Publications: Dr Petroula Proitsi

Gilchrist L, Spargo TP, Green RE, Coleman JRI, Howard DM, Thorp JG, Adey BN, Lord J et al. ( 2025 ) . Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease . Nature Mental Health vol. 3 , ( 2 ) 212 - 228 .

Wretlind A, Xu J, Proitsi P, Legido‐Quigley C ( 2025 ) . Comprehensive lipidomic analysis for identification of lipid biomarkers associated with Alzheimer´s disease . Alzheimer's & Dementia vol. 20 , ( Suppl 2 )

Chandra A, Anjum R, Waters S, Proitsi P, Smith LJ, Marshall CR ( 2025 ) . Investigating mediating influences of β‐amyloid on the relationship between marital dissolution and cognition . Alzheimer's & Dementia vol. 20 , ( Suppl 3 )

Spargo TP, Gilchrist L, Hunt GP, Dobson RJ, Proitsi P, Al-Chalabi A, Pain O, Iacoangeli A ( 2024 ) . Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics . eLife vol. 12 ,

Chandra A, Anjum R, Waters S, Proitsi P, Smith LJ, Marshall CR, Initiative FTADN ( 2024 ) . Marital dissolution and cognition: The mediating effect of Aβ neuropathology . Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring vol. 16 , ( 4 )

Gilchrist L, Marriot H, Pfaff A, Watson C, Pain O, Koks S, Lewis C, Proitsi P ( 2024 ) . 9. INVESTIGATING PSYCHIATRIC AND COGNITIVE SYMPTOM TRAJECTORIES IN PARKINSON'S DISEASE USING NEUROPSYCHIATRIC TRANSCRIPTIONAL RISK SCORES . European Neuropsychopharmacology vol. 87 , 51 - 52 .

Gómez-Pascual A, Naccache T, Xu J, Hooshmand K, Wretlind A, Gabrielli M, Lombardo MT, Shi L et al. ( 2024 ) . Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease . Computers in Biology and Medicine vol. 176 ,

Jacobs BM, Vickaryous N, Giovannoni G, Proitsi P, Waters S, Dobson R ( 2024 ) . Plasma proteomic profiles of UK Biobank participants with multiple sclerosis . Annals of Clinical and Translational Neurology vol. 11 , ( 3 ) 698 - 709 .

Winchester LM, Harshfield EL, Shi L, Badhwar A, Al Khleifat A, Clarke N, Dehsarvi A, Lengyel I et al. ( 2023 ) . Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia . Alzheimer's & Dementia vol. 19 , ( 12 ) 5860 - 5871 .

Green RE, Lord J, Scelsi MA, Xu J, Wong A, Naomi-James S, Handy A, Gilchrist L et al. ( 2023 ) . Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease . Alzheimer's Research & Therapy vol. 15 , ( 1 )

Shi L, Xu J, Green R, Wretlind A, Homann J, Buckley NJ, Tijms BM, Vos SJB et al. ( 2023 ) . Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease . Alzheimer's & Dementia vol. 19 , ( 8 ) 3350 - 3364 .

Leffa DT, Ferrari‐Souza JP, Bellaver B, Ferreira PCL, Tissot C, Brum WS, Caye A, Lord J et al. ( 2022 ) . Genetic risk for attention‐deficit/hyperactivity disorder is associated with amyloid‐dependent cognitive decline in older adults . Alzheimer's & Dementia vol. 18 , ( S3 )

Ranson JM, Al Khleifat A, Lyall DM, Newby D, Winchester LM, Proitsi P, Veldsman M, Rittman T et al. ( 2022 ) . The Deep Dementia Phenotyping (DEMON) Network: A global platform for innovation using data science and artificial intelligence . Alzheimer's & Dementia vol. 18 , ( S2 )

Leffa DT, Ferrari-Souza JP, Bellaver B, Tissot C, Ferreira PCL, Brum WS, Caye A, Lord J et al. ( 2022 ) . Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults . Molecular Psychiatry vol. 28 , ( 3 ) 1248 - 1255 .

Gilchrist L, Green R, Howard D, Coleman J, Lewis C, Proitsi P ( 2022 ) . INVESTIGATING THE GENETIC OVERLAP BETWEEN DIFFERENT DEPRESSION SYMPTOMS AND ALZHEIMER'S DISEASE: FROM GENETIC CORRELATION TO COLOCALIZATION . European Neuropsychopharmacology vol. 63 , e257 - e258 .

