Publications: Prof Claudia Langenberg

Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS et al. ( 2024 ) . Systemic proteome adaptions to 7-day complete caloric restriction in humans . Nature Metabolism1 - 14 .

Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O et al. ( 2024 ) . Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications . Nature Communications vol. 15 , ( 1 )

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Ghasemi-Semeskandeh D, Coassin S et al. ( 2023 ) . Genetic determinants of complement activation in the general population . Cell Reports vol. 43 , ( 1 )

Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw K, Langenberg C et al. ( 2023 ) . Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New‐Onset Type 2 Diabetes: Analyses in the Fenland and EPIC‐Norfolk Studies, United Kingdom . Molecular Nutrition & Food Research vol. 68 , ( 1 )

Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR, Allara E et al. ( 2023 ) . Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses . The Lancet Diabetes & Endocrinology vol. 12 , ( 1 ) e2 - e11 .

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 )

Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I et al. ( 2023 ) . Identification of circulating proteins associated with general cognitive function among middle-aged and older adults . Communications Biology vol. 6 , ( 1 )

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al. ( 2023 ) . INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE . Canadian Journal of Diabetes vol. 47 , ( 7 )

Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ ( 2023 ) . Multi-omic prediction of incident type 2 diabetes . Diabetologia vol. 67 , ( 1 ) 102 - 112 .

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

Hingorani AD, Gratton J, Finan C, Schmidt AF, Patel R, Sofat R, Kuan V, Langenberg C et al. ( 2023 ) . Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog . BMJ Medicine vol. 2 , ( 1 )

Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ, Hemingway H et al. ( 2023 ) . ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon . Nature Communications vol. 14 , ( 1 )

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett JDS, Su C-Y et al. ( 2023 ) . THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis . Journal of the Endocrine Society vol. 7 , ( Supplement_1 )

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al. ( 2023 ) . INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE . Canadian Journal of Cardiology vol. 39 , ( 10 ) s209 - s210 .

Fethnou E, Qafoud F, Alkhayat E, Afifi N, Tomei S, Liu W, Lorenz S, Syed N et al. ( 2023 ) . Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk . Nature Genetics vol. 55 , ( 10 ) 1778 - 1779 .

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Coassin S, Fuchsberger C et al. ( 2023 ) . 176 A genome-wide association screening of complement activation from a general population study . Immunobiology vol. 228 , ( 5 )

Alwan H, Luan J, Williamson A, Steward I, Wareham N, Langenberg C, Pietzner M ( 2023 ) . Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study . Endocrine Abstracts

Zhou S, Sosina OA, Bovijn J, Laurent L, Sharma V, Akbari P, Forgetta V, Jiang L et al. ( 2023 ) . Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis . Nature Genetics vol. 55 , ( 8 ) 1277 - 1287 .

Carland C, Png G, Malarstig A, Kho PF, Gustafsson S, Michaelsson K, Lind L, Tsafantakis E et al. ( 2023 ) . Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases . Clinical Proteomics vol. 20 , ( 1 )

Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H et al. ( 2023 ) . Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization . Arthritis & Rheumatology vol. 75 , ( 10 ) 1781 - 1792 .

van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S et al. ( 2023 ) . Circulating metabolites modulated by diet are associated with depression . Molecular Psychiatry vol. 28 , ( 9 ) 3874 - 3887 .

Langenberg C, Hingorani AD, Whitty CJM ( 2023 ) . Biological and functional multimorbidity—from mechanisms to management . Nature Medicine vol. 29 , ( 7 ) 1649 - 1657 .

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al. ( 2023 ) . Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure . Nature Communications vol. 14 , ( 1 )

Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S et al. ( 2023 ) . Causal associations between cardiorespiratory fitness and type 2 diabetes . Nature Communications vol. 14 , ( 1 )

Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU et al. ( 2023 ) . Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake . Nature Genetics vol. 55 , ( 6 ) 973 - 983 .

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 )

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A et al. ( 2023 ) . Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH . Diabetologia vol. 66 , ( 7 ) 1260 - 1272 .

Zheng B, Vivaldi G, Daines L, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A et al. ( 2023 ) . Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls . The Lancet Regional Health - Europe vol. 29 ,

Su C-Y, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, Jeon W, Morrison DR et al. ( 2023 ) . Circulating proteins to predict COVID-19 severity . Scientific Reports vol. 13 , ( 1 )

Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE et al. ( 2023 ) . Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study . The Lancet Respiratory Medicine vol. 11 , ( 8 ) 673 - 684 .

Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA et al. ( 2023 ) . An atlas of genetic scores to predict multi-omic traits . Nature vol. 616 , ( 7955 ) 123 - 131 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Author Correction: Proteogenomic links to human metabolic diseases . Nature Metabolism vol. 5 , ( 4 ) 710 - 710 .

Fethnou E, Qafoud F, Alkhayat E, Afifi N, Tomei S, Liu W, Lorenz S, Syed N et al. ( 2023 ) . Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk . Nature Genetics vol. 55 , ( 3 ) 410 - 422 .

McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL et al. ( 2023 ) . Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study . EClinicalMedicine vol. 57 ,

Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, Vaez A, van Zuydam N, Bitarello BD et al. ( 2023 ) . Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus . Nature Human Behaviour vol. 7 , ( 5 ) 790 - 801 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Proteogenomic links to human metabolic diseases . Nature Metabolism vol. 5 , ( 3 ) 516 - 528 .

Xu F, Yu EY-W, Cai X, Yue L, Jing L-P, Liang X, Fu Y, Miao Z et al. ( 2023 ) . Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility . Nature Communications vol. 14 , ( 1 )

Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Li T, Twait EL, May-Wilson S et al. ( 2023 ) . Genetic mechanisms of 184 neuro-related proteins in human plasma . vol. 4 , ( 02-23 )

Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E et al. ( 2023 ) . Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults . Diabetes Care vol. 46 , ( 6 ) 1145 - 1155 .

Zhao J, Stewart ID, Baird D, Mason D, Wright J, Zheng J, Gaunt TR, Evans DM et al. ( 2023 ) . Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study . EBioMedicine vol. 88 ,

Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A et al. ( 2023 ) . Loci for insulin processing and secretion provide insight into type 2 diabetes risk . American Journal of Human Genetics vol. 110 , ( 2 ) 284 - 299 .

Vernardis SI, Demichev V, Lemke O, Grüning N-M, Messner C, White M, Pietzner M, Peluso A et al. ( 2023 ) . The Impact of Acute Nutritional Interventions on the Plasma Proteome . The Journal of Clinical Endocrinology & Metabolism vol. 108 , ( 8 ) 2087 - 2098 .

Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart J-A, Bourcier R, Sawada T et al. ( 2023 ) . Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity . Stroke vol. 54 , ( 3 ) 810 - 818 .

Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ et al. ( 2023 ) . Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene . Nature Communications vol. 14 , ( 1 )

Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH et al. ( 2023 ) . Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases . Nature Genetics vol. 55 , ( 1 ) 44 - 53 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D et al. ( 2022 ) . SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination . EBioMedicine vol. 87 ,

Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ et al. ( 2022 ) . Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes . Cell Genomics vol. 2 , ( 12 )

Kuan V, Denaxas S, Patalay P, Nitsch D, Mathur R, Gonzalez-Izquierdo A, Sofat R, Partridge L et al. ( 2022 ) . Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study . The Lancet Digital Health vol. 5 , ( 1 ) e16 - e27 .

Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals . Clinical Proteomics vol. 19 , ( 1 )

( 2022 ) . Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk . Nature Medicine vol. 28 , ( 11 ) 2261 - 2262 .

Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M et al. ( 2022 ) . Proteomic signatures for identification of impaired glucose tolerance . Nature Medicine vol. 28 , ( 11 ) 2293 - 2300 .

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF et al. ( 2022 ) . Rare and common genetic determinants of metabolic individuality and their effects on human health . Nature Medicine vol. 28 , ( 11 ) 2321 - 2332 .

Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S et al. ( 2022 ) . Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses . Circulation vol. 146 , ( 20 ) 1507 - 1517 .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

de Laat KF, van Norden AGW, de Kort PL, Vermeer SE, Brouwers PJAM, Gons RAR, Nederkoorn PJ, den Heijer T et al. ( 2022 ) . Stroke genetics informs drug discovery and risk prediction across ancestries . Nature vol. 611 , ( 7934 ) 115 - 123 .

Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals . Clinical Proteomics vol. 19 , ( 1 )

Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier zu Belzen J, Loock L et al. ( 2022 ) . Metabolomic profiles predict individual multidisease outcomes . Nature Medicine vol. 28 , ( 11 ) 2309 - 2320 .

