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  1. Queen Mary University of London
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Publications: Dr James Buchanan

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Santos-Gonzalez F, Ungar WJ, Buchanan J, Christodoulou J, Stark Z, Goranitis I ( 2024 ) . Micro-costing genomics: Challenges and opportunities . Genetics in Medicine101310 - 101310 .
Mcleod M, Campbell A, Hayhoe B, Borek AJ, Tonkin-Crine S, Moore MV, Butler CC, Walker AS et al. ( 2024 ) . How, why and when are delayed (back-up) antibiotic prescriptions used in primary care? A realist review integrating concepts of uncertainty in healthcare . BMC Public Health vol. 24 , ( 1 )
Weymann D, Buckell J, Fahr P, Loewen R, Ehman M, Pollard S, Friedman JM, Stockler-Ipsiroglu S et al. ( 2024 ) . Health Care Costs After Genome-Wide Sequencing for Children With Rare Diseases in England and Canada . Jama Network Open
Baple EL, Scott RH, Banka S, Buchanan J, Fish L, Wynn S, Wilkinson D, Ellard S et al. ( 2024 ) . Exploring the benefits, harms, and costs of genomic newborn screening for rare diseases . Nature Medicine
Buckell J, Weymann D, Pollard S, Loewen R, Wordsworth S, Buchanan J, Regier DA ( 2024 ) . PCR67 Exploring the Link Between Genomic Testing Decisions and Quality of Life When Diagnosing Rare Childhood Disorders: A Sequential Stated Choice Experiment . Value in Health . Conference: ISPOR vol. 27 , s307 - s308 .
Roope LSJ, Morrell L, Buchanan J, Ledda A, Adler AI, Jit M, Walker AS, Pouwels KB et al. ( 2024 ) . Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use . Communications Medicine vol. 4 , ( 1 )
Marshall DA, Hua N, Buchanan J, Christensen KD, Frederix GWJ, Goranitis I, IJzerman MJ, Jansen JP et al. ( 2024 ) . Paving the path for implementation of clinical genomic sequencing globally - Are we ready? . Health Affairs Scholar
Nolan J, Buchanan J, Almeida J, Bedenham T, Blair E, Broadgate S, Butler S, Cazeaux A et al. ( 2023 ) . Secondary (additional) findings from the 100,000 Genomes Project: disease manifestation, healthcare outcomes and costs of disclosure . Genetics in Medicine
Pan T, Wu Y, Buchanan J, Goranitis I ( 2023 ) . QALYs and Rare Diseases: exploring the responsiveness of SF-6D, EQ-5D-5L and AQoL-8D following genomic testing for childhood and adult-onset rare genetic conditions in Australia . Health and Quality of Life Outcomes
Barbosu S, Wordsworth S, Buckell J, Buchanan J ( 2023 ) . Evaluating the Impact of Genome Sequencing on Healthcare Resource Use: Evidence from Cancer Patients . Academy of Management Proceedings . Conference: Academy of Management Annual Meeting vol. 2023 ,
Wiener EK, Buchanan J, Krause A, Lombard Z ( 2023 ) . Retrospective file review shows limited genetic services fail most patients – an argument for the implementation of exome sequencing as a first-tier test in resource-constrained settings . Orphanet Journal of Rare Diseases vol. 18 , ( 1 )
Liao W, Coupland CAC, Burchardt J, Baldwin DR, initiative D, Gleeson F, Baldwin D, Batchkala G et al. ( 2023 ) . Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models . The Lancet Respiratory Medicine vol. 11 , ( 8 ) 685 - 697 .
Mitropoulou C, Fragoulakis V, Buchanan J, Wordsworth S, Patrinos GP ( 2023 ) . Chapter 1 Introduction to economic evaluation in health sciences . Economic Evaluation in Genomic and Precision Medicine , Elsevier
Wordsworth S, Doble B, Payne K, Buchanan J, Marshall D, McCabe C, Philips K, Fahr P et al. ( 2023 ) . Chapter 8 Using “big data” for economic evaluations in genomics . Economic Evaluation in Genomic and Precision Medicine , Elsevier
Mitropoulou C, Wordsworth S, Buchanan J, Patrinos GP ( 2023 ) . Economic Evaluation in Genomic and Precision Medicine .
Mitropoulou C, Fragoulakis V, Buchanan J, Wordsworth S, Patrinos GP ( 2023 ) . Introduction to economic evaluation in health sciences . Economic Evaluation in Genomic and Precision Medicine ,
Mitropoulou C, Wordsworth S, Buchanan J, Patrinos GP ( 2023 ) . Preface .