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S et al. ( 2022 ) . Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease . Nature Genetics vol. 54 , ( 7 ) 1062 - 1062 .

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R et al. ( 2022 ) . New insights into the genetic etiology of Alzheimer’s disease and related dementias . Nature Genetics vol. 54 , ( 4 ) 412 - 436 .

Sliz E, Shin J, Ahmad S, Williams DM, Frenzel S, Gauß F, Harris SE, Henning A-K et al. ( 2022 ) . Circulating Metabolome and White Matter Hyperintensities in Women and Men . Circulation vol. 145 , ( 14 ) 1040 - 1052 .

Velayudhan L, French T, Ugochukwu A, Corbett A, Brooker H, Aarsland D, Ballard C, Proitsi P ( 2021 ) . Hypertension, brain training and cognition in the healthy adults aged over 50 years: An online longitudinal study . Alzheimer's & Dementia vol. 17 , ( S10 )

Green R, Lord J, Xu J, Maddock J, Kim M, Dobson R, Legido-Quigley C, Wong A et al. ( 2021 ) . Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort . Brain Communications vol. 4 , ( 1 )

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S et al. ( 2021 ) . Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease . Nature Genetics vol. 53 , ( 12 ) 1722 - 1722 .

Xu J, Green R, Kim M, Lord J, Ebshiana A, Westwood S, Baird AL, Nevado-Holgado AJ et al. ( 2021 ) . Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort . Biomedicines vol. 9 , ( 11 )

Handy A, Lord J, Green R, Xu J, Aarsland D, Velayudhan L, Hye A, Dobson R et al. ( 2021 ) . Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 83 , ( 4 ) 1825 - 1839 .

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S et al. ( 2021 ) . A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease . Nature Genetics vol. 53 , ( 9 ) 1276 - 1282 .

Lord J, Green R, Choi SW, Hübel C, Aarsland D, Velayudhan L, Sham P, Legido-Quigley C et al. ( 2021 ) . Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease . Biological Psychiatry Global Open Science vol. 2 , ( 2 ) 167 - 179 .

Proitsi P ( 2021 ) . The key role of apolipoprotein B in major vascular diseases and longevity . The Lancet Healthy Longevity vol. 2 , ( 6 ) e302 - e303 .

Lord J, Zettergren A, Ashton NJ, Karikari TK, Benedet AL, Simrén J, Initiative TADN, Hye A et al. ( 2021 ) . A genome-wide association study of plasma phosphorylated tau181 . Neurobiology of Aging vol. 106 , 304.e1 - 304.e3 .

Lord J, Jermy B, Green R, Wong A, Xu J, Legido-Quigley C, Dobson R, Richards M et al. ( 2021 ) . Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease . Proceedings of the National Academy of Sciences of the United States of America vol. 118 , ( 16 )

Proitsi P ( 2021 ) . Disentangling the Complex Relationship Between Hypertension and Dementia . Biological Psychiatry vol. 89 , ( 8 ) 742 - 744 .

Zettergren A, Lord J, Ashton NJ, Benedet AL, Karikari TK, Lantero Rodriguez J, Snellman A, Suárez-Calvet M et al. ( 2021 ) . Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative . Alzheimer's Research & Therapy vol. 13 , ( 1 )

Kurbatova N, Garg M, Whiley L, Chekmeneva E, Jiménez B, Gómez-Romero M, Pearce J, Kimhofer T et al. ( 2020 ) . Urinary metabolic phenotyping for Alzheimer’s disease . Scientific Reports vol. 10 , ( 1 )

Proitsi P, Ebshiana AA, Hodges A, Legido‐Quigley C ( 2020 ) . Association of TREM2 variants and sphingolipid levels with AD in blood and brain . Alzheimer's & Dementia vol. 16 , ( S4 )

Iacoangeli A, Lin T, Al Khleifat A, Jones AR, Opie-Martin S, Coleman JRI, Shatunov A, Sproviero W et al. ( 2020 ) . Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics . Cell Reports vol. 33 , ( 4 )

Ghatan S, Trajanoska K, Proitsi P, Ikram MA, Uitterlinden A, Hodges A, Oei L, Rivadeneira F ( 2020 ) . Causal assessment of the association between bone mineral density and the risk of dementia . Bone Reports vol. 13 ,

Xu J, Bankov G, Kim M, Wretlind A, Lord J, Green R, Hodges A, Hye A et al. ( 2020 ) . Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease . Translational Neurodegeneration vol. 9 , ( 1 )

Bergland AK, Proitsi P, Kirsebom B-E, Soennesyn H, Hye A, Larsen AI, Xu J, Legido-Quigley C et al. ( 2020 ) . Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 77 , ( 3 ) 1117 - 1127 .

Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I et al. ( 2020 ) . An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene . Neurobiology of Aging vol. 95 , 26 - 45 .

Ghosh A, Mizuno K, Tiwari SS, Proitsi P, Gomez Perez-Nievas B, Glennon E, Martinez-Nunez RT, Giese KP ( 2020 ) . Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing . Translational Psychiatry vol. 10 , ( 1 )

Gohier B, Senior C, Radua J, El-Hage W, Reichenberg A, Proitsi P, Phillips ML, Surguladze SA ( 2020 ) . Genetic modulation of the response bias towards facial displays of anger and happiness . European Psychiatry vol. 29 , ( 4 ) 197 - 202 .

de Lucia C, Murphy T, Steves CJ, Dobson RJB, Proitsi P, Thuret S ( 2020 ) . Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence . Communications Biology vol. 3 , ( 1 )

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK et al. ( 2020 ) . Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk . Nature Genetics vol. 52 , ( 3 ) 354 - 354 .

Pishva E, Creese B, Smith AR, Viechtbauer W, Proitsi P, van den Hove DLA, Ballard C, Mill J et al. ( 2020 ) . Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex . Neurobiology of Aging vol. 89 , 83 - 88 .

Creese B, Vassos E, Bergh S, Athanasiu L, Johar I, Rongve A, Medbøen IT, Vasconcelos Da Silva M et al. ( 2019 ) . Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease . Translational Psychiatry vol. 9 , ( 1 )

Green R, Lord J, Maddock J, Kim M, Dobson R, Legido-Quigley C, Wong A, Richards M et al. ( 2019 ) . S34INVESTIGATING THE ROLE OF BLOOD METABOLITES AS BIOMARKERS OF COGNITIVE FUNCTION AND DEMENTIA IN THE MRC 1946 BRITISH BIRTH COHORT . European Neuropsychopharmacology vol. 29 , s131 - s132 .

Lord J, Green R, Hübel C, Richards M, Sham P, Legido-Quigley C, Dobson R, Proitsi P ( 2019 ) . S35INVESTIGATING THE ROLE OF MODIFIABLE RISK FACTORS ON THE CAUSAL PATHWAY TO ALZHEIMER'S DISEASE . European Neuropsychopharmacology vol. 29 ,

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al. ( 2019 ) . Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing . Nature Genetics vol. 51 , ( 9 ) 1423 - 1424 .

Johar I, Creese B, Bergh S, Athanasiu L, Medboen IT, Da Silva MV, Rongve A, Aakhus E et al. ( 2019 ) . P2‐129: GENOME‐WIDE ASSOCIATION OF ALZHEIMER'S DISEASE WITH DYSPHORIA AND EVALUATION OF GENETIC OVERLAP WITH MAJOR DEPRESSIVE DISORDER . Alzheimer's & Dementia vol. 15 , ( 7S_Part_12 ) p621 - p622 .

Velayudhan L, Ugochukwu A, Wesnes K, Brooker H, Corbett A, Aarsland D, Ballard C, Proitsi P ( 2019 ) . P3‐555: AN ONLINE ASSESSMENT OF THE INFLUENCE OF VASCULAR RISK FACTORS ON COGNITIVE FUNCTION IN HEALTHY ADULTS AGED 50 AND ABOVE . Alzheimer's & Dementia vol. 15 , ( 7S_Part_22 ) p1187 - p1187 .

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S et al. ( 2019 ) . Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection . Nature Genetics vol. 51 , ( 7 ) 1193 - 1193 .

Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A et al. ( 2019 ) . Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort . Alzheimer's & Dementia vol. 15 , ( 6 ) 817 - 827 .

Wulaningsih W, Proitsi P, Wong A, Kuh D, Hardy R ( 2019 ) . Metabolomic correlates of central adiposity and earlier-life body mass index . Journal of Lipid Research vol. 60 , ( 6 ) 1136 - 1143 .

