Publications: Dr Maik Pietzner

Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K et al. ( 2024 ) . Genetic architecture of routinely acquired blood tests in a British South Asian cohort . Nature Communications vol. 15 , ( 1 )

Carrasco-Zanini J, Wheeler E, Uluvar B, Kerrison N, Koprulu M, Wareham NJ, Pietzner M, Langenberg C ( 2024 ) . Mapping biological influences on the human plasma proteome beyond the genome . Nature Metabolism vol. 6 , ( 10 ) 2010 - 2023 .

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J et al. ( 2024 ) . Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health . Nature Metabolism vol. 6 , ( 10 ) 1922 - 1938 .

Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M ( 2024 ) . Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization . EBioMedicine vol. 107 ,

Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al. ( 2024 ) . Proteomic signatures improve risk prediction for common and rare diseases . Nature Medicine vol. 30 , ( 9 ) 2489 - 2498 .

Pietzner M, Denaxas S, Yasmeen S, Ulmer MA, Nakanishi T, Arnold M, Kastenmüller G, Hemingway H et al. ( 2024 ) . Complex patterns of multimorbidity associated with severe COVID-19 and long COVID . Communications Medicine vol. 4 , ( 1 )

Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C ( 2024 ) . Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study . The Lancet Digital Health vol. 6 , ( 7 ) e470 - e479 .

Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al. ( 2024 ) . Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics . EBioMedicine vol. 105 ,

Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al. ( 2024 ) . RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats . Nature Communications vol. 15 , ( 1 )

Smith-Byrne K, Hedman Å, Dimitriou M, Desai T, Sokolov AV, Schioth HB, Koprulu M, Pietzner M et al. ( 2024 ) . Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers . Nature Communications vol. 15 , ( 1 )

Desai TA, Hedman AK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al. ( 2024 ) . Abstract 7330: Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using mendelian randomization and tumor spatial transcriptomics . Cancer Research vol. 84 , ( 6_Supplement ) 7330 - 7330 .

Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS et al. ( 2024 ) . Systemic proteome adaptions to 7-day complete caloric restriction in humans . Nature Metabolism vol. 6 , ( 4 ) 764 - 777 .

Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O et al. ( 2024 ) . Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications . Nature Communications vol. 15 , ( 1 )

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Ghasemi-Semeskandeh D, Coassin S et al. ( 2023 ) . Genetic determinants of complement activation in the general population . Cell Reports vol. 43 , ( 1 )

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 )

Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I et al. ( 2023 ) . Identification of circulating proteins associated with general cognitive function among middle-aged and older adults . Communications Biology vol. 6 , ( 1 )

Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ ( 2023 ) . Multi-omic prediction of incident type 2 diabetes . Diabetologia vol. 67 , ( 1 ) 102 - 112 .

Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ, Hemingway H et al. ( 2023 ) . ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon . Nature Communications vol. 14 , ( 1 )

Breitfeld J, Horn K, Le Duc D, Velluva A, Marzi C, Grallert H, Friedrich N, Pietzner M et al. ( 2023 ) . Genetic dissection of serum vaspin highlights its causal role in lipid metabolism . Obesity vol. 31 , ( 11 ) 2862 - 2874 .

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Coassin S, Fuchsberger C et al. ( 2023 ) . 176 A genome-wide association screening of complement activation from a general population study . Immunobiology vol. 228 , ( 5 )

Alwan H, Luan J, Williamson A, Steward I, Wareham N, Langenberg C, Pietzner M ( 2023 ) . Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study . Endocrine Abstracts

Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H et al. ( 2023 ) . Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization . Arthritis & Rheumatology vol. 75 , ( 10 ) 1781 - 1792 .

van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S et al. ( 2023 ) . Circulating metabolites modulated by diet are associated with depression . Molecular Psychiatry vol. 28 , ( 9 ) 3874 - 3887 .

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al. ( 2023 ) . Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure . Nature Communications vol. 14 , ( 1 )

Phlairaharn T, Ye Z, Krismer E, Pedersen A-K, Pietzner M, Olsen JV, Schoof EM, Searle BC ( 2023 ) . Optimizing Linear Ion-Trap Data-Independent Acquisition toward Single-Cell Proteomics . Analytical Chemistry vol. 95 , ( 26 ) 9881 - 9891 .

