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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Cara Croft

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Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F et al. ( 2024 ) . Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection . Science Advances vol. 10 , ( 12 )
Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp M-D, Jimenez-Sanchez M et al. ( 2023 ) . P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes . Brain Behavior and Immunity vol. 114 , 414 - 429 .
Croft CL, Paterno G, Vause AR, Rowe LA, Ryu DH, Goodwin MS, Moran CA, Cruz PE et al. ( 2022 ) . Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance . npj Parkinson's Disease vol. 8 , ( 1 )
Khalil B, Chhangani D, Wren MC, Smith CL, Lee JH, Li X, Puttinger C, Tsai C-W et al. ( 2022 ) . Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy . Molecular Neurodegeneration vol. 17 , ( 1 )
Xia Y, Prokop S, Bell BM, Gorion K-MM, Croft CL, Nasif L, Xu G, Riffe CJ et al. ( 2022 ) . Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice . Communications Biology vol. 5 , ( 1 )
Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C et al. ( 2022 ) . Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts . Free Neuropathology vol. 3 , ( 9 )
Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G et al. ( 2021 ) . Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions . Acta Neuropathologica vol. 141 , ( 3 ) 359 - 381 .
Goodwin MS, Croft CL, Futch HS, Ryu D, Ceballos-Diaz C, Liu X, Paterno G, Mejia C et al. ( 2020 ) . Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS . Molecular Neurodegeneration vol. 15 , ( 1 )
Croft CL, Futch HS, Moore BD, Golde TE ( 2019 ) . Organotypic brain slice cultures to model neurodegenerative proteinopathies . Molecular Neurodegeneration vol. 14 , ( 1 )
Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR et al. ( 2019 ) . An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes . Journal of Experimental Medicine vol. 216 , ( 11 ) 2479 - 2491 .
Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin W-L, Deture M et al. ( 2019 ) . rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies . Journal of Experimental Medicine vol. 216 , ( 3 ) 539 - 555 .
Futch HS, Croft CL ( 2018 ) . SIRT1: A Novel Way to Target Tau? . Journal of Neuroscience vol. 38 , ( 36 ) 7755 - 7757 .
Croft CL, Noble W ( 2018 ) . Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease . F1000Research vol. 7 ,
Croft CL, Moore BD, Ran Y, Chakrabarty P, Levites Y, Golde TE, Giasson BI ( 2018 ) . Novel monoclonal antibodies targeting the microtubule-binding domain of human tau . PLOS ONE vol. 13 , ( 4 )
Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI ( 2017 ) . Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies . Journal of Biological Chemistry vol. 293 , ( 7 ) 2408 - 2421 .
Croft CL, Kurbatskaya K, Hanger DP, Noble W ( 2017 ) . Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease . Scientific Reports vol. 7 , ( 1 )
Futch HS, Croft CL, Truong VQ, Krause EG, Golde TE ( 2017 ) . Targeting psychologic stress signaling pathways in Alzheimer’s disease . Molecular Neurodegeneration vol. 12 , ( 1 )
Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS et al. ( 2017 ) . Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures . Cell Death & Disease vol. 8 , ( 3 ) e2671 - e2671 .
Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C et al. ( 2016 ) . Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain . Acta Neuropathologica Communications vol. 4 , ( 1 )
Hughes ATL, Croft CL, Samuels RE, Myung J, Takumi T, Piggins HD ( 2015 ) . Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice . Scientific Reports vol. 5 , ( 1 )
Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W ( 2014 ) . Astrocytes and neuroinflammation in Alzheimer's disease . Biochemical Society Transactions vol. 42 , ( 5 ) 1321 - 1325 .
Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A et al. ( 2013 ) . Calpain cleavage and inactivation of the sodium calcium exchanger‐3 occur downstream of Aβ in Alzheimer's disease . Aging Cell vol. 13 , ( 1 ) 49 - 59 .
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