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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Wojciech Kopec

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Mendez-Otalvaro E, Kopec W, de Groot BL ( 2024 ) . Effect of two activators on the gating of a K2P channel . Biophysical Journal vol. 123 , ( 19 ) 3408 - 3420 .
Gapsys V, Kopec W, Matthes D, de Groot BL ( 2024 ) . Biomolecular simulations at the exascale: From drug design to organelles and beyond . Current Opinion in Structural Biology vol. 88 ,
Mironenko A, de Groot BL, Kopec W ( 2024 ) . Selectivity filter mutations shift ion permeation mechanism in potassium channels . PNAS Nexus vol. 3 , ( 7 )
Kopec W, Thomson AS, de Groot BL, Rothberg BS ( 2023 ) . Interactions between selectivity filter and pore helix control filter gating in the MthK channel . The Journal of General Physiology vol. 155 , ( 8 )
Hui C, Kopec W, de Groot BL ( 2023 ) . Ab initio MD for K+ channel parameter optimization . Biophysical Journal vol. 122 , ( 3 )
de Vries R, Kopec W, de Groot BL ( 2023 ) . Gating transitions in the MthK potassium channel . Biophysical Journal vol. 122 , ( 3 )
Otalvaro EFM, Kopec W, de Groot BL ( 2023 ) . Pharmacological modulation of TREK-1 channel . Biophysical Journal vol. 122 , ( 3 )
Shehata M, Kopec W, de Groot BL, Amaro RE ( 2023 ) . The potassium-selective channel “NaK2K”: Why is it a potassium channel? . Biophysical Journal vol. 122 , ( 3 )
Öster C, Movellan KT, Goold B, Hendriks K, Lange S, Becker S, de Groot BL, Kopec W et al. ( 2022 ) . Direct Detection of Bound Ammonium Ions in the Selectivity Filter of Ion Channels by Solid-State NMR . Journal of the American Chemical Society vol. 144 , ( 9 ) 4147 - 4157 .
Mironenko A, Zachariae U, de Groot BL, Kopec W ( 2021 ) . The Persistent Question of Potassium Channel Permeation Mechanisms . Journal of Molecular Biology vol. 433 , ( 17 )
Roy RN, Hendriks K, Kopec W, Abdolvand S, Weiss KL, de Groot BL, Lange A, Sun H et al. ( 2021 ) . Structural plasticity of the selectivity filter in a nonselective ion channel . IUCrJ vol. 8 , ( Pt 3 ) 421 - 430 .
Mironenko A, de Groot BL, Kopec W ( 2021 ) . Conductance Mechanism of Mutant K+ Channels . Biophysical Journal vol. 120 , ( 3 )
Kopec W, Mironenko A, Goold B, de Groot BL ( 2021 ) . Current Regulation in Potassium Channels . Biophysical Journal vol. 120 , ( 3 )
Schewe M, Riel EB, Rinné S, Kopec W, Langer J, Lindemann P, Jürs BC, Nazaré M et al. ( 2021 ) . Structural Basis for Gating of the Two-Pore Domain K+ (K2P) Channels TASK-1 and TALK-2 . Biophysical Journal vol. 120 , ( 3 )
Kopec W, Żak A, Jamróz D, Nakahata R, Yusa S-I, Gapsys V, Kepczynski M ( 2020 ) . Polycation–Anionic Lipid Membrane Interactions . Langmuir vol. 36 , ( 42 ) 12435 - 12450 .
Schubeis T, Le Marchand T, Daday C, Kopec W, Tekwani Movellan K, Stanek J, Schwarzer TS, Castiglione K et al. ( 2020 ) . A β-barrel for oil transport through lipid membranes: Dynamic NMR structures of AlkL . Proceedings of the National Academy of Sciences of the United States of America vol. 117 , ( 35 ) 21014 - 21021 .
Langan PS, Vandavasi VG, Kopec W, Sullivan B, Afonne PV, Weiss KL, de Groot BL, Coates L ( 2020 ) . The structure of a potassium-selective ion channel reveals a hydrophobic gate regulating ion permeation . IUCrJ vol. 7 , ( Pt 5 ) 835 - 843 .
Daday C, Kopec W, de Groot BL ( 2020 ) . Simulating Streaming Potentials in Potassium Channels . Biophysical Journal vol. 118 , ( 3 )
Kopec W, Rothberg BS, de Groot BL ( 2019 ) . Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling . Nature Communications vol. 10 , ( 1 )
Öster C, Hendriks K, Kopec W, Chevelkov V, Shi C, Michl D, Lange S, Sun H et al. ( 2019 ) . The conduction pathway of potassium channels is water free under physiological conditions . Science Advances vol. 5 , ( 7 )
Kopec W, de Groot BL ( 2019 ) . Molecular Simulations of Ion Permeation, Gating and Selectivity in K+ Channels . Biophysical Journal vol. 116 , ( 3 )
Cordeiro S, Finol-Urdaneta RK, Köpfer D, Markushina A, Song J, French RJ, Kopec W, de Groot BL et al. ( 2018 ) . Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 3 ) 1059 - 1064 .
Awasthi N, Kopec W, Wilkosz N, Jamróz D, Hub JS, Zatorska M, Petka R, Nowakowska M et al. ( 2018 ) . Molecular Mechanism of Polycation-Induced Pore Formation in Biomembranes . ACS Biomaterials Science & Engineering vol. 5 , ( 2 ) 780 - 794 .