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 )

Würfel M, Horn K, Le Duc D, Velluva A, Marzi C, Grallert H, Friedrich N, Pietzner M et al. ( 2023 ) . Genetic dissection of serum vaspin highlights its causal role in lipid metabolism . Diabetologie und Stoffwechsel . Conference: Vielfalt & Individualität - Diabetes neu denken www.diabeteskongress.de vol. 18 , s21 - s22 .

Su C-Y, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, Jeon W, Morrison DR et al. ( 2023 ) . Circulating proteins to predict COVID-19 severity . Scientific Reports vol. 13 , ( 1 )

Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA et al. ( 2023 ) . An atlas of genetic scores to predict multi-omic traits . Nature vol. 616 , ( 7955 ) 123 - 131 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Author Correction: Proteogenomic links to human metabolic diseases . Nature Metabolism vol. 5 , ( 4 ) 710 - 710 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Proteogenomic links to human metabolic diseases . Nature Metabolism vol. 5 , ( 3 ) 516 - 528 .

Phlairaharn T, Ye Z, Krismer E, Pedersen A-K, Pietzner M, Olsen JV, Schoof EM, Searle BC ( 2023 ) . Optimizing linear ion trap data independent acquisition towards single cell proteomics . vol. 4 , ( 03-02 )

Vernardis SI, Demichev V, Lemke O, Grüning N-M, Messner C, White M, Pietzner M, Peluso A et al. ( 2023 ) . The Impact of Acute Nutritional Interventions on the Plasma Proteome . The Journal of Clinical Endocrinology & Metabolism vol. 108 , ( 8 ) 2087 - 2098 .

Bengel P, Elkenani M, Beuthner BE, Pietzner M, Mohamed BA, Pollok-Kopp B, Krätzner R, Toischer K et al. ( 2023 ) . Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis . Biomolecules vol. 13 , ( 1 )

Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals . Clinical Proteomics vol. 19 , ( 1 )

Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M et al. ( 2022 ) . Proteomic signatures for identification of impaired glucose tolerance . Nature Medicine vol. 28 , ( 11 ) 2293 - 2300 .

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF et al. ( 2022 ) . Rare and common genetic determinants of metabolic individuality and their effects on human health . Nature Medicine vol. 28 , ( 11 ) 2321 - 2332 .

Bengel P, Beuthner BE, Topci R, Pietzner M, Hasenfuss G, Toischer K, Schnelle M ( 2022 ) . Metabolic modulation as a common adaptive mechanism in patients with different subtypes of aortic valve stenosis . European Heart Journal vol. 43 , ( Supplement_2 )

Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al. ( 2022 ) . The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals . Clinical Proteomics vol. 19 , ( 1 )

Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier zu Belzen J, Loock L et al. ( 2022 ) . Metabolomic profiles predict individual multidisease outcomes . Nature Medicine vol. 28 , ( 11 ) 2309 - 2320 .

Agostini M, Pietzner M, Marelli F, Prapa M, Moran C, Edward VW, Brown D, Thomas E et al. ( 2022 ) . Resistance to thyroid hormone alpha: molecular, biochemical and physiological approach to diagnosis and therapy . Endocrine Abstracts

Pietzner M, Chua RL, Wheeler E, Jechow K, Willett JDS, Radbruch H, Trump S, Heidecker B et al. ( 2022 ) . ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 . Nature Communications vol. 13 , ( 1 )

Li C, Imamura F, Wedekind R, Stewart ID, Pietzner M, Wheeler E, Forouhi NG, Langenberg C et al. ( 2022 ) . Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention . American Journal of Clinical Nutrition vol. 116 , ( 2 ) 511 - 522 .

Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M et al. ( 2022 ) . Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension . American Journal of Respiratory and Critical Care Medicine vol. 205 , ( 12 ) 1449 - 1460 .

Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS et al. ( 2022 ) . Detection and characterization of male sex chromosome abnormalities in the UK Biobank study . Genetics in Medicine vol. 24 , ( 9 ) 1909 - 1919 .

Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N et al. ( 2022 ) . Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases . JCI Insight vol. 7 , ( 10 )

LI Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Quynh Nguyen N, Scherer N et al. ( 2022 ) . MO048: Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases . Nephrology Dialysis Transplantation vol. 37 , ( Supplement_3 )

Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N et al. ( 2022 ) . Genetic Landscape of the ACE2 Coronavirus Receptor . Circulation vol. 145 , ( 18 ) 1398 - 1411 .

Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C et al. ( 2022 ) . Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes . Clinical Epigenetics vol. 14 , ( 1 )

Li Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Nguyen NQ, Scherer N et al. ( 2022 ) . GENOME-WIDE STUDIES REVEAL FACTORS ASSOCIATED WITH CIRCULATING UROMODULIN AND ITS RELATIONS WITH COMPLEX DISEASES . NEPHROLOGY DIALYSIS TRANSPLANTATION . vol. 37 , I28 - I29 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Kerrison N, Wareham N, Pietzner M, Langenberg C ( 2022 ) . Understanding Disease Mechanisms: From Genome to Phenome via the Proteome . GENETIC EPIDEMIOLOGY . vol. 46 , 507 - 507 .

Png G, Barysenka A, Repetto L, Navarro P, Shen X, Pietzner M, Wheeler E, Wareham NJ et al. ( 2021 ) . Mapping the serum proteome to neurological diseases using whole genome sequencing . Nature Communications vol. 12 , ( 1 )

Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, Luan J, Hingorani AD et al. ( 2021 ) . Synergistic insights into human health from aptamer- and antibody-based proteomic profiling . Nature Communications vol. 12 , ( 1 )

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J et al. ( 2021 ) . Mapping the proteo-genomic convergence of human diseases . Science vol. 374 , ( 6569 )

van Vliet NA, Bos MM, Thesing CS, Chaker L, Pietzner M, Houtman E, Neville MJ, Li-Gao R et al. ( 2021 ) . Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling . BMC Medicine vol. 19 , ( 1 )

Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al. ( 2021 ) . 586Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis . International Journal of Epidemiology vol. 50 , ( Supplement_1 )

Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E et al. ( 2021 ) . Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region . Diabetes vol. 70 , ( 11 ) 2706 - 2719 .

Cai N, Gomez-Duran A, Yonova-Doing E, Kundu K, Burgess AI, Golder ZJ, Calabrese C, Bonder MJ et al. ( 2021 ) . Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases . Nature Medicine vol. 27 , ( 9 ) 1564 - 1575 .

Van Vliet NA, Bos MM, Thesing CS, Chaker L, Pietzner M, Houtman E, Neville MJ, Li-Gao R et al. ( 2021 ) . Higher thyroid stimulating hormone leads to cardiovascular disease and an unfavorable lipid profile: EVidence from multi-cohort Mendelian randomization and metabolomic profiling . Atherosclerosis vol. 331 ,

Andörfer L, Holtfreter B, Weiss S, Matthes R, Pitchika V, Schmidt CO, Samietz S, Kastenmüller G et al. ( 2021 ) . Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting . BMC Medicine vol. 19 , ( 1 )

Zhao Y, Stankovic S, Koprulu M, Wheeler E, Day FR, Lango Allen H, Kerrison ND, Pietzner M et al. ( 2021 ) . GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health . Nature Communications vol. 12 , ( 1 )

Zacharias HU, Hertel J, Johar H, Pietzner M, Lukaschek K, Atasoy S, Kunze S, Völzke H et al. ( 2021 ) . A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression . Molecular Psychiatry vol. 26 , ( 12 ) 7372 - 7383 .

Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho Y-L, Iyengar SK et al. ( 2021 ) . Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 . Nature Medicine vol. 27 , ( 4 ) 668 - 676 .

Lietzow J, Golchert J, Pietzner M, Völker U, Poutanen M, Ohlsson C, Homuth G, Köhrle J ( 2021 ) . Comparative Analysis of the Effects of Long-Term 3,5-diiodothyronine Treatment on the Murine Hepatic Proteome and Transcriptome Under Conditions of Normal Diet and High-Fat Diet . Thyroid vol. 31 , ( 7 ) 1135 - 1146 .

Eick C, Klinger-König J, Zylla S, Hannemann A, Budde K, Henning AK, Pietzner M, Nauck M et al. ( 2021 ) . Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women . Metabolites vol. 11 , ( 4 )

Frost F, Kacprowski T, Rühlemann M, Weiss S, Bang C, Franke A, Pietzner M, Aghdassi AA et al. ( 2021 ) . Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis . Scientific Reports vol. 11 , ( 1 )

Pietzner M, Stewart ID, Raffler J, Khaw K-T, Michelotti GA, Kastenmüller G, Wareham NJ, Langenberg C ( 2021 ) . Plasma metabolites to profile pathways in noncommunicable disease multimorbidity . Nature Medicine vol. 27 , ( 3 ) 471 - 479 .

Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M et al. ( 2021 ) . A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity . Nature Medicine vol. 27 , ( 4 ) 659 - 667 .

Storck LJ, Meffert PJ, Rausch J, Gärtner S, Aghdassi AA, Kühn J-P, Kraft M, Pietzner M et al. ( 2021 ) . Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity . Obesity Facts vol. 14 , ( 1 ) 45 - 55 .

Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al. ( 2021 ) . Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection . Nature Communications vol. 12 , ( 1 )

Crawford AA, Bankier S, Altmaier E, Barnes CLK, Clark DW, Ermel R, Friedrich N, van der Harst P et al. ( 2021 ) . Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease . Journal of Human Genetics vol. 66 , ( 6 ) 625 - 636 .

Pietzner M, Budde K, Rühlemann M, Völzke H, Homuth G, Weiss FU, Lerch MM, Frost F ( 2021 ) . Exocrine Pancreatic Function Modulates Plasma Metabolites Through Changes in Gut Microbiota Composition . The Journal of Clinical Endocrinology & Metabolism vol. 106 , ( 5 ) e2290 - e2298 .

Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK et al. ( 2021 ) . A cross-platform approach identifies genetic regulators of human metabolism and health . Nature Genetics vol. 53 , ( 1 ) 54 - 64 .

Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al. ( 2021 ) . Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis . INTERNATIONAL JOURNAL OF EPIDEMIOLOGY . vol. 50 ,

Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al. ( 2020 ) . Genetic architecture of host proteins involved in SARS-CoV-2 infection . Nature Communications vol. 11 , ( 1 )

Zheng J-S, Luan J, Sofianopoulou E, Imamura F, Stewart ID, Day FR, Pietzner M, Wheeler E et al. ( 2020 ) . Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations . Diabetes Care vol. 44 , ( 1 ) 98 - 106 .

Frost F, Kacprowski T, Rühlemann M, Pietzner M, Bang C, Franke A, Nauck M, Völker U et al. ( 2020 ) . Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function . Gut vol. 70 , ( 3 ) 522 - 530 .

Zanini JC, Pietzner M, Langenberg C ( 2020 ) . Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes . Current Diabetes Reports vol. 20 , ( 11 )

Steinke J, Samietz S, Friedrich N, Weiss S, Michalik S, Biffar R, Nauck M, Völker U et al. ( 2020 ) . Associations of plasma YKL-40 concentrations with heel ultrasound parameters and bone turnover markers in the general adult population . Bone vol. 141 ,

Mann JP, Pietzner M, Wittemans LB, De Lucia Rolfe E, Kerrison ND, Imamura F, Forouhi NG, Fauman E et al. ( 2020 ) . Insights into genetic variants associated with NASH-fibrosis from metabolite profiling . Human Molecular Genetics vol. 29 , ( 20 ) 3451 - 3463 .

Friedrich N, Pietzner M, Engelmann B, Homuth G, Führer D, Brabant G, Wallaschofski H, Völker U ( 2020 ) . Screening for New Markers to Assess Thyroid Hormone Action by OMICs Analysis of Human Samples . Experimental and Clinical Endocrinology & Diabetes vol. 128 , ( 06/07 ) 479 - 487 .

Otto L, Budde K, Kastenmüller G, Kaul A, Völker U, Völzke H, Adamski J, Kühn JP et al. ( 2020 ) . Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population . Scientific Reports vol. 10 , ( 1 )

Nag A, Kurushima Y, Bowyer RCE, Wells PM, Weiss S, Pietzner M, Kocher T, Raffler J et al. ( 2020 ) . Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels . Human Molecular Genetics vol. 29 , ( 5 ) 864 - 875 .

Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, Cheng Y, Wuttke M et al. ( 2020 ) . Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans . Nature Genetics vol. 52 , ( 2 ) 167 - 176 .

Köhrle J, Lehmphul I, Pietzner M, Renko K, Rijntjes E, Richards K, Anselmo J, Danielsen M et al. ( 2020 ) . 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action . Frontiers in Endocrinology vol. 10 ,

Hertel J, Harms AC, Heinken A, Baldini F, Thinnes CC, Glaab E, Vasco DA, Pietzner M et al. ( 2019 ) . Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease . Cell Reports vol. 29 , ( 7 ) 1767 - 1777.e8 .

