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  1. Queen Mary University of London
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Publications: Prof Francesca Ciccarelli

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Ng AWT, McClurg DP, Wesley B, Zamani SA, Black E, Miremadi A, Giger O, Hoopen RT et al. ( 2024 ) . Author Correction: Disentangling oncogenic amplicons in esophageal adenocarcinoma . Nature Communications vol. 15 , ( 1 )
Ng AWT, McClurg DP, Wesley B, Zamani SA, Black E, Miremadi A, Giger O, Hoopen RT et al. ( 2024 ) . Disentangling oncogenic amplicons in esophageal adenocarcinoma . Nature Communications vol. 15 , ( 1 )
Montorsi L, Pitcher MJ, Zhao Y, Dionisi C, Demonti A, Tull TJ, Dhami P, Ellis RJ et al. ( 2024 ) . Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue . Nature Communications vol. 15 , ( 1 )
O'Neill JR, Yébenes Mayordomo M, Mitulović G, Al Shboul S, Bedran G, Faktor J, Hernychova L, Uhrik L et al. ( 2024 ) . Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation . Molecular & Cellular Proteomics vol. 23 , ( 6 )
O’Shea R, Withey SJ, Owczarczyk K, Rookyard C, Gossage J, Godfrey E, Jobling C, Parsons SL et al. ( 2024 ) . Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma . European Radiology vol. 34 , ( 10 ) 6919 - 6928 .
Peters CJ, Ang Y, Ciccarelli FD, Coles H, Coleman HG, Contino G, Crosby T, Devonshire G et al. ( 2023 ) . A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium . Nature Medicine vol. 30 , ( 1 ) 14 - 16 .
Märtens K, Bortolomeazzi M, Montorsi L, Spencer J, Ciccarelli F, Yau C ( 2023 ) . Rarity: discovering rare cell populations from single-cell imaging data . Bioinformatics vol. 39 , ( 12 )
Cheung TS, Giacomini C, Cereda M, Avivar-Valderas A, Capece D, Bertolino GM, delaRosa O, Hicks R et al. ( 2023 ) . Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn’s disease . Molecular Therapy vol. 31 , ( 12 ) 3531 - 3544 .
Kazachenka A, Loong JH, Attig J, Young GR, Ganguli P, Devonshire G, Grehan N, Fitzgerald RC et al. ( 2023 ) . The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes . NAR Cancer vol. 5 , ( 3 )
Abbas S, Pich O, Devonshire G, Zamani SA, Katz-Summercorn A, Killcoyne S, Cheah C, Nutzinger B et al. ( 2023 ) . Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma . Nature Communications vol. 14 , ( 1 )
Misetic H, Keddar MR, Jeannon J-P, Ciccarelli FD ( 2023 ) . Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment . Genome Medicine vol. 15 , ( 1 )
Forler D, Rabut G, Ciccarelli FD, Herold A, Köcher T, Niggeweg R, Bork P, Ellenberg J et al. ( 2023 ) . RanBP2/Nup358 Provides a Major Binding Site for NXF1-p15 Dimers at the Nuclear Pore Complex and Functions in Nuclear mRNA Export . Molecular and Cellular Biology vol. 24 , ( 3 ) 1155 - 1167 .
Novellasdemunt L, Kucharska A, Baulies A, Hutton C, Vlachogiannis G, Repana D, Rowan A, Suárez-Bonnet A et al. ( 2023 ) . USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development . Stem Cell Reports vol. 18 , ( 2 ) 570 - 584 .
Acha-Sagredo A, Ganguli P, Ciccarelli FD ( 2022 ) . Somatic variation in normal tissues: friend or foe of cancer early detection? . Annals of Oncology vol. 33 , ( 12 ) 1239 - 1249 .
Marinello J, Arleo A, Russo M, Delcuratolo M, Ciccarelli F, Pommier Y, Capranico G ( 2022 ) . Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway . British Journal of Cancer vol. 127 , ( 7 ) 1214 - 1225 .
Rodrigues FS, Ciccarelli FD, Malanchi I ( 2022 ) . Reflected stemness as a potential driver of the tumour microenvironment . Trends in Cell Biology vol. 32 , ( 12 ) 979 - 987 .
Gunady EF, Ware KE, Plumlee SH, Devos N, Corcoran D, Prinz J, Misetic H, Ciccarelli FD et al. ( 2022 ) . Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers . Evolution Medicine and Public Health vol. 10 , ( 1 ) 221 - 230 .
