
Nature Communications
vol.
14
,
(
1
)
Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU et al.
(
2023
)
.
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
.
Nature Genetics
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55
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(
6
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973
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983
.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al.
(
2023
)
.
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
.
Nature Communications
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14
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(
1
)
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
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2023
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Author Correction: The power of genetic diversity in genome-wide association studies of lipids
.
Nature
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e19
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e20
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Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A et al.
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2023
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Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH
.
Diabetologia
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7
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1260
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1272
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2023
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Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
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The Lancet Regional Health - Europe
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Circulating proteins to predict COVID-19 severity
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Scientific Reports
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1
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Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE et al.
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Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
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The Lancet Respiratory Medicine
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673
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684
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2023
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An atlas of genetic scores to predict multi-omic traits
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Nature
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131
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Author Correction: Proteogenomic links to human metabolic diseases
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710
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710
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2023
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
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Nature Genetics
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3
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410
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422
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2023
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Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
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EClinicalMedicine
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57
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Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, Vaez A, van Zuydam N, Bitarello BD et al.
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2023
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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
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Nature Human Behaviour
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5
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790
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801
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Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C
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2023
)
.
Proteogenomic links to human metabolic diseases
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Nature Metabolism
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3
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516
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528
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Xu F, Yu EY-W, Cai X, Yue L, Jing L-P, Liang X, Fu Y, Miao Z et al.
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2023
)
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Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
.
Nature Communications
vol.
14
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(
1
)
Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Li T, Twait EL, May-Wilson S et al.
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2023
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Genetic mechanisms of 184 neuro-related proteins in human plasma
.
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02-23
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Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E et al.
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2023
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Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults
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Diabetes Care
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1145
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1155
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Zhao J, Stewart ID, Baird D, Mason D, Wright J, Zheng J, Gaunt TR, Evans DM et al.
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2023
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Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study
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EBioMedicine
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Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A et al.
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2023
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