Buchanan J, Goranitis I, Slade I, Kerasidou A, Sheehan M, Sideri K, Wordsworth S ( 2022 ) . Resource allocation in genetic and genomic medicine . Journal of Community Genetics vol. 13 , ( 5 ) 463 - 466 .
Pollard S, Weymann D, Chan B, Ehman M, Wordsworth S, Buchanan J, Hanna TP, Ho C et al. ( 2022 ) . Defining a Core Data Set for the Economic Evaluation of Precision Oncology . Value Health vol. 25 , ( 8 ) 1371 - 1380 .
Buchanan J, Hill M, Vass CM, Hammond J, Riedijk S, Klapwijk JE, Harding E, Lou S et al. ( 2022 ) . Factors that impact on women's decision‐making around prenatal genomic tests: An international discrete choice survey . Prenatal Diagnosis vol. 42 , ( 7 ) 934 - 946 .
Koleva-Kolarova R, Buchanan J, Vellekoop H, Huygens S, Versteegh M, Mölken MR-V, Szilberhorn L, Zelei T et al. ( 2022 ) . Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options . Applied Health Economics and Health Policy vol. 20 , ( 4 ) 501 - 524 .
Lewis C, Buchanan J, Clarke A, Clement E, Friedrich B, Hastings-Ward J, Hill M, Horn R et al. ( 2022 ) . Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol . NIHR Open Research vol. 1 , 23 - 23 .
Yang M, Roope LSJ, Buchanan J, Attema AE, Clarke PM, Walker AS, Wordsworth S ( 2022 ) . Eliciting risk preferences that predict risky health behavior: A comparison of two approaches . Health Economics vol. 31 , ( 5 ) 836 - 858 .
Hammond J, Klapwijk JE, Riedijk S, Lou S, Ormond KE, Vogel I, Hui L, Sziepe E-J et al. ( 2022 ) . Assessing women’s preferences towards tests that may reveal uncertain results from prenatal genomic testing: Development of attributes for a discrete choice experiment, using a mixed-methods design . PLOS ONE vol. 17 , ( 1 )
Lewis C, Buchannan J, Clarke A, Clement E, Friedrich B, Hastings-Ward J, Hill M, Horn R et al. ( 2021 ) . Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol . NIHR Open Research vol. 1 ,
Smedley D, Smith KR, Martin AR, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G et al. ( 2021 ) . 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report . New England Journal of Medicine vol. 385 , ( 20 ) 1868 - 1880 .
Borek AJ, Campbell A, Dent E, Moore M, Butler CC, Holmes A, Walker AS, McLeod M et al. ( 2021 ) . Development of an intervention to support the implementation of evidence-based strategies for optimising antibiotic prescribing in general practice . Implementation Science Communications vol. 2 , ( 1 )
Morrell L, Buchanan J, Roope LSJ, Pouwels KB, Butler CC, Hayhoe B, Tonkin-Crine S, McLeod M et al. ( 2021 ) . Public preferences for delayed or immediate antibiotic prescriptions in UK primary care: A choice experiment . PLOS Medicine vol. 18 , ( 8 )
Morrell L, Buchanan J, Rees S, Barker RW, Wordsworth S ( 2021 ) . What Aspects of Illness Influence Public Preferences for Healthcare Priority Setting? A Discrete Choice Experiment in the UK . PharmacoEconomics vol. 39 , ( 12 ) 1443 - 1454 .
Buchanan J, Altunkaya J, Van Kinh N, Van Vinh Chau N, Ly VT, Thuy PTT, Vinh VH, Hanh DTH et al. ( 2021 ) . Cost-Effectiveness of Amphotericin B Deoxycholate Versus Itraconazole for Induction Therapy of Talaromycosis in Human Immunodeficiency Virus–Infected Adults in Vietnam . Open Forum Infectious Diseases vol. 8 , ( 7 )
Pollard S, Weymann D, Dunne J, Mayanloo F, Buckell J, Buchanan J, Wordsworth S, Friedman JM et al. ( 2021 ) . Correction to: Toward the diagnosis of rare childhood genetic diseases: what do parents value most? . European Journal of Human Genetics vol. 29 , ( 10 ) 1589 - 1589 .
Pollard S, Weymann D, Dunne J, Mayanloo F, Buckell J, Buchanan J, Wordsworth S, Friedman JM et al. ( 2021 ) . Toward the diagnosis of rare childhood genetic diseases: what do parents value most? . European Journal of Human Genetics vol. 29 , ( 10 ) 1491 - 1501 .