Ng AWT, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, Su J, Redmond AM et al. ( 2022 ) . Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas . Communications Biology vol. 5 , ( 1 )
Lockwood N, Martini S, Lopez-Pardo A, Deiss K, Segeren HA, Semple RK, Collins I, Repana D et al. ( 2022 ) . Genome-protective topoisomerase 2a-dependent G2 arrest requires p53 in hTERT-positive cancer cells . Cancer Research vol. 82 , ( 9 ) 1762 - 1773 .
Bortolomeazzi M, Montorsi L, Temelkovski D, Keddar MR, Acha-Sagredo A, Pitcher MJ, Basso G, Laghi L et al. ( 2022 ) . A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution . Nature Communications vol. 13 , ( 1 )
Dressler L, Bortolomeazzi M, Keddar MR, Misetic H, Sartini G, Acha-Sagredo A, Montorsi L, Wijewardhane N et al. ( 2022 ) . Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource . Genome Biology vol. 23 , ( 1 )
Acha-Sagredo A, Malanchi I, Ciccarelli FD ( 2021 ) . Clone competition as a mechanism to reduce tumor formation . Developmental Cell vol. 56 , ( 24 ) 3307 - 3308 .
Bortolomeazzi M, Keddar MR, Montorsi L, Acha-Sagredo A, Benedetti L, Temelkovski D, Choi S, Petrov N et al. ( 2021 ) . Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts . Gastroenterology vol. 161 , ( 4 ) 1179 - 1193 .
Opzoomer JW, Timms JA, Blighe K, Mourikis TP, Chapuis N, Bekoe R, Kareemaghay S, Nocerino P et al. ( 2021 ) . ImmunoCluster provides a computational framework for the non-specialist to profile high- dimensional cytometry data . eLife vol. 10 ,
Nulsen J, Misetic H, Yau C, Ciccarelli FD ( 2021 ) . Pan-cancer detection of driver genes at the single-patient resolution . Genome Medicine vol. 13 , ( 1 )
Wijewardhane N, Dressler L, Ciccarelli FD ( 2020 ) . Normal Somatic Mutations in Cancer Transformation . Cancer Cell vol. 39 , ( 2 ) 125 - 129 .
Ciccarelli FD, DeGregori J ( 2020 ) . Approaching Cancer Evolution from Different Angles . iScience vol. 23 , ( 11 )
Tajadura-Ortega V, Gambardella G, Skinner A, Halim A, Van Coillie J, Schjoldager KT-BG, Beatson R, Graham R et al. ( 2020 ) . O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR . Glycobiology vol. 31 , ( 3 ) 200 - 210 .
Knight WRC, McEwen R, Byrne BE, Habib W, Bott R, Zylstra J, Mahadeva U, Gossage JA et al. ( 2020 ) . Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus . European Journal of Surgical Oncology vol. 46 , ( 12 ) 2257 - 2261 .
Jammula S, Katz-Summercorn AC, Li X, Linossi C, Smyth E, Killcoyne S, Biasci D, Subash VV et al. ( 2020 ) . Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data . Gastroenterology vol. 158 , ( 6 ) 1682 - 1697.e1 .
Rahman SA, Walker RC, Lloyd MA, Grace BL, van Boxel GI, Kingma BF, Ruurda JP, van Hillegersberg R et al. ( 2020 ) . Machine learning to predict early recurrence after oesophageal cancer surgery . British Journal of Surgery vol. 107 , ( 8 ) 1042 - 1052 .
Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG et al. ( 2019 ) . Molecular Biology and Evolution of Cancer: From Discovery to Action . Molecular Biology and Evolution vol. 37 , ( 2 ) 320 - 326 .
Bortolomeazzi M, Keddar MR, Ciccarelli FD, Benedetti L ( 2019 ) . Identification of non-cancer cells from cancer transcriptomic data . Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms vol. 1863 , ( 6 )
Catapano M, Vergnano M, Romano M, Mahil SK, Choon S-E, Burden AD, Young HS, Carr IM et al. ( 2019 ) . Interleukin-36 promotes systemic Type-I IFN responses in severe forms of psoriasis . Journal of Investigative Dermatology vol. 140 , ( Genome biology 14 4 2013 ) 816 - 826.e3 .
Mourikis TP, Benedetti L, Foxall E, Temelkovski D, Nulsen J, Perner J, Cereda M, Lagergren J et al. ( 2019 ) . Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma . Nature Communications vol. 10 , ( 1 )
Bornschein J, Wernisch L, Secrier M, Miremadi A, Perner J, MacRae S, O'Donovan M, Newton R et al. ( 2019 ) . Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction . International Journal of Cancer vol. 145 , ( 12 ) 3389 - 3401 .
