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Publications: Prof Paul Evans

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Zhou Z, Korteland S-A, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M et al. ( 2024 ) . Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques . Atherosclerosis vol. 398 ,
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E et al. ( 2024 ) . Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing . Journal of Cell Science vol. 137 , ( 17 )
Pirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G et al. ( 2024 ) . EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake . Circulation Research vol. 135 , ( 8 ) 822 - 837 .
Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, Weng J, Xu S ( 2024 ) . Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential . Journal of Cardiovascular Pharmacology vol. 84 , ( 3 ) 289 - 302 .
Tian S, Evans PC ( 2024 ) . BMPER regulates arterial adaptation to flow . Nature Cardiovascular Research vol. 3 , ( 7 ) 777 - 779 .
Xu M-Y, Xu J-J, Kang L-J, Liu Z-H, Su M-M, Zhao W-Q, Wang Z-H, Sun L et al. ( 2024 ) . Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice . Acta Pharmacologica Sinica1 - 13 .
Wagner R, Carré MJ, Perrault CM, Evans PC, Lewis R ( 2024 ) . Assessing friction and damage of cell monolayers on soft substrates in vitro . Journal of The Royal Society Interface vol. 21 , ( 215 )
Wentzel JJ, Bos D, White SJ, van der Heiden K, Kavousi M, Evans PC ( 2024 ) . Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging . Atherosclerosis vol. 395 ,
Wei S, Wang L, Evans PC, Xu S ( 2024 ) . NAFLD and NASH: etiology, targets and emerging therapies . Drug Discovery Today vol. 29 , ( 3 )
Evans PC, Pearson J ( 2023 ) . Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology . Current Opinion in Physiology vol. 36 ,
Alfaidi M, Evans PC, Pickering JG ( 2023 ) . Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease . Frontiers in Cardiovascular Medicine vol. 10 ,
Tian S, Pirri D, Tardajos-Ayllon B, Fragiadaki M, Evans PC ( 2023 ) . BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation . Conference: Basic Sciencea247.2 - a2a247 .
Tardajos-Ayllon B, Diagbouga M, Evans PC ( 2023 ) . BS29 Endothelial TWIST1 enhances features of atherosclerotic plaque stability . Conference: Basic Sciencea264.3 - a2a265 .
( 2023 ) . Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy . Arteriosclerosis Thrombosis and Vascular Biology vol. 43 , ( 6 ) e230 - e230 .
Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J, Evans PC ( 2023 ) . DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries . Vascular Pharmacology vol. 150 ,
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Ayllon BT, Feng S, Souilhol C et al. ( 2023 ) . EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy . Arteriosclerosis Thrombosis and Vascular Biology vol. 43 , ( 4 ) 547 - 561 .
de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E et al. ( 2022 ) . Translational opportunities of single-cell biology in atherosclerosis . European Heart Journal vol. 44 , ( 14 ) 1216 - 1230 .
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al. ( 2022 ) . JAG1-NOTCH4 mechanosensing drives atherosclerosis . Science Advances vol. 8 , ( 35 )
Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B et al. ( 2022 ) . From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22 . Cardiovascular Research vol. 118 , ( 13 ) 2754 - 2767 .
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G et al. ( 2022 ) . Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents . PLOS ONE vol. 17 , ( 7 )
Zhou Z, Wu J, Wentzel J, Schenkel T, Diagbouga M, Fragiadaki M, Simons M, Evans P ( 2022 ) . BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaques . Conference: Basic sciencea158 - a159 .
Chen Y, Evans PC, Wilkinson RN ( 2022 ) . A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy . Angiogenesis , vol. 2441 , Springer Nature
Arbustini E, Behr ER, Carrier L, van Duijn C, Evans P, Favalli V, van der Harst P, Haugaa KH et al. ( 2022 ) . Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics . European Heart Journal vol. 43 , ( 20 ) 1901 - 1916 .
Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B et al. ( 2021 ) . Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model . Journal of Cardiovascular Pharmacology vol. 78 , ( 5 ) e656 - e661 .
Chiva-Blanch G, Evans PC ( 2021 ) . Scientists on the Spot: A matter of blood flow . Cardiovascular Research vol. 117 , ( 12 ) e162 - e163 .
Bowley G, Chico TJ, Serbanovic-Canic J, Evans PC ( 2021 ) . Quantifying endothelial cell proliferation in the zebrafish embryo . F1000Research vol. 10 ,
Nataraj R, Hiwarkar P, Bonney D, Campbell H, Jones S, Deambrosis D, Evans P, Poulton K et al. ( 2021 ) . B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome . Bone Marrow Transplantation vol. 57 , ( 1 ) 38 - 42 .
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T et al. ( 2021 ) . The effect of absent blood flow on the zebrafish cerebral and trunk vasculature . Vascular Biology vol. 3 , ( 1 ) 1 - 16 .
Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE et al. ( 2021 ) . Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart . Cardiovascular Research vol. 117 , ( 10 ) 2161 - 2174 .
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L ( 2021 ) . Erratum to: The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics . Cardiovascular Research vol. 117 , ( 9 ) 2107 - 2107 .
Kraler S, Libby P, Evans PC, Akhmedov A, Schmiady MO, Reinehr M, Camici GG, Lüscher TF ( 2021 ) . Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs . Arteriosclerosis Thrombosis and Vascular Biology vol. 41 , ( 8 ) 2237 - 2251 .