Buchanan J, Roope LSJ, Morrell L, Pouwels KB, Robotham JV, Abel L, Crook DW, Peto T et al. ( 2021 ) . Preferences for Medical Consultations from Online Providers: Evidence from a Discrete Choice Experiment in the United Kingdom . Applied Health Economics and Health Policy vol. 19 , ( 4 ) 521 - 535 .
Phillips KA, Douglas MP, Wordsworth S, Buchanan J, Marshall DA ( 2021 ) . Availability and funding of clinical genomic sequencing globally . BMJ Global Health vol. 6 , ( 2 )
Borek AJ, Campbell A, Dent E, Butler CC, Holmes A, Moore M, Walker AS, McLeod M et al. ( 2021 ) . Implementing interventions to reduce antibiotic use: a qualitative study in high-prescribing practices . BMC Primary Care vol. 22 , ( 1 )
Gaille M, Horn R ( 2021 ) . The ethics of genomic medicine: redefining values and norms in the UK and France . European Journal of Human Genetics vol. 29 , ( 5 ) 780 - 788 .
Koleva-Kolarova R, Buchanan J, Wordsworth S, Tsiachristas A ( 2020 ) . RE1 Financing and Reimbursement for Personalised Medicine - Are WE There YET? . Value in Health . Conference: ISPOR Europe 2020 vol. 23 , s756 - s756 .
Pouwels KB, Roope LSJ, Buchanan J, Morrell L, Tonkin-Crine S, Peters M, Jones LF, Castro-Sánchez E et al. ( 2020 ) . Awareness of Appropriate Antibiotic Use in Primary Care for Influenza-Like Illness: Evidence of Improvement from UK Population-Based Surveys . Antibiotics vol. 9 , ( 10 )
Morrell L, Buchanan J, Roope LSJ, Pouwels KB, Butler CC, Hayhoe B, Moore MV, Tonkin-Crine S et al. ( 2020 ) . Delayed Antibiotic Prescription by General Practitioners in the UK: A Stated-Choice Study . Antibiotics vol. 9 , ( 9 )
Phillips K, Wordsworth S, Regier D, Marshall D, Douglas MP, Buchanan J ( 2020 ) . PCV3 Global Landscape of Clinical Genomic Sequencing: Who, Where, and How? . Value in Health Regional Issues vol. 22 ,
Roope LSJ, Buchanan J, Morrell L, Pouwels KB, Sivyer K, Mowbray F, Abel L, Cross ELA et al. ( 2020 ) . Why do hospital prescribers continue antibiotics when it is safe to stop? Results of a choice experiment survey . BMC Medicine vol. 18 , ( 1 )
Marshall DA, Grazziotin LR, Regier DA, Wordsworth S, Buchanan J, Phillips K, Ijzerman M ( 2020 ) . Addressing Challenges of Economic Evaluation in Precision Medicine Using Dynamic Simulation Modeling . Value in Health vol. 23 , ( 5 ) 566 - 573 .
Pouwels KB, Vansteelandt S, Batra R, Edgeworth J, Wordsworth S, Robotham JV, Anyanwu PE, Borek A et al. ( 2020 ) . Estimating the Effect of Healthcare-Associated Infections on Excess Length of Hospital Stay Using Inverse Probability–Weighted Survival Curves . Clinical Infectious Diseases vol. 71 , ( 9 ) e415 - e420 .
Morrison M, Teare H, Bertier G, Buchanan J, Bylstra Y, Gaff C, Jackson L, Kato K et al. ( 2020 ) . Chapter 8 Implications of secondary findings for clinical contexts . Secondary Findings in Genomic Research , Elsevier
Morrison M, Teare H, Bertier G, Buchanan J, Bylstra Y, Gaff C, Jackson L, Kato K et al. ( 2020 ) . Implications of secondary findings for clinical contexts . Secondary Findings in Genomic Research ,
Fahr P, Buchanan J, Wordsworth S ( 2019 ) . A Review of Health Economic Studies Comparing Traditional and Massively Parallel Sequencing Diagnostic Pathways for Suspected Genetic Disorders . PharmacoEconomics vol. 38 , ( 2 ) 143 - 158 .
Schwarze K, Buchanan J, Fermont JM, Dreau H, Tilley MW, Taylor JM, Antoniou P, Knight SJL et al. ( 2019 ) . The complete costs of genome sequencing: a microcosting study in cancer and rare diseases from a single center in the United Kingdom . Genetics in Medicine vol. 22 , ( 1 ) 85 - 94 .
Buchanan J, Blair E, Thomson KL, Ormondroyd E, Watkins H, Taylor JC, Wordsworth S ( 2019 ) . Do health professionals value genomic testing? A discrete choice experiment in inherited cardiovascular disease . European Journal of Human Genetics vol. 27 , ( 11 ) 1639 - 1648 .