Turkington RC, Knight LA, Blayney JK, Secrier M, Douglas R, Parkes EE, Sutton EK, Stevenson L et al. ( 2019 ) . Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma . Gut vol. 68 , ( 11 )
Frankell AM, Jammula S, Li X, Contino G, Killcoyne S, Abbas S, Perner J, Bower L et al. ( 2019 ) . The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic . Nature Genetics vol. 51 , ( 3 ) 506 - 516 .
Repana D, Nulsen J, Dressler L, Bortolomeazzi M, Venkata SK, Tourna A, Yakovleva A, Palmieri T et al. ( 2019 ) . The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens . Genome Biology vol. 20 , ( 1 )
Ciccarelli FD ( 2019 ) . Mutations differ in normal and cancer cells of the oesophagus . Nature vol. 565 , ( 7739 ) 301 - 303 .
Owusu M, Bannauer P, da Silva JF, Mourikis TP, Jones A, Májek P, Caldera M, Wiedner M et al. ( 2019 ) . Mapping the Human Kinome in Response to DNA Damage . Cell Reports vol. 26 , ( 3 ) 555 - 563.e6 .
Zhao Y, Uduman M, Siu JHY, Tull TJ, Sanderson JD, Wu Y-CB, Zhou JQ, Petrov N et al. ( 2018 ) . Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue . Nature Communications vol. 9 , ( 1 )
Sawas T, Killcoyne S, Iyer PG, Wang KK, Smyrk TC, Kisiel JB, Qin Y, Ahlquist DA et al. ( 2018 ) . Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts . Gastroenterology vol. 155 , ( 6 ) 1720 - 1728.e4 .
Mahil SK, Catapano M, Di Meglio P, Dand N, Ahlfors H, Carr IM, Smith CH, Trembath RC et al. ( 2017 ) . An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target . Science Translational Medicine vol. 9 , ( 411 )
Catapano M, Ciccarelli F, Barker J, Capon F ( 2017 ) . 329 An investigation of the molecular pathogenesis of Generalized Pustular Psoriasis and its overlap with Psoriasis Vulgaris . Journal of Investigative Dermatology vol. 137 , ( 10 )
Ciccarelli F ( 2017 ) . Computational approaches in cancer genomics . ACM SIGEVOlution vol. 10 , ( 2 ) 6 - 6 .
Ciccarelli F ( 2017 ) . Computational approaches in cancer genomics . Conference: Proceedings of the Genetic and Evolutionary Computation Conference1 - 1 .
Galazi M, Weitsman G, Monypenny J, Coban O, Milewicz H, Gomez V, Ciccarelli F, Ng T ( 2017 ) . Stratifying Cancer Therapies by Molecular Interactions and Imaging . Mechanisms of Molecular Carcinogenesis – Volume 2 , Springer Nature
Benedetti L, Cereda M, Monteverde L, Desai N, Ciccarelli FD ( 2017 ) . Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1 . Oncotarget vol. 5 , ( 0 ) 37619 - 37632 .
Gambardella G, Cereda M, Benedetti L, Ciccarelli FD ( 2016 ) . MEGA-V: detection of variant gene sets in patient cohorts . Bioinformatics vol. 33 , ( 8 )
Marschall T, Marz M, Abeel T, Dijkstra L, Dutilh BE, Ghaffaari A, Kersey P, Kloosterman WP et al. ( 2016 ) . Computational pan-genomics: status, promises and challenges . Briefings in Bioinformatics vol. 19 , ( 1 ) 118 - 135 .
Cereda M, Gambardella G, Benedetti L, Iannelli F, Patel D, Basso G, Guerra RF, Mourikis TP et al. ( 2016 ) . Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes . Nature Communications vol. 7 , ( 1 )
Cereda M, Mourikis TP, Ciccarelli FD ( 2016 ) . Genetic Redundancy, Functional Compensation, and Cancer Vulnerability . Trends in Cancer vol. 2 , ( 4 ) 160 - 162 .
An O, Dall'Olio GM, Mourikis TP, Ciccarelli FD ( 2015 ) . NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings . Nucleic Acids Research vol. 44 , ( D1 ) d992 - d999 .
Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D’Antiga L, Sonzogni A, Faivre J et al. ( 2015 ) . Erratum: Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency . Nature Communications vol. 6 , ( 1 )
De Grassi A, Iannelli F, Cereda M, Volorio S, Melocchi V, Viel A, Basso G, Laghi L et al. ( 2014 ) . Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas . Genome Biology vol. 15 , ( 8 )
Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D’Antiga L, Sonzogni A, Faivre J et al. ( 2014 ) . Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency . Nature Communications vol. 5 , ( 1 )
An O, Pendino V, D’Antonio M, Ratti E, Gentilini M, Ciccarelli FD ( 2014 ) . NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes . Database vol. 2014 ,
D’Antonio M, Guerra RF, Cereda M, Marchesi S, Montani F, Nicassio F, Di Fiore PP, Ciccarelli FD ( 2013 ) . Recessive Cancer Genes Engage in Negative Genetic Interactions with Their Functional Paralogs . Cell Reports vol. 5 , ( 6 ) 1519 - 1526 .