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al. ( 2019 ) . Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing . Nature Genetics vol. 51 , ( 3 ) 414 - 430 .

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK et al. ( 2019 ) . Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk . Nature Genetics vol. 51 , ( 3 ) 404 - 413 .

Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado‐Holgado A, Hye A, Bos I et al. ( 2019 ) . A metabolite‐based machine learning approach to diagnose Alzheimer‐type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort . Alzheimer's & Dementia: Translational Research & Clinical Interventions vol. 5 , ( 1 ) 933 - 938 .

Proitsi P, Kuh D, Wong A, Maddock J, Bendayan R, Wulaningsih W, Hardy R, Richards M ( 2018 ) . Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort . Translational Psychiatry vol. 8 , ( 1 )

Peloso GM, van der Lee SJ, Project IGOA, Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N et al. ( 2018 ) . Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease . Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring vol. 10 , ( 1 ) 595 - 598 .

Creese B, Pishva E, Proitsi P, Smith RG, Ballard C, van den Hove DLA, Mill J, Lunnon K ( 2018 ) . P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS . Alzheimer's & Dementia vol. 14 , ( 7S_Part_13 ) p723 - p723 .

Kim M, Snowden SG, Ahmad T, Westwood S, Baird AL, Proitsi P, Nevado-Holgado AJ, Hye A et al. ( 2018 ) . P3‐233: PLASMA PRIMARY FATTY AMIDES ASSOCIATE TO CSF AMYLOID LEVELS AND ALZHEIMER'S DISEASE PROGRESSION IN THE EMIF‐AD BIOMARKER DISCOVERY COHORT . Alzheimer's & Dementia vol. 14 , ( 7S_Part_22 ) p1161 - p1161 .

Consortium TB, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V et al. ( 2018 ) . Analysis of shared heritability in common disorders of the brain . Science vol. 360 , ( 6395 )

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S et al. ( 2018 ) . Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection . Nature Genetics vol. 50 , ( 3 ) 381 - 389 .

Velayudhan L, Poppe M, Archer N, Proitsi P, Brown RG, Lovestone S ( 2018 ) . Risk of developing dementia in people with diabetes and mild cognitive impairment . The British Journal of Psychiatry vol. 196 , ( 1 ) 36 - 40 .

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T et al. ( 2017 ) . Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity . Nature Communications vol. 8 , ( 1 )

Policicchio S, Ahmad AN, Powell JF, Proitsi P ( 2017 ) . Rheumatoid arthritis and risk for Alzheimer’s disease: a systematic review and meta-analysis and a Mendelian Randomization study . Scientific Reports vol. 7 , ( 1 )

Kim M, Nevado-Holgado A, Whiley L, Snowden SG, Soininen H, Kloszewska I, Mecocci P, Tsolaki M et al. ( 2017 ) . Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 60 , ( 3 ) 809 - 817 .

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A et al. ( 2017 ) . Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease . Nature Genetics vol. 49 , ( 9 ) 1373 - 1384 .

Westwood S, Hye A, Lleó A, Nevado‐Holgado AJ, Baird AL, Wallin A, Leslie A, Jimenez B et al. ( 2017 ) . [F1–02–02]: DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION . Alzheimer's & Dementia vol. 13 , ( 7S_Part_3 ) p174 - p175 .

Lupton MK, Benyamin B, Proitsi P, Nyholt DR, Ferreira MA, Montgomery GW, Heath AC, Madden PA et al. ( 2017 ) . No Genetic Overlap Between Circulating Iron Levels and Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 59 , ( 1 ) 85 - 99 .

Ostergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Day F, Boehme KL, Walter S, Kauwe JS et al. ( 2017 ) . ASSOCIATIONS BETWEEN POTENTIALLY MODIFIABLE RISK FACTORS AND ALZHEIMER DISEASE: A MENDELIAN RANDOMIZATION STUDY . EUROPEAN NEUROPSYCHOPHARMACOLOGY . vol. 27 , S166 - S167 .

Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H et al. ( 2016 ) . Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis . Alzheimer's & Dementia vol. 13 , ( 2 ) 140 - 151 .

Fogh I, Lin K, Tiloca C, Rooney J, Gellera C, Diekstra FP, Ratti A, Shatunov A et al. ( 2016 ) . Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis . JAMA Neurology vol. 73 , ( 7 ) 812 - 820 .