Ayllón BT, Souilhol C, Oakley F, Evans PC ( 2021 ) . A c-REL drives atherosclerosis at sites of disturbed blood flow . Heart . Conference: Young investigators award vol. 107 , a176 - a176 .
Bowley G, Evans P, Serbanovic-Canic J, Chico T ( 2021 ) . BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation . Heart . Conference: Basic science vol. 107 , a163 - a164 .
Zhou Z, Van-Hateren N, Francis S, Fragiadaki M, Evans P ( 2021 ) . BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques . Heart . Conference: Basic science vol. 107 , a172 - a173 .
Bowley G, Kugler E, Wilkinson R, Lawrie A, van Eeden F, Chico TJA, Evans PC, Noël ES et al. ( 2021 ) . Zebrafish as a tractable model of human cardiovascular disease . British Journal of Pharmacology vol. 179 , ( 5 ) 900 - 917 .
Ward AO, Sala-Newby GB, Ladak S, Angelini GD, Caputo M, Suleiman M-S, Evans PC, George SJ et al. ( 2021 ) . Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells . Perfusion vol. 37 , ( 6 ) 582 - 589 .
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C ( 2021 ) . The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics . Cardiovascular Research vol. 117 , ( 8 ) 1814 - 1822 .
Wagner RMF, Maiti R, Carré MJ, Perrault CM, Evans PC, Lewis R ( 2021 ) . Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research . Biotribology vol. 25 ,
An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K et al. ( 2021 ) . Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling . Cardiovascular Research vol. 118 , ( 2 ) 638 - 653 .
Wang M, Murdoch CE, Brewer AC, Ivetic A, Evans P, Shah AM, Zhang M ( 2021 ) . Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation . ESC Heart Failure vol. 8 , ( 2 ) 1427 - 1437 .
Evans PC, Fragiadaki M, Morris PD, Serbanovic-Canic J ( 2020 ) . Shear stress: the dark energy of atherosclerotic plaques . Cardiovascular Research vol. 117 , ( 8 ) 1811 - 1813 .
Ward AO, Angelini GD, Caputo M, Evans PC, Johnson JL, Suleiman MS, Tulloh RM, George SJ et al. ( 2020 ) . NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium . Scientific Reports vol. 10 , ( 1 )
Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME et al. ( 2020 ) . Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging . European Heart Journal - Cardiovascular Imaging vol. 21 , ( 11 ) 1177 - 1183 .
Pirri D, Fragiadaki M, Evans PC ( 2020 ) . Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors? . Bioscience Reports vol. 40 , ( 8 )
Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE et al. ( 2020 ) . Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science . Cardiovascular Research vol. 116 , ( 14 ) 2177 - 2184 .
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR et al. ( 2020 ) . A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease . Cardiovascular Research vol. 117 , ( 6 ) 1567 - 1577 .
Naase H, Harling L, Kidher E, Sepehripour A, Nguyen B, Kapelouzou A, Cokkinos D, Stavridis G et al. ( 2020 ) . Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass . Journal of Cardiothoracic Surgery vol. 15 , ( 1 )
Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M et al. ( 2020 ) . Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis . Cardiovascular Research vol. 117 , ( 1 ) 29 - 42 .
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J et al. ( 2020 ) . Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail . Scientific Reports vol. 10 , ( 1 )
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M et al. ( 2020 ) . Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium . Nature Communications vol. 11 , ( 1 )
Zun PS, Narracott AJ, Evans PC, van Rooij BJM, Hoekstra AG ( 2019 ) . A particle-based model for endothelial cell migration under flow conditions . Biomechanics and Modeling in Mechanobiology vol. 19 , ( 2 ) 681 - 692 .
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J et al. ( 2019 ) . Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications . European Heart Journal
Souilhol C, Gauci I, Feng S, Ayllon BT, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J et al. ( 2019 ) . Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites . Cardiovascular Research vol. 116 , ( 7 ) 1300 - 1310 .
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC ( 2019 ) . Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes . Nature Reviews Cardiology vol. 17 , ( 1 ) 52 - 63 .
Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I et al. ( 2019 ) . Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology . Cardiovascular Research vol. 115 , ( 9 ) 1385 - 1392 .
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al. ( 2019 ) . β1 integrin is a sensor of blood flow direction . Journal of Cell Science vol. 132 , ( 11 )
Ayllón BT, Souilhol C, Oakley F, Evans P ( 2019 ) . BS14 c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium . Heart . Conference: Basic Science vol. 105 ,
Roddie H, Fragiadaki M, Evans P ( 2019 ) . BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stress . Heart . Conference: Basic Science vol. 105 ,
Souilhol C, Canham L, Xueqi J, Evans P ( 2019 ) . BS3 Notch ligand JAG1 promotes endothelial-to-mesenchymal transition and atherosclerosis at regions of disturbed flow . Heart . Conference: Basic Science vol. 105 ,
Serbanovic-Canic J, Souilhol C, Evans PC ( 2019 ) . Shear stress makes its mark on the endothelial genome . Cardiovascular Research vol. 115 , ( 10 ) 1449 - 1451 .
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR et al. ( 2019 ) . Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo . Sci Rep vol. 9 , ( 1 ) 4738 - 4738 .