Pietzner M, Köhrle J, Lehmphul I, Budde K, Kastenmüller G, Brabant G, Völzke H, Artati A et al. ( 2019 ) . A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans . Thyroid vol. 29 , ( 12 ) 1743 - 1754 .

Menni C, McCallum L, Pietzner M, Zierer J, Aman A, Suhre K, Mohney RP, Mangino M et al. ( 2019 ) . Metabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns . Scientific Reports vol. 9 , ( 1 )

Urbaneck I, Lorenz F, Materzok I, Maletzki L, Pietzner M, Budde K, Nauck M, Felix SB et al. ( 2019 ) . P6277The impact of exercise training in combination with statin use on skeletal muscle mitochondrial oxidative phosphorylation and metabolomics in obese rats . European Heart Journal vol. 40 , ( Supplement_1 )

Wildberg C, Masuch A, Budde K, Kastenmüller G, Artati A, Rathmann W, Adamski J, Kocher T et al. ( 2019 ) . Plasma Metabolomics to Identify and Stratify Patients With Impaired Glucose Tolerance . The Journal of Clinical Endocrinology & Metabolism vol. 104 , ( 12 ) 6357 - 6370 .

Del Greco M F, Foco L, Teumer A, Verweij N, Paglia G, Meraviglia V, Melotti R, Vukovic V et al. ( 2019 ) . Lipidomics, Atrial Conduction, and Body Mass Index . Circulation Genomic and Precision Medicine vol. 12 , ( 7 )

Masuch A, Budde K, Kastenmüller G, Artati A, Adamski J, Völzke H, Nauck M, Pietzner M ( 2019 ) . Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals . Journal of Cellular and Molecular Medicine vol. 23 , ( 8 ) 5144 - 5153 .

Bahls M, Friedrich N, Pietzner M, Wachter R, Budde K, Hasenfuß G, Nauck M, Pressler A et al. ( 2019 ) . Heterogeneous Metabolic Response to Exercise Training in Heart Failure with Preserved Ejection Fraction . Journal of Clinical Medicine vol. 8 , ( 5 )

Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmüller G, Artati A, Suhre K, Adamski J et al. ( 2019 ) . The Saliva Metabolome in Association to Oral Health Status . Journal of Dental Research vol. 98 , ( 6 ) 642 - 651 .

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al. ( 2019 ) . Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids . Nature Genetics vol. 51 , ( 4 ) 636 - 648 .

Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE et al. ( 2019 ) . Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation . JAMA Cardiology vol. 4 , ( 2 ) 144 - 152 .

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT et al. ( 2019 ) . Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions . American Journal of Epidemiology vol. 188 , ( 6 ) 1033 - 1054 .

Kaul A, Masuch A, Budde K, Kastenmüller G, Artati A, Adamski J, Völzke H, Nauck M et al. ( 2018 ) . Molecular Fingerprints of Iron Parameters among a Population-Based Sample . Nutrients vol. 10 , ( 11 )

Hertel J, Frenzel S, König J, Wittfeld K, Füllen G, Pietzner M, Völzke H, Grabe H ( 2018 ) . MEASURING BIOLOGICAL AGE AS A TASK OF INDIVIDUALIZATION: A FRAMEWORK FOR PREDICTOR SELECTION AND MODEL VALIDATION . Innovation in Aging vol. 2 , ( suppl_1 ) 837 - 837 .

Frost F, Kacprowski T, Rühlemann M, Bülow R, Kühn J-P, Franke A, Heinsen F-A, Pietzner M et al. ( 2018 ) . Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity . Gastroenterology vol. 156 , ( 4 ) 1010 - 1015 .

Masuch A, Pietzner M, Bahls M, Budde K, Kastenmüller G, Zylla S, Artati A, Adamski J et al. ( 2018 ) . Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP . Cardiovascular Diabetology vol. 17 , ( 1 )

Süße M, Hannich M, Petersmann A, Zylla S, Pietzner M, Nauck M, Dressel A ( 2018 ) . P96. Intrathecal immunglobulin synthesis: Sensitivity of kappa free light chains in cerebrospinal fluid to identify patients with oligoclonal bands . Clinical Neurophysiology vol. 129 , ( 8 )

Pietzner M, Budde K, Homuth G, Kastenmüller G, Henning A-K, Artati A, Krumsiek J, Völzke H et al. ( 2018 ) . Hepatic Steatosis Is Associated With Adverse Molecular Signatures in Subjects Without Diabetes . The Journal of Clinical Endocrinology & Metabolism vol. 103 , ( 10 ) 3856 - 3868 .