Dubey V, Han M, Kopec W, Solov’yov IA, Abe K, Khandelia H ( 2018 ) . K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase . Scientific Reports vol. 8 , ( 1 )
Kopec W, Köpfer DA, Vickery ON, Bondarenko AS, Jansen TLC, de Groot BL, Zachariae U ( 2018 ) . Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels . Nature Chemistry vol. 10 , ( 8 ) 813 - 820 .
Heinz LP, Kopec W, de Groot BL, Fink RHA ( 2018 ) . In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways . Scientific Reports vol. 8 , ( 1 )
Tranebjærg L, Strenzke N, Lindholm S, Rendtorff ND, Poulsen H, Khandelia H, Kopec W, Lyngbye TJB et al. ( 2018 ) . Correction to: The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management . Human Genetics vol. 137 , ( 3 ) 279 - 280 .
Tranebjærg L, Strenzke N, Lindholm S, Rendtorff ND, Poulsen H, Khandelia H, Kopec W, Lyngbye TJB et al. ( 2018 ) . The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management . Human Genetics vol. 137 , ( 2 ) 111 - 127 .
Wilkosz N, Jamróz D, Kopeć W, Nakai K, Yusa S-I, Wytrwal-Sarna M, Bednar J, Nowakowska M et al. ( 2017 ) . Effect of Polycation Structure on Interaction with Lipid Membranes . The Journal of Physical Chemistry B vol. 121 , ( 30 ) 7318 - 7326 .
Kopec W, de Groot B ( 2017 ) . Molecular Simulations of Ion Permeation in Potassium Channels . Biophysical Journal vol. 112 , ( 3 )
Han M, Kopeć W, Solov’yov IA, Khandelia H ( 2017 ) . Protonation Dependent Water Permeation of Ion Binding Pocket of Na+ Bound Na+, K+-ATPase . Biophysical Journal vol. 112 , ( 3 )
Han M, Kopec W, Solov’yov IA, Khandelia H ( 2017 ) . Glutamate Water Gates in the Ion Binding Pocket of Na+ Bound Na+, K+-ATPase . Scientific Reports vol. 7 , ( 1 )
Hilbers F, Kopec W, Isaksen TJ, Holm TH, Lykke-Hartmann K, Nissen P, Khandelia H, Poulsen H ( 2016 ) . Tuning of the Na,K-ATPase by the beta subunit . Scientific Reports vol. 6 , ( 1 )
Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Bruhn DS, Kopec W, Khandelia H, Periasamy M ( 2016 ) . The N-Termini of Sarcolipin and Phospholamban Play an Important Role in Distinct Regulation of Sarco-Endoplasmic Reticulum Ca2+ ATPase (SERCA) Function . Biophysical Journal vol. 110 , ( 3 ) 367a - 368a .
Garcia A, Eljack ND, Sani M-A, Separovic F, Rasmussen HH, Kopec W, Khandelia H, Cornelius F et al. ( 2015 ) . Membrane accessibility of glutathione . Biochimica et Biophysica Acta vol. 1848 , ( 10 ) 2430 - 2436 .
Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Bruhn DS, Kopec W, Khandelia H, Periasamy M ( 2015 ) . The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport* . Journal of Biological Chemistry vol. 290 , ( 22 ) 14057 - 14067 .
Mahmmoud YA, Kopec W, Khandelia H ( 2014 ) . K+ Congeners That Do Not Compromise Na+ Activation of the Na+,K+-ATPase HYDRATION OF THE ION BINDING CAVITY LIKELY CONTROLS ION SELECTIVITY* . Journal of Biological Chemistry vol. 290 , ( 6 ) 3720 - 3731 .
Loubet B, Kopec W, Khandelia H ( 2014 ) . Accelerating All-Atom MD Simulations of Lipids Using a Modified Virtual-Sites Technique . Journal of Chemical Theory and Computation vol. 10 , ( 12 ) 5690 - 5695 .
Chaban VV, Nielsen MB, Kopec W, Khandelia H ( 2014 ) . Insights into the role of cyclic ladderane lipids in bacteria from computer simulations . Chemistry and Physics of Lipids vol. 181 , 76 - 82 .
Kopec W, Khandelia H ( 2014 ) . Reinforcing the membrane-mediated mechanism of action of the anti-tuberculosis candidate drug thioridazine with molecular simulations . Journal of Computer-Aided Molecular Design vol. 28 , ( 2 ) 123 - 134 .
Kopec W, Loubet B, Poulsen H, Khandelia H ( 2014 ) . Molecular Mechanism of Na+,K+‑ATPase Malfunction in Mutations Characteristic of Adrenal Hypertension . Biochemistry vol. 53 , ( 4 ) 746 - 754 .
Loubet B, Kopec W, Khandelia H ( 2014 ) . Application of the Virtual Site Technique to Lipids in Gromacs, Hydrogens Degrees of Freedom Removal and Performance Increase . Biophysical Journal vol. 106 , ( 2 )
Kopec W, Loubet B, Khandelia H ( 2014 ) . Glutathionylation of the Na K Pump . Biophysical Journal vol. 106 , ( 2 )
Kopec W, Loubet B, Poulsen H, Khandelia H ( 2014 ) . The Molecular Mechanism of Na+, K+-ATPase Malfunction in Mutations Characteristic for Adrenal Hypertension . Biophysical Journal vol. 106 , ( 2 ) 582a - 583a .
Kopeć W, Telenius J, Khandelia H ( 2013 ) . Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes . The FEBS Journal vol. 280 , ( 12 ) 2785 - 2805 .
Hermetter A, Kopec W, Khandelia H ( 2013 ) . Conformations of double-headed, triple-tailed phospholipid oxidation lipid products in model membranes . Biochimica et Biophysica Acta vol. 1828 , ( 8 ) 1700 - 1706 .
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