P K, ID S, RS K, M S, K M, A D, DI S, SH C et al. ( 2022 ) . Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma .

Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S et al. ( 2022 ) . Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention . Nature Genetics vol. 54 , ( 9 ) 1332 - 1344 .

Pietzner M, Chua RL, Wheeler E, Jechow K, Willett JDS, Radbruch H, Trump S, Heidecker B et al. ( 2022 ) . ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 . Nature Communications vol. 13 , ( 1 )

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Kuo F-C, Neville MJ, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans LBL, van Dam AD, Loh NY et al. ( 2022 ) . HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution . Cell Reports vol. 40 , ( 4 )

Taylor K, McBride N, Zhao J, Oddie S, Azad R, Wright J, Andreassen OA, Stewart ID et al. ( 2022 ) . The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses . Journal of Cardiovascular Development and Disease vol. 9 , ( 8 )

Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al. ( 2022 ) . Author Correction: Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma . Nature Medicine vol. 28 , ( 8 ) 1723 - 1723 .

Li C, Imamura F, Wedekind R, Stewart ID, Pietzner M, Wheeler E, Forouhi NG, Langenberg C et al. ( 2022 ) . Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention . American Journal of Clinical Nutrition vol. 116 , ( 2 ) 511 - 522 .

Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS et al. ( 2022 ) . Detection and characterization of male sex chromosome abnormalities in the UK Biobank study . Genetics in Medicine vol. 24 , ( 9 ) 1909 - 1919 .

Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N et al. ( 2022 ) . Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases . JCI Insight vol. 7 , ( 10 )

Bomba L, Walter K, Guo Q, Surendran P, Kundu K, Nongmaithem S, Karim MA, Stewart ID et al. ( 2022 ) . Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites . American Journal of Human Genetics vol. 109 , ( 6 ) 1038 - 1054 .

Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S et al. ( 2022 ) . Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation . Nature Genetics vol. 54 , ( 5 ) 560 - 572 .

Guyatt A, John C, Williams AT, Shrine N, Reeve NF, consortium S, Sayers I, Hall I et al. ( 2022 ) . Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease . Thorax vol. 78 , ( 5 ) 496 - 503 .

LI Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Quynh Nguyen N, Scherer N et al. ( 2022 ) . MO048: Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases . Nephrology Dialysis Transplantation vol. 37 , ( Supplement_3 )

Evans RA, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M et al. ( 2022 ) . Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study . The Lancet Respiratory Medicine vol. 10 , ( 8 ) 761 - 775 .

Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, Ekelund U, Aleksandrova K et al. ( 2022 ) . Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study . European Journal of Preventive Cardiology vol. 29 , ( 12 ) 1618 - 1629 .

Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N et al. ( 2022 ) . Genetic Landscape of the ACE2 Coronavirus Receptor . Circulation vol. 145 , ( 18 ) 1398 - 1411 .

Temprano‐Sagrera G, Sitlani CM, Bone WP, Martin‐Bornez M, Voight BF, Morrison AC, Damrauer SM, de Vries PS et al. ( 2022 ) . Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations . Journal of Thrombosis and Haemostasis vol. 20 , ( 6 ) 1331 - 1349 .

Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al. ( 2022 ) . Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma . Nature Medicine vol. 28 , ( 4 ) 814 - 822 .

Dam V, Onland-Moret NC, Burgess S, Chirlaque M-D, Peters SAE, Schuit E, Tikk K, Weiderpass E et al. ( 2022 ) . Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization . The Journal of Clinical Endocrinology & Metabolism vol. 107 , ( 7 ) e2952 - e2961 .

Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C et al. ( 2022 ) . Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes . Clinical Epigenetics vol. 14 , ( 1 )

John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH et al. ( 2022 ) . Genetic Associations and Architecture of Asthma-COPD Overlap . CHEST Journal vol. 161 , ( 5 ) 1155 - 1166 .

Murphy N, Song M, Papadimitriou N, Carreras-Torres R, Langenberg C, Martin RM, Tsilidis KK, Barroso I et al. ( 2022 ) . Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis . Journal of the National Cancer Institute vol. 114 , ( 5 ) 740 - 752 .

Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM ( 2022 ) . Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses . Schizophrenia Bulletin Open vol. 3 , ( 1 )

Li Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Nguyen NQ, Scherer N et al. ( 2022 ) . GENOME-WIDE STUDIES REVEAL FACTORS ASSOCIATED WITH CIRCULATING UROMODULIN AND ITS RELATIONS WITH COMPLEX DISEASES . NEPHROLOGY DIALYSIS TRANSPLANTATION . vol. 37 , I28 - I29 .

Warren H, Keaton J, Kamali Z, Vaez A, Xie T, Ani A, Evangelou E, Levy D et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 7 - 8 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Kerrison N, Wareham N, Pietzner M, Langenberg C ( 2022 ) . Understanding Disease Mechanisms: From Genome to Phenome via the Proteome . GENETIC EPIDEMIOLOGY . vol. 46 , 507 - 507 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, Griffin JD, Patel S et al. ( 2021 ) . Identification of rare loss of function genetic variation regulating body fat distribution . The Journal of Clinical Endocrinology & Metabolism vol. 107 , ( 4 )

Png G, Barysenka A, Repetto L, Navarro P, Shen X, Pietzner M, Wheeler E, Wareham NJ et al. ( 2021 ) . Mapping the serum proteome to neurological diseases using whole genome sequencing . Nature Communications vol. 12 , ( 1 )

Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, Luan J, Hingorani AD et al. ( 2021 ) . Synergistic insights into human health from aptamer- and antibody-based proteomic profiling . Nature Communications vol. 12 , ( 1 )

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J et al. ( 2021 ) . Mapping the proteo-genomic convergence of human diseases . Science vol. 374 , ( 6569 )

Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P et al. ( 2021 ) . MC3R links nutritional state to childhood growth and the timing of puberty . Nature vol. 599 , ( 7885 ) 436 - 441 .

Collaboration ERFCE-CVDS, Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR et al. ( 2021 ) . Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses . The Lancet Diabetes & Endocrinology vol. 9 , ( 12 ) 837 - 846 .

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT et al. ( 2021 ) . Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization . JAMA vol. 326 , ( 16 ) 1614 - 1621 .

Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, Timpson NJ, Higgins JPT et al. ( 2021 ) . Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration . The BMJ vol. 375 ,

Kelly RS, Stewart ID, Bayne H, Kachroo P, Spiro A, Vokonas P, Sparrow D, Weiss ST et al. ( 2021 ) . Metabolomic differences in lung function metrics: evidence from two cohorts . Thorax vol. 77 , ( 9 ) 919 - 928 .

Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB et al. ( 2021 ) . Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study . The Lancet Respiratory Medicine vol. 9 , ( 11 ) 1275 - 1287 .

Guida F, Tan VY, Corbin LJ, Smith-Byrne K, Alcala K, Langenberg C, Stewart ID, Butterworth AS et al. ( 2021 ) . The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium . PLOS Medicine vol. 18 , ( 9 )

Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C et al. ( 2021 ) . The genomics of heart failure: design and rationale of the HERMES consortium . ESC Heart Failure vol. 8 , ( 6 ) 5531 - 5541 .

Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al. ( 2021 ) . 586Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis . International Journal of Epidemiology vol. 50 , ( Supplement_1 )

Katsoulis M, Lai AG, Diaz-Ordaz K, Gomes M, Pasea L, Banerjee A, Denaxas S, Tsilidis K et al. ( 2021 ) . Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records . The Lancet Diabetes & Endocrinology vol. 9 , ( 10 ) 681 - 694 .

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Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS et al. ( 2011 ) . Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile . Nature Genetics vol. 43 , ( 8 ) 753 - 760 .

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Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S et al. ( 2011 ) . Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children . Diabetes vol. 60 , ( 6 ) 1805 - 1812 .

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Langenberg C, Savage DB ( 2011 ) . An amino acid profile to predict diabetes? . Nature Medicine vol. 17 , ( 4 ) 418 - 420 .

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De Silva NMG, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN et al. ( 2011 ) . Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance . Diabetes vol. 60 , ( 3 ) 1008 - 1018 .

( 2011 ) . Erratum . Diabetes Care vol. 34 , ( 3 ) 785 - 786 .

Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, Wareham NJ, Loos RJF ( 2011 ) . Genetic predisposition to obesity leads to increased risk of type 2 diabetes . Diabetologia vol. 54 , ( 4 ) 776 - 782 .