Mahmoud M, Souilhol C, Serbanovic-Canic J, Evans P ( 2019 ) . GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis . Cardiovascular Drugs and Therapy vol. 33 , ( 2 ) 231 - 237 .
Fragiadaki M, Evans PC ( 2018 ) . The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018 . Cardiovascular Drugs and Therapy vol. 33 , ( 2 ) 203 - 205 .
Tuñón J, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE et al. ( 2018 ) . Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology . Cardiovascular Research vol. 115 , ( 1 ) 10 - 19 .
Weaver D, Densmore Z, Evans P ( 2018 ) . Lessons Learned from Bacteria Monitoring and Treatment in Marcellus Production Operations . Conference: Day 3 Tue, October 09, 2018
Xing R, Moerman AM, Ridwan RY, Gaalen KV, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH et al. ( 2018 ) . The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice . Scientific Reports vol. 8 , ( 1 )
Caporali A, Bäck M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat M-L et al. ( 2018 ) . Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology . Cardiovascular Research vol. 114 , ( 11 ) 1411 - 1421 .
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol M, Hadoke P, Wu J, Schenkel T et al. ( 2018 ) . Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism . Journal of the American Heart Association vol. 7 , ( 13 )
Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC et al. ( 2018 ) . Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice . European Journal of Preventive Cardiology vol. 25 , ( 9 ) 948 - 955 .
Souilhol C, Evans PC ( 2018 ) . Notching Up Vascular Inflammation . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( 4 ) 698 - 699 .
Evans PC, Gijsen FJH, Wentzel JJ, van der Heiden K ( 2018 ) . Biomechanics in vascular biology and cardiovascular disease . Thrombosis and Haemostasis vol. 115 , ( 03 ) 465 - 466 .
Souilhol C, Harmsen MC, Evans PC, Krenning G ( 2018 ) . Endothelial–mesenchymal transition in atherosclerosis . Cardiovascular Research vol. 114 , ( 4 ) 565 - 577 .
Feng S, Fragiadaki M, Souilhol C, Ridger V, Evans PC ( 2017 ) . Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites” . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 12 ) e199 - e200 .
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI et al. ( 2017 ) . Microvesicles in vascular homeostasis and diseases . Thrombosis and Haemostasis vol. 117 , ( 07 ) 1296 - 1316 .
Luong L, Duckles H, Schenkel T, Mahmoud M, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP et al. ( 2017 ) . Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries . Thrombosis and Haemostasis vol. 116 , ( 01 ) 181 - 190 .
Green JP, Souilhol C, Xanthis I, Martinez-Campesino L, Bowden NP, Evans PC, Wilson HL ( 2017 ) . Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling . Cardiovascular Research vol. 114 , ( 2 ) 324 - 335 .
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D et al. ( 2017 ) . Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 11 ) 2087 - 2101 .
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J et al. ( 2017 ) . Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail . Scientific Reports vol. 7 , ( 1 )
Mann P, Khamis RY, Haskard D, Ta M, Kojima C, Ammari T, Caga-Anan M, Nguyen BA et al. ( 2017 ) . 169 Developing capture assays to measure circulating crp/oxidised low density lipoprotein complexes in patients undergoing cardiopulmonary bypass and examining use of crp/oxidised low density lipoprotein complexes as a biomarker of atherosclerosis . Heart vol. 103 , ( Suppl 5 )
Nguyen BA, McDonald G, Fiorentino F, Reeves BC, Kwak J, Pyo S, Angelini GD, Anderson JR et al. ( 2017 ) . Consumption of Broccoli Sprouts Attenuates Intracellular P38 Map Kinase and Reactive Oxygen Species Pro-Inflammatory Activation in Human Leukocytes: A Randomised- Controlled Trial . Journal of Clinical Nutrition & Dietetics vol. 3 , ( 4 )
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M et al. ( 2016 ) . Zebrafish Model for Functional Screening of Flow-Responsive Genes . Arterioscler Thromb Vasc Biol vol. 37 , ( 1 ) 130 - 143 .
Nguyen B, Reeves B, Angelini G, Haskard D, Evans P ( 2016 ) . Reply . The Annals of Thoracic Surgery vol. 102 , ( 5 ) 1765 - 1766 .
Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY et al. ( 2016 ) . Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase . Cardiovascular Research vol. 112 , ( 3 ) 689 - 701 .
Halliday I, Lishchuk SV, Spencer TJ, Pontrelli G, Evans PC ( 2016 ) . Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method . Physical Review E vol. 94 , ( 2 )
Holloway PM, Gillespie S, Becker F, Vital SA, Nguyen V, Alexander JS, Evans PC, Gavins FNE ( 2016 ) . Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways . Vascular Pharmacology vol. 85 , Article C , 29 - 38 .
Green J, Evans P, Wilson H ( 2016 ) . 191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium . Heart vol. 102 , ( Suppl 6 )
Bowden N, Feng S, Francis S, Evans P ( 2016 ) . 211 Non-Canonical NF-Κb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress . Heart vol. 102 , ( Suppl 6 )
Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S et al. ( 2016 ) . TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis . Circulation Research vol. 119 , ( 3 ) 450 - 462 .
Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B et al. ( 2016 ) . Experimental Approaches to Study Endothelial Responses to Shear Stress . Antioxidants & Redox Signaling vol. 25 , ( 7 ) 389 - 400 .
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR ( 2016 ) . Role of biomechanical forces in the natural history of coronary atherosclerosis . Nature Reviews Cardiology vol. 13 , ( 4 ) 210 - 220 .
Maguire R, Duckles H, Evans PC, Chico T ( 2016 ) . How does blood flow regulate vascular notch signalling? . Atherosclerosis vol. 244 ,
Nguyen BAV, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD et al. ( 2015 ) . Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial . The Annals of Thoracic Surgery vol. 101 , ( 4 ) 1454 - 1463 .
Morris PD, Narracott A, von Tengg-Kobligk H, Soto DAS, Hsiao S, Lungu A, Evans P, Bressloff NW et al. ( 2015 ) . Computational fluid dynamics modelling in cardiovascular medicine . Heart vol. 102 , ( 1 )
Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, Frangi AF ( 2015 ) . Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles . Neurobiology of Disease vol. 82 , 593 - 606 .
Green J, Wilson H, Evans P ( 2015 ) . 185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium . Heart vol. 101 , ( Suppl 4 )
Alfaidi M, Schenkel T, Evans P, Chamberlain J, Francis S ( 2015 ) . 192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions . Heart vol. 101 , ( Suppl 4 )
Mahmoud M, Kim R, Hsiao S, Xing R, Van der Heiden K, Mammoto A, Chen J, Gauci I et al. ( 2015 ) . 204 Disturbed Flow Promotes Atherogenesis through the Activation of Endothelial-Mesenchymal Transition . Heart vol. 101 , ( Suppl 4 )
Bryan M, Xanthis I, Hsiao S, Evans P ( 2015 ) . 206 Using Magnetic Tweezers to probe Mechanically-Induced Signalling in Endothelial Cells . Heart . vol. 101 ,
Gomez I, Ward B, Evans P, Hellewell P, Ridger V ( 2015 ) . YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna . Heart vol. 101 , ( Suppl 4 )
Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat M-L, Boulanger CM, Caligiuri G et al. ( 2015 ) . Novel methodologies for biomarker discovery in atherosclerosis . European Heart Journal vol. 36 , ( 39 ) 2635 - 2642 .
Evans P, Nederlof E, Richmond W ( 2015 ) . Souring Development Associated with PWRI in a North Sea Field . Conference: All Days
Gomez I, Ward B, Evans P, Hellewell P, Ridger V ( 2015 ) . Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( suppl_1 )
Kidher E, Jarral OA, Harling L, Anderson JR, Chukwuemeka A, Ashrafian H, Evans PC, Athanasiou T ( 2015 ) . NR2 antibody is associated with quality of life in aortic valve replacement . Asian Cardiovascular and Thoracic Annals vol. 23 , ( 6 ) 690 - 700 .
Mylroie H, Dumont O, Bauer A, Thornton CC, Mackey J, Calay D, Hamdulay SS, Choo JR et al. ( 2015 ) . PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis . Cardiovascular Research vol. 106 , ( 3 ) 509 - 519 .
Enesa K, Moll HP, Luong L, Ferran C, Evans PC ( 2015 ) . A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes . The FASEB Journal vol. 29 , ( 5 ) 1869 - 1878 .
Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE, Evans PC ( 2014 ) . Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne . Atherosclerosis vol. 237 , ( 2 )
Gauci I, Mahmoud M, Duckles H, Feng S, Hsiao S, Evans PC ( 2014 ) . Disturbed flow influences endothelial activation by inducing homeobox transcription factors . Atherosclerosis vol. 237 , ( 2 )
Mahmoud M, Hsiao S, Gauci I, Kim HR, Evans PC ( 2014 ) . GATA4 promotes endothelial cell turnover at regions of arteries exposed to disturbed flow . Atherosclerosis vol. 237 , ( 2 ) e2 - e3 .
Duckles H, Mahmoud M, Hsiao S, Gauci I, Bowden N, Luong L, Evans PC ( 2014 ) . Identification of a molecular switch controlling the induction of senescence or quiescence by flow . Atherosclerosis vol. 237 , ( 2 )
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P et al. ( 2014 ) . Biomechanical factors in atherosclerosis: mechanisms and clinical implications† . European Heart Journal vol. 35 , ( 43 ) 3013 - 3020 .
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ et al. ( 2014 ) . Piezo1 integration of vascular architecture with physiological force . Nature vol. 515 , ( 7526 ) 279 - 282 .
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106 . Molecular Imaging vol. 13 , ( 6 )
Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C, Evans P ( 2014 ) . 292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition . Cardiovascular Research vol. 103 , ( suppl_1 ) s53 - s53 .
Mahmoud M, Kim R, De Luca A, Gauci I, Hsiao S, Evans P ( 2014 ) . P470Disturbed flow promotes endothelial cell injury via the induction of developmental genes . Cardiovascular Research . vol. 103 , s86 - s86 .
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J, Evans PC ( 2014 ) . Mechanoresponsive Networks Controlling Vascular Inflammation . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( 10 ) 2199 - 2205 .