Süße M, Hannich M, Petersmann A, Zylla S, Pietzner M, Nauck M, Dressel A ( 2018 ) . Kappa free light chains in cerebrospinal fluid to identify patients with oligoclonal bands . European Journal of Neurology vol. 25 , ( 9 ) 1134 - 1139 .

Pietzner M, Homuth G, Kohrle J, Budde K, Kastenmuller G, Brabant G, Volzke H, Artati A et al. ( 2018 ) . A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans . Endocrine Abstracts

Pietzner M, Kacprowski T, Friedrich N ( 2018 ) . Empowering thyroid hormone research in human subjects using OMICs technologies . Journal of Endocrinology vol. 238 , ( 1 ) r13 - r29 .

Lange T, Budde K, Homuth G, Kastenmüller G, Artati A, Krumsiek J, Völzke H, Adamski J et al. ( 2018 ) . Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters . The Journal of Clinical Endocrinology & Metabolism vol. 103 , ( 5 ) 2050 - 2060 .

Hertel J, Frenzel S, König J, Wittfeld K, Fuellen G, Holtfreter B, Pietzner M, Friedrich N et al. ( 2018 ) . The informative error: A framework for the construction of individualized phenotypes . Statistical Methods in Medical Research vol. 28 , ( 5 ) 1427 - 1438 .

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, van Lent DM, Tynkkynen J et al. ( 2018 ) . Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies . Alzheimer's & Dementia vol. 14 , ( 6 ) 707 - 722 .

Auer MK, Ebert T, Pietzner M, Defreyne J, Fuss J, Stalla GK, T’Sjoen G ( 2017 ) . Effects of Sex Hormone Treatment on the Metabolic Syndrome in Transgender Individuals: Focus on Metabolic Cytokines . The Journal of Clinical Endocrinology & Metabolism vol. 103 , ( 2 ) 790 - 802 .

Pietzner M, Kaul A, Henning A-K, Kastenmüller G, Artati A, Lerch MM, Adamski J, Nauck M et al. ( 2017 ) . Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals . BMC Medicine vol. 15 , ( 1 )

Hertel J, König J, Homuth G, Van der Auwera S, Wittfeld K, Pietzner M, Kacprowski T, Pfeiffer L et al. ( 2017 ) . Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives . Scientific Reports vol. 7 , ( 1 )

Do KT, Pietzner M, Rasp DJ, Friedrich N, Nauck M, Kocher T, Suhre K, Mook-Kanamori DO et al. ( 2017 ) . Phenotype-driven identification of modules in a hierarchical map of multifluid metabolic correlations . npj Systems Biology and Applications vol. 3 , ( 1 )

Entenmann L, Pietzner M, Artati A, Hannemann A, Henning A-K, Kastenmüller G, Völzke H, Nauck M et al. ( 2017 ) . Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample . PLOS ONE vol. 12 , ( 9 )

Genske F, Kühn J-P, Pietzner M, Homuth G, Rathmann W, Grabe HJ, Völzke H, Wallaschofski H et al. ( 2017 ) . Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population . International Journal of Obesity vol. 42 , ( 2 ) 183 - 189 .

Friedrich N, Skaaby T, Pietzner M, Budde K, Thuesen BH, Nauck M, Linneberg A ( 2017 ) . Identification of urine metabolites associated with 5-year changes in biomarkers of glucose homoeostasis . Diabetes & Metabolism vol. 44 , ( 3 ) 261 - 268 .

Li M, Maruthur NM, Loomis SJ, Pietzner M, North KE, Mei H, Morrison AC, Friedrich N et al. ( 2017 ) . Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism . Scientific Reports vol. 7 , ( 1 )

Piontek U, Wallaschofski H, Kastenmüller G, Suhre K, Völzke H, Do KT, Artati A, Nauck M et al. ( 2017 ) . Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes . Scientific Reports vol. 7 , ( 1 )

Friedrich N, Pietzner M, Cannet C, Thuesen BH, Hansen T, Wallaschofski H, Grarup N, Skaaby T et al. ( 2017 ) . Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts . PLOS ONE vol. 12 , ( 3 )

Hertel J, Van der Auwera S, Friedrich N, Wittfeld K, Pietzner M, Budde K, Teumer A, Kocher T et al. ( 2017 ) . Two statistical criteria to choose the method for dilution correction in metabolomic urine measurements . Metabolomics vol. 13 , ( 4 )

Zylla S, Pietzner M, Kühn J, Völzke H, Dörr M, Nauck M, Friedrich N ( 2017 ) . Serum chemerin is associated with inflammatory and metabolic parameters—results of a population‐based study . Obesity vol. 25 , ( 2 ) 468 - 475 .

