Publications: Dr Mohsin Badat

Badat M, Davies J ( 2025 ) . Clinical applications of gene editing and therapy . Hoffbrand's Postgraduate Haematology , Wiley

Preston AE, Frost JN, Teh MR, Badat M, Armitage AE, Norfo R, Wideman SK, Hanifi M et al. ( 2025 ) . Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis . Nature Communications vol. 16 , ( 1 )

Tummala H, Walne AJ, Badat M, Patel M, Walne AM, Alnajar J, Chow CC, Albursan I et al. ( 2024 ) . The evolving genetic landscape of telomere biology disorder dyskeratosis congenita . EMBO Molecular Medicine vol. 16 , ( 10 ) 2560 - 2582 .

Higgs D, Badat M ( 2024 ) . Beginnings: the molecular pathology of hemoglobin . Molecular Hematology , Wiley

Badat M, Ejaz A, Hua P, Rice S, Zhang W, Hentges LD, Fisher CA, Denny N et al. ( 2023 ) . Direct correction of haemoglobin E β-thalassaemia using base editors . Nature Communications vol. 14 , ( 1 )

Badat M, Sivaguru G, Bain BJ ( 2023 ) . Ophthalmic presentation of chronic myeloid leukemia in two adolescents . American Journal of Hematology vol. 98 , ( 7 ) 1117 - 1118 .

Preston AE, Frost JN, Badat M, Armitage AE, Wideman S, Teh M, Norfo R, Roy N et al. ( 2022 ) . An Ancient Transcriptional Hub Couples Developmentally Regulated Gene Expression with Metabolism during Erythropoiesis . Blood vol. 140 , ( Supplement 1 ) 4 - 5 .

Badat M, Hua P, Mettananda S, Fisher C, Roy N, Rice S, Roy A, Higgs D et al. ( 2022 ) . P104: BASE EDITING REPAIRS THE HBE MUTATION RESTORING THE PRODUCTION OF NORMAL GLOBIN CHAINS IN SEVERE HBE/β‐THALASSEMIA PATIENT HEMATOPOIETIC STEM AND ERYTHROID CELLS . HemaSphere vol. 6 , ( Suppl ) 19 - 20 .

Platton S, Schönborn L, Charrot S, Badat M, Boot J, McDonald V, Sivapalaratnam S, Bariana T et al. ( 2021 ) . Vaccine‐induced immune thrombocytopenia and thrombosis: The decline in anti‐platelet factor 4 antibodies is assay‐dependent . British Journal of Haematology vol. 197 , ( 4 ) 428 - 430 .

Badat M, Hua P, Mettananda S, Fisher C, Roy N, Rice S, Roy A, Higgs DR et al. ( 2021 ) . Base Editing Repairs the HbE Mutation Restoring the Production of Normal Globin Chains in Severe HbE/β-Thalassemia Patient Hematopoietic Stem Cells and Erythroid Cells . Blood vol. 138 , ( Supplement 1 )

Hua P, Badat M, Hanssen LLP, Hentges LD, Crump N, Downes DJ, Jeziorska DM, Oudelaar AM et al. ( 2021 ) . Defining genome architecture at base-pair resolution . Nature vol. 595 , ( 7865 ) 125 - 129 .

Badat M, Davies JOJ, Fisher CA, Downes DJ, Rose A, Glenthøj AB, van Beers EJ, Harteveld CL et al. ( 2021 ) . A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression . Blood vol. 137 , ( 4 ) 572 - 575 .

Badat M, Davies JOJ, van Beers EJ, Harteveld C, Downes D, Higgs DR ( 2018 ) . Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2 . Blood vol. 132 , ( Supplement 1 )

Higgs DR, Badat M ( 2018 ) . Switching genes on and off during Erythropoiesis . HemaSphere vol. 2 , ( Suppl 2 ) 24 - 26 .

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D et al. ( 2017 ) . Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia . Nature Communications vol. 8 , ( 1 )

Badat M, Davies J ( 2017 ) . Gene Therapy in a Patient with Sickle Cell Disease . New England Journal of Medicine vol. 376 , ( 21 ) 2093 - 2094 .

( 2016 ) . Ibrutinib for relapsed/refractory chronic lymphocytic leukemia: a UK and Ireland analysis of outcomes in 315 patients . Haematologica vol. 101 , ( 12 ) 1563 - 1572 .

Badat M, Oyesanya F, Cervi P ( 2016 ) . CLL with intra-cytoplasmic lymphocytic inclusion bodies . International Journal of Hematology vol. 104 , ( 4 ) 411 - 412 .

Maciocia P, Badat M, Cheesman S, D'Sa S, Joshi R, Lambert J, Mohamedbhai S, Pule M et al. ( 2015 ) . Treatment of diffuse large B‐cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS‐penetrating R‐IDARAM chemotherapy . British Journal of Haematology vol. 172 , ( 4 ) 545 - 553 .

Badat M, Kaya B, Telfer P ( 2015 ) . Combination‐therapy with concurrent deferoxamine and deferiprone is effective in treating resistant cardiac iron‐loading in aceruloplasminaemia . British Journal of Haematology vol. 171 , ( 3 ) 430 - 432 .

Maciocia PM, Badat M, Cheesman S, Lambert J, Pule M, Linch DC, Ardeshna KM ( 2013 ) . Treatment Of Non-Hodgkin's Lymphoma With Secondary Central Nervous System Involvement: Encouraging Response Rates Using CNS-Penetrating Idaram Chemotherapy . Blood vol. 122 , ( 21 )

Marzolini M, Poggiali E, Badat M, Cassinerio E, Cappellini MD, Porter JB ( 2012 ) . Spinal Artery Thrombosis: An Unrecognized Severe Complication in Thalassemia and Sickle Disorders . Blood vol. 120 , ( 21 )

Badat M ( 2011 ) . Red Beard . The BMJ vol. 342 , ( jan19 1 )