Kidher E, Harling L, Ashrafian H, Naase H, Francis DP, Evans P, Athanasiou T ( 2014 ) . Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement . Journal of Cardiothoracic Surgery vol. 9 , ( 1 )
Nguyen BAV, Suleiman M-S, Anderson JR, Evans PC, Fiorentino F, Reeves BC, Angelini GD ( 2014 ) . Metabolic derangement and cardiac injury early after reperfusion following intermittent cross-clamp fibrillation in patients undergoing coronary artery bypass graft surgery using conventional or miniaturized cardiopulmonary bypass . Molecular and Cellular Biochemistry vol. 395 , ( 1-2 ) 167 - 175 .
Kidher E, Harling L, Sugden C, Ashrafian H, Casula R, Evans P, Nihoyannopoulos P, Athanasiou T ( 2014 ) . Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis . Interdisciplinary CardioVascular and Thoracic Surgery vol. 19 , ( 4 ) 595 - 604 .
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC et al. ( 2014 ) . Requirement of JNK1 for endothelial cell injury in atherogenesis . Atherosclerosis vol. 235 , ( 2 ) 613 - 618 .
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S, Evans P ( 2014 ) . 189 Disturbed Flow Promotes Endothelial Cell Injury Via the Induction of Developmental Genes . Heart . vol. 100 ,
Gauci I, Luong L, Mahmoud M, Duckles H, Hsiao S, DeLuca A, Evans P ( 2014 ) . 192 The Induction of Homeobox Genes by Disturbed Flow Limits Inflammation at Atherosusceptible Sites . Heart . vol. 100 ,
Hsiao S, Tovar F, Gunn J, Spencer T, Halliday I, Perrault C, Evans P ( 2014 ) . 219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI . Heart vol. 100 , ( Suppl 3 )
Luong L, Duckles H, Schenkel T, Arnold N, Gsell W, Lungu A, Spencer T, Hose R et al. ( 2014 ) . Abstract 258: A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( suppl_1 )
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S, Evans PC ( 2014 ) . Abstract 266: Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( suppl_1 )
Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C, Evans P ( 2014 ) . Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( suppl_1 )
Enesa K, Evans P ( 2014 ) . The Biology of A20-Like Molecules . The Multiple Therapeutic Targets of A20 , vol. 809 , Springer Nature
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S et al. ( 2014 ) . Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( 5 ) 985 - 995 .
Nguyen B, Luong L, Naase H, Vives M, Jakaj G, Finch J, Boyle J, Mulholland JW et al. ( 2014 ) . Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass . Journal of Thoracic and Cardiovascular Surgery vol. 148 , ( 2 ) 690 - 697.e3 .
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . European Heart Journal vol. 34 , ( suppl_1 )
Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D, Zeidler MP ( 2013 ) . Control of tissue morphology by Fasciclin III-mediated intercellular adhesion . Development vol. 140 , ( 18 ) 3858 - 3868 .
De Luca A, Warboys CM, Amini N, Ferreira P, Gatehouse P, Firmin D, Mason J, Sherwin S et al. ( 2012 ) . Image-Based Computational Hemodynamics and Microarray Analysis of the Porcine Aortic Arch Reveals a Correlation Between Shear Stress and Endothelial Cell Apoptosis . Conference: ASME 2012 Summer Bioengineering Conference, Parts A and B923 - 924 .
Van der Heiden K, Groen HC, Evans PC, Speelman L, Gijsen F, de Jong M, van der Steen AFW, Wentzel JJ ( 2012 ) . Non-Invasive Molecular Imaging of Shear Stress-Induced Endothelial Activation and Atherosclerotic Plaque Vulnerability . Conference: ASME 2012 Summer Bioengineering Conference, Parts A and B91 - 92 .
Evans PC, Kwak BR ( 2013 ) . Biomechanical factors in cardiovascular disease . Cardiovascular Research vol. 99 , ( 2 ) 229 - 231 .
De Luca A, Warboys C, Amini N, Ferreira P, Firmin D, Mason J, Sherwin S, Evans P ( 2013 ) . 170 TRANSCRIPTOME PROFILING IN PORCINE ARTERIES TO IDENTIFY NOVEL SHEAR-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL FATE . Heart vol. 99 , ( suppl 2 )
Serbanovic-Canic J, de Luca A, Warboys C, Chico T, Evans P ( 2013 ) . YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL . Heart vol. 99 , ( suppl 2 )
Van der Heiden K, Gijsen FJH, Narracott A, Hsiao S, Halliday I, Gunn J, Wentzel JJ, Evans PC ( 2013 ) . The effects of stenting on shear stress: relevance to endothelial injury and repair . Cardiovascular Research vol. 99 , ( 2 ) 269 - 275 .
Haskard DO, Boyle JJ, Evans PC, Mason JC, Randi AM ( 2013 ) . Cytoprotective Signaling and Gene Expression in Endothelial Cells and Macrophages—Lessons for Atherosclerosis . Microcirculation vol. 20 , ( 3 ) 203 - 216 .
Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M et al. ( 2013 ) . Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination . Circulation Research vol. 112 , ( 12 ) 1583 - 1591 .
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S et al. ( 2013 ) . Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development . Arteriosclerosis Thrombosis and Vascular Biology vol. 33 , ( 6 ) 1257 - 1263 .
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . EUROPEAN HEART JOURNAL . vol. 34 , 110 - 110 .