Pietzner M, Engelmann B, Kacprowski T, Golchert J, Dirk A-L, Hammer E, Iwen KA, Nauck M et al. ( 2017 ) . Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model . BMC Medicine vol. 15 , ( 1 )

Allin KH, Friedrich N, Pietzner M, Grarup N, Thuesen BH, Linneberg A, Pisinger C, Hansen T et al. ( 2016 ) . Genetic determinants of serum vitamin B12 and their relation to body mass index . European Journal of Epidemiology vol. 32 , ( 2 ) 125 - 134 .

Knacke H, Pietzner M, Trinh K, Römisch-Margl W, Kastenmüller G, Völker U, Völzke H, Krumsiek J et al. ( 2016 ) . Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study . The Journal of Clinical Endocrinology & Metabolism vol. 101 , ( 12 ) 4730 - 4742 .

Cornelis MC, Kacprowski T, Menni C, Gustafsson S, Pivin E, Adamski J, Artati A, Eap CB et al. ( 2016 ) . Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior . Human Molecular Genetics vol. 25 , ( 24 ) 5472 - 5482 .

Pietzner M, Engelmann B, Kacprowski T, Golchert J, Dirk A-L, Homuth G, Hammer E, Nauck M et al. ( 2016 ) . Molecular fingerprint of experimental thyrotoxicosis on human metabolism: combined metabolome and proteome study . Endocrine Abstracts

Hertel J, Friedrich N, Wittfeld K, Pietzner M, Budde K, Van der Auwera S, Lohmann T, Teumer A et al. ( 2015 ) . Measuring Biological Age via Metabonomics: The Metabolic Age Score . Journal of Proteome Research vol. 15 , ( 2 ) 400 - 410 .

Ameling S, Kacprowski T, Chilukoti RK, Malsch C, Liebscher V, Suhre K, Pietzner M, Friedrich N et al. ( 2015 ) . Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study . BMC Medical Genomics vol. 8 , ( 1 )

Raffler J, Friedrich N, Arnold M, Kacprowski T, Rueedi R, Altmaier E, Bergmann S, Budde K et al. ( 2015 ) . Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality . PLOS Genetics vol. 11 , ( 9 )

Tsourdi E, Wallaschofski H, Rauner M, Nauck M, Pietzner M, Rettig R, Ittermann T, Völzke H et al. ( 2015 ) . Thyrotropin serum levels are differentially associated with biochemical markers of bone turnover and stiffness in women and men: results from the SHIP cohorts . Osteoporosis International vol. 27 , ( 2 ) 719 - 727 .

Budde K, Gök Ö-N, Pietzner M, Meisinger C, Leitzmann M, Nauck M, Köttgen A, Friedrich N ( 2015 ) . Quality assurance in the pre-analytical phase of human urine samples by 1H NMR spectroscopy . Archives of Biochemistry and Biophysics vol. 589 , 10 - 17 .

Krumsiek J, Mittelstrass K, Do KT, Stückler F, Ried J, Adamski J, Peters A, Illig T et al. ( 2015 ) . Gender-specific pathway differences in the human serum metabolome . Metabolomics vol. 11 , ( 6 ) 1815 - 1833 .

Pietzner M, Homuth G, Budde K, Lehmphul I, Völker U, Völzke H, Nauck M, Köhrle J et al. ( 2015 ) . Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans . European Thyroid Journal vol. 4 , ( Suppl 1 ) 92 - 100 .

Pietzner M, Budde K, Homuth G, Völker U, Völzke H, Nauck M, Wallaschofski H, Friedrich N ( 2015 ) . Distinct urinary metabolic profiles associated with serum TSH and FT4 concentrations . Metabolomics vol. 11 , ( 5 ) 1316 - 1326 .

Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, Pattaro C, Teumer A et al. ( 2014 ) . Genome-wide association study of kidney function decline in individuals of European descent . Kidney International vol. 87 , ( 5 ) 1017 - 1029 .

Pietzner M, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R et al. ( 2014 ) . Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2? . Thyroid vol. 25 , ( 2 ) 188 - 197 .