Traylor M, Adib‐Samii P, Harold D, Dichgans M, Williams J, Lewis CM, Markus HS, Fornage M et al. ( 2016 ) . Shared genetic contribution to ischemic stroke and Alzheimer's disease . Annals of Neurology vol. 79 , ( 5 ) 739 - 747 .

Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S et al. ( 2016 ) . Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins . Translational Psychiatry vol. 6 , ( 1 ) e719 - e719 .

Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL et al. ( 2016 ) . The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume . Neurobiology of Aging vol. 40 , 68 - 77 .

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M et al. ( 2016 ) . Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 49 , ( 4 ) 1105 - 1114 .

Xu J, Casas-Ferreira AM, Ma Y, Sen A, Kim M, Proitsi P, Shkodra M, Tena M et al. ( 2015 ) . Lipidomics comparing DCD and DBD liver allografts uncovers lysophospholipids elevated in recipients undergoing early allograft dysfunction . Scientific Reports vol. 5 , ( 1 )

Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, GERAD/PERADES et al. ( 2015 ) . Common polygenic variation enhances risk prediction for Alzheimer’s disease . Brain vol. 138 , ( 12 ) 3673 - 3684 .

Proitsi P, Min K, Whiley L, Newhouse S, Johnston C, Soininen H, Kloszewska I, Mecocci P et al. ( 2015 ) . O4‐05‐05: Genetic influences on metabolite levels in Alzheimer's disease . Alzheimer's & Dementia vol. 11 , ( 7S_Part_6 ) p279 - p280 .

Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JRB, Boehme KL et al. ( 2015 ) . Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study . PLOS Medicine vol. 12 , ( 6 )

Hosp F, Vossfeldt H, Heinig M, Vasiljevic D, Arumughan A, Wyler E, Consortium TGAERFAD, Landthaler M et al. ( 2015 ) . Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins . Cell Reports vol. 11 , ( 7 ) 1134 - 1146 .

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S et al. ( 2015 ) . A novel Alzheimer disease locus located near the gene encoding tau protein . Molecular Psychiatry vol. 21 , ( 1 ) 108 - 117 .

Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P et al. ( 2015 ) . Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease . Translational Psychiatry vol. 5 , ( 1 ) e494 - e494 .

Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C et al. ( 2015 ) . No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 47 , ( 3 ) 741 - 750 .

Velayudhan L, Gasper A, Pritchard M, Baillon S, Messer C, Proitsi P ( 2015 ) . Pattern of Smell Identification Impairment in Alzheimer’s Disease . Journal of Alzheimer's Disease vol. 46 , ( 2 ) 381 - 387 .

Consortium IGOAD, Jones L, Lambert J, Wang L, Choi S, Harold D, Vedernikov A, Escott‐Price V et al. ( 2014 ) . Convergent genetic and expression data implicate immunity in Alzheimer's disease . Alzheimer's & Dementia vol. 11 , ( 6 ) 658 - 671 .

Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M et al. ( 2014 ) . Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis . PLOS Medicine vol. 11 , ( 9 )

Proitsi P, Lupton MK, Velayudhan L, Hunter G, Newhouse S, Lin K, Fogh I, Tsolaki M et al. ( 2014 ) . Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease . Neurobiology of Aging vol. 35 , ( 12 ) 2883.e3 - 2883.e10 .

Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A et al. ( 2014 ) . Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease . PLOS ONE vol. 9 , ( 6 )

Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, Johnston C, Killick R et al. ( 2014 ) . Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology . Alzheimer's & Dementia vol. 10 , ( 6 ) 724 - 734 .

Gui H, Tang W-K, So M-T, Proitsi P, Sham PC, Tam PK, Ngan ES-W, Cherny SS et al. ( 2014 ) . Erratum to: RET and NRG1 interplay in Hirschsprung disease . Human Genetics vol. 133 , ( 5 ) 677 - 677 .

Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J et al. ( 2014 ) . Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain . Neurobiology of Aging vol. 35 , ( 8 ) 1850 - 1854 .

Lupton MK, Proitsi P, Lin K, Hamilton G, Daniilidou M, Tsolaki M, Powell JF ( 2013 ) . The Role of ABCA1 Gene Sequence Variants on Risk of Alzheimer's Disease . Journal of Alzheimer's Disease vol. 38 , ( 4 ) 897 - 906 .

Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S et al. ( 2013 ) . Candidate Blood Proteome Markers of Alzheimer's Disease Onset and Progression: A Systematic Review and Replication Study . Journal of Alzheimer's Disease vol. 38 , ( 3 ) 515 - 531 .

Lambert J-C, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, DeStefano AL et al. ( 2013 ) . Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease . Nature Genetics vol. 45 , ( 12 ) 1452 - 1458 .

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S et al. ( 2013 ) . Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood . Neurobiology of Aging vol. 35 , ( 2 ) 279 - 290 .

Whiley L, Sen A, Heaton J, Proitsi P, García-Gómez D, Leung R, Smith N, Thambisetty M et al. ( 2013 ) . Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease . Neurobiology of Aging vol. 35 , ( 2 ) 271 - 278 .

Mikula M, Proitsi P, Sattlecker M, O'Sullivan M, Simmons A, Mecocci P, Soininen H, Tsolaki M et al. ( 2013 ) . O4–09–04: Association of magnetic resonance imaging white matter lesions and cognitive decline in Alzheimer's disease . Alzheimer's & Dementia vol. 9 , ( 4S_Part_17 ) p701 - p701 .

Bazenet C, Kiddle S, Sattlecker M, Proitsi P, Simmons A, Westman E, Nelson S, Sterling D et al. ( 2013 ) . P4–344: Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study . Alzheimer's & Dementia vol. 9 , ( 4S_Part_22 ) p857 - p858 .

Sattlecker M, Pritchard M, Proitsi P, Kiddle S, Newhouse S, Simmons A, Johnston C, Leung R et al. ( 2013 ) . P4–354: Blood‐based biomarker discovery using aptamer capture (SOMAscan) platform technology . Alzheimer's & Dementia vol. 9 , ( 4S_Part_22 ) p861 - p861 .

Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M et al. ( 2013 ) . Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease . PLOS ONE vol. 8 , ( 6 )

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V et al. ( 2013 ) . Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease . Nature Genetics vol. 45 , ( 6 ) 712 - 712 .

Zou F, Belbin O, Carrasquillo MM, Culley OJ, Hunter TA, Ma L, Bisceglio GD, Allen M et al. ( 2013 ) . Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology . PLOS ONE vol. 8 , ( 5 )

Velayudhan L, Pritchard M, Powell JF, Proitsi P, Lovestone S ( 2013 ) . Smell identification function as a severity and progression marker in Alzheimer's disease . International Psychogeriatrics vol. 25 , ( 7 ) 1157 - 1166 .

Koutroumani M, Daniilidou M, Giannakouros T, Proitsi P, Liapi D, Germanou A, Nikolakaki E, Tsolaki M ( 2013 ) . The deletion variant of α2b-adrenergic receptor is associated with decreased risk in Alzheimer's disease and mild cognitive impairment . Journal of the Neurological Sciences vol. 328 , ( 1-2 ) 19 - 23 .

Seto W-K, Wong DK-H, Kopaniszen M, Proitsi P, Sham P-C, Hung IF-N, Fung J, Lai C-L et al. ( 2013 ) . HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B . Clinical Infectious Diseases vol. 56 , ( 12 ) 1695 - 1703 .

Gui H, Tang W-K, So M-T, Proitsi P, Sham PC, Tam PK, Sau-Wai Ngan E, Cherny SS et al. ( 2013 ) . RET and NRG1 interplay in Hirschsprung disease . Human Genetics vol. 132 , ( 5 ) 591 - 600 .

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A et al. ( 2013 ) . A Blood Gene Expression Marker of Early Alzheimer's Disease . Journal of Alzheimer's Disease vol. 33 , ( 3 ) 737 - 753 .

Velayudhan L, Proitsi P, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I et al. ( 2013 ) . Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease . Journal of Alzheimer's Disease vol. 33 , ( 3 ) 755 - 766 .

Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C et al. ( 2012 ) . TREM2 Variants in Alzheimer's Disease . New England Journal of Medicine vol. 368 , ( 2 ) 117 - 127 .

Newhouse S, Proitsi P, Sattlecker M, Lunnon K, Ibrahim Z, Johnston C, Lourdusamy A, Lupton M et al. ( 2012 ) . O1‐09‐03: Genome‐wide association analysis identifies common variants associated with measures of disease progression in patients with Alzheimer's disease . Alzheimer's & Dementia vol. 8 , ( 4S_Part_3 ) p101 - p101 .