Copsey B, Buchanan J, Fitzpatrick R, Lamb SE, Dutton SJ, Cook JA ( 2019 ) . Duration of Treatment Effect Should Be Considered in the Design and Interpretation of Clinical Trials: Results of a Discrete Choice Experiment . Medical Decision Making vol. 39 , ( 4 ) 461 - 473 .
Roope LSJ, Smith RD, Pouwels KB, Buchanan J, Abel L, Eibich P, Butler CC, Tan PS et al. ( 2019 ) . The challenge of antimicrobial resistance: What economics can contribute . Science vol. 364 , ( 6435 )
Fahr P, Buchanan J, Wordsworth S ( 2019 ) . A Review of the Challenges of Using Biomedical Big Data for Economic Evaluations of Precision Medicine . Applied Health Economics and Health Policy vol. 17 , ( 4 ) 443 - 452 .
Leal J, Manetti S, Buchanan J ( 2019 ) . Correction to: The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study . PharmacoEconomics vol. 37 , ( 6 ) 867 - 867 .
Yang Y, Abel L, Buchanan J, Fanshawe T, Shinkins B ( 2018 ) . Use of Decision Modelling in Economic Evaluations of Diagnostic Tests: An Appraisal and Review of Health Technology Assessments in the UK . PharmacoEconomics - Open vol. 3 , ( 3 ) 281 - 291 .
Buchanan J, Wordsworth S ( 2018 ) . Evaluating the Outcomes Associated with Genomic Sequencing: A Roadmap for Future Research . PharmacoEconomics - Open vol. 3 , ( 2 ) 129 - 132 .
Regier DA, Weymann D, Buchanan J, Marshall DA, Wordsworth S ( 2018 ) . Valuation of Health and Nonhealth Outcomes from Next-Generation Sequencing: Approaches, Challenges, and Solutions . Value in Health vol. 21 , ( 9 ) 1043 - 1047 .
Wordsworth S, Doble B, Payne K, Buchanan J, Marshall DA, McCabe C, Regier DA ( 2018 ) . Using “Big Data” in the Cost-Effectiveness Analysis of Next-Generation Sequencing Technologies: Challenges and Potential Solutions . Value in Health vol. 21 , ( 9 ) 1048 - 1053 .
Phillips KA, Deverka PA, Marshall DA, Wordsworth S, Regier DA, Christensen KD, Buchanan J ( 2018 ) . Methodological Issues in Assessing the Economic Value of Next-Generation Sequencing Tests: Many Challenges and Not Enough Solutions . Value in Health vol. 21 , ( 9 ) 1033 - 1042 .
Leal J, Manetti S, Buchanan J ( 2018 ) . The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study . PharmacoEconomics vol. 36 , ( 10 ) 1263 - 1272 .
Schwarze K, Buchanan J, Taylor J, Wordsworth S ( 2018 ) . PHP83 Are whole Exome and whole Genome Sequencing Approaches Cost-Effective? A Systematic Review of the Literature . Value in Health vol. 21 ,
Schwarze K, Buchanan J, Taylor JC, Wordsworth S ( 2018 ) . Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature . Genetics in Medicine vol. 20 , ( 10 ) 1122 - 1130 .
Parker B, Buchanan J, Wordsworth S, Keshav S, George B, East JE ( 2017 ) . Surgery versus surveillance in ulcerative colitis patients with endoscopically invisible low-grade dysplasia: a cost-effectiveness analysis . Gastrointestinal Endoscopy vol. 86 , ( 6 ) 1088 - 1099.e5 .
Buchanan J, Wordsworth S, Clifford R, Robbe P, Taylor JC, Schuh A, Knight SJL ( 2017 ) . Using Genomic Information to Guide Ibrutinib Treatment Decisions in Chronic Lymphocytic Leukaemia: A Cost-Effectiveness Analysis . PharmacoEconomics vol. 35 , ( 8 ) 845 - 858 .
Monahan KJ, Alsina D, Bach S, Buchanan J, Burn J, Clark S, Dawson P, De Souza B et al. ( 2017 ) . Urgent improvements needed to diagnose and manage Lynch syndrome . The BMJ vol. 356 ,
Hollowell J, Li Y, Malouf R, Buchanan J ( 2016 ) . Women’s birth place preferences in the United Kingdom: a systematic review and narrative synthesis of the quantitative literature . BMC Pregnancy and Childbirth vol. 16 , ( 1 )
Buchanan J, Wordsworth S, Schuh A ( 2016 ) . Patients’ Preferences for Genomic Diagnostic Testing in Chronic Lymphocytic Leukaemia: A Discrete Choice Experiment . The Patient - Patient-Centered Outcomes Research vol. 9 , ( 6 ) 525 - 536 .
