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Research

Publications: Dr Annemieke Apergis-Schoute

Apergis-Schoute AM, van der Flier FE, Ip SHY, Kanen JW, Vaghi MM, Fineberg NA, Sahakian BJ, Cardinal RN et al. ( 2023 ) . Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication . Biological Psychiatry Global Open Science
Roberts C, Apergis-Schoute AM, Bruhl A, Nowak M, Baldwin DS, Sahakian BJ, Robbins TW ( 2022 ) . Threat reversal learning and avoidance habits in generalised anxiety disorder . Translational Psychiatry vol. 12 , ( 1 )
Marzuki AA, Vaghi MM, Conway‐Morris A, Kaser M, Sule A, Apergis‐Schoute A, Sahakian BJ, Robbins TW ( 2022 ) . Atypical action updating in a dynamic environment associated with adolescent obsessive–compulsive disorder . Journal of Child Psychology and Psychiatry vol. 63 , ( 12 ) 1591 - 1601 .
Kanen JW, Apergis-Schoute AM, Yellowlees R, Arntz FE, van der Flier FE, Price A, Cardinal RN, Christmas DM et al. ( 2021 ) . Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans . Molecular Psychiatry vol. 26 , ( 12 ) 7200 - 7210 .
Isobe M, Vaghi M, Fineberg NA, Apergis-Schoute AM, Bullmore ET, Sahakian BJ, Robbins TW, Chamberlain SR ( 2021 ) . Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive–compulsive disorder . The British Journal of Psychiatry vol. 220 , ( 6 ) 314 - 317 .
Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Apergis-Schoute AM, Sahakian BJ et al. ( 2021 ) . Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality . Translational Psychiatry vol. 11 , ( 1 )
Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Sahakian BJ, Apergis-Schoute AM et al. ( 2020 ) . Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis . Journal of Psychopharmacology vol. 34 , ( 5 ) 580 - 583 .
Fineberg NA, Dell'Osso B, Albert U, Maina G, Geller D, Carmi L, Sireau N, Walitza S et al. ( 2019 ) . Early intervention for obsessive compulsive disorder: An expert consensus statement . European Neuropsychopharmacology vol. 29 , ( 4 ) 549 - 565 .
Tyagi H, Apergis-Schoute AM, Akram H, Foltynie T, Limousin P, Drummond LM, Fineberg NA, Matthews K et al. ( 2019 ) . A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects . Biological Psychiatry vol. 85 , ( 9 ) 726 - 734 .
Apergis-Schoute AM, Bijleveld B, Gillan CM, Fineberg NA, Sahakian BJ, Robbins TW ( 2018 ) . Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder . Brain and Neuroscience Advances vol. 2 ,
Vaghi MM, Cardinal RN, Apergis-Schoute AM, Fineberg NA, Sule A, Robbins TW ( 2018 ) . Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation . Biological Psychiatry Cognitive Neuroscience and Neuroimaging vol. 4 , ( 2 ) 200 - 209 .
Gottwald J, de Wit S, Apergis-Schoute AM, Morein-Zamir S, Kaser M, Cormack F, Sule A, Limmer W et al. ( 2018 ) . Impaired cognitive plasticity and goal-directed control in adolescent obsessive–compulsive disorder . Psychological Medicine vol. 48 , ( 11 ) 1900 - 1908 .
Fineberg NA, Apergis-Schoute AM, Vaghi MM, Banca P, Gillan CM, Voon V, Chamberlain SR, Cinosi E et al. ( 2017 ) . Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment . The International Journal of Neuropsychopharmacology vol. 21 , ( 1 ) 42 - 58 .
Apergis-Schoute AM, Gillan CM, Fineberg NA, Fernandez-Egea E, Sahakian BJ, Robbins TW ( 2017 ) . Neural basis of impaired safety signaling in Obsessive Compulsive Disorder . Proceedings of the National Academy of Sciences of the United States of America vol. 114 , ( 12 ) 3216 - 3221 .
Vaghi MM, Vértes PE, Kitzbichler MG, Apergis-Schoute AM, van der Flier FE, Fineberg NA, Sule A, Zaman R et al. ( 2016 ) . Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity . Biological Psychiatry vol. 81 , ( 8 ) 708 - 717 .
Gillan CM, Apergis-Schoute AM, Morein-Zamir S, Urcelay GP, Sule A, Fineberg NA, Sahakian BJ, Robbins TW ( 2014 ) . Functional Neuroimaging of Avoidance Habits in Obsessive-Compulsive Disorder . American Journal of Psychiatry vol. 172 , ( 3 ) 284 - 293 .
Apergis-Schoute AM, Schiller D, LeDoux JE, Phelps EA ( 2014 ) . Extinction resistant changes in the human auditory association cortex following threat learning . Neurobiology of Learning and Memory vol. 113 , 109 - 114 .
Ersche KD, Hagan CC, Smith DG, Abbott S, Jones PS, Apergis-Schoute AM, Döffinger R ( 2013 ) . Aberrant Disgust Responses and Immune Reactivity in Cocaine-Dependent Men . Biological Psychiatry vol. 75 , ( 2 ) 140 - 147 .
Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ et al. ( 2013 ) . Enhanced Avoidance Habits in Obsessive-Compulsive Disorder . Biological Psychiatry vol. 75 , ( 8 ) 631 - 638 .
Crockett MJ, Apergis-Schoute A, Herrmann B, Lieberman MD, Müller U, Robbins TW, Clark L ( 2013 ) . Serotonin Modulates Striatal Responses to Fairness and Retaliation in Humans . Journal of Neuroscience vol. 33 , ( 8 ) 3505 - 3513 .
Crockett MJ, Clark L, Apergis-Schoute AM, Morein-Zamir S, Robbins TW ( 2012 ) . Serotonin Modulates the Effects of Pavlovian Aversive Predictions on Response Vigor . Neuropsychopharmacology vol. 37 , ( 10 ) 2244 - 2252 .
Studer B, Apergis-Schoute AM, Robbins TW, Clark L ( 2012 ) . What are the Odds? The Neural Correlates of Active Choice during Gambling . Frontiers in Neuroscience vol. 6 ,
Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ, Robbins TW ( 2011 ) . Effects of Acute Tryptophan Depletion on Prefrontal-Amygdala Connectivity While Viewing Facial Signals of Aggression . Biological Psychiatry vol. 71 , ( 1 ) 36 - 43 .
Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, den Ouden H, Apergis-Schoute A et al. ( 2011 ) . Converging evidence for central 5-HT effects in acute tryptophan depletion . Molecular Psychiatry vol. 17 , ( 2 ) 121 - 123 .
Apergis-Schoute AM, Debiec J, Doyère V, LeDoux JE, Schafe GE ( 2005 ) . Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System . Journal of Neuroscience vol. 25 , ( 24 ) 5730 - 5739 .