Leung R, Simmons A, Proitsi P, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Oszewska I et al. ( 2012 ) . P1‐037: Plasma inflammatory markers correlate with severity in Alzheimer's disease . Alzheimer's & Dementia vol. 8 , ( 4S_Part_3 ) p119 - p120 .

Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M et al. ( 2012 ) . Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood . Journal of Alzheimer's Disease vol. 30 , ( 3 ) 685 - 710 .

Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A et al. ( 2012 ) . Identification of cis-regulatory variation influencing protein abundance levels in human plasma . Human Molecular Genetics vol. 21 , ( 16 ) 3719 - 3726 .

Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J et al. ( 2012 ) . Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS) . Neurobiology of Aging vol. 33 , ( 8 ) 1849.e5 - 1849.e18 .

Hudson G, Sims R, Harold D, Chapman J, Hollingworth P, Gerrish A, Russo G, Hamshere M et al. ( 2012 ) . No consistent evidence for association between mtDNA variants and Alzheimer disease . Neurology vol. 78 , ( 14 ) 1038 - 1042 .

Proitsi P, Powell JF ( 2012 ) . Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD) . Brain Research Bulletin vol. 88 , ( 5 ) 394 - 405 .

Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, Pritchard M, Lord K et al. ( 2012 ) . Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation . Neurobiology of Aging vol. 33 , ( 8 ) 1843.e9 - 1843.e17 .

Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R et al. ( 2012 ) . The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease . Journal of Alzheimer's Disease vol. 28 , ( 2 ) 377 - 387 .

Surguladze SA, Radua J, El-Hage W, Gohier B, Sato JR, Kronhaus DM, Proitsi P, Powell J et al. ( 2012 ) . Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitry . Translational Psychiatry vol. 2 , ( 1 ) e70 - e70 .

Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R et al. ( 2011 ) . No evidence that extended tracts of homozygosity are associated with Alzheimer's disease . Am J Med Genet B Neuropsychiatr Genet vol. 156B , ( 7 ) 764 - 771 .

Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R et al. ( 2011 ) . No evidence that extended tracts of homozygosity are associated with Alzheimer's disease . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 156 , ( 7 ) 764 - 771 .

Aiyaz M, Lupton MK, Proitsi P, Powell JF, Lovestone S ( 2011 ) . Complement activation as a biomarker for Alzheimer's disease . Immunobiology vol. 217 , ( 2 ) 204 - 215 .

Shi H, Medway C, Brown K, Kalsheker N, Goate A, Proitsi P, Powell J, Lovestone S et al. ( 2011 ) . P1‐262: Genetic Variants Influencing Human Longevity from Late‐Onset Alzheimer's Disease (LOAD) Genome‐Wide Association Studies (GWAS) . Alzheimer's & Dementia vol. 7 , ( 4S_Part_6 ) s195 - s195 .

Hodges A, Lunnon K, Furney S, Proitsi P, Sattlecker M, Dobson R, Lourdusamy A, Simmons A et al. ( 2011 ) . P4‐292: A blood gene expression biomarker of early Alzheimer's disease . Alzheimer's & Dementia vol. 7 , ( 4S_Part_24 ) e13 - e14 .

Proitsi P, Lupton M, Tsolaki M, Daniilidou M, Soininen H, Vellas B, Kloszewska I, Mecocci P et al. ( 2011 ) . P4‐337: A genotype risk score based on Type 2 diabetes risk factors is associated with lower risk for Alzheimer's disease in APOE e4 carriers . Alzheimer's & Dementia vol. 7 , ( 4S_Part_24 ) e28 - e29 .

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J-C, Carrasquillo MM, Abraham R, Hamshere ML et al. ( 2011 ) . Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease . Nature Genetics vol. 43 , ( 5 ) 429 - 435 .

Lupton MK, Proitsi P, Danillidou M, Tsolaki M, Hamilton G, Wroe R, Pritchard M, Lord K et al. ( 2011 ) . Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease . PLOS ONE vol. 6 , ( 2 )

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R et al. ( 2011 ) . Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease . PLOS ONE vol. 6 , ( 2 )

Furney Simon J., Kronenberg Deborah, Simmons Andrew, Güntert Andreas, Dobson Richard J., Proitsi Petroula, Wahlund Lars Olof, Kloszewska Iwona et al. ( 2011 ) . Combinatorial Markers of Mild Cognitive Impairment Conversion to Alzheimer's Disease - Cytokines and MRI Measures Together Predict Disease Progression . Advances in Alzheimer's Disease

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J et al. ( 2010 ) . Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease . Molecular Psychiatry vol. 16 , ( 11 ) 1130 - 1138 .