Wordsworth S, Buchanan J, Towse A ( 2016 ) . Health Economic Perspectives of Genomics . Genomics and Society: Ethical, Legal, Cultural and Socioeconomic Implications ,
Peters JL, Cooper C, Buchanan J ( 2015 ) . Evidence used in model-based economic evaluations for evaluating pharmacogenetic and pharmacogenomic tests: a systematic review protocol . BMJ Open vol. 5 , ( 11 )
Buchanan J, Wordsworth S, Taylor J, Jewell D ( 2015 ) . PTU-029 Managing the long-term care of inflammatory bowel disease patients: the cost to European health care providers . Gut vol. 59 , ( Suppl 1 )
Parker B, Buchanan J, Wordsworth S, East J, Keshav S, George B ( 2015 ) . OC-014 Management of low-grade dysplasia in ulcerative colitis in the uk national health service: the cost-effectiveness of immediate surgery versus ongoing surveillance . Gut vol. 64 , ( Suppl 1 )
Buchanan J, Wordsworth S, O'Connor L, Pike G, Walker AS, Wilcox MH, Crook DW ( 2015 ) . Management of patients with suspected infectious diarrhoea in hospitals in England . Journal of Hospital Infection vol. 90 , ( 3 ) 199 - 207 .
Buchanan J, Wordsworth S ( 2015 ) . Welfarism Versus Extra-Welfarism: Can the Choice of Economic Evaluation Approach Impact on the Adoption Decisions Recommended by Economic Evaluation Studies? . PharmacoEconomics vol. 33 , ( 6 ) 571 - 579 .
Wordsworth S, Buchanan J, Towse A ( 2015 ) . Health Economic Perspectives of Genomics . Genomics and Society: Ethical, Legal, Cultural and Socioeconomic Implications ,
Pankhurst L, Macfarlane-Smith L, Buchanan J, Anson L, Davies K, O'Connor L, Ashwin H, Pike G et al. ( 2014 ) . Can rapid integrated Polymerase Chain Reaction (PCR)-based diagnostics for Gastrointestinal pathogens improve routine hospital infection control practice? A diagnostic study . Health Technology Assessment vol. 18 , ( 53 ) 1 - 167 .
Buchanan J, Wordsworth S, Schuh A ( 2013 ) . Issues surrounding the health economic evaluation of genomic technologies . Pharmacogenomics vol. 14 , ( 15 ) 1833 - 1847 .
Buchanan J, Wordsworth S, Ahmad T, Perrin A, Vermeire S, Sans M, Taylor J, Jewell D ( 2011 ) . Managing the long term care of inflammatory bowel disease patients: The cost to European health care providers . Journal of Crohn's and Colitis vol. 5 , ( 4 ) 301 - 316 .
Buchanan J, Mihaylova B, Gray A, White N ( 2010 ) . Cost-Effectiveness of Pre-Referral Antimalarial, Antibacterial, and Combined Rectal Formulations for Severe Febrile Illness . PLOS ONE vol. 5 , ( 12 )
Wordsworth S, Buchanan J, Mollison J, Harrild K, Robertson L, Tay C, Harrold A, McQueen D et al. ( 2010 ) . Clomifene citrate and intrauterine insemination as first-line treatments for unexplained infertility: are they cost-effective? . Human Reproduction vol. 26 , ( 2 ) 369 - 375 .
Buchanan J, Wordsworth S, Taylor J, Jewell DP ( 2010 ) . M1032 Managing the Long Term Care of Inflammatory Bowel Disease Patients: the Cost to European Health Care Providers . Gastroenterology vol. 138 , ( 5 ) s - 317 .
Wordsworth S, Buchanan J, Papanicolas I, Taylor J, Frayling I, Tomlinson I ( 2008 ) . Molecular testing for somatic mutations in common cancers: the views of UK oncologists . Journal of Clinical Pathology vol. 61 , ( 6 )
Wordsworth S, Papanicolas I, Buchanan J, Frayling I, Taylor J, Tomlinson I ( 2008 ) . Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories . Journal of Clinical Pathology vol. 61 , ( 3 )
Wordsworth S, Buchanan J, Regan R, Davison V, Smith K, Dyer S, Campbell C, Blair E et al. ( 2007 ) . Diagnosing idiopathic learning disability: a cost-effectiveness analysis of microarray technology in the National Health Service of the United Kingdom . The HUGO Journal vol. 1 , ( 1-2 ) 35 - 45 .
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