Adler A, Langenberg C, Sims M, Wareham NJ ( 2011 ) . Are population-based carriers of a mutation associated with cystic fibrosis patients more likely to have diabetes? . DIABETOLOGIA . vol. 54 , S154 - S154 .

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Elks CE, Loos RJF, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, Ness AR, Smith GD et al. ( 2010 ) . Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth . PLOS Medicine vol. 7 , ( 5 )

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Liu C, Wu Y, Li H, Qi Q, Langenberg C, Loos RJ, Lin X ( 2010 ) . MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai . BMC Medical Genomics vol. 11 , ( 1 )

Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE et al. ( 2010 ) . Analysis of TBC1D4 in patients with severe insulin resistance . Diabetologia vol. 53 , ( 6 ) 1239 - 1242 .

Bouatia-Naji N, Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow J, Vollenweider P, Lyssenko V et al. ( 2010 ) . O10 Une méta-analyse GWA de la glycémie après 2 h d’HGPO révèle que GIPR est associé avec la sécrétion de l’insuline en réponse au glucose et que ADCY5 est un nouveau gène de susceptibilité au diabète de type 2 . Diabetes & Metabolism vol. 36 ,

Ingelsson E, Langenberg C, Hivert M-F, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S et al. ( 2010 ) . Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans . Diabetes vol. 59 , ( 5 ) 1266 - 1275 .

Saxena R, Hivert M-F, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N et al. ( 2010 ) . Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge . Nature Genetics vol. 42 , ( 2 ) 142 - 148 .

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Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A et al. ( 2009 ) . Parental origin of sequence variants associated with complex diseases . Nature vol. 462 , ( 7275 ) 868 - 874 .

Perry JRB, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H et al. ( 2009 ) . Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes . Human Molecular Genetics vol. 19 , ( 3 ) 535 - 544 .

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Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM et al. ( 2009 ) . Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations . American Journal of Epidemiology vol. 170 , ( 5 ) 537 - 545 .

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Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF et al. ( 2009 ) . Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response . Diabetologia vol. 52 , ( 8 )

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Prokopenko I, Hottenga JJ, Aulchenko YS, Thorleifsson G, Dupuis J, Florez JC, Go MJ, Jackson AU et al. ( 2009 ) . Variants in the DGKB Gene Influence Fasting Glucose Levels in Populations of European and East Asian Descent . DIABETES . vol. 58 , A48 - A48 .

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJF, Manning AK et al. ( 2008 ) . Variants in MTNR1B influence fasting glucose levels . Nature Genetics vol. 41 , ( 1 ) 77 - 81 .

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR et al. ( 2008 ) . Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes . Nature Genetics vol. 40 , ( 5 ) 638 - 645 .

Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E ( 2008 ) . Prevalence of Angina in Women Versus Men . Circulation vol. 117 , ( 12 ) 1526 - 1536 .

Jassal SK, Langenberg C, von Mühlen D, Bergstrom J, Barrett-Connor E ( 2008 ) . Usefulness of Microalbuminuria Versus the Metabolic Syndrome as a Predictor of Cardiovascular Disease in Women and Men >40 Years of Age (from the Rancho Bernardo Study) . The American Journal of Cardiology vol. 101 , ( 9 ) 1275 - 1280 .

Batty GD, Gale CR, Mortensen LH, Langenberg C, Shipley MJ, Deary IJ ( 2008 ) . Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study . Diabetologia vol. 51 , ( 3 ) 436 - 443 .

Langenberg C, Loos RJF, Brage S, Sardinha LB, Andersen LB, Ekelund U, Wareham NJ ( 2008 ) . Novel type 2 diabetes susceptibility loci and measures of glycaemic control in a population based study of healthy children . DIABETOLOGIA . vol. 51 , S31 - S31 .

Langenberg C, Araneta MRG, Bergstrom J, Marmot M, Barrett-Connor E ( 2007 ) . Diabetes and Coronary Heart Disease in Filipino-American Women Role of growth and life-course socioeconomic factors . Diabetes Care vol. 30 , ( 3 ) 535 - 541 .

Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ ( 2007 ) . Life course body size and lipid levels at 53 years in a British birth cohort . Journal of Epidemiology & Community Health vol. 61 , ( 3 )

Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M ( 2006 ) . Household Wealth and the Metabolic Syndrome in the Whitehall II Study . Diabetes Care vol. 29 , ( 12 ) 2694 - 2700 .