D'Antonio M, Ciccarelli FD ( 2013 ) . Integrated analysis of recurrent properties of cancer genes to identify novel drivers . Genome Biology vol. 14 , ( 5 )
Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK et al. ( 2013 ) . Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma . Cell vol. 153 , ( 1 ) 101 - 111 .
D'Antonio M, Pendino V, Sinha S, Ciccarelli FD ( 2011 ) . Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes . Nucleic Acids Research vol. 40 , ( D1 ) d978 - d983 .
D'Antonio M, Ciccarelli FD ( 2011 ) . Modification of Gene Duplicability during the Evolution of Protein Interaction Network . PLOS Computational Biology vol. 7 , ( 4 )
Miklos I, Ciccarelli FD ( 2010 ) . Preface . Journal of Computational Biology vol. 17 , ( 9 ) 1095 - 1096 .
Ciccarelli FD ( 2010 ) . The (r)evolution of cancer genetics . BMC Biology vol. 8 , ( 1 )
Çivril F, Wehenkel A, Giorgi FM, Santaguida S, Di Fonzo A, Grigorean G, Ciccarelli FD, Musacchio A ( 2010 ) . Structural Analysis of the RZZ Complex Reveals Common Ancestry with Multisubunit Vesicle Tethering Machinery . Structure vol. 18 , ( 5 ) 616 - 626 .
De Grassi A, Segala C, Iannelli F, Volorio S, Radice P, Ciccarelli FD ( 2010 ) . Highly sensitive detection of genomic instability by ultradeep sequencing . New Biotechnology vol. 27 ,
De Grassi A, Segala C, Iannelli F, Volorio S, Bertario L, Radice P, Bernard L, Ciccarelli FD ( 2010 ) . Ultradeep Sequencing of a Human Ultraconserved Region Reveals Somatic and Constitutional Genomic Instability . PLOS Biology vol. 8 , ( 1 )
De Grassi A, Ciccarelli FD ( 2009 ) . Tandem repeats modify the structure of human genes hosted in segmental duplications . Genome Biology vol. 10 , ( 12 )
Anelli V, Santoriello C, Distel M, Köster RW, Ciccarelli FD, Mione M ( 2009 ) . Global Repression of Cancer Gene Expression in a Zebrafish Model of Melanoma Is Linked to Epigenetic Regulation . Zebrafish vol. 6 , ( 4 ) 417 - 424 .
Ciccarelli F, Miklós I ( 2009 ) . Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics): Preface . Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) vol. 5817 LNBI ,
Syed AS, D'Antonio M, Ciccarelli FD ( 2009 ) . Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes . Nucleic Acids Research vol. 38 , ( suppl_1 ) d670 - d675 .
Rambaldi D, Ciccarelli FD ( 2009 ) . FancyGene: dynamic visualization of gene structures and protein domain architectures on genomic loci . Bioinformatics vol. 25 , ( 17 ) 2281 - 2282 .
Rambaldi D, Giorgi FM, Capuani F, Ciliberto A, Ciccarelli FD ( 2008 ) . Low duplicability and network fragility of cancer genes . Trends in Genetics vol. 24 , ( 9 ) 427 - 430 .
Soldà G, Suyama M, Pelucchi P, Boi S, Guffanti A, Rizzi E, Bork P, Tenchini ML et al. ( 2008 ) . Non-random retention of protein-coding overlapping genes in Metazoa . BMC Genomics vol. 9 , ( 1 )
Fumasoni I, Meani N, Rambaldi D, Scafetta G, Alcalay M, Ciccarelli FD ( 2007 ) . Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates . BMC Ecology and Evolution vol. 7 , ( 1 )
( 2006 ) . Corrections and Clarifications . Science vol. 312 , ( 5774 ) 697 - 697 .
Ciccarelli FD, Doerks T, von Mering C, Creevey CJ, Snel B, Bork P ( 2006 ) . Toward Automatic Reconstruction of a Highly Resolved Tree of Life . Science vol. 311 , ( 5765 ) 1283 - 1287 .