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R et al. ( 2010 ) . Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease . PLOS ONE vol. 5 , ( 11 )

Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund L-O, Simmons A, Tunnard C, Sobow T et al. ( 2010 ) . APOE ε2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes . Dementia and Geriatric Cognitive Disorders vol. 30 , ( 3 ) 229 - 237 .

Liu Y, Paajanen T, Westman E, Wahlund L-O, Simmons A, Tunnard C, Sobow T, Proitsi P et al. ( 2010 ) . Effect of APOE ε4 Allele on Cortical Thicknesses and Volumes: The AddNeuroMed Study . Journal of Alzheimer's Disease vol. 21 , ( 3 ) 947 - 966 .

Proitsi P, Lupton MK, Reeves SJ, Hamilton G, Archer N, Martin BM, Iyegbe C, Hollingworth P et al. ( 2010 ) . Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia . Neurobiology of Aging vol. 33 , ( 4 ) 791 - 803 .

Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E et al. ( 2010 ) . Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease . JAMA Psychiatry vol. 67 , ( 7 ) 739 - 748 .

Lunnon KS, Sivapalan H, Vincent A, Proitsi P, Pritchard M, Martin B, Lord K, Tunnard C et al. ( 2010 ) . P4‐114: Small Chronic Alterations in Gene Expression and Circulating Blood Cells in Alzheimer's Disease . Alzheimer's & Dementia vol. 6 , ( 4S_Part_21 ) e56 - e56 .

Smillie LD, Cooper AJ, Proitsi P, Powell JF, Pickering AD ( 2009 ) . Variation in DRD2 dopamine gene predicts Extraverted personality . Neuroscience Letters vol. 468 , ( 3 ) 234 - 237 .

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V et al. ( 2009 ) . Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease . Nature Genetics vol. 41 , ( 10 ) 1156 - 1156 .

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V et al. ( 2009 ) . Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease . Nature Genetics vol. 41 , ( 10 ) 1088 - 1093 .

Raznahan A, Toro R, Proitsi P, Powell J, Paus T, F. Bolton P, Murphy DGM ( 2009 ) . A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder . Journal of Neurodevelopmental Disorders vol. 1 , ( 3 ) 215 - 223 .

Proitsi P, Hamilton G, Tsolaki M, Lupton M, Daniilidou M, Hollingworth P, Archer N, Foy C et al. ( 2009 ) . A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD) . Neurobiology of Aging vol. 32 , ( 3 ) 434 - 442 .

Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PWJ, Landers JE, Sapp P et al. ( 2008 ) . Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration . Human Molecular Genetics vol. 18 , ( 3 ) 472 - 481 .

Hamilton G, Proitsi P, Williams J, O’Donovan M, Owen M, Powell J, Lovestone S ( 2007 ) . Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer’s Disease . NeuroMolecular Medicine vol. 9 , ( 4 ) 331 - 334 .

Proitsi P, Li T, Hamilton G, Di Forti M, Collier D, Killick R, Chen R, Sham P et al. ( 2007 ) . Positional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4 . Biological Psychiatry vol. 63 , ( 1 ) 13 - 16 .

Hamilton G, Proitsi P, Jehu L, Morgan A, Williams J, O'Donovan MC, Owen MJ, Powell JF et al. ( 2007 ) . Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 144B , ( 4 ) 508 - 516 .

Proitsi P, Hamilton G, Archer N, Foy C, Hollinworth P, Owen M, Williams J, Lovestone S et al. ( 2006 ) . P1–326: Statistical and genetic studies on the psychosis sub–phenotype in Alzheimer's disease . Alzheimer's & Dementia vol. 2 , ( 3S_Part_7 ) s192 - s192 .

Hollingworth P, Hamshere ML, Hill GT, Moore PJ, Ludford RM, Foy C, Archer N, Edmondson A et al. ( 2004 ) . P1-014 Principal components analysis of the neuropsychiatric inventory in Alzheimer's disease . Neurobiology of Aging vol. 25 ,