Batty GD, Gunnell D, Langenberg C, Smith GD, Marmot MG, Shipley MJ ( 2006 ) . Adult height and lung function as markers of life course exposures: Associations with risk factors and cause-specific mortality . European Journal of Epidemiology vol. 21 , ( 11 ) 795 - 801 .

Langenberg C, Kuh D, Wadsworth MEJ, Brunner E, Hardy R ( 2006 ) . Social Circumstances and Education: Life Course Origins of Social Inequalities in Metabolic Risk in a Prospective National Birth Cohort . American Journal of Public Health vol. 96 , ( 12 ) 2216 - 2221 .

Laughlin GA, Barrett-Connor E, May S, Langenberg C ( 2006 ) . Association of Adiponectin with Coronary Heart Disease and Mortality . American Journal of Epidemiology vol. 165 , ( 2 ) 164 - 174 .

Ferrie JE, Langenberg C, Shipley MJ, Marmot MG ( 2006 ) . Birth weight, components of height and coronary heart disease: evidence from the Whitehall II study . International Journal of Epidemiology vol. 35 , ( 6 ) 1532 - 1542 .

Langenberg C, Bergstrom J, Scheidt-Nave C, Pfeilschifter J, Barrett-Connor E ( 2006 ) . Cardiovascular Death and the Metabolic Syndrome Role of adiposity-signaling hormones and inflammatory markers . Diabetes Care vol. 29 , ( 6 ) 1363 - 1369 .

Langenberg C, Barrett-Connor E, Damant J, Hemingway H ( 2006 ) . Sex differences in angina pectoris: meta-analysis of international variations in 53 studies in 23 countries . European Journal of Preventive Cardiology vol. 13 , ( Supplement 1 )

Jassal SK, Langenberg C, Bergstrom J, von Muhlen D, Barrett-Connor E ( 2006 ) . Albuminuria improves prediction of cardiovascular disease mortality in older women with or without metabolic syndrome . CIRCULATION . vol. 113 , E344 - E345 .

Langenberg C, Allison M, Wong N, Detrano R, Shea S, Carr J, Criqui M ( 2006 ) . Aortic and coronary calcium in diabetic and nondiabetic men and women in the Multi-Ethnic Study of Atherosclerosis (MESA) . CIRCULATION . vol. 113 , E358 - E358 .

Langenberg C, Bergstrom J, Von Mühlen D, Barrett-Connor E ( 2006 ) . Metabolic syndrome improves the prediction of coronary heart disease mortality in diabetes . CIRCULATION . vol. 113 , E343 - E343 .

Bergstrom J, Langenberg C, von Muhlen D, Barrett-Connor E ( 2006 ) . Novel risk factors do not improve prediction of cardiovascular mortality: Evidence from the Rancho Bernardo Study . CIRCULATION . vol. 113 , E334 - E334 .

Batty GD, Shipley MJ, Langenberg C, Marmot MG, Smith GD ( 2005 ) . Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study . Annals of Oncology vol. 17 , ( 1 ) 157 - 166 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Ghrelin, Adiponectin, and Leptin Do Not Predict Long-term Changes in Weight and Body Mass Index in Older Adults: Longitudinal Analysis of the Rancho Bernardo Cohort . American Journal of Epidemiology vol. 162 , ( 12 ) 1189 - 1197 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Ghrelin and the metabolic syndrome in older adults . The Journal of Clinical Endocrinology & Metabolism vol. 90 , ( 12 ) 6448 - 6453 .

Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M ( 2005 ) . 211-S: Household Wealth and the Metabolic Syndrome in the Whitehall II Cohort . American Journal of Epidemiology vol. 161 , ( Supplement_1 ) s53 - s53 .

( 2005 ) . Department of Error . The Lancet vol. 365 , ( 9471 )

Langenberg C, Hardy R, Breeze E, Kuh D, Wadsworth ME ( 2005 ) . Influence of short stature on the change in pulse pressure, systolic and diastolic blood pressure from age 36 to 53 years: an analysis using multilevel models . International Journal of Epidemiology vol. 34 , ( 4 ) 905 - 913 .