Mees A, Rock R, Ciccarelli FD, Leberfinger CB, Borawski JM, Bork P, Wiese S, Gessler M et al. ( 2005 ) . Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases . Gene Expression Patterns vol. 6 , ( 1 ) 79 - 85 .
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D et al. ( 2005 ) . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature vol. 434 , ( 7034 ) 724 - 731 .
Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P ( 2005 ) . Complex genomic rearrangements lead to novel primate gene function . Genome Research vol. 15 , ( 3 ) 343 - 351 .
Ciccarelli FD, Bork P ( 2004 ) . The WHy domain mediates the response to desiccation in plants and bacteria . Bioinformatics vol. 21 , ( 8 ) 1304 - 1307 .
Rehwinkel J, Herold A, Gari K, Köcher T, Rode M, Ciccarelli FL, Wilm M, Izaurralde E ( 2004 ) . Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster . Nature Structural & Molecular Biology vol. 11 , ( 6 ) 558 - 566 .
Letunic I, Copley RR, Schmidt S, Ciccarelli FD, Doerks T, Schultz J, Ponting CP, Bork P ( 2004 ) . SMART 4.0: towards genomic data integration . Nucleic Acids Research vol. 32 , ( suppl_1 ) d142 - d144 .
Ciccarelli FD, Izaurralde E, Bork P ( 2003 ) . The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold . BMC Bioinformatics vol. 4 , ( 1 )
von Mering C, Zdobnov EM, Tsoka S, Ciccarelli FD, Pereira-Leal JB, Ouzounis CA, Bork P ( 2003 ) . Genome evolution reveals biochemical networks and functional modules . Proceedings of the National Academy of Sciences of the United States of America vol. 100 , ( 26 ) 15428 - 15433 .
Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E ( 2003 ) . Nonsense‐mediated mRNA decay in Drosophila:at the intersection of the yeast and mammalian pathways . The EMBO Journal vol. 22 , ( 15 ) 3960 - 3970 .
Ciccarelli FD, Bork P, Kerkhoff E ( 2003 ) . The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold . vol. 28 , is. 7 , pp. 349 - 352 . Elsevier
Ciccarelli FD, Proukakis C, Patel H, Cross H, Azam S, Patton MA, Bork P, Crosby AH ( 2003 ) . The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia . Genomics vol. 81 , ( 4 ) 437 - 441 .
Perez-Iratxeta C, Astola N, Ciccarelli FD, Sha PK, Bork P, Andrade MA ( 2003 ) . A protocol for the update of references to scientific literature in biological databases . Applied Bioinformatics vol. 2 , ( 3 ) 189 - 191 .
Andrade MA, Ciccarelli FD, Perez-Iratxeta C, Bork P ( 2002 ) . NEAT: a domain duplicated in genes near the components of a putative Fe3+siderophore transporter from Gram-positive pathogenic bacteria . Genome Biology vol. 3 , ( 9 )
Patel H, Cross H, Proukakis C, Hershberger R, Bork P, Ciccarelli FD, Patton MA, McKusick VA et al. ( 2002 ) . SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia . Nature Genetics vol. 31 , ( 4 ) 347 - 348 .
Aloy P, Ciccarelli FD, Leutwein C, Gavin A, Superti‐Furga G, Bork P, Böttcher B, Russell RB ( 2002 ) . A complex prediction: three‐dimensional model of the yeast exosome . EMBO Reports vol. 3 , ( 7 ) 628 - 635 .
Ciccarelli FD, Doerks T, Bork P ( 2002 ) . AMOP, a protein module alternatively spliced in cancer cells . vol. 27 , is. 3 , pp. 113 - 115 . Elsevier
Ciccarelli FD, Copley RR, Doerks T, Russell RB, Bork P ( 2002 ) . CASH – a β-helix domain widespread among carbohydrate-binding proteins . vol. 27 , is. 2 , pp. 59 - 62 . Elsevier
Letunic I, Goodstadt L, Dickens NJ, Doerks T, Schultz J, Mott R, Ciccarelli F, Copley RR et al. ( 2002 ) . Recent improvements to the SMART domain-based sequence annotation resource . Nucleic Acids Research vol. 30 , ( 1 ) 242 - 244 .
Guerra E, Sacchetti A, Zanna P, Ciccarelli F, Capri, Alberti S ( 2001 ) . Trop Molecules Are Novel Controllers of Tumor Growth and Efficient Immunotherapy Targets . Tumori Journal vol. 87 , ( 6 ) 26 - 26 .
Ciccarelli FD, Acciarito A, Alberti S ( 2000 ) . Large and diverse numbers of human diseases with HIKE mutations . Human Molecular Genetics vol. 9 , ( 6 ) 1001 - 1007 .
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