Warboys CM, de Luca A, Amini N, Evans PC ( 2012 ) . The influence of flow on vascular endothelial cell senescence . Atherosclerosis . vol. 225 ,
Golubnitschaja O, Costigliola V, EPMA ( 2012 ) . General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine . EPMA Journal vol. 3 , ( 1 )
Nayak A, König CS, Kishore U, Evans PC ( 2012 ) . Regulation of Endothelial Activation and Vascular Inflammation by Shear Stress . Micro and Nano Flow Systems for Bioanalysis , Springer Nature
Dumont O, Mylroie H, Bauer A, Calay D, Sperone A, Thornton C, Hamdulay SS, Ali N et al. ( 2012 ) . Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection . Biochemical Journal vol. 447 , ( 2 ) 193 - 204 .
Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VWY, Evans PC, Liu Y, Johns M et al. ( 2012 ) . Solid-Phase Immunoglobulins IgG and IgM Activate Macrophages with Solid-Phase IgM Acting via a Novel Scavenger Receptor A Pathway . American Journal Of Pathology vol. 181 , ( 1 ) 347 - 361 .
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC et al. ( 2012 ) . Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells . Journal of Molecular and Cellular Cardiology vol. 53 , ( 2 ) 299 - 309 .
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al. ( 2012 ) . Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice . Journal of Visualized Experiments ( 59 )
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al. ( 2012 ) . Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice . Journal of Visualized Experiments ( 59 )
Boyle JJ, Johns M, Lo J, Chiodini A, Ambrose N, Evans PC, Mason JC, Haskard DO ( 2011 ) . Heme Induces Heme Oxygenase 1 via Nrf2 . Arteriosclerosis Thrombosis and Vascular Biology vol. 31 , ( 11 ) 2685 - 2691 .
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al. ( 2011 ) . Inhibition of NF-kB signaling in human dendritic cells the enterpathogenic Escherichia coli effector protein NIeE . J Immunol vol. 185 , 4118 - 4127 .
Luong LA, Evans PC ( 2011 ) . Targeting Inhibitor of Apoptosis Proteins to Block Vascular Inflammation . Arteriosclerosis Thrombosis and Vascular Biology vol. 31 , ( 10 ) 2165 - 2166 .
Harling L, Warren OJ, Martin A, Kemp PR, Evans PC, Darzi A, Athanasiou T ( 2011 ) . Do Miniaturized Extracorporeal Circuits Confer Significant Clinical Benefit Without Compromising Safety? A Meta-Analysis of Randomized Controlled Trials . ASAIO Journal vol. 57 , ( 3 ) 141 - 151 .
Zuluaga E, Evans P, Nesom P, Spratt T, Daniels E ( 2011 ) . Technical Evaluations To Support the Decision To Reinject Produced Water . SPE Production & Operations vol. 26 , ( 02 ) 128 - 139 .
Warboys CM, Amini N, de Luca A, Evans PC ( 2011 ) . The role of blood flow in determining the sites of atherosclerotic plaques . F1000 Medicine Reports vol. 3 ,
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al. ( 2011 ) . Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1 . Circulation Research vol. 108 , ( 8 ) 950 - 959 .
Evans PC ( 2011 ) . The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease . EPMA Journal vol. 2 , ( 1 ) 9 - 14 .
Warboys CM, Amini N, Luca AD, Evans PC ( 2011 ) . When stress is good . Scientist vol. 25 , ( 2 )
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT et al. ( 2011 ) . Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1 . Circulation vol. 123 , ( 5 ) 524 - 532 .
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al. ( 2011 ) . <SUP>18</SUP>FEDAA is a more specific probe than <SUP>18</SUP>FDG for imaging vascular inflammation . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S210 - S210 .
Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2011 ) . Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2 . EUROPEAN HEART JOURNAL . vol. 32 , 937 - 937 .
Sperone A, Dryden N, Birdsey GM, Madden LE, Evans P, Mason JC, Boyle J, Paleolog E et al. ( 2010 ) . The transcription factor Erg represses ICAM-1 expression and vascular inflammation . Atherosclerosis . vol. 213 ,
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW et al. ( 2010 ) . Multi-scale interaction of particulate flow and the artery wall . Medical Engineering & Physics vol. 33 , ( 7 ) 840 - 848 .
Sperone A, Dryden NH, Birdsey GM, Madden L, Johns M, Evans PC, Mason JC, Haskard DO et al. ( 2010 ) . The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-&kgr;B Activation and Proinflammatory Gene Expression in Endothelial Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 31 , ( 1 ) 142 - 150 .
Zuluaga E, Evans P, Nesom P, Spratt T, Daniels E ( 2010 ) . Technical Evaluations to Support the Decision to Reinject Produced Water . Conference: All Days
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H et al. ( 2010 ) . YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors . Heart vol. 96 , ( 17 )
Jevon M, Ansari TI, Finch J, Zakkar M, Evans PC, Shurey S, Sibbons PD, Hornick P et al. ( 2010 ) . Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall . Cardiovascular Pathology vol. 20 , ( 3 ) e91 - e94 .
van der Heiden K, Cuhlmann S, Luong LA, Zakkar M, Evans PC ( 2010 ) . Role of nuclear factor κB in cardiovascular health and disease . Clinical Science vol. 118 , ( 10 ) 593 - 605 .
Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP et al. ( 2010 ) . Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium . Free Radical Biology and Medicine vol. 48 , ( 8 ) 1013 - 1023 .
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A et al. ( 2010 ) . c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 3 ) 546 - 553 .
Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2010 ) . Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells . CIRCULATION . vol. 122 ,
Krams R, Cuhlmann S, Foin N, Evans P ( 2010 ) . Shear stress, inflammation and Atherosclerosis . Artery Research vol. 4 , ( 2 ) 41 - 46 .
Amirak E, Zakkar M, Evans PC, Kemp PR ( 2009 ) . Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells . Biochemical and Biophysical Research Communications vol. 391 , ( 1 ) 818 - 823 .
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I et al. ( 2009 ) . Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State . Arteriosclerosis Thrombosis and Vascular Biology vol. 29 , ( 11 ) 1851 - 1857 .
Evans P ( 2008 ) . Reservoir Souring Modelling, Prediction and Mitigation . Conference: Volume 5: Materials Technology; CFD and VIV67 - 73 .
Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A et al. ( 2009 ) . Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow* . Journal of Biological Chemistry vol. 284 , ( 28 ) 18882 - 18892 .
Evans PC ( 2009 ) . Nur77 . Circulation Research vol. 104 , ( 6 ) 707 - 709 .
Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC, Evans PC ( 2009 ) . ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE . HEART . vol. 95 ,
Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM et al. ( 2009 ) . ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES . HEART . vol. 95 ,
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R et al. ( 2009 ) . HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM . HEART . vol. 95 ,
Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS . HEART . vol. 95 ,
Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells . ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY . vol. 29 , E78 - E78 .
Evans PC ( 2008 ) . Effects of shear stress on endothelial activation and vascular inflammation . Biomedicine & Pharmacotherapy vol. 62 , ( 8 ) 503 - 504 .
Lutz J, Luong LA, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K et al. ( 2008 ) . The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation . Journal of Molecular Medicine vol. 86 , ( 12 ) 1329 - 1339 .
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R et al. ( 2008 ) . Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis . Circulation Research vol. 103 , ( 7 ) 726 - 732 .
Ridger V, Krams R, Carpi A, Evans PC ( 2008 ) . Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update . Biomedicine & Pharmacotherapy vol. 62 , ( 8 ) 536 - 540 .
Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO, Evans PC ( 2008 ) . MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS . Atherosclerosis . vol. 199 ,
Enesa K, Ito K, Le A. Luong, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO et al. ( 2008 ) . Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms* . Journal of Biological Chemistry vol. 283 , ( 27 ) 18582 - 18590 .
Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H et al. ( 2008 ) . Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy . Cardiovascular Research vol. 79 , ( 3 ) 472 - 480 .
Kinderlerer AR, Ali F, Johns M, Lidington EA, Leung V, Boyle JJ, Hamdulay SS, Evans PC et al. ( 2008 ) . KLF2-dependent, Shear Stress-induced Expression of CD59 . Journal of Biological Chemistry . vol. 283 , 14636 - 14644 .
Mason JC, Kinderlerer A, Ali F, Johns M, Leung V, Boyle J, Evans P, Haskard DO ( 2008 ) . KLF‐2‐dependent, shear stress‐induced expression of CD59: a novel cytoprotective mechanism against complement‐mediated injury in the vasculature . The FASEB Journal vol. 22 , ( S1 ) 471.2 - 471.2 .
Foin N, Evans P, Krams R ( 2008 ) . Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque . Current Opinion in Lipidology vol. 19 , ( 1 ) 98 - 100 .
Enesa K, Zakkar M, Chaudhury H, Le A. Luong, Rawlinson L, Mason JC, Haskard DO, Dean JLE et al. ( 2008 ) . NF-κB Suppression by the Deubiquitinating Enzyme Cezanne A NOVEL NEGATIVE FEEDBACK LOOP IN PRO-INFLAMMATORY SIGNALING* . Journal of Biological Chemistry vol. 283 , ( 11 ) 7036 - 7045 .
Zakkar M, Chaudhury H, Punjabi PP, Haskard DO, Evans PC ( 2008 ) . Acute high shear stress activates venous but not arterial endothelial cells by signalling through the p38 MAP kinase pathway . HEART . vol. 94 ,
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, Krams R ( 2007 ) . Effect of shear stress on vascular inflammation and plaque development . Current Opinion in Lipidology vol. 18 , ( 5 ) 527 - 533 .
Evans KEAPC ( 2007 ) . Chains of command: Ubiquitin in proinflammatory signalling . The Biochemist vol. 29 , ( 4 ) 24 - 27 .
Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M et al. ( 2007 ) . Laminar shear stress acts as a switch to regulate divergent functions of NF‐κB in endothelial cells . The FASEB Journal vol. 21 , ( 13 ) 3553 - 3561 .
Adcock I, Evans PC ( 2007 ) . Resolution of Inflammatory Responses: a brief introduction . Biochemical Society Transactions . vol. 35 , 261 - 262 .
Partridge J, Enesa K, Kinderlerer A, Johns M, Mason JC, Haskard DO, Evans PC ( 2007 ) . Shear stress modulates endothelial responses to TNFα by suppressing proinflammatory transcripts and enhancing cytoprotective transcripts . HEART . vol. 93 ,
Evans P, Dunsmore B ( 2006 ) . Reservoir simulation of sulfate-reducing bacteria activity in the deep sub-surface . NACE - International Corrosion Conference Series . 066641 - 0666417 .
Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC, Shang F ( 2006 ) . The triage of damaged proteins: degradation by the ubiquitin‐proteasome pathway or repair by molecular chaperones . The FASEB Journal vol. 20 , ( 6 ) 741 - 743 .
Evans PC ( 2005 ) . Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs . Expert Reviews in Molecular Medicine vol. 7 , ( 12 ) 1 - 19 .
Goodman RS, Ewing J, Evans PC, Craig J, Poulton K, Dyer PA, Marcus RE, Taylor CJ ( 2005 ) . Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation . Bone Marrow Transplantation vol. 36 , ( 2 ) 151 - 156 .
EVANS PC, Huib O, HAMON M, KILSHAW PJ, Svetlana H, BAUER S, PLOEGH HL, SMITH TS ( 2004 ) . Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity . Biochemical Journal vol. 378 , ( 3 ) 727 - 734 .
Evans PC, Smith TS, Lai M-J, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R et al. ( 2003 ) . A Novel Type of Deubiquitinating Enzyme* . Journal of Biological Chemistry vol. 278 , ( 25 ) 23180 - 23186 .
Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ ( 2001 ) . Isolation and characterization of two novel A20-like proteins . Biochemical Journal vol. 357 , ( Pt 3 ) 617 - 623 .
EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R, KILSHAW PJ ( 2001 ) . Isolation and characterization of two novel A20-like proteins . Biochemical Journal vol. 357 , ( 3 ) 617 - 623 .
Corps E, Carter C, Karecla P, Ahrens T, Evans P, Kilshaw P ( 2001 ) . Recognition of E-cadherin by Integrin αEβ7 REQUIREMENT FOR CADHERIN DIMERIZATION AND IMPLICATIONS FOR CADHERIN AND INTEGRIN FUNCTION* . Journal of Biological Chemistry vol. 276 , ( 33 ) 30862 - 30870 .
Evans PC, Smith S, Hirschfield G, Rigopoulou E, Wreghitt TG, Wight DGD, Taylor CJ, Alexander GJM ( 2001 ) . Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts . Journal of Hepatology vol. 34 , ( 5 ) 711 - 715 .
Evans PC, Taylor ER, Kilshaw PJ ( 2001 ) . SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS . Transplantation vol. 71 , ( 3 ) 457 - 460 .
Buckley CD ( 2001 ) . Signaling Through CD31 Protects Endothelial Cells from Apoptosis. Transplantation 2001; 71: 457 . Transplantation vol. 71 , ( 3 ) 343 - 344 .
Evans PC, Kilshaw PJ ( 2000 ) . INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION . Transplantation vol. 70 , ( 6 ) 928 - 934 .
Lambert NC, Evans PC, Hashizumi TL, Maloney S, Gooley T, Furst DE, Nelson JL ( 2000 ) . Cutting Edge: Persistent Fetal Microchimerism in T Lymphocytes Is Associated with HLA-DQA1*0501: Implications in Autoimmunity . The Journal of Immunology vol. 164 , ( 11 ) 5545 - 5548 .
Evans PC, Soin A, Wreghitt TG, Taylor CJ, Wight DGD, Alexander GJM ( 2000 ) . AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION . Transplantation vol. 69 , ( 1 )
EVANS PC, GRAY JJ, WREGHITT TG, MARCUS RE, ALEXANDER GJM ( 1999 ) . Comparison of three PCR techniques for detecting cytomegalovirus (CMV) DNA in serum, detection of early antigen fluorescent foci and culture for the diagnosis of CMV infection . Journal of Medical Microbiology vol. 48 , ( 11 ) 1029 - 1035 .
Evans PC, Coleman N, Wreghitt TG, Wight DGD, Alexander GJM ( 1999 ) . Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts . Journal of Hepatology vol. 31 , ( 5 ) 913 - 920 .
Nasu K, Whyte A, Green SJ, Evans PC, Kilshaw PJ ( 1999 ) . α-GALACTOSYL-MEDIATED ACTIVATION OF PORCINE ENDOTHELIAL CELLS . Transplantation vol. 68 , ( 6 ) 861 - 867 .
Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, Nelson JL ( 1999 ) . Microchimerism of maternal origin persists into adult life . Journal of Clinical Investigation vol. 104 , ( 1 ) 41 - 47 .
Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL ( 1999 ) . Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma . Blood vol. 93 , ( 6 ) 2033 - 2037 .
Evans PC, Soin A, Wreghitt TG, Alexander GJ ( 1998 ) . Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients . Journal of Clinical Pathology vol. 51 , ( 12 )
Evans PC, Gray J, Wreghitt TG, Alexander GJM ( 1998 ) . Optimisation of the polymerase chain reaction and dot-blot hybridisation for detecting cytomegalovirus DNA in urine: comparison with detection of early antigen fluorescent foci and culture . Journal of Virological Methods vol. 73 , ( 1 ) 41 - 52 .
Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C et al. ( 1998 ) . Microchimerism and HLA-compatible relationships of pregnancy in scleroderma . The Lancet vol. 351 , ( 9102 ) 559 - 562 .
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