Langenberg C, Shipley MJ, Batty GD, Marmot MG ( 2005 ) . Adult Socioeconomic Position and the Association Between Height and Coronary Heart Disease Mortality: Findings From 33 Years of Follow-Up in the Whitehall Study . American Journal of Public Health vol. 95 , ( 4 ) 628 - 632 .

Kuh D, Langenberg C, Hardy R, Kok H, Cooper R, Butterworth S, Wadsworth MEJ ( 2005 ) . Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study . BJOG An International Journal of Obstetrics & Gynaecology vol. 112 , ( 4 ) 476 - 485 .

Hardy R, Kuh D, Langenberg C, Wadsworth MEJ ( 2005 ) . Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort (vol 362, pg 1178, 2003) . LANCET vol. 365 , ( 9471 ) 1620 - 1620 .

Langenberg C, Bergstrom J, Barrett-Connor E ( 2005 ) . Cardiovascular death and the metabolic syndrome: Role of inflammatory cytokines and adiposity signaling hormones . CIRCULATION . vol. 112 , U889 - U889 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Hormonal signals of weight homeostasis and 18-year weight change in older adults: Longitudinal analysis of the Rancho Bernardo cohort . CIRCULATION . vol. 111 , E205 - E205 .

Hardy R, Wadsworth ME, Langenberg C, Kuh D ( 2004 ) . Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort . International Journal of Epidemiology vol. 33 , ( 1 ) 121 - 129 .

Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ ( 2004 ) . Birth Weight and Lipids in a National Birth Cohort Study . Arteriosclerosis Thrombosis and Vascular Biology vol. 24 , ( 3 ) 588 - 594 .

Hardy R, Langenberg C ( 2003 ) . Commentary: The association between height growth and cholesterol levels during puberty: implications for adult health . International Journal of Epidemiology vol. 32 , ( 6 ) 1110 - 1111 .

Wadsworth MEJ, Butterworth SL, Hardy RJ, Kuh DJ, Richards M, Langenberg C, Hilder WS, Connor M ( 2003 ) . The life course prospective design: an example of benefits and problems associated with study longevity . Social Science & Medicine vol. 57 , ( 11 ) 2193 - 2205 .

Langenberg C, Hardy R, Kuh D, Brunner E, Wadsworth M ( 2003 ) . Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: evidence from a national birth cohort . Journal of Epidemiology & Community Health vol. 57 , ( 10 )

Hardy R, Kuh D, Langenberg C, Wadsworth ME ( 2003 ) . Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort . The Lancet vol. 362 , ( 9391 ) 1178 - 1183 .

Langenberg C, Marmot M ( 2003 ) . Commentary: Disentangling the association between short height and cardiovascular risk—genes or environment? . International Journal of Epidemiology vol. 32 , ( 4 ) 614 - 616 .

Langenberg C, Hardy R, Kuh D, Wadsworth ME ( 2003 ) . Influence of height, leg and trunk length on pulse pressure, systolic and diastolic blood pressure . Journal of Hypertension vol. 21 , ( 3 ) 537 - 543 .

Asif AR, Grunewald RW, Langenberg C, Metten M, Jarry H, Müller GA, Burckhardt G, Hagos Y ( 2003 ) . Human organic anion transporter 3 (hOAT3) in human adrenocortical cells transports cortisol . FASEB JOURNAL . vol. 17 , A477 - A477 .

Kuh D, Hardy R, Langenberg C, Richards M, Wadsworth MEJ ( 2002 ) . Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study . The BMJ vol. 325 , ( 7372 )

Pritsche L, Donner-Banzhoff N, Druck G, Kunz R, Langenberg C, Lelgemann M, Pientka L, Von Maxen A et al. ( 2001 ) . EbM-courses for hospital and practise settings - Current models in Germany . Zeitschrift fur Arztliche Fortbildung und Qualitatssicherung vol. 95 , ( 4 ) 297 - 298 .

Helou A, Perleth M, Lühmann D, Langenberg C, Busse R ( 2001 ) . Evidence-based medicine: What kind of competencies should medical education provide? . Medizinische Ausbildung . vol. 18 , 31 - 37 .

Raspe H, Langenberg C ( 1999 ) . Final and causal foundations of medical practice--two achievements of evidence-based medicine . Zeitschrift für Evidenz Fortbildung und Qualität im Gesundheitswesen vol. 93 , ( 4 )