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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Ianos-Robert Adalbert

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Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F et al. ( 2023 ) . Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects . Nature Communications vol. 14 , ( 1 )
Adalbert R, Cahalan S, Hopkins EL, Almuhanna A, Loreto A, Pór E, Körmöczy L, Perkins J et al. ( 2022 ) . Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport . Journal of Anatomy vol. 241 , ( 5 ) 1211 - 1218 .
Gould SA, Adalbert R, Milde S, Coleman M ( 2022 ) . Imaging Axonal Transport in Ex Vivo Central and Peripheral Nerves . Axonal Transport , vol. 2431 , Springer Nature
Gould SA, White M, Wilbrey AL, Pór E, Coleman MP, Adalbert R ( 2021 ) . Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1 −/− mice . Experimental Neurology vol. 338 ,
Dembny P, Newman AG, Singh M, Hinz M, Szczepek M, Krüger C, Adalbert R, Dzaye O et al. ( 2020 ) . Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors . JCI Insight vol. 5 , ( 7 )
Adalbert R, Kaieda A, Antoniou C, Loreto A, Yang X, Gilley J, Hoshino T, Uga K et al. ( 2019 ) . Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot–Marie–Tooth Type 2F . ACS Chemical Neuroscience vol. 11 , ( 3 ) 258 - 267 .
White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S et al. ( 2018 ) . Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD . Nature Neuroscience vol. 21 , ( 8 ) 1138 - 1138 .
Adalbert R, Milde S, Durrant C, Ando K, Stygelbout V, Yilmaz Z, Gould S, Brion J-P et al. ( 2018 ) . Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport . Neurobiology of Aging vol. 68 , 68 - 75 .
White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S et al. ( 2018 ) . TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD . Nature Neuroscience vol. 21 , ( 4 ) 552 - 563 .
Clark DE, Waszkowycz B, Wong M, Lockey PM, Adalbert R, Gilley J, Clark J, Coleman MP ( 2016 ) . Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies . Bioorganic & Medicinal Chemistry Letters vol. 26 , ( 12 ) 2920 - 2926 .
Milde S, Adalbert R, Elaman MH, Coleman MP ( 2014 ) . Axonal transport declines with age in two distinct phases separated by a period of relative stability . Neurobiology of Aging vol. 36 , ( 2 ) 971 - 981 .
Marangoni M, Adalbert R, Janeckova L, Patrick J, Kohli J, Coleman MP, Conforti L ( 2014 ) . Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease . Neurobiology of Aging vol. 35 , ( 10 ) 2382 - 2393 .
Gilley J, Adalbert R, Yu G, Coleman MP ( 2013 ) . Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2 . Journal of Neuroscience vol. 33 , ( 33 ) 13410 - 13424 .
Adalbert R, Coleman MP ( 2013 ) . Review: Axon pathology in age‐related neurodegenerative disorders . Neuropathology and Applied Neurobiology vol. 39 , ( 2 ) 90 - 108 .
Adalbert R, Morreale G, Paizs M, Conforti L, Walker SA, Roderick HL, Bootman MD, Siklós L et al. ( 2012 ) . Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons . Neuroscience vol. 225 , 44 - 54 .
Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA et al. ( 2012 ) . dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway . Science vol. 337 , ( 6093 ) 481 - 484 .
Gilley J, Adalbert R, Coleman MP ( 2011 ) . Modelling early responses to neurodegenerative mutations in mice . Biochemical Society Transactions vol. 39 , ( 4 ) 933 - 938 .
Salek RM, Xia J, Innes A, Sweatman BC, Adalbert R, Randle S, McGowan E, Emson PC et al. ( 2010 ) . A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease . Neurochemistry International vol. 56 , ( 8 ) 937 - 947 .
Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M et al. ( 2009 ) . WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice . Journal of Cell Biology vol. 184 , ( 4 ) 491 - 500 .
Adalbert R, Nogradi A, Babetto E, Janeckova L, Walker SA, Kerschensteiner M, Misgeld T, Coleman MP ( 2008 ) . Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies . Brain vol. 132 , ( 2 ) 402 - 416 .
Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R et al. ( 2008 ) . VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, WldS . Molecular and Cellular Neuroscience vol. 38 , ( 3 ) 325 - 340 .
Bridge KE, Berg N, Adalbert R, Babetto E, Dias T, Spillantini M-G, Ribchester RR, Coleman MP ( 2007 ) . Late onset distal axonal swelling in YFP-H transgenic mice . Neurobiology of Aging vol. 30 , ( 2 ) 309 - 321 .
Adalbert R, Gilley J, Coleman MP ( 2007 ) . Aβ, tau and ApoE4 in Alzheimer's disease: the axonal connection . Trends in Molecular Medicine vol. 13 , ( 4 ) 135 - 142 .
Conforti L, Adalbert R, Coleman MP ( 2007 ) . Neuronal death: where does the end begin? . Trends in Neurosciences vol. 30 , ( 4 ) 159 - 166 .
Adalbert R, Nógrádi A, Szabó A, Coleman MP ( 2006 ) . The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy . European Journal of Neuroscience vol. 24 , ( 8 ) 2163 - 2168 .
Conforti L, Fang G, Beirowski B, Wang MS, Sorci L, Asress S, Adalbert R, Silva A et al. ( 2006 ) . NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degeneration . Cell Death & Differentiation vol. 14 , ( 1 ) 116 - 127 .
Laser H, Conforti L, Morreale G, Mack TGM, Heyer M, Haley JE, Wishart TM, Beirowski B et al. ( 2005 ) . The Slow Wallerian Degeneration Protein, WldS, Binds Directly to VCP/p97 and Partially Redistributes It within the Nucleus . Molecular Biology of the Cell vol. 17 , ( 3 ) 1075 - 1084 .
Coleman MP, Adalbert R, Beirowski B ( 2005 ) . Neuroprotective strategies in MS: Lessons from C57BL/WldS mice . Journal of the Neurological Sciences . vol. 233 , 133 - 138 .
Fischer LR, Culver DG, Davis AA, Tennant P, Wang M, Coleman M, Asress S, Adalbert R et al. ( 2005 ) . The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse . Neurobiology of Disease vol. 19 , ( 1-2 ) 293 - 300 .
Beirowski B, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP ( 2005 ) . The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves . BMC Neuroscience vol. 6 , ( 1 )
Adalbert R, Gillingwater TH, Haley JE, Bridge K, Beirowski B, Berek L, Wagner D, Grumme D et al. ( 2005 ) . A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses . European Journal of Neuroscience vol. 21 , ( 1 ) 271 - 277 .
Mi W, Beirowski B, Gillingwater TH, Adalbert R, Wagner D, Grumme D, Osaka H, Conforti L et al. ( 2004 ) . The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice . Brain vol. 128 , ( 2 ) 405 - 416 .
Beirowski B, Berek L, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP ( 2004 ) . Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice . Journal of Neuroscience Methods vol. 134 , ( 1 ) 23 - 35 .
Adalbert R, Engelhardt JI, Siklós L ( 2002 ) . DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo . Acta Neuropathologica vol. 103 , ( 5 ) 428 - 436 .
Siklós L, Engelhardt JI, Reaume AG, Scott RW, Adalbert R, Obál I, Appel SH ( 2000 ) . Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice . Acta Neuropathologica vol. 99 , ( 5 ) 517 - 524 .
Siklós L, Engelhardt JI, Adalbert R, Appel SH ( 1999 ) . Calcium-containing endosomes at oculomotor terminals in animal models of ALS . Neuroreport vol. 10 , ( 12 ) 2539 - 2545 .
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